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31. 发明申请

WO2006078775A1 IMIDAZOLE AND BENZIMIDAZOLE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS 审中-公开
标题翻译：作为组胺H3拮抗剂有用的咪唑和苯并咪唑衍生物
公开(公告)号：WO2006078775A1
公开(公告)日：2006-07-27
申请号：PCT/US2006/001832
申请日：2006-01-19
申请人： SCHERING CORPORATION , ASLANIAN, Robert, G. , TOM, Wing, C. , ZHU, Xiaohong
发明人： ASLANIAN, Robert, G. , TOM, Wing, C. , ZHU, Xiaohong
IPC分类号： C07D233/84 , C07D235/26 , C07D235/28 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D491/10 , A61K31/4164 , A61P11/06 , A61P37/08 , A61K31/4184 , A61K31/4439 , A61K31/4545 , A61K31/496
CPC分类号： C07D491/10 , C07D233/84 , C07D235/26 , C07D235/28 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14
摘要： Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein: n is 2-5; R is R 3 -aryl, R 3 -heteroaryl, R 3 -cycloalkyl, R 3 -heterocycloalkyl, alkyl, haloalkyl, -OR 4 , -SR 4 or -S(O) 1-2 R 5 ; R 1 and R 2 are H or optionally substituted phenyl or optionally substituted ; and X is -O- or -S-; or R 1 and R 2 , together with the carbon atoms to which they are attached form optionally substituted (a or b) ; and X is -O-, -S- or -NR 7 -; Z is (c, d, e, f, g or h) ; and the remaining variables are as defined in the specification; also disclosed are pharmaceutical compositions comprising the compounds of formula (I); also disclosed are methods of treating allergy, allergy-induced airway responses, congestion, obesity and metabolic syndrome using the compounds of formula (I), as well as combinations with other drugs useful for treating those diseases.
摘要翻译：公开了式（I）化合物或其药学上可接受的盐或溶剂化物，其中：n为2-5; R是R 3 - 芳基，R 3 - 杂芳基，R 3 - 环烷基，R 3 - 杂环烷基，烷基，卤代烷基，-OR 4，-SR 4或-S（O）2 1-2 R 5， ; R 1和R 2均为H或任选取代的苯基或任选取代的; 且X为-O-或-S-; 或R 1和R 2与它们所连接的碳原子一起形成任选取代的（a或b）; X是-O - ， - S-或-NR 7 - 。 Z是（c，d，e，f，g或h）; 剩余的变量如规范中所定义; 还公开了包含式（I）化合物的药物组合物; 还公开了使用式（I）化合物治疗过敏，过敏诱发的气道反应，充血，肥胖和代谢综合征的方法，以及与用于治疗这些疾病的其它药物的组合。

32. 发明申请

WO2004108133A3 MODULATORS OF VR1 RECEPTOR 审中-公开
标题翻译： VR1受体的调节剂
公开(公告)号：WO2004108133A3
公开(公告)日：2005-03-31
申请号：PCT/US2004017779
申请日：2004-06-04
申请人： VERTEX PHARMA , MAKINGS LEWIS R , GROOTENHUIS PETER , HURLEY DENNIS JAMES , TUNG ROGER D , TERMIN ANDREAS P
发明人： MAKINGS LEWIS R , GROOTENHUIS PETER , HURLEY DENNIS JAMES , TUNG ROGER D , TERMIN ANDREAS P
IPC分类号： A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/497 , A61K31/501 , A61K31/506 , A61P1/00 , A61P11/00 , A61P11/06 , A61P13/10 , A61P17/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P29/02 , A61P43/00 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/44 , C07D263/58 , C07D277/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/02 , C07D498/02
CPC分类号： A61K31/497 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/501 , A61K31/506 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/44 , C07D263/58 , C07D277/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds useful as modulators of the vanilloid receptor, and also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译：本发明涉及可用作香草素受体调节剂的化合物，并且还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。

33. 发明申请

WO2005025498A3 SUBSTITUTED ACETANILIDES AND BENZAMIDES FOR THE TREATMENT OF ASTHMA AND PULMONARY INFLAMMATION 审中-公开
公开(公告)号：WO2005025498A3
公开(公告)日：2005-03-24
申请号：PCT/US2004/028063
申请日：2004-08-26
申请人： CORUS PHARMA , BAKER, William, R , STASIAK, Marcin , MACLEOD, David
发明人： BAKER, William, R , STASIAK, Marcin , MACLEOD, David
IPC分类号： A61K31/17 , A61K31/36 , A61K31/40 , A61K31/55 , A61K31/167 , A61K31/495 , A61K31/535 , A61K31/565 , A61K31/4015 , A61K31/4453 , C07D207/09 , C07D207/46 , C07D211/22 , C07D211/32 , C07D223/04 , C07D225/02 , C07D233/64 , C07D237/28 , C07D241/04 , C07D241/36 , C07D265/30 , C07D295/24 , C07D295/104 , C07D401/04 , C07D405/00 , C07D471/04 , C07D487/04 , C07D235/26 , C07D295/12
摘要： Substituted acetanilide or benzamide compositions or formulations for delivery by aerosolization are described. The formulation contains an efficacious amount of acetanilide or benzamide compound able to inhibit inflammation in asthmatic lungs. Compounds of the invention are formulated in 5 ml solution of a quarter normal saline having pH between 5.0 and 7.0. The method for treatment of respiratory tract inflammation by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 µ, produced by nebulization or dry powder inhaler.

34. 发明申请

WO2004052847A3 TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS 审中-公开
标题翻译：三环类甾体激素核受体调节剂
公开(公告)号：WO2004052847A3
公开(公告)日：2004-09-10
申请号：PCT/US0316213
申请日：2003-06-13
申请人： LILLY CO ELI , COGHLAN MICHAEL JOSEPH , GREEN JONATHAN EDWARD , GRESE TIMOTHY ALAN , JADHAV PRABHAKAR KONDAJI , MATTHEWS DONALD PAUL , STEINBERG MITCHELL IRVIN , FALES KEVIN ROBERT , BELL MICHAEL GREGORY
发明人： COGHLAN MICHAEL JOSEPH , GREEN JONATHAN EDWARD , GRESE TIMOTHY ALAN , JADHAV PRABHAKAR KONDAJI , MATTHEWS DONALD PAUL , STEINBERG MITCHELL IRVIN , FALES KEVIN ROBERT , BELL MICHAEL GREGORY
IPC分类号： C07D295/08 , A61K31/015 , A61K31/03 , A61K31/04 , A61K31/045 , A61K31/055 , A61K31/09 , A61K31/10 , A61K31/335 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4436 , A61K31/4453 , A61K31/4965 , A61K31/5377 , A61K31/55 , A61P1/04 , A61P1/16 , A61P3/04 , A61P3/08 , A61P3/10 , A61P3/12 , A61P3/14 , A61P5/26 , A61P5/38 , A61P5/46 , A61P7/04 , A61P7/10 , A61P9/00 , A61P9/02 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P17/10 , A61P19/02 , A61P19/10 , A61P25/02 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07C22/04 , C07C22/08 , C07C25/22 , C07C25/24 , C07C33/38 , C07C39/17 , C07C39/23 , C07C39/42 , C07C43/215 , C07C43/225 , C07C43/23 , C07C47/548 , C07C47/57 , C07C49/835 , C07C205/06 , C07C205/35 , C07C211/32 , C07C211/45 , C07C215/76 , C07C217/84 , C07C233/07 , C07C233/65 , C07C233/84 , C07C235/16 , C07C251/40 , C07C251/48 , C07C255/50 , C07C261/04 , C07C271/14 , C07C275/28 , C07C307/10 , C07C311/03 , C07C311/08 , C07C311/09 , C07C311/16 , C07C311/20 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/32 , C07C321/28 , C07C323/49 , C07D209/08 , C07D209/34 , C07D211/18 , C07D213/127 , C07D213/16 , C07D213/65 , C07D213/73 , C07D213/76 , C07D213/81 , C07D221/16 , C07D223/20 , C07D231/12 , C07D231/18 , C07D233/26 , C07D233/64 , C07D233/84 , C07D235/26 , C07D241/12 , C07D241/20 , C07D241/26 , C07D261/08 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D295/092 , C07D295/22 , C07D295/26 , C07D313/14 , C07D333/80 , C07D337/12 , C07D337/14 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D471/04 , C07D487/04 , C07D491/044 , A61K31/18 , A61K31/553 , C07D235/14 , C07D313/12
CPC分类号： C07D213/16 , C07C22/04 , C07C22/08 , C07C25/24 , C07C33/38 , C07C39/17 , C07C39/23 , C07C39/42 , C07C43/215 , C07C43/225 , C07C43/23 , C07C47/548 , C07C47/57 , C07C49/835 , C07C69/00 , C07C69/618 , C07C69/65 , C07C205/06 , C07C205/34 , C07C205/35 , C07C211/28 , C07C211/32 , C07C211/45 , C07C215/76 , C07C217/84 , C07C233/07 , C07C233/65 , C07C233/84 , C07C235/16 , C07C251/40 , C07C251/48 , C07C255/50 , C07C261/04 , C07C271/14 , C07C275/28 , C07C307/10 , C07C311/03 , C07C311/08 , C07C311/09 , C07C311/16 , C07C311/20 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/32 , C07C321/28 , C07C323/49 , C07C2601/02 , C07C2603/32 , C07C2603/40 , C07C2603/78 , C07C2603/86 , C07D209/08 , C07D209/34 , C07D211/96 , C07D213/06 , C07D213/73 , C07D213/76 , C07D213/81 , C07D221/16 , C07D223/20 , C07D231/12 , C07D231/18 , C07D233/26 , C07D233/68 , C07D233/84 , C07D235/26 , C07D241/12 , C07D241/20 , C07D261/08 , C07D261/10 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D295/088 , C07D295/26 , C07D313/12 , C07D333/78 , C07D333/80 , C07D337/12 , C07D401/06 , C07D405/06 , C07D409/04 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/044
摘要： The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula (I): or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula (I), including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula (I).
摘要翻译：本发明涉及治疗对类固醇激素核受体调节敏感的病理性疾病的方法，该方法包括给需要治疗的患者施用有效量的式（I）化合物或其药学上可接受的盐。此外，本发明提供了式（I）的新型药物化合物，包括其药学上可接受的盐，以及包含式（I）化合物作为活性成分的药物组合物。

35. 发明申请

WO2004032861A2 HEXAHYDRO-BENZIMIDAZOLONE COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：十六氢苯并咪唑化合物有效用作抗炎剂
公开(公告)号：WO2004032861A2
公开(公告)日：2004-04-22
申请号：PCT/US0331960
申请日：2003-10-09
申请人： SQUIBB BRISTOL MYERS CO , DHAR T G MURALI , POTIN DOMINIQUE , MAILLET MAGALI JEANNINE BLANDI , LAUNAY MICHELE , NICOLAI ERIC ANTOINE , IWANOVICZ EDWIN J
发明人： DHAR T G MURALI , POTIN DOMINIQUE , MAILLET MAGALI JEANNINE BLANDI , LAUNAY MICHELE , NICOLAI ERIC ANTOINE , IWANOVICZ EDWIN J
IPC分类号： A61K20060101 , A61K31/415 , A61K31/4184 , A61K31/4188 , A61K31/437 , A61K31/4745 , C07D235/26 , C07D237/26 , C07D403/10 , C07D471/02 , A61K
CPC分类号： C07D235/26 , C07D403/10
摘要： The present invention is directed to compounds having the formula (I) useful in treating inflammatory and immune diseases, in which K is O or S; Q is -C(=O)- or optionally substituted C1-4alkylene; Ar is optionally-substituted aryl or heteroaryl; J1, J2, J3, and Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; Z is N or C(R9); and R1, R2, R3 and R9 are as defined in the specification.
摘要翻译：本发明涉及具有式（I）的化合物，其可用于治疗炎症和免疫疾病，其中K是O或S; Q是-C（= O） - 或任选取代的C 1-4亚烷基; Ar是任选取代的芳基或杂芳基; 选择J1，J2，J3和Y，使得环A为具有0至2个氮杂原子的5至6元任选取代的环烯基或杂环; Z是N或C（R9）; 并且R1，R2，R3和R9如本说明书中所定义。

36. 发明申请

WO2004002962A1 NOVEL BENZIMIDAZOL-2-ONE DERIVATIVES AND THEIR USE 审中-公开
标题翻译：新的苯并咪唑-2-酮衍生物及其用途
公开(公告)号：WO2004002962A1
公开(公告)日：2004-01-08
申请号：PCT/DK2003/000402
申请日：2003-06-17
申请人： POSEIDON PHARMACEUTICALS A/S , MADSEN, Lars, Siim , BÆK, Camilla, Ærteberg , LAURIDSEN, Annette , OLESEN, Søren, Peter
发明人： MADSEN, Lars, Siim , BÆK, Camilla, Ærteberg , LAURIDSEN, Annette , OLESEN, Søren, Peter
IPC分类号： C07D235/26
CPC分类号： C07D235/26
摘要： The present invention provides novel benzimidazol-2-one derivatives useful as therapeutic agents.
摘要翻译：本发明提供可用作治疗剂的新型苯并咪唑-2-酮衍生物。

37. 发明申请

WO2003104203A1 THERAPEUTIC MOLECULES AND METHODS-1 审中-公开
标题翻译：治疗分子与方法1
公开(公告)号：WO2003104203A1
公开(公告)日：2003-12-18
申请号：PCT/AU2003/000717
申请日：2003-06-06
申请人： CORTICAL PTY LTD , MORAND, Eric, Francis , ISKANDER, Magdy, Naguib
发明人： MORAND, Eric, Francis , ISKANDER, Magdy, Naguib
IPC分类号： C07D235/26
CPC分类号： C07D403/12 , A61K31/4184 , A61K31/585 , C07C43/225 , C07C43/23 , C07C45/004 , C07C45/46 , C07C59/58 , C07C65/24 , C07C65/28 , C07C69/94 , C07C205/59 , C07C229/70 , C07C255/37 , C07C309/60 , C07C309/75 , C07C333/04 , C07D235/26 , C07D235/28 , C07D263/58 , C07D307/83 , C07D319/18 , C07H13/10 , Y02A50/401 , Y02A50/411 , C07C47/575 , C07C49/84
摘要： Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) as defined herein, is provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as part of a combination therapy. Novel heterocyclic compounds are also provided for.
摘要翻译：提供了抑制巨噬细胞迁移抑制因子（MIF）的细胞因子或生物活性的方法，其包括使MIF与本文定义的式（I）化合物接触。本发明还涉及治疗涉及MIF细胞因子或生物学活性的疾病或病症的方法，包括单独施用或作为组合疗法的一部分施用式（I）化合物。还提供了新的杂环化合物。

38. 发明申请

WO0236075A3 SMALL MOLECULE COMPOSITIONS FOR BINDING TO HSP90 审中-公开
标题翻译：用于绑定到HSP90的小分子组合物
公开(公告)号：WO0236075A3
公开(公告)日：2003-06-05
申请号：PCT/US0146303
申请日：2001-11-01
申请人： SLOAN KETTERING INST CANCER , CHIOSIS GABRIELA , ROSEN NEAL
发明人： CHIOSIS GABRIELA , ROSEN NEAL
IPC分类号： G01N33/53 , A61K31/52 , A61K45/00 , A61P35/00 , A61P43/00 , C07D209/36 , C07D473/00 , C07D473/34 , C07D473/40 , C07K14/47 , G01N33/15 , G01N33/566 , C07D487/04 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/519 , A61K31/522 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/26 , C07D263/56 , C07D263/57 , C07D277/64 , C07D277/66 , C07D471/04 , C07D473/02 , C07D473/18 , C07D473/22 , C07D473/24 , C07D473/28 , C07D473/30 , C07D473/36 , C07D498/04 , C07D513/04 , G01N33/543
CPC分类号： C07D473/00 , A61K31/52 , C07D209/36 , C07D473/34 , C07D473/40
摘要： Structural differences in binding pockets of members of the HSP90 family are exploited to achieve differential degradation of k nases and other signaling proteins by using small molecules which interact with the N-terminal binding pocket with an affinity greater than ADP and different from ansamycin antibiotics for at least one HSP90 family species (Figure 5). These small molecules are soluble in aqueous media, providing a further advantage over ansamycins. Pharmaceutical compositions contain a carrier and a molecule that includes a moiety which binds to the N-terminal pocket of at least one member of the HSP90 family. Such binding moieties have anti proliferative activity against tumor cells which depend on proteins requiring chaperones of the HSP90 family. Different chemical species have different activity, allowing the selection of Her2 degradation without degradation of Raf kinase. Thus, the binding moieties possess inherent targeting capacity. The small molecules can be linked to targeting moieties to target the activity to specific classes of cells. The invention includes treatment of diseases, including cancers. Dimeric forms of the binding moieties may be employed.
摘要翻译：利用HSP90家族成员结合口袋的结构差异，通过使用与N-末端结合口袋相互作用的小分子，以比ADP更大的亲和力和不同于安莎霉素抗生素的小分子来实现k蛋白和其他信号蛋白的差异降解至少有一个HSP90家族（图5）。这些小分子可溶于含水介质，提供了比安莎霉素更优越的优点。药物组合物含有载体和分子，其包括结合HSP90家族的至少一个成员的N末端口袋的部分。这种结合部分具有抗肿瘤细胞的抗增殖活性，其依赖于需要HSP90家族伴侣蛋白质的蛋白质。不同的化学物种具有不同的活性，允许选择Her2降解而不降解Raf激酶。因此，结合部分具有固有的靶向能力。小分子可以连接到靶向部分以将活性靶向特定类别的细胞。本发明包括治疗疾病，包括癌症。可以使用结合部分的二聚体形式。

39. 发明申请

WO02092088A3 NOVEL USE OF 2H-BENZIMIDAZOL-2-ONE, 1,3-DIHADRO-1-(2{4-{3-(TRIFLUOROMETHYL}PHENYL]-1-PIPERAZINYL}ETHYL)- AND ITS PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION SALTS 审中-公开
标题翻译： 2H-苯并咪唑-2-酮，1,3-二氢-1-（2 {4- {3-（三氟甲基）苯基] -1-哌嗪基}乙基） - 及其生理学上可接受的酸添加剂的新用途
公开(公告)号：WO02092088A3
公开(公告)日：2003-01-30
申请号：PCT/EP0205182
申请日：2002-05-10
申请人： BECK JUERGEN K
发明人： BECK JUERGEN K
IPC分类号： C07D235/26 , A61K31/165 , A61K31/198 , A61K31/495 , A61K31/496 , A61P25/02 , A61P25/14 , A61P25/16
CPC分类号： A61K31/496 , A61K31/495
摘要： Use of 2H-benzimidazol-2-one, 1,3-dihydro-1-(2{4-[-(trifluoromethyl)phenyl]-1-piperazinyl}ethyl)-or a physiologically acceptable acid addition salt thereof, for the manufacture of a medicament for the treatment of extrapyramidal movement disorders. These extrapyramidal movement disorders may result from idopathic Parkinson's disease, from the adverse effects of the administration of anti-Parkinson drugs in idiopathic Parkinson's disease, from dyskinesias caused by idiopathic Parkinson's disease and/or long-term administration of anti-Parkinson drugs, from Parkinson-like or Parkinson-related syndromes of from Parkinsonoid symptomes. Another aspect of the present invention concerns a pharmaceutical composition comprising, as active ingredients -(I) 2H-benzimidazol-2-one, 1,3-dihydro-1-(2-{4-[3-(trifluoromethyl)phenyl]-1-piperazinyl}ethyl)-or a physiologically acceptable acid addition salt thereof, and (II) at least one anti-Parkinson drug, in combination with one or more pharmaceutically acceptable excipients.
摘要翻译：使用2H-苯并咪唑-2-酮，1,3-二氢-1-（2 - { - [ - （ - 三氟甲基）苯基] -1-哌嗪基}乙基）或其生理上可接受的酸加成盐，用于制造的用于治疗锥体束外运动障碍的药物。这些锥体外系运动障碍可能是由于帕金森氏病，由帕金森病，特发性帕金森病引起的运动障碍和/或帕金森病药物长期服用引起的帕金森病药物的不良反应，类似帕金森病或帕金森综合征。本发明的另一方面涉及一种药物组合物，其包含作为活性成分的（I）2H-苯并咪唑-2-酮，1,3-二氢-1-（2- {4- [3-（三氟甲基）苯基] - 1-哌嗪基}乙基）或其生理上可接受的酸加成盐，和（II）至少一种抗帕金森药物，与一种或多种药学上可接受的赋形剂组合。

40. 发明申请

WO0224632A3 SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR 审中-公开
标题翻译：取代的氨基磷酸衍生物有助于LXR的激素
公开(公告)号：WO0224632A3
公开(公告)日：2002-07-11
申请号：PCT/US0127622
申请日：2001-09-06
申请人： GLAXO GROUP LTD , COLLINS JON LOREN , FIVUSH ADAM M , MALONEY PATRICK REED , STEWART EUGENE L , WILLSON TIMOTHY MARK
发明人： COLLINS JON LOREN , FIVUSH ADAM M , MALONEY PATRICK REED , STEWART EUGENE L , WILLSON TIMOTHY MARK
IPC分类号： C07D233/64 , A61K31/165 , A61K31/192 , A61K31/216 , A61K31/277 , A61K31/341 , A61K31/343 , A61K31/351 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4045 , A61K31/415 , A61K31/417 , A61K31/4184 , A61K31/42 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4409 , A61K31/4468 , A61K31/513 , A61K45/00 , A61P3/06 , A61P9/00 , A61P9/10 , A61P43/00 , C07C217/22 , C07C217/58 , C07C235/34 , C07C235/46 , C07C255/58 , C07C317/32 , C07C323/32 , C07D207/09 , C07D209/14 , C07D211/58 , C07D213/36 , C07D213/38 , C07D213/74 , C07D213/78 , C07D213/82 , C07D231/16 , C07D233/54 , C07D235/10 , C07D235/14 , C07D235/16 , C07D235/26 , C07D239/52 , C07D261/08 , C07D277/28 , C07D307/52 , C07D307/79 , C07D307/81 , C07D309/20 , C07D317/58 , C07D317/62 , C07D317/64 , C07D319/18 , C07D333/20 , A61K31/19 , A61K31/33 , C07D209/16 , C07D211/26
CPC分类号： C07D213/82 , C07C217/22 , C07C217/58 , C07C235/34 , C07C235/46 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/42 , C07D207/09 , C07D209/14 , C07D211/58 , C07D213/38 , C07D231/16 , C07D233/64 , C07D235/14 , C07D235/16 , C07D239/52 , C07D261/08 , C07D277/28 , C07D307/52 , C07D307/79 , C07D307/81 , C07D309/20 , C07D317/58 , C07D317/62 , C07D317/64 , C07D319/18 , C07D333/20
摘要： The invention relates to a compound of formula (I), wherein all variables are as defined herein, and pharmaceutically acceptable salts or solvates thereof. The compounds of formula (I) are useful as LXR agonists.
摘要翻译：本发明涉及式（I）化合物，其中所有变量如本文所定义，及其药学上可接受的盐或溶剂化物。式（I）化合物可用作LXR激动剂。

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