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21. 发明申请

WO2015191771A1 SELECTING ENERGY ESCALATION FOR DEFIBRILLATION 审中-公开
标题翻译：选择能源自动化进行定位
公开(公告)号：WO2015191771A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/035189
申请日：2015-06-10
申请人： ZOLL MEDICAL CORPORATION , FREEMAN, Gary, A.
发明人： FREEMAN, Gary, A. , QUAN, Weilun
IPC分类号： A61N1/39
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0402 , A61B5/053 , A61B5/4836 , A61B5/7257 , A61H31/004 , A61H31/005 , A61H31/006 , A61H31/007 , A61H2230/045 , A61N1/3906 , A61N1/3925 , A61N1/3937 , A61N1/3968 , A61N1/3993
摘要： In an aspect, a system for treating a patient in cardiac arrest is described and includes memory, one or more electronic ports for receiving signals from sensors for obtaining indications of an electrocardiogram (ECG) of the patient, one or more sensors for obtaining a transthoracic impedance of the patient, and a patient treatment module executable on one or more processing devices that is configured to generate, from the ECG, transform values that represent magnitudes of two or more frequency components of the ECG, and modify, based on at least one transform value, at least one shock delivery parameter.
摘要翻译：一方面，描述了用于治疗心脏骤停患者的系统，并且包括存储器，用于接收来自传感器的信号的一个或多个电子端口，用于获得患者的心电图（ECG）的指示，用于获得经胸廓的一个或多个传感器患者的阻抗以及可在一个或多个处理设备上执行的患者治疗模块，其被配置为从ECG生成表示ECG的两个或更多个频率分量的量值的值，并基于至少一个变换值，至少一个冲击输送参数。

22. 发明申请

WO2015079387A1 AUTOMATED DETECTION OF PATIENT AGE BY ECG 审中-公开
标题翻译：通过心电图自动检测患者年龄
公开(公告)号：WO2015079387A1
公开(公告)日：2015-06-04
申请号：PCT/IB2014/066348
申请日：2014-11-26
申请人： KONINKLIJKE PHILIPS N.V.
发明人： GREGG, Richard E.
IPC分类号： A61N1/39 , A61B5/0404 , A61B5/0452 , A61B5/00
CPC分类号： A61B5/0452 , A61B5/0404 , A61B5/7264 , A61B5/7271 , A61B5/7405 , A61B5/742 , A61N1/08 , A61N1/3937
摘要： An automated age detection system employing a patient monitoring lead assembly and a patent monitoring device. In operation, the patient monitoring lead assembly conducts electrical activity of a heart of a patient to the patient monitoring device. In response thereto, the patient monitoring device classifying the patient as an adult patient or a pediatric patient as a function of electrocardiogram feature(s) derived from electrocardiogram measurement(s) of the electrical heart activity. The patient monitoring device may further estimate the age as a function of electrocardiogram feature(s). The classification facilitates an appropriate application of an adult analysis or a pediatric analysis of the electrical heart activity.
摘要翻译：一种使用患者监测引线组件和专利监测装置的自动化年龄检测系统。在操作中，患者监测导线组件将患者心脏的电活动传导到患者监护装置。响应于此，患者监视装置将患者作为成年患者或儿科患者分类，其作为来自心电图心电图的心电图测量的心电图特征的函数。患者监视装置可进一步估计年龄作为心电图特征的函数。分类有助于适当应用成人分析或儿童心脏电活动分析。

23. 发明申请

WO2013071280A2 DETERMINATION FOR EFFECTIVE DEFIBRILLATION 审中-公开
标题翻译：确定有效的定律
公开(公告)号：WO2013071280A2
公开(公告)日：2013-05-16
申请号：PCT/US2012/064779
申请日：2012-11-13
申请人： ZOLL MEDICAL CORPORATION , QUAN, Weilun , TAN, Qing , FREEMAN, Gary A.
发明人： QUAN, Weilun , TAN, Qing , FREEMAN, Gary A.
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/3937 , A61N1/3987 , A61N1/3993
摘要： A method for managing care of a person receiving emergency cardiac is disclosed and involves monitoring, with an external defibrillator, multiple parameters of the person receiving emergency cardiac assistance; determining from at least one of the parameters, an indication of trans-thoracic impedance of the person receiving emergency cardiac care; determining, from at least one of the parameters corresponding to an electrocardiogram of the person receiving emergency cardiac assistance, an initial indication of likely shock effectiveness; determining, as a function of at least the indication of trans-thoracic impedance and the initial indication of likely shock effectiveness, an indication of whether a shock provided to the person receiving emergency medical assistance will be effective; and affecting control of the defibrillator by a caregiver as a result of determining the indication of whether a shock will be effective.
摘要翻译：公开了一种用于管理接收紧急心脏的人的护理的方法，并且涉及用外部除颤器监测接收紧急心脏辅助的人的多个参数; 从所述参数中的至少一个确定接受紧急心脏保健的人的胸部阻抗的指示; 从对应于接受紧急心脏辅助的人的心电图的参数中的至少一个确定可能的休克有效性的初始指示; 确定作为至少是跨胸阻抗的指示和可能的冲击有效性的初始指示的函数，指示是否向接受紧急医疗援助的人提供的冲击是有效的; 并且由于确定是否有效的冲击的指示，由照护者影响除颤器的控制。

24. 发明申请

WO2012051016A1 SAMPLE AND HOLD CIRCUITRY FOR MONITORING VOLTAGES IN AN IMPLANTABLE NEUROSTIMULATOR 审中-公开
标题翻译：采样和保持电路用于监测可植入神经元的电压
公开(公告)号：WO2012051016A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/054879
申请日：2011-10-05
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , SHI, Jess, W. , FELDMAN, Emanuel , PARRAMON, Jordi
发明人： SHI, Jess, W. , FELDMAN, Emanuel , PARRAMON, Jordi
IPC分类号： A61N1/08 , A61B5/04 , A61N1/372
CPC分类号： A61N1/36125 , A61B5/04001 , A61N1/025 , A61N1/08 , A61N1/378 , A61N1/3937
摘要： Sample and hold circuitry for monitoring electrodes and other voltages in an implantable neurostimulator is disclosed. The sample and hold circuitry in one embodiment contains multiplexers to selected appropriate voltages and to pass them to two storage capacitors during two different measurement phases. The capacitors are in a later stage serially connected to add the two voltages stored on the capacitors, and voltages present at the top and bottom of the serial connection are then input to a differential amplifier to compute their difference. The sample and hold circuitry is particularly useful in calculating the resistance between two electrodes, and is further particularly useful when resistance is measured using a biphasic pulse. The sample and hold circuitry is flexible, and can be used to measure other voltages of interest during biphasic or monophasic pulsing.
摘要翻译：公开了用于在可植入神经刺激器中监测电极和其它电压的采样和保持电路。在一个实施例中，采样和保持电路包含多个选择的合适电压，并在两个不同的测量阶段期间将其传送到两个存储电容器。电容器串联连接以增加存储在电容器上的两个电压，然后将串联连接顶部和底部的电压输入到差分放大器以计算其差值。采样和保持电路在计算两个电极之间的电阻时特别有用，当使用双相脉冲测量电阻时，采样和保持电路特别有用。采样和保持电路是灵活的，并且可以用于在双相或单相脉冲期间测量感兴趣的其他电压。

25. 发明申请

WO2012003124A3 THERAPY CIRCUIT PROTECTION FOR IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械的治疗电路保护
公开(公告)号：WO2012003124A3
公开(公告)日：2012-02-23
申请号：PCT/US2011041414
申请日：2011-06-22
申请人： CARDIAC PACEMAKERS INC , LUDWIG JACOB M , LINDER WILLIAM J , BRANDNER DOUGLAS J , STESSMAN NICHOLAS J , HANNAN DOUGLAS MICHAEL , STUBBS SCOTT R , STAHMANN JEFFREY E , FOSTER ARTHUR
发明人： LUDWIG JACOB M , LINDER WILLIAM J , BRANDNER DOUGLAS J , STESSMAN NICHOLAS J , HANNAN DOUGLAS MICHAEL , STUBBS SCOTT R , STAHMANN JEFFREY E , FOSTER ARTHUR
IPC分类号： A61N1/08 , A61N1/37 , A61N1/39
CPC分类号： A61N1/3931 , A61N1/025 , A61N1/3706 , A61N1/3937 , A61N1/3962 , A61N2001/083
摘要： A medical device can include a therapy circuit configured to provide a specified electrostimulation therapy to a tissue site, the specified electrostimulation therapy including a scheduled completion, the therapy circuit including a protection circuit configured to adjust specification of the electrostimulation therapy being provided so as to provide an adjusted electrostimulation therapy before the scheduled completion. The medical device can include a monitoring circuit comprising a comparator. The monitoring circuit can be configured to trigger the protection circuit to inhibit the therapy circuit when the therapy circuit output parameter exceeds the specified threshold as indicated by the comparator.
摘要翻译：医疗设备可以包括治疗电路，其被配置为向组织部位提供特定的电刺激治疗，所述指定的电刺激治疗包括计划完成，所述治疗电路包括保护电路，该保护电路被配置为调整提供的电刺激治疗的规格，在计划完成之前进行调整的电刺激治疗。医疗装置可以包括包括比较器的监视电路。当比较器所指示的治疗电路输出参数超过指定的阈值时，监视电路可被配置为触发保护电路来抑制治疗电路。

26. 发明申请

WO2012021488A1 WIRELESS CARDIAC PULSATILITY SENSING 审中-公开
标题翻译：无线心脏脉搏传感
公开(公告)号：WO2012021488A1
公开(公告)日：2012-02-16
申请号：PCT/US2011/047037
申请日：2011-08-09
申请人： MEDTRONIC, INC. , SHEN, Xiaonan , CINBIS, Can
发明人： SHEN, Xiaonan , CINBIS, Can
IPC分类号： A61N1/39 , A61B5/053 , A61B5/0295
CPC分类号： A61B5/6846 , A61B5/0245 , A61B5/0538 , A61N1/3937 , A61N1/3956 , A61N1/3987
摘要： An implantable medical device system and associated method monitor changes in transimpedance in a body tissue due to changes in cardiac pulsatility. A first dipole is used to deliver a non-stimulating electrical current. The first dipole includes a first electrode and a second electrode adapted to be deployed along a first body location. A second dipole is used to measure a voltage resulting from the non-stimulating electrical current being conducted through a portion of a patient's body. The second dipole includes a third electrode and a fourth electrode different than the first electrode and the second electrode and adapted to be deployed along a second body location spaced apart from the first body location.
摘要翻译：可植入医疗装置系统和相关方法监测由于心脏搏动的变化而在身体组织中的跨阻变化。使用第一偶极子来传递非刺激电流。第一偶极子包括第一电极和适于沿着第一身体位置展开的第二电极。使用第二偶极子来测量由通过患者身体的一部分传导的非刺激性电流产生的电压。第二偶极子包括不同于第一电极和第二电极的第三电极和第四电极，并且适于沿着与第一身体位置间隔开的第二身体位置展开。

27. 发明申请

WO2007088507A3 ENERGY EFFICIENT DEFIBRILLATION CURRENT LIMITER 审中-公开
标题翻译：能量有效的定义电流限制
公开(公告)号：WO2007088507A3
公开(公告)日：2007-11-22
申请号：PCT/IB2007050295
申请日：2007-01-29
申请人： KONINKL PHILIPS ELECTRONICS NV , POWERS DANIEL
发明人： POWERS DANIEL
IPC分类号： A61N1/39
CPC分类号： A61N1/3906 , A61N1/3912 , A61N1/3931 , A61N1/3937
摘要： A current limiter for a defibrillation pulse is powered by the defibrillation pulse and switches the current delivery path open and closed when an excessive current condition exists. The excessive current condition is sensed by a sense resistor of the current limiter. The controlled current is delivered by an inductor which delivers a current which varies in a range about a predetermined current level during excessive current conditions . The current limiter dissipates little energy of the defibrillation pulse so that most of the energy produced by the defibrillator is delivered to the patient.
摘要翻译：用于除颤脉冲的电流限制器由除颤脉冲供电，并且当存在过度电流条件时，将当前输送路径切换并打开和关闭。过电流状态由电流限制器的检测电阻器感测。受控电流由电感器传递，该电感器在过电流条件下传递在大约预定电流电平范围内变化的电流。电流限制器耗散除颤脉冲的很少的能量，使得由除颤器产生的大部分能量被传递给患者。

28. 发明申请

WO2006115922A2 METHODS AND IMPLANTABLE DEVICES FOR INDUCING FIBRILLATION BY ALTERNATING CONSTANT CURRENT 审中-公开
标题翻译：用于通过替代恒定电流来诱导颤动的方法和可植入装置
公开(公告)号：WO2006115922A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/014670
申请日：2006-04-18
申请人： CAMERON HEALTH, INC. , OSTROFF, Alan H.
发明人： OSTROFF, Alan H.
CPC分类号： A61N1/3937 , A61N1/385 , A61N1/3906 , A61N1/3912
摘要： The present invention is directed toward methods for inducing fibrillation in a patient using a controlled current AC signal applied via an implanted ICD. In some embodiments, the AC signal is applied as a series of alternating constant current pulses. Some embodiments make use of a specialized H-bridge circuit for applying the AC signal. A low-side current controlling portion of an ICD's circuitry may make up part of the specialized H-bridge circuit. Further embodiments include devices embodying these methods.
摘要翻译：本发明涉及使用经由植入的ICD施加的受控电流AC信号在患者中诱导原纤维化的方法。在一些实施例中，AC信号作为一系列交流恒定电流脉冲施加。一些实施例利用专用的H桥电路来施加AC信号。 ICD电路的低端电流控制部分可以构成专门的H桥电路的一部分。其他实施例包括体现这些方法的装置。

29. 发明申请

WO03047685A2 CONTROL OF ARBITRARY WAVEFORMS FOR CONSTANT DELIVERED ENERGY 审中-公开
标题翻译：用于恒定供应能量的仲裁波的控制
公开(公告)号：WO03047685A2
公开(公告)日：2003-06-12
申请号：PCT/US0240037
申请日：2002-12-03
申请人： MEDTRONIC INC
发明人： HAVEL WILLIAM J , DEGROOT PAUL J , SINNER THOMAS W , KUEHN KEVIN , KEMMETMUELLER GARY , WOLD WARREN W
IPC分类号： A61B5/05 , A61N1/04 , A61N1/08 , A61N1/39 , A61N
CPC分类号： A61N1/3906 , A61N1/3912 , A61N1/3937
摘要： The present invention outlines structures and methods for delivering a controllable amount of energy to a patient by automatically compensating for the load impedance detected by an implantable-cardioverter defibrillator (ICD). The invention employs high speed, switching power converter technology for the efficient generation of high energy, arbitrary waveforms. Unlike a linear amplifier, switching power converters deliver high-energy waveforms with an efficiency that is independent of the size and amplitude of the desired waveform. An ICD that uses a switching power converter to deliver the desired energy to the patient stores the energy to be delivered in a storage capacitor. The converter then transforms this energy into an arbitrarily shaped output voltage-controlled or current-controlled waveform by switching the storage capacitor in and out of the output circuit at a high rate of speed. Preferably, the waveform comprises a ramp-type waveform.
摘要翻译：本发明概述了通过自动补偿由可植入式心律转复除颤器（ICD）检测的负载阻抗来向患者传送可控量的能量的结构和方法。本发明采用高速，开关电源转换器技术，高效生成高能量，任意波形。与线性放大器不同，开关电源转换器提供高能量波形，效率与所需波形的大小和幅度无关。使用开关功率转换器将期望的能量递送到患者的ICD存储要在存储电容器中传递的能量。然后，转换器通过以高速率切换存储电容器输入和输出输出电路，将该能量转换成任意形状的输出电压控制或电流控制波形。优选地，波形包括斜坡型波形。

30. 发明申请

WO02028479A1 METHOD AND APPARATUS FOR DELIVERING A BIPHASIC DEFIBRILLATION PULSE WITH VARIABLE ENERGY 审中-公开
标题翻译：用于提供具有可变能量的双相断裂脉冲的方法和装置
公开(公告)号：WO02028479A1
公开(公告)日：2002-04-11
申请号：PCT/US2001/028899
申请日：2001-09-18
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/39 , A61N1/3906 , A61N1/3912
摘要： An apparatus and method for determining an optimal transchest external defibrillation waveform that provides for variable energy in the first or second phase of a biphasic waveform that, when applied through a plurality of electrodes (24) positioned on the patient's torso, will produce a desired response in the patient's cardiac cell membranes. The method includes the steps of providing a quantitative model of a defibrillator circuit for producing external defibrillation waveforms, the quantitative model of a patient includes a chest component, a heart component, a cell membrane component and a quantitative description of the desired cardiac membrane response function. Finally, a quantitative description of a transchest external defibrillation waveform that will produce the desired cardiac membrane response function is computed. The computation is made as a function of the desired cardiac membrane response function, the patient model and the defibrillator circuit model.
摘要翻译：一种用于确定在双相波形的第一或第二相位中提供可变能量的最佳经折叠外部除颤波形的装置和方法，当通过位于患者躯干上的多个电极（24）施加时，将产生期望的响应在患者的心脏细胞膜中。该方法包括提供用于产生外部除颤波形的除颤器电路的定量模型的步骤，患者的定量模型包括胸部组分，心脏组分，细胞膜组分和所需心脏膜响应函数的定量描述。最后，计算将产生期望的心脏膜响应函数的经外科除颤波形的定量描述。作为所需心脏膜响应函数，患者模型和除颤器电路模型的函数进行计算。

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