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1. 发明申请

WO2007002133A2 STRUCTURALLY VARIABLE STENTS 审中-公开
标题翻译：结构可变的支架
公开(公告)号：WO2007002133A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/024057
申请日：2006-06-20
申请人： JAYARAMAN, Swaminathan
发明人： JAYARAMAN, Swaminathan
IPC分类号： A61F2/90
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2002/91575 , A61F2002/91583 , A61F2230/0054 , A61F2250/0068
摘要： The present invention provides a tubular stent including a longitudinal cylindrical base structure having a first end portion, a second end portion, a mid-portion interposed between the first and second end portions. A plurality of linear strut members connect the mid-portion to the first and second end portions, where the first and second end portions has a first pattern and the mid portion has a second pattern different from the first pattern. The second pattern includes a plurality of articulations. Reservoirs are disposed on at least one of the first end portion, the second end portions, or the mid-portion, where the reservoirs include a pharmaceutical agent therein.
摘要翻译：本发明提供了一种管状支架，其包括纵向圆柱形基部结构，该纵向圆柱形基部结构具有第一端部，第二端部，介于第一和第二端部之间的中间部。多个线性支柱部件将中间部分连接到第一和第二端部，其中第一和第二端部具有第一图案，并且中部具有不同于第一图案的第二图案。第二图案包括多个关节。储器设置在第一末端部分，第二末端部分或中间部分中的至少一个上，其中储器中包括药剂。

2. 发明申请

WO2007118139A2 DRUG ELUTING STRUCTURALLY VARIABLE STENT 审中-公开
标题翻译：药物结构可变的手段
公开(公告)号：WO2007118139A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/066050
申请日：2007-04-05
申请人： VASCULAR CONCEPTS HOLDINGS LIMITED , JAYARAMAN, Swaminathan
发明人： JAYARAMAN, Swaminathan
IPC分类号： A61F2/90
CPC分类号： A61F2/86 , A61F2/88 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2230/0008 , A61F2230/0017 , A61F2230/0021 , A61F2230/0023 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/45
摘要： The present invention provides a stent including a tubular body having a plurality of reservoirs disposed therein and a therapeutic agent located in the reservoirs or located in the reservoirs and on a surface portion of the tubular body, wherein the stent is free of polymeric material. The invention also provides a drug-eluting stent made from the process of providing a polymer- free stent body having a plurality of reservoirs disposed therein, diluting a therapeutic agent in a polymer- free solvent to form an agent-solvent mixture, coating the stent with the agent-solvent mixture, and allowing the solvent to dissipate from the stent thereby leaving the agent disposed on the stent.
摘要翻译：本发明提供了一种支架，其包括管状主体，其具有设置在其中的多个储存器，以及位于储存器中或位于储存器中以及管状体的表面部分上的治疗剂，其中支架不含聚合材料。本发明还提供了一种药物洗脱支架，其由提供无聚合物支架体的方法制成，该支架主体具有设置在其中的多个储液器，在不含聚合物的溶剂中稀释治疗剂以形成药剂 - 溶剂混合物，与试剂 - 溶剂混合物，并且允许溶剂从支架中消散，从而使放置在支架上的试剂留下。

3. 发明申请

WO2003045456A1 PROCESS FOR COATING A SURFACE OF A STENT 审中-公开
标题翻译：涂覆一个表面的方法
公开(公告)号：WO2003045456A1
公开(公告)日：2003-06-05
申请号：PCT/US2002/037522
申请日：2002-11-22
申请人： JAYARAMAN, Swaminathan
发明人： JAYARAMAN, Swaminathan
IPC分类号： A61L27/00
CPC分类号： A61L31/10 , A61F2/91 , A61L2420/02
摘要： The invention relates to a method of coating a surface of a stent by contacting the stent with a coating solution containing a coating material, insenrting a thread through the lumen of the stent, and producing relative motion between the stent and the thread to substantially remove coating material located within the openings of the stent. Eliminating or minimizing coating material located within the openings preserves the functionality of the stent. The method can be used to apply a primer layer, a polymer, either with or without a therapeutic agent, and/or a top layer on the stent.
摘要翻译：本发明涉及一种通过使支架与含有涂层材料的涂层溶液接触来涂覆支架表面的方法，该方法使穿过支架内腔的螺纹不会发生，并且在支架和螺纹之间产生相对运动以基本上去除涂层位于支架开口内的材料。消除或最小化位于开口内的涂层材料保持了支架的功能。该方法可用于在支架上施用底涂层，聚合物，无论是否含有治疗剂，和/或顶层。

4. 发明申请

WO2017066262A1 SYSTEM AND METHOD FOR DELIVERY OF A THERAPEUTIC AGENT THROUGH A CATHETER 审中-公开
标题翻译：通过导管递送治疗剂的系统和方法
公开(公告)号：WO2017066262A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/056559
申请日：2016-10-12
申请人： JAYARAMAN, Swaminathan
发明人： JAYARAMAN, Swaminathan
IPC分类号： A61M5/00 , A61M25/00
CPC分类号： A61M5/00 , A61M5/14526 , A61M5/2053 , A61M5/31581 , A61M25/0084 , A61M2025/0086 , A61M2025/0087
摘要： A system and method for delivering a therapeutic agent such as filler materials, biocompatible gels, and other substances through a catheter. The therapeutic agent can be a single component or multiple components that are delivered separately or mixed just prior to delivery or at the delivery site. The system and method use an automated delivery mechanism to maximize delivery of the therapeutic agent to the target tissue and minimize loss of the therapeutic agent within the catheter. The system and method are particularly useful for interventional approaches that deliver therapeutic agents to the wall of the heart.
摘要翻译：通过导管递送治疗剂例如填充材料，生物相容性凝胶和其它物质的系统和方法。治疗剂可以是单一组分或多种组分，它们在分娩前或分娩部位分开或混合输送。该系统和方法使用自动输送机构来最大化治疗剂到靶组织的递送并且使导管内治疗剂的损失最小化。该系统和方法对于将治疗剂递送到心脏壁的介入方法特别有用。

5. 发明申请

WO2009092015A1 DELIVERY OF THERAPEUTIC AND MARKING SUBSTANCE THROUGH INTRA LUMEN EXPANSION OF A DELIVERY DEVICE 审中-公开
标题翻译：通过输送装置的内部扩张来输送治疗和标记物质
公开(公告)号：WO2009092015A1
公开(公告)日：2009-07-23
申请号：PCT/US2009/031300
申请日：2009-01-16
申请人： JAYARAMAN, Swaminathan
发明人： JAYARAMAN, Swaminathan
IPC分类号： A61M31/00
CPC分类号： A61M25/1002 , A61F2/958 , A61F2250/0067 , A61M25/1027 , A61M2025/105 , A61M2025/1088 , A61M2025/1095
摘要： A balloon catheter is formed with a plurality of depressions. The balloon is coated with a matrix incorporating a therapeutic substance, which additionally fills the depressions. When the balloon is expanded within a body lumen, the therapeutic substance may diffuse into the lumen wall, or all or a portion of the coating transfers to the lumen wall. A lattice frame may surround the balloon, applied prior to coating if the coating is to transfer, operative to maintain a more linear balloon profile during inflation, promoting more even transfer pressure. A contrast dye is incorporated into the transferred coating, enabling ready location and inspection of the treated lumen area. Projections may alternately be formed in the balloon surface, operative to urge the coating and therapeutic substance between cells, or past cell layers of the lumen, to the interior of the lumen wall.
摘要翻译：气囊导管形成有多个凹陷。用包含治疗物质的基质涂覆气球，其另外填充凹陷。当气囊在体腔内扩张时，治疗物质可以扩散到管腔壁中，或者全部或部分涂层转移到管腔壁。格子框架可以包围气囊，如果涂层要被涂覆，则在涂覆之前施加，以在充气期间维持更线性的球形轮廓，从而促进更均匀的转印压力。将对比染料并入转移的涂层中，使得能够准确定位和检查经处理的管腔区域。可以在气球表面中替代地形成投影，用于将细胞之间的涂层和治疗物质或腔的过去的细胞层推动到管腔壁的内部。

6. 发明申请

WO2008127328A1 INFERIOR VENA CAVA FILTER 审中-公开
标题翻译： INFERIOR VENA CAVA过滤器
公开(公告)号：WO2008127328A1
公开(公告)日：2008-10-23
申请号：PCT/US2007/066483
申请日：2007-04-12
申请人： JAYARAMAN, Swaminathan
发明人： JAYARAMAN, Swaminathan
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61F2/88 , A61F2002/016 , A61F2002/068 , A61F2230/0006 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2230/0091 , A61F2230/0093
摘要： The present invention relates to a vascular filter including a coiled wire formed of a shape memory material for implantation into a vessel. The vascular filter captures particulates within the blood flow in the vessel, without substantially interfering with the normal blood flow. Prior to implantation, the coiled wire is generally elongated and thereafter it reverts to a predetermined shape that is suitable for filtering the blood flow. The predetermined shape of the vascular filter includes a plurality of loops coaxially disposed about a longitudinal axis and has a conical portion and a cylindrical portion.
摘要翻译：本发明涉及一种血管过滤器，其包括由用于注入血管的形状记忆材料形成的盘绕线。血管过滤器捕获血管内血液中的微粒，而不会基本上干扰正常的血流。在植入之前，螺旋线通常是细长的，之后它回复到适合于过滤血流的预定形状。血管过滤器的预定形状包括围绕纵向轴线同轴设置的多个环，并且具有圆锥形部分和圆柱形部分。

7. 发明申请

WO2007118139A3 DRUG ELUTING STRUCTURALLY VARIABLE STENT 审中-公开
标题翻译：药物缓释结构可变支架
公开(公告)号：WO2007118139A3
公开(公告)日：2008-02-21
申请号：PCT/US2007066050
申请日：2007-04-05
申请人： VASCULAR CONCEPTS HOLDINGS LTD , JAYARAMAN SWAMINATHAN
发明人： JAYARAMAN SWAMINATHAN
IPC分类号： A61F2/86
CPC分类号： A61F2/86 , A61F2/88 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2230/0008 , A61F2230/0017 , A61F2230/0021 , A61F2230/0023 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/45
摘要： The present invention provides a stent including a tubular body having a plurality of reservoirs disposed therein and a therapeutic agent located in the reservoirs or located in the reservoirs and on a surface portion of the tubular body, wherein the stent is free of polymeric material. The invention also provides a drug-eluting stent made from the process of providing a polymer- free stent body having a plurality of reservoirs disposed therein, diluting a therapeutic agent in a polymer- free solvent to form an agent-solvent mixture, coating the stent with the agent-solvent mixture, and allowing the solvent to dissipate from the stent thereby leaving the agent disposed on the stent.
摘要翻译：本发明提供了一种支架，该支架包括具有设置在其中的多个储存器的管状体和位于储存器中或位于储存器中和管状体的表面部分上的治疗剂，其中支架不含聚合物材料。本发明还提供了一种药物洗脱支架，该支架由提供不含聚合物的支架主体的方法制成，所述支架主体具有设置在其中的多个储存器，将治疗剂稀释在无聚合物溶剂中以形成药剂 - 溶剂混合物，与药剂 - 溶剂混合物混合，并使溶剂从支架中消散，从而使药剂置于支架上。

8. 发明申请

WO2003045523A2 THERAPEUTIC COATING FOR AN INTRAVASCULAR IMPLANT 审中-公开
标题翻译：用于静脉内植入物的治疗涂层
公开(公告)号：WO2003045523A2
公开(公告)日：2003-06-05
申请号：PCT/US2002/037523
申请日：2002-11-22
申请人： JAYARAMAN, Swaminathan
发明人： JAYARAMAN, Swaminathan
IPC分类号： A64K
CPC分类号： A61K31/4745 , A61K31/436 , A61K38/13 , A61K45/06 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/45 , A61L2300/606 , A61K2300/00
摘要： The invention relates to a coating for an intravascular implant that prevents hyperproliferative vascular disease after a mechanical injury, such as angioplasty. The coating includes first and second agents, with the first agent acting on a calcium independent cellular pathway and the second agent acting on a calcium dependent cellular pathway. In an exemplary embodiment, the first agent is rapamycin and the second agent is cyclosporine A. The agents can be incorporated in a polymeric agent and can be applied either directly to the implant or on top of a primer layer placed on the implant. A top coat can be applied to the therapeutic coating, if desired.
摘要翻译：本发明涉及用于血管内植入物的涂层，其在机械损伤（例如血管成形术）之后预防过度增生性血管疾病。该涂层包括第一和第二试剂，其中第一试剂作用于不依赖钙的细胞通路，第二试剂作用于钙依赖性细胞通路。在一个示例性实施方案中，第一药剂是雷帕霉素，第二药剂是环孢霉素A.所述药剂可以掺入聚合剂中，并且可以直接施加到植入物上，或者施加在放置在植入物上的底漆层的顶部。如果需要，可以将面漆施用于治疗涂层。

9. 发明申请

WO2003043507A3 MODIFICATION OF PROPERTIES AND GEOMETRY OF HEART TISSUE TO INFLUENCE HEART FUNCTION 审中-公开
公开(公告)号：WO2003043507A3
公开(公告)日：2003-05-30
申请号：PCT/US2002/036929
申请日：2002-11-18
申请人： JAYARAMAN, Swaminathan
发明人： JAYARAMAN, Swaminathan
IPC分类号： A61B17/12
摘要： Materials, devices and methods for the treatment of congestive heart failure are disclosed. In these methods, the volume of the left ventricle is reduced, thereby increasing the efficiency of the pumping action of the heart. Volume reduction is accomplished by introduction of biocompatible materials into the wall of the left ventricle, or into the ventricle itself. Suitable biocompatible materials include those that undergo a phase transition within the ventricle or within the wall of the ventricle, and are thereby converted from a substantially liquid state to a substantially solid state. Such materials also include those which increase in volume during the transition from the liquid state to the solid state. Also disclosed is a method for ventricular geometry reduction wherein flexible, elastic bands are attached to the external surface of the heart to effect a decrease in the volume of the left ventricle. Finally, disclosed are devices including catheters and elastic bands that are usable in these treatments.

10. 发明申请

WO2017161283A1 OCCLUDING ANATOMICAL STRUCTURES 审中-公开
标题翻译：包括解剖结构
公开(公告)号：WO2017161283A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022986
申请日：2017-03-17
申请人： JAYARAMAN, Swaminathan
发明人： JAYARAMAN, Swaminathan
IPC分类号： A61B17/03 , A61F2/90
摘要： An elongate resilient tube of a mesh of shape memory alloy is used to therapeutically occlude an opening in body tissue. The tube is compressible so that it can be delivered to the opening in the body within a catheter. The tube self-expands as it is released from the catheter to contiguously form, sequentially, the following shapes: an outer bell-shaped structure; an inner bell-shaped structure disposed within the outer bell-shaped structure to conformingly engage an inner side of the outer bell-shaped structure; a tubular connector having a diameter substantially smaller than the inner bell-shaped structure, the tubular connector extending away from an apex of the inner bell-shaped structure; an inner plate- shaped structure; an outer plate-shaped structure; and a releasable connector. The bell shape is placed on one side of the opening, and the plate shape is placed on the other side of the opening, the connector passing through the opening.
摘要翻译：使用形状记忆合金网的细长弹性管来治疗性地阻塞身体组织中的开口。该管是可压缩的，以便它可以被输送到导管内的体内开口。当管从导管中释放时，管自扩张，以连续地形成以下形状：外钟形结构; 设置在外部钟形结构内的内部钟形结构，以与外部钟形结构的内侧一致地啮合; 管形连接器，其直径实质上小于内部钟形结构，管形连接器延伸远离内部钟形结构的顶点; 内部板状结构; 外部板状结构; 和一个可释放的连接器。钟形放置在开口的一侧，而板形放置在开口的另一侧，连接器穿过开口。

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