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1. 发明申请

WO9934787A3 FAT-BINDING POLYMERS 审中-公开
标题翻译：脂肪结合聚合物
公开(公告)号：WO9934787A3
公开(公告)日：2000-01-20
申请号：PCT/US9900028
申请日：1999-01-04
申请人： GELTEX PHARMA INC
发明人： MANDEVILLE W HARRY III , WHITESIDES GEORGE M , HOLMES-FARLEY STEPHEN RANDALL
IPC分类号： A61K31/74 , A61K31/205 , A61K31/765 , A61K31/78 , A61K31/785 , A61P3/04
CPC分类号： A61K31/765 , A61K31/78 , A61K31/785 , A61K31/365 , A61K2300/00
摘要： The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.
摘要翻译：本发明涉及一种治疗肥胖症的方法，一种减少膳食脂肪吸收的方法，以及用于治疗患者中的高甘油三酯血症的方法以及用于该方法或用于制备药物的具体聚合物。所述方法包括向哺乳动物（例如人）口服施用治疗有效量的一种或多种脂肪结合聚合物的步骤。本发明的脂肪结合聚合物的施用有利于在消化之前从身体去除脂肪，具有最小的副作用和低毒性。在一个优选的实施方案中，一种或多种脂肪结合聚合物与一种或多种脂肪酶抑制剂，例如脂抑素和四氢脂抑素组合施用。

2. 发明申请

WO9915186A8 CATIONIC POLYMERS AS TOXIN-BINDING AGENTS 审中-公开
标题翻译：阳离子聚合物作为毒素结合剂
公开(公告)号：WO9915186A8
公开(公告)日：1999-07-01
申请号：PCT/US9818881
申请日：1998-09-08
申请人： GELTEX PHARMA INC
发明人： MANDEVILLE W HARRY III , NEENAN THOMAS X
IPC分类号： A61K31/785 , A61P31/00 , A61P43/00
CPC分类号： A61K31/785
摘要： A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.
摘要翻译：治疗哺乳动物例如人的致病毒素的方法，包括用治疗有效量的聚合物治疗哺乳动物，所述聚合物包含连接到聚合物主链上的阳离子基团。该聚合物可以是均聚物或共聚物。在一个实施方案中，聚合物是包含具有侧链铵基团的单体和疏水性单体的共聚物。

3. 发明申请

WO0069428A3 ANIONIC POLYMERS AS TOXIN BINDERS AND ANTIBACTERIAL AGENTS 审中-公开
标题翻译：阴离子聚合物作为毒素粘合剂和抗菌剂
公开(公告)号：WO0069428A3
公开(公告)日：2002-01-24
申请号：PCT/US0012943
申请日：2000-05-11
申请人： GELTEX PHARMA INC , KURTZ CAROLINE , FITZPATRICK RICHARD
发明人： KURTZ CAROLINE , FITZPATRICK RICHARD
IPC分类号： A61K31/78 , A61K31/00 , A61K31/74 , A61K31/795 , A61K38/14 , A61P1/00 , A61P31/00 , A61P31/04 , C08F20/06 , C08F20/54 , C08K5/00 , C08L25/18 , A61K31/765
CPC分类号： A61K31/74 , A61K31/795 , A61K38/14 , A61K31/415 , A61K2300/00
摘要： The present invention relates to a method of inhibiting a toxin in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer having a plurality of pendant acid functional groups which are directly attached to the polymer backbone or attached to the polymer backbone by a spacer group. The spacer group can have a length in the range from 0 to about 20 atoms. The toxin is, typically, an exotoxin secreted by a pathogenic microorganism, such as a bacterium.
摘要翻译：本发明涉及一种通过向动物施用治疗有效量的具有多个直接连接到聚合物主链或附着的侧链酸官能团的聚合物来抑制动物如人的毒素的方法通过间隔基团与聚合物主链结合。间隔基可以具有在0至约20个原子范围内的长度。毒素通常是由病原微生物如细菌分泌的外毒素。

4. 发明申请

WO9829107A3 POLY(DIALLYLAMINE)-BASED BILE ACID SEQUESTRANTS 审中-公开
标题翻译：聚（氨基甲酸） - 双酯酸序列
公开(公告)号：WO9829107A3
公开(公告)日：2001-03-01
申请号：PCT/US9723899
申请日：1997-12-29
申请人： GELTEX PHARMA INC , HOLMES FARLEY STEPHEN RANDALL , DHAL PRADEEP K , PETERSEN JOHN S
发明人： HOLMES-FARLEY STEPHEN RANDALL , DHAL PRADEEP K , PETERSEN JOHN S
IPC分类号： A61K31/785 , A61K31/787 , A61K31/795 , A61K47/48 , A61P3/06 , A61P9/10 , A61P43/00 , C08F26/04 , C08G61/12 , A61K31/14
CPC分类号： B82Y5/00 , A61K31/785 , A61K31/787 , A61K31/795 , A61K47/6949 , C08G61/12 , Y10S514/824
摘要： The present invention relates to a method for removing bile acids from a patient and certain polymers of use in the method. The method comprises the step of administering to the patient a therapeutically effective amount of a polymer composition which includes a poly(diallylamine) polymer which is substituted with hydrophobic groups. The hydrophobic groups can be a substituted or unsubstituted, straight chain or branched C3-C24-alkyl group, an aralkyl group or an aryl group.
摘要翻译：本发明涉及一种从患者中除去胆汁酸的方法以及在该方法中使用的某些聚合物。该方法包括向患者施用治疗有效量的聚合物组合物的步骤，所述聚合物组合物包括被疏水基团取代的聚（二烯丙基胺）聚合物。疏水基团可以是取代或未取代的直链或支链C 3 -C 24 - 烷基，芳烷基或芳基。

5. 发明申请

WO9922721A3 UNSUBSTITUTED POLYDIALLYLAMINE FOR TREATING HYPERCHOLESTEROLEMIA 审中-公开
标题翻译：用于治疗高胆固醇的非取代聚异丁烯
公开(公告)号：WO9922721A3
公开(公告)日：1999-08-05
申请号：PCT/US9822605
申请日：1998-10-26
申请人： GELTEX PHARMA INC
发明人： HUVAL CHAD CORI , HOLMES-FARLEY STEPHEN RANDALL , PETERSEN JOHN S , DHAL PRADEEP K
IPC分类号： A61K31/785 , A61P3/06 , A61P7/02 , A61P9/10
CPC分类号： A61K31/785 , Y10S514/824
摘要： A method for removing bile salts from a patient that includes administering to the patient a therapeutically effective amount of a non-absorbable polydiallylamine polymers.
摘要翻译：一种从患者中除去胆汁盐的方法，包括向患者施用治疗有效量的不可吸收的聚二烯丙基胺聚合物。

6. 发明申请

WO9639156A2 PHOSPHATE-BINDING POLYMERS FOR ORAL ADMINISTRATION 审中-公开
标题翻译：用于口服给药的磷酸盐结合聚合物
公开(公告)号：WO9639156A2
公开(公告)日：1996-12-12
申请号：PCT/US9608529
申请日：1996-06-03
申请人： GELTEX PHARMA INC , HOLMES FARLEY STEPHEN RANDALL , MANDEVILLE W HARRY III , WHITESIDES GEORGE M
发明人： HOLMES-FARLEY STEPHEN RANDALL , MANDEVILLE W HARRY III , WHITESIDES GEORGE M
IPC分类号： A61K9/14 , A61K31/00 , A61K31/785 , A61K31/795 , A61K45/08 , A61K47/30 , A61P3/00 , C08F8/00 , C08F20/00 , C08F20/02 , C08F20/52 , C08F22/38 , C08F26/00 , C08F26/02 , C08G59/40 , C08G73/00 , C08G73/02 , C08K5/02 , C08K5/09 , C08K5/11 , C08K5/1515 , C08K5/29 , C08L39/02 , C08L79/02
CPC分类号： A61K31/662 , A61K31/785 , A61K31/795
摘要： Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.
摘要翻译：提供磷酸盐结合聚合物用于从胃肠道去除磷酸盐。聚合物是口服给药的，并且可用于治疗高磷酸盐血症。

7. 发明申请

WO0193878A8 BISMUTH COMPOUNDS FOR THE TREATMENT AND PREVENTION OF MUCOSITIS 审中-公开
标题翻译：用于治疗和预防粘液病的双酚A化合物
公开(公告)号：WO0193878A8
公开(公告)日：2002-06-27
申请号：PCT/US0118722
申请日：2001-06-08
申请人： GELTEX PHARMA INC
发明人： GODDARD PHILIP J , KLINGER JEFFREY D , DHAL PRADEEP K , MANDEVILLE W HARRY III , FITZPATRICK RICHARD J , NEENAN THOMAS X
IPC分类号： A61K31/28 , A61K31/60 , A61K33/12 , A61K33/24 , A61P11/12
CPC分类号： A61K33/12 , A61K31/28 , A61K31/60 , A61K33/24 , A61K33/245 , Y10S514/901 , Y10S514/902 , Y10S514/925 , Y10S514/928 , A61K31/715 , A61K31/00 , A61K2300/00

8. 发明申请

WO0064428A3 POLYETHER-BASED BILE ACID SEQUESTRANTS 审中-公开
标题翻译：基于聚醚的双酸序列
公开(公告)号：WO0064428A3
公开(公告)日：2001-02-08
申请号：PCT/US0010808
申请日：2000-04-20
申请人： GELTEX PHARMA INC
发明人： HOLMES-FARLEY STEPHEN RANDALL , HUVAL CHAD CORI
IPC分类号： A61K31/785
CPC分类号： A61K31/785
摘要： The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The invention further relates to a method for reducing blood cholesterol, treating atherosclerosis, treating hypercholesterolemia and/or reducing plasma lipid content of a mammal. The methods of the invention comprise orally administering to the patient a therapeutically effective amount of a polymer characterized by a polyether backbone and amino or ammonium groups pendant therefrom. The amino nitrogen atoms can be substituted by one or more substituents independently selected from among substituted and unsubstituted, normal, branched and cyclic alkyl groups, and aryl groups. When the polymer comprises pendant ammonium or quaternary ammonium groups, the polymer will be associated with a pharmaceutically acceptable anion.
摘要翻译：本发明涉及一种用于隔离患者中胆汁酸的方法和用于该方法的特定聚合物。本发明还涉及降低血液胆固醇，治疗动脉粥样硬化，治疗高胆固醇血症和/或降低哺乳动物血浆脂质含量的方法。本发明的方法包括向患者口服给予治疗有效量的聚合物主链和由其悬挂的氨基或铵基团的聚合物。氨基氮原子可以被一个或多个独立地选自取代的和未取代的，正常的，支链的和环状的烷基和芳基中的取代基取代。当聚合物包含侧铵或季铵基团时，聚合物将与药学上可接受的阴离子缔合。

9. 发明申请

WO0032656A3 POLYMERS CONTAINING SPIROBICYCLIC AMMONIUM MOIETIES AND USE THEREOF 审中-公开
标题翻译：含有螺环铵的聚合物及其用途
公开(公告)号：WO0032656A3
公开(公告)日：2000-11-16
申请号：PCT/US9928139
申请日：1999-11-24
申请人： GELTEX PHARMA INC
发明人： DHAL PRADEEP K , POLOMOSCANIK STEVEN C
IPC分类号： A61K31/787 , C08F220/04 , C08F220/06 , C08F8/44 , A61K31/785 , C08F26/06
CPC分类号： A61K31/787 , C08F220/04 , C08F220/06
摘要： The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective amount of a spirobicyclic ammonium moiety-containing polymer composition to a mammal, such as a human, whereby bile acids are sequestered. The polymers of the invention comprise spirobicyclic ammonium moieties and optionally, further comprise a hydrophobic substituent, a quaternary ammonium-containing substituent or a combination thereof.
摘要翻译：本发明涉及用于螯合患者胆汁酸的方法和用于该方法的特定聚合物。该方法包括给哺乳动物如人施用治疗有效量的含螺双环铵部分的聚合物组合物，由此将胆汁酸螯合。本发明的聚合物包含螺二环铵部分并且任选地还包含疏水取代基，含季铵取代基或其组合。

10. 发明申请

WO9934786A3 LIPASE INHIBITING POLYMERS 审中-公开
标题翻译：脂肪抑制聚合物
公开(公告)号：WO9934786A3
公开(公告)日：2000-02-03
申请号：PCT/US9900195
申请日：1999-01-06
申请人： GELTEX PHARMA INC
发明人： MANDEVILLE W HARRY III , BOIE MOLLY KATE , GARIGAPATI VENKATA R
IPC分类号： A61K31/74 , A61K31/00 , A61K31/77 , A61K31/795 , A61K31/80 , A61P3/04 , A61P43/00
CPC分类号： A61K31/00 , Y10S514/909
摘要： The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.
摘要翻译：本发明的特征在于通过向患者施用已经被一个或多个抑制脂肪酶的基团取代的聚合物来治疗患者的肥胖症，脂肪酶是负责脂肪水解的酶。本发明还涉及本文所述方法中使用的聚合物以及新型中间体和制备聚合物的方法。

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