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41. 发明申请

WO0189788A9 PATTERNING OF SURFACES UTILIZING MICROFLUIDIC STAMPS INCLUDING THREE-DIMENSIONALLY ARRAYED CHANNEL NETWORKS 审中-公开
标题翻译：使用包括三维阵列通道网络在内的微流感标记的表面图案
公开(公告)号：WO0189788A9
公开(公告)日：2002-12-12
申请号：PCT/US0117246
申请日：2001-05-25
申请人： HARVARD COLLEGE , CHILDRENS MEDICAL CENTER , CHIU DANIEL T , JEON NOO-LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
发明人： CHIU DANIEL T , JEON NOO-LI , HUANG SUI , KANE RAVI , CHOI INSUNG S , INGBER DONALD E , WHITESIDES GEORGE M , ANDERSON JANELLE R
IPC分类号： B01F13/00 , B01L3/00 , B01L3/02 , B29C31/04 , B29C33/42 , B29C39/10 , B81B1/00 , B81C1/00 , C40B40/10 , C40B60/14 , G01N33/50 , B01J4/00 , B29C39/02
CPC分类号： C12N11/00 , B01F13/0059 , B01J2219/00382 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00725 , B01J2219/00743 , B01L3/0258 , B01L3/0262 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B29C31/04 , B29C33/424 , B29C39/10 , B33Y80/00 , B81B1/00 , B81C99/009 , B82Y5/00 , B82Y30/00 , C40B40/10 , C40B60/14 , G01N33/5005 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/815
摘要： The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods for fabrication the systems disclosed can provide a convenient route to topologically complex and improved microfluidic systems. The microfluidic systems can include three-dimensionally arrayed networks of fluid flow paths therein including channels that cross over or under other channels of the network without physical intersection at the points of cross over. The microfluidic networks can be fabricated via replica molding processes utilizing mold masters including surfaces having topological features formed by photolithography. The present invention also involves microfluidic systems and methods for fabricating complex patterns of materials, such as biological materials and cells, on surfaces utilizing the microfluidic systems. Specifically, the invention provides microfluidic surface patterning systems and methods for fabricating complex, discontinuous patterns on surfaces that can incorporate or deposit multiple materials onto the surfaces. The present invention also provides improved microfluidic stamps or applicators for microcontact surface patterning, which are able to pattern onto a surface arbitrary two-dimensional patterns, and which are able to pattern multiple substances onto a surface without the need for multiple steps of registration or stamping during patterning and without the need to selectively "ink" different regions of the stamp with different materials.
摘要翻译：本发明描述了改进的微流体系统和用于制造改进的微流体系统的程序，其包含一个或多个水平的微流体通道。用于制造所公开的系统的方法可以提供拓扑复杂和改进的微流体系统的方便的途径。微流体系统可以包括其中的流体流动路径的三维排列的网络，其中包括在交叉点处交叉的网络上或下方的通道，而没有物理交叉点。微流体网络可以通过使用模具主体的复制模制工艺制造，其中包括具有通过光刻形成的拓扑特征的表面。本发明还涉及在利用微流体系统的表面上制造诸如生物材料和细胞的复杂图案的微流体系统和方法。具体地，本发明提供了微流体表面图案化系统和用于在表面上制造复杂的不连续图案的方法，所述图案可以将多种材料结合或沉积到表面上。本发明还提供了用于微接触表面图案化的改进的微流体标记或涂布器，其能够将图案图案化成任意的二维图案，并且能够将多种物质图案化到表面上，而不需要多个对准或冲压的步骤在图案化期间，并且不需要使用不同材料选择性地“印刷”印模的不同区域。

42. 发明申请

WO9954786A9 ELASTOMERIC MASK AND USE IN FABRICATION OF DEVICES, INLCUDING PIXELATED ELECTROLUMINESCENT DISPLAYS 审中-公开
标题翻译：弹性掩模和在器件制造中的应用，嵌入像素电致发光显示器
公开(公告)号：WO9954786A9
公开(公告)日：2000-02-03
申请号：PCT/US9908623
申请日：1999-04-20
申请人： HARVARD COLLEGE , MASSACHUSETTS INST TECHNOLOGY , JACKMAN REBECCA J , DUFFY DAVID C , WHITESIDES GEORGE M , VAETH KATHLEEN M , JENSEN KLAVS F
发明人： JACKMAN REBECCA J , DUFFY DAVID C , WHITESIDES GEORGE M , VAETH KATHLEEN M , JENSEN KLAVS F
IPC分类号： B41C1/14 , B05D1/32 , G03F1/00 , G03F7/00 , G03F7/12 , H01L27/32 , H01L51/50 , H05B33/10
CPC分类号： C23C14/042 , B82Y10/00 , B82Y30/00 , B82Y40/00 , G03F1/00 , G03F7/0002 , G03F7/0007 , G03F7/12 , H01L27/32 , H01L27/3211 , H01L51/0011 , H01L51/56
摘要： An elastomeric mask is provided that allows deposition of a variety of materials through mask openings. The mask seals effectively against substrate surfaces, allowing simple deposition from fluid phase, gas phase, and the like or removal of material using gaseous or liquid etchants. The mask then can be simply peeled from the surface of the substrate leaving the patterned material behind. Multi-layered mask techniques are described in which openings in an upper mask allow selected openings of a lower mask to remain unshielded, while other openings of the lower mask are shielded. A first deposition step, followed by re-orientation of the upper mask to expose a different set of lower mask openings, allows selective deposition of different materials in different openings of the lower mask. Pixelated organic electroluminescent devices are provided via the described technique.
摘要翻译：提供了一种弹性体掩模，其允许通过掩模开口沉积各种材料。掩模有效地密封衬底表面，允许从流体相，气相等简单沉积或使用气体或液体蚀刻剂去除材料。然后可以从掩模的表面简单地剥离掩模，留下图案化材料。描述了多层掩模技术，其中上掩模中的开口允许下掩模的选定开口保持未屏蔽，而下掩模的其它开口被屏蔽。第一沉积步骤，随后重新取向上掩模以暴露不同组的下掩模开口，允许不同材料在下掩模的不同开口中的选择性沉积。通过所述技术提供像素化的有机电致发光器件。

43. 发明申请

WO9929280A2 ANTI-PICORNAVIRAL LIGANDS VIA A COMBINATORIAL COMPUTATIONAL AND SYNTHETIC APPROACH 审中-公开
标题翻译：通过组合计算和合成方法的反潜系统
公开(公告)号：WO9929280A2
公开(公告)日：1999-06-17
申请号：PCT/US9826352
申请日：1998-12-11
申请人： HARVARD COLLEGE , JOSEPH MCCARTHY DIANE M , ISAACS LYLE D , WHITESIDES GEORGE M , KARPLUS MARTIN , HOGLE JAMES M , CHEH JAMES LI WEN
发明人： JOSEPH-MCCARTHY DIANE M , ISAACS LYLE D , WHITESIDES GEORGE M , KARPLUS MARTIN , HOGLE JAMES M , CHEH JAMES LI-WEN
IPC分类号： A61K47/48 , A61K
CPC分类号： A61K47/6901 , Y10T436/14 , Y10T436/141111 , Y10T436/147777
摘要： The present invention provides structure-based combinatorial libraries of compounds containing the functional group minima of picornaviruses including poliovirus and rhinovirus. The libraries can be used to screen for therapeutical antiviral compounds, e.g., anti-picornaviral capsid-binding compounds.
摘要翻译：本发明提供了包含小核糖核酸病毒（包括脊髓灰质炎病毒和鼻病毒）的功能组最小值的化合物的基于结构的组合文库。文库可以用于筛选治疗性抗病毒化合物，例如抗小RNA病毒衣壳结合化合物。

44. 发明申请

WO2008070088A3 EDGE-EMITTING LIGHT-EMITTING DIODE ARRAYS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：边发射发光二极管阵列及其制造和使用方法
公开(公告)号：WO2008070088A3
公开(公告)日：2008-09-25
申请号：PCT/US2007024855
申请日：2007-12-05
申请人： NANO TERRA INC , MAYERS BRIAN T , CARBECK JEFFREY , SAADI WAJEEH , WHITESIDES GEORGE M
发明人： MAYERS BRIAN T , CARBECK JEFFREY , SAADI WAJEEH , WHITESIDES GEORGE M
IPC分类号： H01L33/20 , H01L33/24
CPC分类号： H01L33/24 , H01L33/20
摘要： The present invention is directed to edge-emitting light-emitting diode arrays, a process to prepare the edge-emitting light-emitting diode arrays, and process products prepared by the process.
摘要翻译：本发明涉及边缘发射型发光二极管阵列，制备边缘发射型发光二极管阵列的工艺以及由该工艺制备的工艺产品。

45. 发明申请

WO9639156A2 PHOSPHATE-BINDING POLYMERS FOR ORAL ADMINISTRATION 审中-公开
标题翻译：用于口服给药的磷酸盐结合聚合物
公开(公告)号：WO9639156A2
公开(公告)日：1996-12-12
申请号：PCT/US9608529
申请日：1996-06-03
申请人： GELTEX PHARMA INC , HOLMES FARLEY STEPHEN RANDALL , MANDEVILLE W HARRY III , WHITESIDES GEORGE M
发明人： HOLMES-FARLEY STEPHEN RANDALL , MANDEVILLE W HARRY III , WHITESIDES GEORGE M
IPC分类号： A61K9/14 , A61K31/00 , A61K31/785 , A61K31/795 , A61K45/08 , A61K47/30 , A61P3/00 , C08F8/00 , C08F20/00 , C08F20/02 , C08F20/52 , C08F22/38 , C08F26/00 , C08F26/02 , C08G59/40 , C08G73/00 , C08G73/02 , C08K5/02 , C08K5/09 , C08K5/11 , C08K5/1515 , C08K5/29 , C08L39/02 , C08L79/02
CPC分类号： A61K31/662 , A61K31/785 , A61K31/795
摘要： Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.
摘要翻译：提供磷酸盐结合聚合物用于从胃肠道去除磷酸盐。聚合物是口服给药的，并且可用于治疗高磷酸盐血症。

46. 发明申请

WO2009158039A8 PATTERNING PROCESSES COMPRISING AMPLIFIED PATTERNS 审中-公开
标题翻译：包含放大图案的图案处理方法
公开(公告)号：WO2009158039A8
公开(公告)日：2010-03-11
申请号：PCT/US2009003861
申请日：2009-06-29
申请人： NANO TERRA INC , MAYERS BRIAN T , CARBECK JEFFREY , SAADI WAJEEH , WHITESIDES GEORGE M
发明人： MAYERS BRIAN T , CARBECK JEFFREY , SAADI WAJEEH , WHITESIDES GEORGE M
IPC分类号： B05D1/28 , H01L21/70
CPC分类号： B05D5/00 , B82Y10/00 , B82Y40/00 , G03F7/0002 , H01L21/306
摘要： The present invention is directed to substrates comprising amplified patterns, methods for making the amplified patterns, and methods of using the amplified patterns to form surface features on the substrates.
摘要翻译：本发明涉及包括放大图案的基板，用于制作放大图案的方法，以及使用放大图案在基板上形成表面特征的方法。

47. 发明申请

WO2008070087A3 METHOD FOR PATTERNING A SURFACE 审中-公开
标题翻译：表面方法
公开(公告)号：WO2008070087A3
公开(公告)日：2009-04-30
申请号：PCT/US2007024854
申请日：2007-12-05
申请人： NANO TERRA INC , MERCK KGAA , MAYERS BRIAN T , CARBECK JEFF , SAADI WAJEEH , WHITESIDES GEORGE M , KUGLER RALF , KURSAWE MONIKA , CANISIUS JOHANNES
发明人： MAYERS BRIAN T , CARBECK JEFF , SAADI WAJEEH , WHITESIDES GEORGE M , KUGLER RALF , KURSAWE MONIKA , CANISIUS JOHANNES
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： The present invention is directed to methods for patterning surfaces using contact printing and pastes, pastes for use with the processes, and products formed therefrom.
摘要翻译：本发明涉及使用接触印刷和糊剂，用于该方法的浆料以及由其形成的产品来图案化表面的方法。

48. 发明申请

WO2016003519A3 HIGH THROUGHPUT FABRICATION OF SOFT MACHINES 审中-公开
标题翻译：软件机械的高速铣削加工
公开(公告)号：WO2016003519A3
公开(公告)日：2016-02-25
申请号：PCT/US2015025588
申请日：2015-04-13
申请人： HARVARD COLLEGE
发明人： TING JASON MING , TAYI ALOK SURYAVAMSEE , MOSADEGH BOBAK , WHITESIDES GEORGE M
IPC分类号： F03G7/06 , B32B27/08
CPC分类号： F03G7/06 , B29C65/02 , B29C66/0342 , B29C66/1122 , B29C66/45 , B29C66/5346 , B29C66/71 , B29C66/712 , B29C66/73921 , B32B3/26 , B32B5/028 , B32B7/02 , B32B27/08 , B32B27/40 , B32B37/04 , B32B37/18 , B32B2307/51 , Y10T156/10 , Y10T156/1041 , Y10T428/24331 , Y10T428/24612 , Y10T428/24942 , Y10T428/2495 , Y10T428/24983 , B29K2021/003 , B29K2075/00
摘要： A soft robot device includes at least a first thermoplastic layer and a second thermoplastic layer, wherein at least one layer is comprised of an extensible thermoplastic material; at least one layer is an inextensible layer; and at least one layer comprises a pneumatic network, wherein the pneumatic network is configured to be in fluidic contact with a pressurizing source, wherein the first and second thermoplastic layers are thermally bonded to each other.
摘要翻译：软的机器人装置至少包括第一热塑性层和第二热塑性层，其中至少一层由可伸长的热塑性材料构成; 至少一层是不可伸展的层; 并且至少一层包括气动网络，其中所述气动网络构造成与加压源流体接触，其中所述第一和第二热塑性层彼此热粘合。

49. 发明申请

WO2015160717A1 SOFT BUCKLING ACTUATORS 审中-公开
标题翻译：软起动执行机构
公开(公告)号：WO2015160717A1
公开(公告)日：2015-10-22
申请号：PCT/US2015025603
申请日：2015-04-13
申请人： HARVARD COLLEGE
发明人： YANG DIAN , WHITESIDES GEORGE M
IPC分类号： F15B7/06
CPC分类号： F15B15/10 , F15B15/02
摘要： A soft actuator is described, including: a rotation center having a center of mass; a plurality of bucklable, elastic structural components each comprising a wall defining an axis along its longest dimension, the wall connected to the rotation center in a way that the axis is offset from the center of mass in a predetermined direction; and a plurality of cells each disposed between two adjacent bucklable, elastic structural components and configured for connection with a fluid inflation or deflation source; wherein upon the deflation of the cell, the bucklable, elastic structural components are configured to buckle in the predetermined direction. A soft actuating device including a plurality of the soft actuators and methods of actuation using the soft actuator or soft actuating device disclosed herein are also described.
摘要翻译：描述了一种柔性致动器，包括：具有质心的旋转中心; 多个可屈曲的弹性结构部件，每个包括限定沿着其最长尺寸的轴线的壁，所述壁以沿着预定方向偏离质心的方式连接到旋转中心; 以及多个单元，每个单元均设置在两个相邻的可屈曲的弹性结构构件之间，并且构造成用于与流体充气或放气源连接; 其中，在所述电池放气时，所述可屈曲的弹性结构部件构造成沿所述预定方向弯曲。还描述了包括多个软致动器的软致动装置和使用本文公开的软致动器或软致动装置的致动方法。

50. 发明申请

WO2015069360A9 LOW STRAIN PNEUMATIC NETWORKS FOR SOFT ROBOTS 审中-公开
标题翻译：用于软运动的低应变气动网络
公开(公告)号：WO2015069360A9
公开(公告)日：2015-06-25
申请号：PCT/US2014051818
申请日：2014-08-20
申请人： HARVARD COLLEGE
发明人： MOSADEGH BOBAK , SHEPHERD ROBERT F , WHITESIDES GEORGE M
IPC分类号： B25J9/14
CPC分类号： B25J15/0023 , B25J9/142 , B25J15/12 , B25J18/06 , B29C65/70 , B29L2009/00 , F15B15/08 , F15B15/103
摘要： An actuator includes a plurality of chambers comprised of an extensible material, the chambers having interior side walls and exterior walls, wherein at least a portion of the interior side wall is separated from an interior side wall of an adjacent chamber; and a strain limiting base; and a channel that fluidically interconnects the plurality of chambers, wherein the interior walls are configured to be more compliant than the exterior walls.
摘要翻译：致动器包括由可伸展材料构成的多个室，所述室具有内侧壁和外壁，其中内侧壁的至少一部分与相邻室的内侧壁分离; 和应变限制基; 以及使所述多个室流体互连的通道，其中所述内壁被配置为比所述外壁更顺从。

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