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1. 发明授权

US08951781B2 Systems, methods, and apparatuses to image a sample for biological or chemical analysis 有权
标题翻译：用于对样品进行成像以进行生物或化学分析的系统，方法和装置
公开(公告)号：US08951781B2
公开(公告)日：2015-02-10
申请号：US13273666
申请日：2011-10-14
申请人： Mark T. Reed , Eric Williamson , Bryan Crane , Patrick Leung , Dale Buermann , Alexander P. Kindwall , Frederick Erie , Mark Pratt , Jason Harris , Andrew James Carson , Stanley S. Hong , Jason Bryant , Mark Wang , Drew Verkade
发明人： Mark T. Reed , Eric Williamson , Bryan Crane , Patrick Leung , Dale Buermann , Alexander P. Kindwall , Frederick Erie , Mark Pratt , Jason Harris , Andrew James Carson , Stanley S. Hong , Jason Bryant , Mark Wang , Drew Verkade
IPC分类号： C12M3/00 , B01L9/00 , B01L3/00
CPC分类号： B01L3/502715 , B01L7/52 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2300/022 , B01L2300/041 , B01L2300/043 , B01L2300/0816 , B01L2300/0877 , G01N21/05 , G01N2021/058 , Y10T436/25
摘要： A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.
摘要翻译：流体装置保持器，其构造成定向流体装置。装置保持器包括构造成接收流体装置的支撑结构。所述支撑结构包括在Z轴方向上面对并且被配置成具有定位在其上的流体装置的基面。装置保持器还包括沿着XY平面在各个方向上面对的多个参考表面。装置保持器还包括具有致动器和可操作地联接到致动器的可动定位臂的对准组件。定位臂具有接合端。致动器将定位臂移动到缩回位置和偏置位置之间，以使接合端远离参考表面移动。定位臂构造成当定位臂处于偏置位置时将流体装置保持在参考表面上。

2. 发明申请

US20100111768A1 SYSTEMS AND DEVICES FOR SEQUENCE BY SYNTHESIS ANALYSIS 有权
标题翻译：通过合成分析进行序列的系统和设备
公开(公告)号：US20100111768A1
公开(公告)日：2010-05-06
申请号：US12295337
申请日：2007-03-30
申请人： Saibal Banerjee , Colin Barnes , Kevin Benson , John Bridgham , Jason Bryant , Dale Buermann , Sergey Etchin , Jonny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Isabelle Rasolonjatovo , Mark Reed , Chiara Rodighiero , Subra Sankar , Gary Schroth , Ning Sizto , Harold Swerdlow , Eric Vermaas
发明人： Saibal Banerjee , Colin Barnes , Kevin Benson , John Bridgham , Jason Bryant , Dale Buermann , Sergey Etchin , Jonny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Isabelle Rasolonjatovo , Mark Reed , Chiara Rodighiero , Subra Sankar , Gary Schroth , Ning Sizto , Harold Swerdlow , Eric Vermaas
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6869 , C12Q2535/122 , C12Q2565/60 , G01N21/6456
摘要： The present invention comprises systems and devices for sequencing of nucleic acid, such as short DNA sequences from clonally amplified single-molecule arrays.
摘要翻译：本发明包括用于核酸测序的系统和装置，例如来自克隆扩增的单分子阵列的短DNA序列。

3. 发明授权

US08241573B2 Systems and devices for sequence by synthesis analysis 有权
标题翻译：通过合成分析进行序列的系统和装置
公开(公告)号：US08241573B2
公开(公告)日：2012-08-14
申请号：US12295337
申请日：2007-03-30
申请人： Saibal Banerjee , Colin Barnes , Kevin Benson , Jason Bryant , Dale Buermann , Sergey Etchin , Johnny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Mark Reed , Chiara Rodighiero , Subra Sankar , Harold Swerdlow , Eric Vermaas
发明人： Saibal Banerjee , Colin Barnes , Kevin Benson , Jason Bryant , Dale Buermann , Sergey Etchin , Johnny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Mark Reed , Chiara Rodighiero , Subra Sankar , Harold Swerdlow , Eric Vermaas
IPC分类号： G01N21/64 , G06K9/00 , C12M1/36
CPC分类号： C12Q1/6869 , C12Q2535/122 , C12Q2565/60 , G01N21/6456
摘要： The present invention comprises systems and devices for sequencing of nucleic acid, such as short DNA sequences from clonally amplified single-molecule arrays.
摘要翻译：本发明包括用于核酸测序的系统和装置，例如来自克隆扩增的单分子阵列的短DNA序列。

4. 发明授权

US08422031B2 Focusing methods and optical systems and assemblies using the same 有权
标题翻译：聚焦方法和使用其的光学系统和组件
公开(公告)号：US08422031B2
公开(公告)日：2013-04-16
申请号：US12947367
申请日：2010-11-16
申请人： Dale Buermann , Alexander P. Kindwall
发明人： Dale Buermann , Alexander P. Kindwall
IPC分类号： G01B11/24 , G01B11/30
CPC分类号： G02B21/247 , G02B21/245
摘要： A method for controlling a focus of an optical system. The method includes providing a pair of incident light beams to a conjugate lens. The incident light beams are directed by the lens to converge toward a focal region. The method also includes reflecting the incident light beams with an object positioned proximate to the focal region. The reflected light beams return to and propagate through the lens. The method also includes determining relative separation measured between the reflected light beams and determining a degree-of-focus of the optical system with respect to the sample based upon the relative separation.
摘要翻译：一种用于控制光学系统的焦点的方法。该方法包括将一对入射光束提供给共轭透镜。入射光束被透镜引导以朝向焦点区域会聚。该方法还包括用邻近聚焦区域定位的物体反射入射光束。反射光束返回并传播通过透镜。该方法还包括确定在反射光束之间测量的相对间隔，并基于相对间隔确定光学系统相对于样品的焦度。

5. 发明授权

US6084666A Apparatus for multiple positioning of a planar sample at a repeatable distance and angle from a testing device 有权
标题翻译：用于以与来自测试装置的重复距离和角度多个定位平面样品的装置
公开(公告)号：US6084666A
公开(公告)日：2000-07-04
申请号：US233692
申请日：1999-01-19
申请人： Alexander P. Kindwall , Dale Buermann
发明人： Alexander P. Kindwall , Dale Buermann
IPC分类号： G01N21/01
CPC分类号： G01N21/01
摘要： An apparatus for rotationally positioning a disk on a stationary stage at a constant and repeatable distance and angle for a device to perform an operation on several positions of the disk surface is disclosed. The disk apparatus has a manipulating member that operates from a central portion of the stationary stage. The member raises the disk, rotates the disk to a new position and sets the disk back down on a planar portion of the same stationary stage. The apparatus uses vacuum to secure the disk to the stage and to the member during manipulation. The member is raised by a spring and lowered by vacuum. The apparatus is easily incorporated into an optical system for performing reflectance and transmitance on both side of the disk simultaneously allowing for the analyses of the disk layers for composition and consistency.
摘要翻译：公开了一种用于以恒定且可重复的距离和角度将盘定位在固定台上的装置，用于使设备在盘表面的多个位置上执行操作。盘装置具有从固定台的中心部分操作的操作构件。该成员升起磁盘，将磁盘旋转到一个新位置，并将磁盘设置在相同固定平台的平面部分上。该装置在操作期间使用真空将盘固定到台架和构件上。该构件由弹簧升起并由真空降低。该装置容易地结合到光学系统中，用于在盘的两侧执行反射和透射，同时允许分析磁盘层的组成和一致性。

6. 发明申请

US20110072914A1 Flow Cells And Manifolds Having An Electroosmotic Pump 有权
标题翻译：具有电渗泵的流动池和歧管
公开(公告)号：US20110072914A1
公开(公告)日：2011-03-31
申请号：US12031054
申请日：2008-02-14
申请人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
发明人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
IPC分类号： G01N1/14 , F04B37/10 , B01L3/02
CPC分类号： F04B19/006 , B01L3/502715 , B01L3/50273 , B01L7/00 , B01L2300/0816 , B01L2300/0877 , B01L2400/0418 , G01N35/00613 , G01N35/1095 , Y10T436/2575
摘要： A flows cell for use in a microfluidic detection system is provided. The flow cell includes a flows cell body having a channel that is configured to convey a solution through the flows cell body. The flow cell also includes a bottom surface and a top surface. The bottom surface is configured to be removably held by the detection system and the top surface is transparent and permits light to pass therethrough. The flow cell body also includes fluidic inlet and outlet ports that are in fluid communication with the channel. A pump cavity is also provided in the flow cell body. The pump cavity fluidly communicates with, and is interposed between, an end of the channel and one of the fluidic inlet and outlet ports. An electroosmotic (EO) pump is held in the pump cavity. The EO pump induces flow of the solution through the EO pump and channel between the fluidic inlet and outlet ports.
摘要翻译：提供了一种用于微流体检测系统的流通池。流动池包括具有通道的流动池主体，该通道被配置为将溶液输送通过流动池主体。流动池还包括底面和顶面。底表面被构造成由检测系统可移除地保持，并且顶表面是透明的并且允许光通过。流动池体还包括与通道流体连通的流体入口和出口。在流动池主体中还设有泵腔。泵腔与通道的端部和流体入口和出口之一流体连通并且介于其间。电渗（EO）泵保持在泵腔中。 EO泵通过EO泵和流体入口和出口之间的通道引起溶液的流动。

7. 发明授权

US09347440B2 Flow cells and manifolds having an electroosmotic pump 有权
标题翻译：具有电渗泵的流通池和歧管
公开(公告)号：US09347440B2
公开(公告)日：2016-05-24
申请号：US13442013
申请日：2012-04-09
申请人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
发明人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
IPC分类号： G01N33/48 , B01L3/00 , F04B19/00 , G01N35/00 , G01N35/10 , B01L7/00
CPC分类号： F04B19/006 , B01L3/502715 , B01L3/50273 , B01L7/00 , B01L2300/0816 , B01L2300/0877 , B01L2400/0418 , G01N35/00613 , G01N35/1095 , Y10T436/2575
摘要： A flow cell for use in a microfluidic detection system. The flow cell includes a flow cell body having a channel that extends along the flow cell body. The flow cell body has a substrate material that extends along the channel and that is transparent to at least one of excitation light or light emissions. The channel has a functionalized channel surface that includes reactive groups configured to attach to molecules for biochemical analysis. The flow cell also includes fluidic inlet and fluidic outlet ports provided on the flow cell body and an electroosmotic (EO) pump held within the flow cell body in fluid communication with the channel. The EO pump is operable to induce flow of a solution from the inlet port to the outlet port and along the functionalized channel surface.
摘要翻译：用于微流体检测系统的流动池。流动池包括具有沿着流动池体延伸的通道的流动池主体。流动池体具有沿着通道延伸并且对于激发光或光发射中的至少一种是透明的基底材料。通道具有功能化的通道表面，其包括配置成附着于分子用于生物化学分析的反应性基团。流动池还包括设置在流动池主体上的流体入口和流体出口以及保持在流动池主体内与通道流体连通的电渗（EO）泵。 EO泵可操作地引导溶液从入口流到出口并沿着官能化通道表面流动。

8. 发明申请

US20120195794A1 FLOW CELLS AND MANIFOLDS HAVING AN ELECTROOSMOTIC PUMP 有权
标题翻译：流动电池和具有电动泵的流量计
公开(公告)号：US20120195794A1
公开(公告)日：2012-08-02
申请号：US13442013
申请日：2012-04-09
申请人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
发明人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
IPC分类号： G01N33/48 , B01L3/00
CPC分类号： F04B19/006 , B01L3/502715 , B01L3/50273 , B01L7/00 , B01L2300/0816 , B01L2300/0877 , B01L2400/0418 , G01N35/00613 , G01N35/1095 , Y10T436/2575
摘要： A flow cell for use in a microfluidic detection system is provided. The flow cell includes a flow cell body having a channel that is configured to convey a solution through the flow cell body. The flow cell also includes a bottom surface and a top surface. The bottom surface is configured to be removably held by the detection system, and the top surface is transparent and permits light to pass therethrough. The flow cell body also includes fluidic inlet and outlet ports that are in fluid communication with the channel. A pump cavity is also provided in the flow cell body. The pump cavity fluidly communicates with, and is interposed between, an end of the channel and one of the fluidic inlet and outlet ports. An electroosmotic (EO) pump is held in the pump cavity. The EO pump induces flow of the solution through the EO pump and channel between the fluidic inlet and outlet ports.
摘要翻译：提供了一种用于微流体检测系统的流通池。流动池包括具有通道的流动池主体，该通道被配置为将溶液输送通过流动池主体。流动池还包括底面和顶面。底表面被构造成由检测系统可移除地保持，并且顶表面是透明的并且允许光通过。流动池体还包括与通道流体连通的流体入口和出口。在流动池主体中还设有泵腔。泵腔与通道的端部和流体入口和出口之一流体连通并且介于其间。电渗（EO）泵保持在泵腔中。 EO泵通过EO泵和流体入口和出口之间的通道引起溶液的流动。

9. 发明授权

US08173080B2 Flow cells and manifolds having an electroosmotic pump 有权
标题翻译：具有电渗泵的流通池和歧管
公开(公告)号：US08173080B2
公开(公告)日：2012-05-08
申请号：US12031054
申请日：2008-02-14
申请人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
发明人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
IPC分类号： B01L3/00
CPC分类号： F04B19/006 , B01L3/502715 , B01L3/50273 , B01L7/00 , B01L2300/0816 , B01L2300/0877 , B01L2400/0418 , G01N35/00613 , G01N35/1095 , Y10T436/2575
摘要： A flows cell for use in a microfluidic detection system is provided. The flow cell includes a flows cell body having a channel that is configured to convey a solution through the flows cell body. The flow cell also includes a bottom surface and a top surface. The bottom surface is configured to be removably held by the detection system, and the top surface is transparent and permits light to pass therethrough. The flow cell body also includes fluidic inlet and outlet ports that are in fluid communication with the channel. A pump cavity is also provided in the flow cell body. The pump cavity fluidly communicates with, and is interposed between, an end of the channel and one of the fluidic inlet and outlet ports. An electroosmotic (EO) pump is held in the pump cavity. The EO pump induces flow of the solution through the EO pump and channel between the fluidic inlet and outlet ports.
摘要翻译：提供了一种用于微流体检测系统的流通池。流动池包括具有通道的流动池主体，该通道被配置为将溶液输送通过流动池主体。流动池还包括底面和顶面。底表面被构造成由检测系统可移除地保持，并且顶表面是透明的并且允许光通过。流动池体还包括与通道流体连通的流体入口和出口。在流动池主体中还设有泵腔。泵腔与通道的端部和流体入口和出口之一流体连通并且介于其间。电渗（EO）泵保持在泵腔中。 EO泵通过EO泵和流体入口和出口之间的通道引起溶液的流动。

10. 发明申请

US20120292190A1 APPARATUS FOR FRAGMENTING NUCLEIC ACIDS 有权
标题翻译：装备核酸的装置
公开(公告)号：US20120292190A1
公开(公告)日：2012-11-22
申请号：US13551704
申请日：2012-07-18
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
IPC分类号： C25B7/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.
摘要翻译：核酸分裂装置。该装置包括包含具有核酸的流体的样品储存器。该装置还可以包括位于样品容器内的剪切壁。剪切壁包括多孔芯介质，其具有尺寸允许核酸流过其中的孔。该装置还包括被剪力墙隔开的第一和第二室。第一和第二腔室通过剪切壁的多孔纤维介质彼此流体连通。此外，该装置可以包括分别位于第一和第二室内的第一和第二电极。第一和第二电极被配置成产生诱发样品流体流动的电场。核酸通过剪切壁移动，从而使核酸分裂。

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