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1. 发明申请

WO2014197596A1 SYSTEM FOR DELIVERING MODULATED SUB-THRESHOLD THERAPY 审中-公开
标题翻译：用于递送调制子阈值治疗的系统
公开(公告)号：WO2014197596A1
公开(公告)日：2014-12-11
申请号：PCT/US2014/040910
申请日：2014-06-04
申请人： DOAN, Que T. , PARRAMON, Jordi , KOTHANDARAMAN, Sridhar , GILLESPIE, Christopher Ewan , LEE, Dongchul , GRANDHE, Sarvani
发明人： DOAN, Que T. , PARRAMON, Jordi , KOTHANDARAMAN, Sridhar , GILLESPIE, Christopher Ewan , LEE, Dongchul , GRANDHE, Sarvani
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36164 , A61N1/36071 , A61N1/36139 , A61N1/36178 , A61N1/36185 , A61N1/36189 , A61N1/37241 , A61N1/37247
摘要： A neuromodulation system and method of providing therapy to a patient. Electrical energy is delivered to the patient in accordance with a modulation parameter, thereby providing therapy to the patient, and the modulation parameter of the delivered electrical energy is varied over a period of time, such that the delivered electrical energy is continually maintained at a sub-threshold level throughout the period of time. The sub-threshold level may be referred to as a patient-perception threshold, which may be referred to as a boundary below which a patient does not sense delivery of the electrical energy. For example, in a spinal cord modulation system, the patient-perception threshold may be a boundary below which a patient does not experience paresthesia.
摘要翻译：一种向患者提供治疗的神经调节系统和方法。根据调制参数将电能输送给患者，由此向患者提供治疗，并且所输送的电能的调制参数在一段时间内变化，使得所输送的电能不断地保持在子在整个时期内的阈值水平。子阈值水平可以被称为患者感知阈值，其可以被称为边界，在该边界下，患者不感测电能的递送。例如，在脊髓调节系统中，患者感知阈值可以是患者不经历感觉异常的边界。

2. 发明申请

WO2010056501A1 IMPLANTABLE MEDICAL DEVICE THAT USES ELECTRICAL CURRENT STEERING BY MEANS OF OUTPUT IMPEDANCE MODULATION 审中-公开
标题翻译：通过输出阻抗调制方式使用电流转向的可植入医疗器械
公开(公告)号：WO2010056501A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/062115
申请日：2009-10-26
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PARRAMON, Jordi , PETERSON, David K., L. , BRADLEY, Kerry , CARBUNARU, Rafael , DIGIORE, Andrew
发明人： PARRAMON, Jordi , PETERSON, David K., L. , BRADLEY, Kerry , CARBUNARU, Rafael , DIGIORE, Andrew
IPC分类号： A61N1/32 , A61N1/34 , A61N1/36
CPC分类号： A61N1/36125 , A61N1/0551 , A61N1/36157 , A61N1/36185
摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. Electrical stimulation current is conveyed from at least two of the electrodes to at least one of the electrodes along at least two electrical paths through tissue of the patient, and the electrical stimulation current is shifted between the electrical paths by actively adjusting one or more finite resistances respectively associated with one or more of the electrical paths.
摘要翻译：提供了向植入电极阵列的患者提供治疗的方法和系统。电刺激电流沿着沿着患者组织的至少两条电路径从至少两个电极传送到至少一个电极，并且电刺激电流通过主动调节一个或多个有限电阻而在电路径之间移动分别与一个或多个电路径相关联。

3. 发明申请

WO2013012487A1 BATTERY MANAGEMENT FOR AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械的电池管理
公开(公告)号：WO2013012487A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/041551
申请日：2012-06-08
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PARRAMON, Jordi , MARNFELDT, Goran, N. , OZAWA, Robert , FELDMAN, Emanuel , PETERSON, Dave , HE, Yuping
发明人： PARRAMON, Jordi , MARNFELDT, Goran, N. , OZAWA, Robert , FELDMAN, Emanuel , PETERSON, Dave , HE, Yuping
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/08
摘要： Battery management circuitry for an implantable medical device such as an implantable neurostimulator is described. The circuitry has a T-shape with respect to the battery terminal, with charging circuitry coupled between rectifier circuitry and the battery terminal on one side of the T, and load isolation circuitry coupled between the load and the battery terminal on the other side. The load isolation circuitry can comprise two switches wired in parallel. An undervoltage fault condition opens both switches to isolate the battery terminal from the load to prevent further dissipation of the battery. Other fault conditions will open only one the switches leaving the other closed to allow for reduced power to the load to continue implant operations albeit at safer low-power levels. The battery management circuitry can be fixed in a particular location on an integrated circuit which also includes for example the stimulation circuitry for the electrodes.
摘要翻译：描述了诸如可植入神经刺激器的可植入医疗装置的电池管理电路。电路相对于电池端子具有T形，充电电路耦合在整流器电路和T的一侧上的电池端子之间，负载隔离电路耦合在另一侧的负载和电池端子之间。负载隔离电路可以包括并联的两个开关。欠压故障条件打开两个开关以将电池端子与负载隔离，以防止电池进一步耗散。其他故障条件将只打开一个开关，使另一个闭合，以允许减小负载的电力，以继续进行种植体操作，尽管处于更安全的低功率水平。电池管理电路可以固定在集成电路的特定位置，该集成电路还包括例如用于电极的刺激电路。

4. 发明申请

WO2011059565A1 STRUCTURE FOR AN IMPLANTABLE MEDICAL DEVICE HAVING TELEMETRY AND CHARGING COILS WITHIN A CASE 审中-公开
标题翻译：具有电子邮件的可移植医疗设备结构和案例中的充电线圈
公开(公告)号：WO2011059565A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/049215
申请日：2010-09-17
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , RAHMAN, Md. Mizanur , NIMMAGADDA, Kiran , PARRAMON, Jordi , FELDMAN, Emanuel
发明人： RAHMAN, Md. Mizanur , NIMMAGADDA, Kiran , PARRAMON, Jordi , FELDMAN, Emanuel
IPC分类号： A61N1/372 , A61N1/375
CPC分类号： A61N1/37217 , A61N1/3718 , A61N1/37211 , A61N1/37229 , A61N1/3758 , A61N1/3787
摘要： An implantable medical device is disclosed comprising a conductive case; a charging coil within the case for receiving power from an external charger, the charging coil wound around an area having a first extent; and a telemetry coil within the case for receiving data from an external controller, or for transmitting data to the external controller, or for receiving and transmitting data from and to the external controller, the telemetry coil would around an area having a second extent, in which the second extent of the telemetry coil at least overlaps the first extent of the charging coil. The charging coil can be proximate to one side of a circuit board, with the telemetry coil is proximate to the other side. The implantable medical device further comprises a non-conductive header comprising at least one lead connector for coupling to an electrode lead.
摘要翻译：公开了一种植入式医疗装置，其包括导电壳体; 所述壳体内的充电线圈用于从外部充电器接收电力，所述充电线圈缠绕在具有第一范围的区域上; 壳体内的遥测线圈用于从外部控制器接收数据，或者用于向外部控制器发送数据，或用于从外部控制器接收和发送数据，遥测线圈将围绕具有第二范围的区域其中遥测线圈的第二范围至少与充电线圈的第一范围重叠。充电线圈可以靠近电路板的一侧，遥测线圈靠近另一侧。可植入医疗装置还包括非导电头部，其包括用于耦合到电极引线的至少一个引线连接器。

5. 发明申请

WO2009139968A2 CURRENT STEERING FOR AN IMPLANTABLE STIMULATOR DEVICE INVOLVING FRACTIONALIZED STIMULATION PULSES 审中-公开
标题翻译：涉及分类刺激脉冲的可植入刺激装置的电流转向
公开(公告)号：WO2009139968A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/038741
申请日：2009-03-30
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , PARRAMON, Jordi , CARBUNARU, Rafael , HALLER, Matthew, I.
发明人： PARRAMON, Jordi , CARBUNARU, Rafael , HALLER, Matthew, I.
IPC分类号： A61N1/34
CPC分类号： A61N1/36171 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36071 , A61N1/36125 , A61N1/36175 , A61N1/36178 , A61N1/37235

6. 发明申请

WO2011063111A4 AN EFFICIENT EXTERNAL CHARGER FOR CHARGING A PLURALITY OF IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：一种有效的外部充电器，用于充电多个可植入的医疗设备
公开(公告)号：WO2011063111A4
公开(公告)日：2011-09-29
申请号：PCT/US2010057212
申请日：2010-11-18
申请人： BOSTON SCIENT NEUROMODULATION , CARBUNARU RAFAEL , PARRAMON JORDI , OZAWA ROBERT , SHI JESS , CHEN JOEY , RAHMAN MIZANUR
发明人： CARBUNARU RAFAEL , PARRAMON JORDI , OZAWA ROBERT , SHI JESS , CHEN JOEY , RAHMAN MIZANUR
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/37223 , A61N1/37288
摘要： An improved external charger for a battery in an implantable medical device (implant), and technique for charging batteries in multiple implants using such improved external charger, is disclosed. During charging, values for a parameter measured in the implants are reported from the implants to the external charger. The external charger infers from the magnitudes of the parameters which of the implants has the highest and lowest coupling to the external charger, and so designates those implants as "hot" and "cold." The intensity of the magnetic charging field is optimized for the cold implant consistent with the simulation to ensure that that the cold implant is charged with a maximum (fastest) battery charging current. The duty cycle of the magnetic charging field is also optimized for the hot implant consistent with the simulation to ensure that the hot implant does not exceed the power dissipation limit. As a result, charging is optimized to be fast for all of the implants, while still safe from a tissue heating perspective.
摘要翻译：公开了用于可植入医疗装置（植入物）中的电池的改进的外部充电器，以及使用这种改进的外部充电器为多个植入物中的电池充电的技术。在充电过程中，植入物中测量的参数值将从植入物报告给外部充电器。外部充电器根据参数的大小推断哪些植入物与外部充电器具有最高和最低的耦合，并且因此将这些植入物指定为“热”和“冷”。对于与模拟一致的冷植入物，磁充电场的强度被优化，以确保冷植入物以最大（最快）电池充电电流充电。磁充电场的占空比也针对与仿真一致的热注入进行优化，以确保热注入不超过功耗限制。因此，对于所有植入物来说，充电都经过优化，以便从组织加热的角度来看仍然安全。

7. 发明申请

WO2011059564A1 MINIMIZING INTERFERENCE BETWEEN CHARGING AND TELEMETRY COILS IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：最小化可插入医疗器械中的充电和电流线圈之间的干扰
公开(公告)号：WO2011059564A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/049210
申请日：2010-09-17
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , RAHMAN, Md. Mizanur , NIMMAGADDA, Kiran , PARRAMON, Jordi , FELDMAN, Emanuel
发明人： RAHMAN, Md. Mizanur , NIMMAGADDA, Kiran , PARRAMON, Jordi , FELDMAN, Emanuel
IPC分类号： A61N1/378 , A61N1/375
CPC分类号： A61N1/37217 , A61N1/3718 , A61N1/37211 , A61N1/37229 , A61N1/3758 , A61N1/3787
摘要： An improved implantable pulse generator (IPG) containing improved telemetry circuitry is disclosed. The IPG includes charging and telemetry coils within the IPG case, which increases their mutual inductance and potential to interfere with each other; particularly problematic is interference to the telemetry coil caused by the charging coil. To combat this, improved telemetry circuitry includes decoupling circuitry for decoupling the charging coil during periods of telemetry between the IPG and an external controller. Such decoupling circuitry can comprise use of pre-existing LSK circuitry during telemetry, or new discrete circuitry dedicated to decoupling. The decoupling circuitry is designed to prevent or at least reduce induced current flowing through the charging coil during data telemetry. The decoupling circuitry can be controlled by the microcontroller in the IPG, or can automatically decouple the charging coil at appropriate times to mitigate an induced current without instruction from the microcontroller.
摘要翻译：公开了一种包含改进的遥测电路的改进的可植入脉冲发生器（IPG）。 IPG包括IPG案例中的充电和遥测线圈，增加了互感和相互干扰的潜力; 特别有问题的是由充电线圈引起的遥测线圈的干扰。为了解决这个问题，改进的遥测电路包括去耦电路，用于在IPG和外部控制器之间的遥测期间解耦充电线圈。这种去耦电路可以包括在遥测期间使用预先存在的LSK电路，或者专用于解耦的新的分立电路。去耦电路设计为在数据遥测期间防止或至少减少流过充电线圈的感应电流。去耦电路可以由IPG中的微控制器控制，或者可以在适当的时间自动去耦充电线圈，以缓解感应电流，而无需微控制器的指令。

8. 发明申请

WO2009002579A1 IMPROVED ARCHITECTURES FOR AN IMPLANTABLE MEDICAL DEVICE SYSTEM 审中-公开
标题翻译：改进的医疗设备系统的架构
公开(公告)号：WO2009002579A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/059134
申请日：2008-04-02
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , GRIFFITH, Paul, J. , PARRAMON, Jordi , MARNFELDT, Goran, N. , AGHASSIAN, Daniel , NIMMAGADDA, Kiran , FELDMAN, Emanuel , SHI, Jess, W.
发明人： GRIFFITH, Paul, J. , PARRAMON, Jordi , MARNFELDT, Goran, N. , AGHASSIAN, Daniel , NIMMAGADDA, Kiran , FELDMAN, Emanuel , SHI, Jess, W.
IPC分类号： A61N1/372 , G06F13/12
CPC分类号： A61N1/36125 , A61N1/025 , A61N1/0551 , A61N1/0553 , A61N1/36071
摘要： An improved architecture for an implantable medical device such as an implantable pulse generator (IPG) is disclosed. In one embodiment, the various functional blocks for the IPG are incorporated into a signal integrated circuit (IC). Each of the functional blocks communicate with each other, and with other off-chip devices if necessary, via a centralized bus governed by a communication protocol. To communicate with the bus and to adhere to the protocol, each circuit block includes bus interface circuitry adherent with that protocol. Because each block complies with the protocol, any given block can easily be modified or upgraded without affecting the design of the other blocks, facilitating debugging and upgrading of the IPG circuitry. Moreover, because the centralized bus can be taken off the integrated circuit, extra circuitry can easily be added off chip to modify or add functionality to the IPG without the need for a major redesign of the main IPG IC.
摘要翻译：公开了一种用于植入式医疗装置（例如植入式脉冲发生器（IPG））的改进的架构。在一个实施例中，用于IPG的各种功能块被并入到信号集成电路（IC）中。每个功能块通过由通信协议管理的集中式总线彼此通信，并且如果需要，与其他片外设备通信。为了与总线通信并遵守协议，每个电路块都包含与该协议相关的总线接口电路。由于每个块符合协议，任何给定的块都可以轻松修改或升级，而不影响其他块的设计，便于IPG电路的调试和升级。此外，由于集中式总线可以从集成电路中取出，所以额外的电路可以轻松地从芯片上添加到IPG中，以便对IPG进行主要的重新设计。

9. 发明申请

WO2012051016A1 SAMPLE AND HOLD CIRCUITRY FOR MONITORING VOLTAGES IN AN IMPLANTABLE NEUROSTIMULATOR 审中-公开
标题翻译：采样和保持电路用于监测可植入神经元的电压
公开(公告)号：WO2012051016A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/054879
申请日：2011-10-05
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , SHI, Jess, W. , FELDMAN, Emanuel , PARRAMON, Jordi
发明人： SHI, Jess, W. , FELDMAN, Emanuel , PARRAMON, Jordi
IPC分类号： A61N1/08 , A61B5/04 , A61N1/372
CPC分类号： A61N1/36125 , A61B5/04001 , A61N1/025 , A61N1/08 , A61N1/378 , A61N1/3937
摘要： Sample and hold circuitry for monitoring electrodes and other voltages in an implantable neurostimulator is disclosed. The sample and hold circuitry in one embodiment contains multiplexers to selected appropriate voltages and to pass them to two storage capacitors during two different measurement phases. The capacitors are in a later stage serially connected to add the two voltages stored on the capacitors, and voltages present at the top and bottom of the serial connection are then input to a differential amplifier to compute their difference. The sample and hold circuitry is particularly useful in calculating the resistance between two electrodes, and is further particularly useful when resistance is measured using a biphasic pulse. The sample and hold circuitry is flexible, and can be used to measure other voltages of interest during biphasic or monophasic pulsing.
摘要翻译：公开了用于在可植入神经刺激器中监测电极和其它电压的采样和保持电路。在一个实施例中，采样和保持电路包含多个选择的合适电压，并在两个不同的测量阶段期间将其传送到两个存储电容器。电容器串联连接以增加存储在电容器上的两个电压，然后将串联连接顶部和底部的电压输入到差分放大器以计算其差值。采样和保持电路在计算两个电极之间的电阻时特别有用，当使用双相脉冲测量电阻时，采样和保持电路特别有用。采样和保持电路是灵活的，并且可以用于在双相或单相脉冲期间测量感兴趣的其他电压。

10. 发明申请

WO2011139536A1 POWER CIRCUITRY FOR AN IMPLANTABLE MEDICAL DEVICE USING A DC-DC CONVERTER 审中-公开
标题翻译：使用DC-DC转换器的可植入医疗设备的电源电路
公开(公告)号：WO2011139536A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/032843
申请日：2011-04-18
申请人： BOSTON SCIENTIFIC NEUROMODULATION CORPORATION , WHITEHURST, Todd , CARBUNARU, Rafael , PARRAMON, Jordi
发明人： WHITEHURST, Todd , CARBUNARU, Rafael , PARRAMON, Jordi
IPC分类号： A61N1/378 , H02J7/02 , A61N1/372 , A61N1/39
CPC分类号： A61N1/3787 , A61N1/37205 , H02M3/33592 , Y02B70/1475
摘要： Improved power circuitry for charging a battery in an implantable medical device is disclosed. The improved power circuitry uses a DC-DC converter positioned between the rectifier and the battery in the implant to be charged, and operates to boost the voltage produced by the rectifier to a higher compliance voltage used to charge the battery. Because the rectifier can now produce a smaller DC voltage, the AC voltage preceding the rectifier (the coil voltage), can also be lessened. Lowering the coil voltage reduces the amount of heat generated by the coil, which reduces the overall heat generated by the implant during receipt of a magnetic charging field from an external charger during a charging session, which improves patient safety. Additionally, a reduced coil voltage means that the external charger can reduce the intensity of the magnetic charging field, which also reduces heat generated in the external charger during the charging session.
摘要翻译：公开了用于对可植入医疗装置中的电池充电的改进的电源电路。改进的电源电路使用位于植入物中的整流器和电池之间的DC-DC转换器来充电，并且操作以将由整流器产生的电压升高到用于对电池充电的较高顺应性电压。因为整流器现在可以产生较小的直流电压，整流器之前的交流电压（线圈电压）也可以减小。降低线圈电压可减少线圈产生的热量，从而减少了在充电期间从外部充电器接收到磁性充电场期间由植入物产生的总体热量，从而提高了患者的安全性。此外，减小的线圈电压意味着外部充电器可以减小磁充电场的强度，这也减少了充电阶段期间在外部充电器中产生的热量。

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