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1. 发明申请

WO2009002579A1 IMPROVED ARCHITECTURES FOR AN IMPLANTABLE MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：改进的医疗设备系统的架构
公开(公告)号：WO2009002579A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/059134
申请日：2008-04-02
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , GRIFFITH, Paul, J. , PARRAMON, Jordi , MARNFELDT, Goran, N. , AGHASSIAN, Daniel , NIMMAGADDA, Kiran , FELDMAN, Emanuel , SHI, Jess, W.
发明人： GRIFFITH, Paul, J. , PARRAMON, Jordi , MARNFELDT, Goran, N. , AGHASSIAN, Daniel , NIMMAGADDA, Kiran , FELDMAN, Emanuel , SHI, Jess, W.
IPC分类号： A61N1/372 , G06F13/12
CPC分类号： A61N1/36125 , A61N1/025 , A61N1/0551 , A61N1/0553 , A61N1/36071
摘要： An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicate with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG without the need for a major redesign of the main IPG IC.
摘要翻译：公开了一种用于植入式医疗装置（例如植入式脉冲发生器（IPG））的改进的架构。在一个实施例中，用于IPG的各种功能块被并入到信号集成电路（IC）中。每个功能块通过由通信协议管理的集中式总线彼此通信，并且如果需要，与其他片外设备通信。为了与总线通信并遵守协议，每个电路块都包含与该协议相关的总线接口电路。由于每个块符合协议，任何给定的块都可以轻松修改或升级，而不影响其他块的设计，便于IPG电路的调试和升级。此外，由于集中式总线可以从集成电路中取出，所以额外的电路可以轻松地从芯片上添加到IPG中，以便对IPG进行主要的重新设计。

2. 发明申请

WO2012051016A1 SAMPLE AND HOLD CIRCUITRY FOR MONITORING VOLTAGES IN AN IMPLANTABLE NEUROSTIMULATOR 审中-公开
标题翻译：采样和保持电路用于监测可植入神经元的电压
公开(公告)号：WO2012051016A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/054879
申请日：2011-10-05
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , SHI, Jess, W. , FELDMAN, Emanuel , PARRAMON, Jordi
发明人： SHI, Jess, W. , FELDMAN, Emanuel , PARRAMON, Jordi
IPC分类号： A61N1/08 , A61B5/04 , A61N1/372
CPC分类号： A61N1/36125 , A61B5/04001 , A61N1/025 , A61N1/08 , A61N1/378 , A61N1/3937
摘要： Sample and hold circuitry for monitoring electrodes and other voltages in an implantable neurostimulator is disclosed. The sample and hold circuitry in one embodiment contains multiplexers to selected appropriate voltages and to pass them to two storage capacitors during two different measurement phases. The capacitors are in a later stage serially connected to add the two voltages stored on the capacitors, and voltages present at the top and bottom of the serial connection are then input to a differential amplifier to compute their difference. The sample and hold circuitry is particularly useful in calculating the resistance between two electrodes, and is further particularly useful when resistance is measured using a biphasic pulse. The sample and hold circuitry is flexible, and can be used to measure other voltages of interest during biphasic or monophasic pulsing.
摘要翻译：公开了用于在可植入神经刺激器中监测电极和其它电压的采样和保持电路。在一个实施例中，采样和保持电路包含多个选择的合适电压，并在两个不同的测量阶段期间将其传送到两个存储电容器。电容器串联连接以增加存储在电容器上的两个电压，然后将串联连接顶部和底部的电压输入到差分放大器以计算其差值。采样和保持电路在计算两个电极之间的电阻时特别有用，当使用双相脉冲测量电阻时，采样和保持电路特别有用。采样和保持电路是灵活的，并且可以用于在双相或单相脉冲期间测量感兴趣的其他电压。

3. 发明申请

WO2012051015A1 MONITORING ELECTRODE VOLTAGES IN AN IMPLANTABLE MEDICAL DEVICE SYSTEM HAVING DAISY-CHAINED ELECTRODE-DRIVER INTEGRATED CIRCUITS 审中-公开
标题翻译：在具有电连接电极驱动器集成电路的可植入医疗设备系统中监测电极电压
公开(公告)号：WO2012051015A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/054876
申请日：2011-10-05
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PARRAMON, Jordi , SHI, Jess, W. , FELDMAN, Emanuel
发明人： PARRAMON, Jordi , SHI, Jess, W. , FELDMAN, Emanuel
IPC分类号： A61N1/36
CPC分类号： A61N1/37241 , A61N1/025 , A61N1/05 , A61N1/0551 , A61N1/08 , A61N1/3605 , A61N1/36125 , A61N1/36153
摘要： Electrode voltage monitoring circuitry for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. Electrodes voltages on the slave IC are routed to the master IC, and thus the master IC can monitor both electrode voltages on the slave as well as electrode voltages on the master. Such voltages can be monitored for a variety of purposes, and in particular use of such voltage is disclosed for determining the resistance between electrodes and to set a compliance voltage for stimulation.
摘要翻译：一种具有多个电极驱动器集成电路（IC）的可植入神经刺激器系统的电极电压监视电路。可以选择来自任一个或两个IC的电极以提供刺激，并且IC中的一个用作主器件，而另一个用作从器件。从IC上的电极电压被路由到主IC，因此主IC可以监控从站上的两个电极电压以及主站上的电极电压。为了各种目的可以监视这样的电压，并且特别地使用这种电压来确定电极之间的电阻并设置用于刺激的顺应性电压。

4. 发明申请

WO2012050998A1 ARCHITECTURES FOR AN IMPLANTABLE MEDICAL DEVICE SYSTEM HAVING DAISY-CHAINED ELECTRODE-DRIVE INTEGRATED CIRCUITS 审中-公开
标题翻译：具有电连接电极驱动集成电路的可植入医疗器械系统的结构
公开(公告)号：WO2012050998A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/054599
申请日：2011-10-03
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PARRAMON, Jordi , FELDMAN, Emanuel , GRIFFITH, Paul, J. , SHI, Jess, W.
发明人： PARRAMON, Jordi , FELDMAN, Emanuel , GRIFFITH, Paul, J. , SHI, Jess, W.
IPC分类号： A61N1/372
CPC分类号： A61N1/372 , A61N1/025 , A61N1/36125
摘要： Architectures for an implantable neurostimulator system having a plurality of electrode-driver integrated circuits (ICs) in provided. Electrodes from either or both ICs can be chosen to provide stimulation, and one of the IC acts as the master while the other acts as the slave. A parallel bus operating in accordance with a communication protocol couples the ICs, and certain functional blocks not needed in the slave are disabled. Stimulation parameters are loaded via the bus into each IC, and a stimulation enable command is issued on the bus to ensure simultaneous stimulation from the electrodes on both ICs. Clocking strategies are also disclosed to allow clocking of the master and slave ICs to be independently controlled, and to ensure that relevant internal and bus clocks used in the system are synchronized.
摘要翻译：具有提供的多个电极驱动器集成电路（IC）的可植入神经刺激器系统的结构。可以选择来自任一个或两个IC的电极以提供刺激，并且IC中的一个用作主器件，而另一个用作从器件。根据通信协议操作的并行总线耦合IC，并且禁用从机中不需要的某些功能块。刺激参数通过总线加载到每个IC中，并且在总线上发出刺激使能命令，以确保同时从两个IC上的电极刺激。还公开了时钟策略，以允许主控和从属IC的时钟被独立控制，并确保系统中使用的相关内部和总线时钟同步。

5. 发明申请

WO2009009290A1 TELEMETRY LISTENING WINDOW MANAGEMENT FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：远程医疗窗口管理用于可植入医疗设备
公开(公告)号：WO2009009290A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/068079
申请日：2008-06-25
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PARRAMON, Jordi , SHI, Jess, W.
发明人： PARRAMON, Jordi , SHI, Jess, W.
IPC分类号： A61N1/372 , A61N1/378
CPC分类号： A61N1/37252 , A61N1/3605 , A61N1/37205 , Y10S128/903
摘要： An improved arbitration scheme for allowing concurrent stimulation and telemetry listening in a microstimulator is disclosed. A listening window for telemetry is permitted to proceed, and access to the microstimulator' s coil granted, during at least a portion of the inter-pulse period that follows the issuance of a stimulation pulse. This is permissible because access to the coil is not needed during the entirety of the inter-pulse period. For example, the listening window can issue during that portion of the inter-pulse period when the decoupling capacitor is discharged, but cannot issue during that portion of the inter-pulse period when the compliance voltage is being generated for the next stimulation pulse. However, because compliance voltage generation occupies only a small portion of the inter-pulse period, the technique is not substantially limited. By allowing the listening window to issue during the majority of the inter-pulse period, the listening window produces smaller gaps between the pulses, and stimulation therapy is thus brought closer to its ideal.
摘要翻译：公开了一种用于允许微型激励器中的并发刺激和遥测监听的改进的仲裁方案。允许进行遥测的监听窗口，并且在发出刺激脉冲之后的脉冲间期间的至少一部分期间允许访问微型激励器的线圈。这是允许的，因为在整个脉冲间期间不需要对线圈的访问。例如，当解耦电容器放电时，在脉冲周期的该部分期间可以发出监听窗口，但是当为下一个刺激脉冲产生顺从性电压时，不能在脉冲间期间的那部分期间发出监听窗口。然而，由于顺应性电压产生仅占脉冲周期的一小部分，所以该技术基本上不受限制。通过允许在大多数脉冲间期间发出听音窗口，收听窗口在脉冲之间产生较小的间隙，因此刺激疗法更接近其理想。

6. 发明申请

WO2013012487A1 BATTERY MANAGEMENT FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械的电池管理
公开(公告)号：WO2013012487A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/041551
申请日：2012-06-08
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PARRAMON, Jordi , MARNFELDT, Goran, N. , OZAWA, Robert , FELDMAN, Emanuel , PETERSON, Dave , HE, Yuping
发明人： PARRAMON, Jordi , MARNFELDT, Goran, N. , OZAWA, Robert , FELDMAN, Emanuel , PETERSON, Dave , HE, Yuping
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/08
摘要： Battery management circuitry for an implantable medical device such as an implantable neurostimulator is described. The circuitry has a T-shape with respect to the battery terminal, with charging circuitry coupled between rectifier circuitry and the battery terminal on one side of the T, and load isolation circuitry coupled between the load and the battery terminal on the other side. The load isolation circuitry can comprise two switches wired in parallel. An undervoltage fault condition opens both switches to isolate the battery terminal from the load to prevent further dissipation of the battery. Other fault conditions will open only one the switches leaving the other closed to allow for reduced power to the load to continue implant operations albeit at safer low-power levels. The battery management circuitry can be fixed in a particular location on an integrated circuit which also includes for example the stimulation circuitry for the electrodes.
摘要翻译：描述了诸如可植入神经刺激器的可植入医疗装置的电池管理电路。电路相对于电池端子具有T形，充电电路耦合在整流器电路和T的一侧上的电池端子之间，负载隔离电路耦合在另一侧的负载和电池端子之间。负载隔离电路可以包括并联的两个开关。欠压故障条件打开两个开关以将电池端子与负载隔离，以防止电池进一步耗散。其他故障条件将只打开一个开关，使另一个闭合，以允许减小负载的电力，以继续进行种植体操作，尽管处于更安全的低功率水平。电池管理电路可以固定在集成电路的特定位置，该集成电路还包括例如用于电极的刺激电路。

7. 发明申请

WO2011059565A1 STRUCTURE FOR AN IMPLANTABLE MEDICAL DEVICE HAVING TELEMETRY AND CHARGING COILS WITHIN A CASE 审中-公开
标题翻译：具有电子邮件的可移植医疗设备结构和案例中的充电线圈
公开(公告)号：WO2011059565A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/049215
申请日：2010-09-17
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , RAHMAN, Md. Mizanur , NIMMAGADDA, Kiran , PARRAMON, Jordi , FELDMAN, Emanuel
发明人： RAHMAN, Md. Mizanur , NIMMAGADDA, Kiran , PARRAMON, Jordi , FELDMAN, Emanuel
IPC分类号： A61N1/372 , A61N1/375
CPC分类号： A61N1/37217 , A61N1/3718 , A61N1/37211 , A61N1/37229 , A61N1/3758 , A61N1/3787
摘要： An implantable medical device is disclosed comprising a conductive case; a charging coil within the case for receiving power from an external charger, the charging coil wound around an area having a first extent; and a telemetry coil within the case for receiving data from an external controller, or for transmitting data to the external controller, or for receiving and transmitting data from and to the external controller, the telemetry coil would around an area having a second extent, in which the second extent of the telemetry coil at least overlaps the first extent of the charging coil. The charging coil can be proximate to one side of a circuit board, with the telemetry coil is proximate to the other side. The implantable medical device further comprises a non-conductive header comprising at least one lead connector for coupling to an electrode lead.
摘要翻译：公开了一种植入式医疗装置，其包括导电壳体; 所述壳体内的充电线圈用于从外部充电器接收电力，所述充电线圈缠绕在具有第一范围的区域上; 壳体内的遥测线圈用于从外部控制器接收数据，或者用于向外部控制器发送数据，或用于从外部控制器接收和发送数据，遥测线圈将围绕具有第二范围的区域其中遥测线圈的第二范围至少与充电线圈的第一范围重叠。充电线圈可以靠近电路板的一侧，遥测线圈靠近另一侧。可植入医疗装置还包括非导电头部，其包括用于耦合到电极引线的至少一个引线连接器。

8. 发明申请

WO2011059564A1 MINIMIZING INTERFERENCE BETWEEN CHARGING AND TELEMETRY COILS IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：最小化可插入医疗器械中的充电和电流线圈之间的干扰
公开(公告)号：WO2011059564A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/049210
申请日：2010-09-17
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , RAHMAN, Md. Mizanur , NIMMAGADDA, Kiran , PARRAMON, Jordi , FELDMAN, Emanuel
发明人： RAHMAN, Md. Mizanur , NIMMAGADDA, Kiran , PARRAMON, Jordi , FELDMAN, Emanuel
IPC分类号： A61N1/378 , A61N1/375
CPC分类号： A61N1/37217 , A61N1/3718 , A61N1/37211 , A61N1/37229 , A61N1/3758 , A61N1/3787
摘要： An improved implantable pulse generator (IPG) containing improved telemetry circuitry is disclosed. The IPG includes charging and telemetry coils within the IPG case, which increases their mutual inductance and potential to interfere with each other; particularly problematic is interference to the telemetry coil caused by the charging coil. To combat this, improved telemetry circuitry includes decoupling circuitry for decoupling the charging coil during periods of telemetry between the IPG and an external controller. Such decoupling circuitry can comprise use of pre-existing LSK circuitry during telemetry, or new discrete circuitry dedicated to decoupling. The decoupling circuitry is designed to prevent or at least reduce induced current flowing through the charging coil during data telemetry. The decoupling circuitry can be controlled by the microcontroller in the IPG, or can automatically decouple the charging coil at appropriate times to mitigate an induced current without instruction from the microcontroller.
摘要翻译：公开了一种包含改进的遥测电路的改进的可植入脉冲发生器（IPG）。 IPG包括IPG案例中的充电和遥测线圈，增加了互感和相互干扰的潜力; 特别有问题的是由充电线圈引起的遥测线圈的干扰。为了解决这个问题，改进的遥测电路包括去耦电路，用于在IPG和外部控制器之间的遥测期间解耦充电线圈。这种去耦电路可以包括在遥测期间使用预先存在的LSK电路，或者专用于解耦的新的分立电路。去耦电路设计为在数据遥测期间防止或至少减少流过充电线圈的感应电流。去耦电路可以由IPG中的微控制器控制，或者可以在适当的时间自动去耦充电线圈，以缓解感应电流，而无需微控制器的指令。

9. 发明申请

WO2010056501A1 IMPLANTABLE MEDICAL DEVICE THAT USES ELECTRICAL CURRENT STEERING BY MEANS OF OUTPUT IMPEDANCE MODULATION 审中-公开
标题翻译：通过输出阻抗调制方式使用电流转向的可植入医疗器械
公开(公告)号：WO2010056501A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/062115
申请日：2009-10-26
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PARRAMON, Jordi , PETERSON, David K., L. , BRADLEY, Kerry , CARBUNARU, Rafael , DIGIORE, Andrew
发明人： PARRAMON, Jordi , PETERSON, David K., L. , BRADLEY, Kerry , CARBUNARU, Rafael , DIGIORE, Andrew
IPC分类号： A61N1/32 , A61N1/34 , A61N1/36
CPC分类号： A61N1/36125 , A61N1/0551 , A61N1/36157 , A61N1/36185
摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. Electrical stimulation current is conveyed from at least two of the electrodes to at least one of the electrodes along at least two electrical paths through tissue of the patient, and the electrical stimulation current is shifted between the electrical paths by actively adjusting one or more finite resistances respectively associated with one or more of the electrical paths.
摘要翻译：提供了向植入电极阵列的患者提供治疗的方法和系统。电刺激电流沿着沿着患者组织的至少两条电路径从至少两个电极传送到至少一个电极，并且电刺激电流通过主动调节一个或多个有限电阻而在电路径之间移动分别与一个或多个电路径相关联。

10. 发明申请

WO2009139968A2 CURRENT STEERING FOR AN IMPLANTABLE STIMULATOR DEVICE INVOLVING FRACTIONALIZED STIMULATION PULSES 审中-公开
标题翻译：涉及分类刺激脉冲的可植入刺激装置的电流转向
公开(公告)号：WO2009139968A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/038741
申请日：2009-03-30
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PARRAMON, Jordi , CARBUNARU, Rafael , HALLER, Matthew, I.
发明人： PARRAMON, Jordi , CARBUNARU, Rafael , HALLER, Matthew, I.
IPC分类号： A61N1/34
CPC分类号： A61N1/36171 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36071 , A61N1/36125 , A61N1/36175 , A61N1/36178 , A61N1/37235

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