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1. 发明申请

WO2017024044A1 ENHANCED ELECTROCHEMICAL DETECTION USING NANOPARTICLES AND PRECIPITATION 审中-公开
标题翻译：使用纳米颗粒和降解增强电化学检测
公开(公告)号：WO2017024044A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/045369
申请日：2016-08-03
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , INGBER, Donald E. , HENRY, Olivier Y.F. , SUPER, Michael
发明人： INGBER, Donald E. , HENRY, Olivier Y.F. , SUPER, Michael
IPC分类号： B01J14/00 , C12Q1/68 , G01F1/64 , G01N27/416 , G01N33/50
CPC分类号： G01N33/581 , B01J2219/00653 , B82Y30/00 , C12Q1/68 , C12Q1/6816 , G01F1/64 , G01N33/5438 , C12Q2565/607
摘要： The invention described herein relates generally to methods, sensors, devices and kits for electrochemical detection of a target analyte in a sample. In certain aspects, the methods, sensors, devices and kits described herein can be used to detect low concentrations of at least one target analyte using small sample volumes. In some embodiments, methods, sensors and kits for detecting a microbe, microbe fragment or released endotoxin in a test sample, including bodily fluids such as blood and tissues of a subject, food, water, and environmental surfaces, are also provided herein.
摘要翻译：本文描述的发明一般涉及用于电化学检测样品中目标分析物的方法，传感器，装置和试剂盒。在某些方面，本文描述的方法，传感器，装置和试剂盒可用于使用小样品体积检测至少一种靶分析物的低浓度。在一些实施例中，本文还提供了用于检测测试样品中的微生物，微生物碎片或释放的内毒素的方法，传感器和试剂盒，包括体液如受试者的血液和组织，食物，水和环境表面。

2. 发明申请

WO2011091037A2 RAPID PATHOGEN DIAGNOSTIC DEVICE AND METHOD 审中-公开
标题翻译：快速病原体诊断装置和方法
公开(公告)号：WO2011091037A2
公开(公告)日：2011-07-28
申请号：PCT/US2011/021718
申请日：2011-01-19
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , YUNG, Chong Wing , INGBER, Donald E. , COOPER, Ryan Mcomber , VOLLMER, Frank , DOMANSKY, Karel , LESLIE, Daniel Christopher , SUPER, Michael
发明人： YUNG, Chong Wing , INGBER, Donald E. , COOPER, Ryan Mcomber , VOLLMER, Frank , DOMANSKY, Karel , LESLIE, Daniel Christopher , SUPER, Michael
IPC分类号： G01N35/08 , G01N33/48 , G01N33/52 , G01N33/58 , G01N1/38
CPC分类号： C12Q1/04 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2400/043 , G01N33/54306 , G01N33/54333 , G01N33/54366 , G01N35/0098
摘要： A microfluidic device of a diagnostic and detection system includes an inlet port connected by one or more microchannels to an outlet port and includes a capture and visualization chamber (CVC) connected to at least one microchannel. A fluid to be analyzed can be mixed with magnetic microbeads that have an affinity to become bound to target components, such as pathogens in the fluid. The fluid including the magnetically bound target components can be injected through the microfluidic device. Magnetic field gradient, such as provided by permanent or elecrto-magnets, can be applied to the fluid and the magnetically bound target components flowing through the microfluidic device to cause the magnetically bound target components to migrate into the (CVC) and become separated from the fluid. The magnetically bound target components can be analyzed and tested using various techniques to detect the presence of specific organic and inorganic materials, such as pathogens in bio-fluids and contamination in liquid food sources (e.g. water). The device and method provide a system for rapidly detecting pathogens and contamination in relatively small fluid samples.
摘要翻译：诊断和检测系统的微流体装置包括通过一个或多个微通道连接到出口端口的入口端口，并且包括连接到至少一个微通道的捕获和可视化腔室（CVC）。待分析的流体可以与具有亲和力的磁性微珠混合，以与目标组分（例如流体中的病原体）结合。包括磁性结合的目标组分的流体可以通过微流体装置注入。诸如由永久磁体或电磁体提供的磁场梯度可以施加到流体和流过微流体装置的磁性结合的目标组分，以使磁性结合的目标组分迁移到（CVC）中并与流体。可以使用各种技术来分析和测试磁性结合的目标组分，以检测特定有机和无机材料（例如生物流体中的病原体和液体食物源（例如水）中的污染）的存在。该装置和方法提供了用于快速检测相对较小的流体样品中的病原体和污染物的系统。

3. 发明申请

WO2010123545A3 ANGIOGENESIS INHIBITORS 审中-公开
公开(公告)号：WO2010123545A3
公开(公告)日：2010-10-28
申请号：PCT/US2010/001121
申请日：2010-04-16
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORPORATION , COREY, Elias, James , CZAKÓ, Barbara , KÜRTI, László , MAMMOTO, Akiko , INGBER, Donald, E.
发明人： COREY, Elias, James , CZAKÓ, Barbara , KÜRTI, László , MAMMOTO, Akiko , INGBER, Donald, E.
IPC分类号： C07J41/00 , C07J43/00 , A61K31/56 , A61P35/00
摘要： Compounds of Structural Formula I or pharmaceutically acceptable salts thereof, are effective inhibitors of angiogenesis:

4. 发明申请

WO2009149239A1 METHODS OF MODULATING ANGIOGENESIS VIA TRPV4 审中-公开
标题翻译：通过TRPV4调节血管生成的方法
公开(公告)号：WO2009149239A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046219
申请日：2009-06-04
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , INGBER, Donald, E. , THODETI, Charles, K.
发明人： INGBER, Donald, E. , THODETI, Charles, K.
IPC分类号： A61K38/00 , A61K31/70
CPC分类号： C12N15/1138 , A61K31/70 , A61K31/713 , A61K45/06 , C07K16/2842 , C12N2310/14 , G01N33/5064
摘要： The present invention relates to methods of inhibiting capillary endothelial (CE) cell migration, the formation of CE networks and angiogenesis, and uses thereof for the purpose of treating angiogenesis-related diseases and disorders, particularly when the diseases or disorders are directly related aberrant angiogenesis. Inhibition is achieved by inhibiting TRPV4 activity, such as the levels of TRPV4 expression, calcium influx through TRPV4, and/or the intracellular signaling from TRPV4 via β1 integrin activation.
摘要翻译：本发明涉及抑制毛细血管内皮细胞迁移，CE网络形成和血管生成的方法及其用于治疗血管生成相关疾病和病症的用途，特别是当疾病或病症直接相关异常血管生成。通过抑制TRPV4活性，例如TRPV4表达的水平，通过TRPV4的钙流入和/或通过β1整联蛋白激活来自TRPV4的细胞内信号传导来实现抑制。

5. 发明申请

WO2008156904A3 SYSTEMS AND METHODS FOR NANOMAGNETIC ACTUATION OF MOLECULAR CELL SIGNALING 审中-公开
标题翻译：用于分子细胞信号的纳米分解的系统和方法
公开(公告)号：WO2008156904A3
公开(公告)日：2009-03-19
申请号：PCT/US2008059738
申请日：2008-04-09
申请人： CHILDRENS MEDICAL CENTER , INGBER DONALD E , MANNIX ROBERT J , KUMAR SANJAY
发明人： INGBER DONALD E , MANNIX ROBERT J , KUMAR SANJAY
IPC分类号： A61K47/48 , A61N2/02
CPC分类号： A61K41/0052 , A61K47/48507 , A61K47/6835 , A61N2/00 , Y10S977/904
摘要： The present invention relates to signaling mechanisms that transduce magnetic inputs into physiological cellular outputs. More particularly, the present invention relates to systems and methods for non-invasively controlling cellular signaling functions and behaviors by harnessing receptor-mediated and intracellular molecular-mediated signal transduction using nanomagnetic cellular switches.
摘要翻译：本发明涉及将磁输入转换成生理细胞输出的信号传导机制。更具体地，本发明涉及通过利用纳米磁性细胞开关利用受体介导的和细胞内分子介导的信号转导来非侵入性地控制细胞信号传导功能和行为的系统和方法。

6. 发明申请

WO2008127295A3 GUIDED SELF-ASSEMBLY OF MATRICES WITH ORDERD NANO-SCALE STRUCTURE FOR TISSUE ENGINEERING 审中-公开
公开(公告)号：WO2008127295A3
公开(公告)日：2008-10-23
申请号：PCT/US2007/022397
申请日：2007-10-22
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , INGBER, Donald, E.
发明人： INGBER, Donald, E.
IPC分类号： A61F13/00
摘要： Described herein are methods for producing structures useful, for example, for tissue engineering. In their most general form, the methods described herein involve an enzyme activity immobilized on a surface, which is placed in contact with a solution comprising polypeptide monomers. The activity of the enzyme modifies the polypeptide monomers to promote polymerization of the monomers to form polymer structures associated with the surface. Thus, the methods described herein provide a guided self-assembly of polypeptide structures. In preferred embodiments, the self assembly is guided to form regular lattices or other specific structures by specifying the arrangement of the surfaces to which the enzyme, optionally with one or more co-factors, is attached.

7. 发明申请

WO2008127295A2 GUIDED SELF-ASSEMBLY OF MATRICES WITH ORDERD NANO-SCALE STRUCTURE FOR TISSUE ENGINEERING 审中-公开
标题翻译：指导用于组织工程的订单纳米尺度结构的矩阵自组装
公开(公告)号：WO2008127295A2
公开(公告)日：2008-10-23
申请号：PCT/US2007022397
申请日：2007-10-22
申请人： CHILDRENS MEDICAL CENTER , INGBER DONALD E
发明人： INGBER DONALD E
IPC分类号： H04Q7/22
CPC分类号： C12N5/0075 , C12N2533/56 , C12N2535/10
摘要： Described herein are methods for producing structures useful, for example, for tissue engineering. In their most general form, the methods described herein involve an enzyme activity immobilized on a surface, which is placed in contact with a solution comprising polypeptide monomers. The activity of the enzyme modifies the polypeptide monomers to promote polymerization of the monomers to form polymer structures associated with the surface. Thus, the methods described herein provide a guided self-assembly of polypeptide structures. In preferred embodiments, the self assembly is guided to form regular lattices or other specific structures by specifying the arrangement of the surfaces to which the enzyme, optionally with one or more co-factors, is attached.
摘要翻译：这里描述的是用于产生可用于例如组织工程的结构的方法。在其最一般的形式中，本文描述的方法涉及固定在表面上的酶活性，其被置于与包含多肽单体的溶液接触。酶的活性改变多肽单体以促进单体的聚合以形成与表面相关的聚合物结构。因此，本文所述的方法提供多肽结构的引导自组装。在优选的实施方案中，通过指定酶，任选地与一个或多个辅因子连接的表面的布置，引导自组装形成规则晶格或其它特定结构。

8. 发明申请

WO2007044642A3 DEVICE AND METHOD FOR COMBINED MICROFLUIDIC-MICROMAGNETIC SEPARATION OF MATERIAL IN CONTINUOUS FLOW 审中-公开
标题翻译：用于连续流动的材料组合微流化 - 微磁性分离的装置和方法
公开(公告)号：WO2007044642A3
公开(公告)日：2007-11-15
申请号：PCT/US2006039344
申请日：2006-10-06
申请人： HARVARD COLLEGE , INGBER DONALD E , XIA SHANNON , HUNT TOM P , WESTERVELT ROBERT M
发明人： INGBER DONALD E , XIA SHANNON , HUNT TOM P , WESTERVELT ROBERT M
IPC分类号： B01D35/06
CPC分类号： A61M1/3618 , A61M1/36 , A61M2205/0244 , A61M2206/11 , B01L3/502761 , B01L2200/0636 , B01L2200/0668 , B01L2300/06 , B01L2300/0864 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N2015/149 , Y10T436/25375
摘要： A miniaturized, integrated, microfluidic device pulls materials bound to magnetic particles from one laminar flow path to another by applying a local magnetic field gradient. The device removes microbial and mammalian cells from flowing biological fluids without any wash steps. A microfabricated high-gradient magnetic field concentrator (HGMC) is integrated at one side of a microfluidic channel. When magnetic particles are introduced into one flow path, they remain limited to that flow path. When the HGMC is magnetized, the magnetic beads are pulled from the initial flow path into the collection stream, thereby cleansing the fluid. The microdevice allows large numbers of beads and materials to be sorted simultaneously, has no capacity limit, does not lose separation efficiency as particles are removed, and is useful for cell separations from blood and other biological fluids. This on-chip separator allows cell separations to be performed in the field outside of hospitals and laboratories.
摘要翻译：小型化，集成化的微流体装置通过施加局部磁场梯度将结合到磁性粒子的材料从一个层流路径拉到另一层流路径。该装置不需要任何清洗步骤即可从流动的生物流体中去除微生物和哺乳动物细胞微制造的高梯度磁场集中器（HGMC）集成在微流体通道的一侧。当磁性颗粒被引入到一个流动路径中时，它们仍然限于该流动路径。当HGMC被磁化时，磁珠从初始流动路径被拉入收集流中，从而清洁流体。微装置允许大量的珠子和材料同时分选，没有容量限制，不会因为颗粒被去除而失去分离效率，并且可用于从血液和其他生物流体中分离细胞。这种片上分离器可以在医院和实验室以外的地方进行细胞分离。

9. 发明申请

WO2006039675A3 APPARATUS AND METHOD FOR NANOMANIPULATION OF BIOMOLECULES AND LIVING CELLS 审中-公开
标题翻译：生物分子和生物细胞纳米生物的装置和方法
公开(公告)号：WO2006039675A3
公开(公告)日：2006-06-29
申请号：PCT/US2005035551
申请日：2005-10-03
申请人： CHILDRENS MEDICAL CENTER , INGBER DONALD E , MATTHEWS BENJAMIN D , LAVAN DAVID A , OVERBY DARRYL
发明人： INGBER DONALD E , MATTHEWS BENJAMIN D , LAVAN DAVID A , OVERBY DARRYL
IPC分类号： A61N2/00
CPC分类号： A61B18/08 , A61M2037/0046 , A61N2/002
摘要： The present invention relates to an electromagnetic needle for magnetically manipulating microscopic particles and a method of making the same, and more particularly, to a method for nanomanipulating biomolecules and/or living cells using the electromagnetic needle of the present invention. The temperature-controlled electromagnetic microneedle includes an electromagnetic core having a magnetic probe tip. A wire coil is wound around at least a portion of the core and electrically isolated from the core. A thermo-regulating water jacket having a first and second end and enveloping the electromagnetic core and wire coil allows the probe tip to extend from the first end. Magnetically responsive particles upon which a biologically active substance is absorbed are administered to a subject. A catheter having a magnet attached thereto is inserted into the body of the subject. The magnet guides the particles to a site to be treated with the biologically active substance.
摘要翻译：本发明涉及一种用于磁微操作微粒的电磁针及其制造方法，更具体地说，涉及使用本发明的电磁针对生物分子和/或活细胞进行纳米操作的方法。温度控制电磁微针包括具有磁性探头尖端的电磁铁心。线圈缠绕在芯的至少一部分上并与芯电隔离。具有第一端和第二端并包封电磁铁芯和线圈线圈的热调节水套允许探针尖端从第一端延伸。对受试者施用吸收了生物活性物质的磁性响应性颗粒。具有附着于其上的磁体的导管插入到受试者的身体中。磁体将颗粒引导到要用生物活性物质处理的部位。

10. 发明申请

WO2004081729A3 A METHOD AND APPARATUS FOR DISPLAYING INFORMATION 审中-公开
标题翻译：一种用于显示信息的方法和装置
公开(公告)号：WO2004081729A3
公开(公告)日：2005-06-02
申请号：PCT/US2004006901
申请日：2004-03-05
申请人： CHILDRENS MEDICAL CENTER , INGBER DONALD E , HUANG SUI , EICHLER GABRIEL
发明人： INGBER DONALD E , HUANG SUI , EICHLER GABRIEL
IPC分类号： G06T11/60 , G09G5/22
CPC分类号： G06T11/60
摘要： A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles (Fig. 2, tiles A-I) each corresponding to a representative reference element; mapping (Fig. 3) observed elements onto the spatial layout of tiles of representative reference elements; assigning (Fig. 1, Table 1) a respective value to each respective tile of the spatial layout of the representative elements; and display (Fig. 4) an image of the spatial layout of tiles of representative elements. Each tile includes atomic attributes of representative elements. Each tile includes atomic attributes of representative elements. The invention also relates to an apparatus for displaying large amounts of information. The apparatus includes a tiler (SOM) forming a spatial layout of tiles, each corresponding to a representative reference element; a comparator (Fig. 3) mapping observed elements onto said spatial layout of tiles of representative reference elements; an assigner (Fig. 1, Table 1) assigning a respective value to each respective tile of said spatial layout of representative reference elements; and a display (Fig. 4) displaying an image of the spatial layout of tiles of representative reference elements.
摘要翻译：一种显示大量信息的方法。该方法包括以下步骤：形成每个对应于代表性参考元素的瓦片（图2，瓦片A-I）的空间布局; 将图像（图3）观察到元素到代表参考元素的瓦片的空间布局上; 将代表元素的空间布局的每个相应瓦片分配（图1，表1）相应的值; 并显示（图4）代表元素的瓦片的空间布局的图像。每个瓦片包括代表元素的原子属性。每个瓦片包括代表元素的原子属性。本发明还涉及一种用于显示大量信息的装置。该装置包括形成瓦片的空间布局的分片器（SOM），每个对应于代表参考元件; 将观察到的元素映射到代表性参考元素的瓦片的所述空间布局上的比较器（图3）分配器（图1，表1）为代表参考元件的所述空间布局的每个相应瓦片分配相应的值; 以及显示代表参考元素的瓦片的空间布局的图像的显示器（图4）。

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