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1. 发明授权

US08951781B2 Systems, methods, and apparatuses to image a sample for biological or chemical analysis 有权
标题翻译：用于对样品进行成像以进行生物或化学分析的系统，方法和装置
公开(公告)号：US08951781B2
公开(公告)日：2015-02-10
申请号：US13273666
申请日：2011-10-14
申请人： Mark T. Reed , Eric Williamson , Bryan Crane , Patrick Leung , Dale Buermann , Alexander P. Kindwall , Frederick Erie , Mark Pratt , Jason Harris , Andrew James Carson , Stanley S. Hong , Jason Bryant , Mark Wang , Drew Verkade
发明人： Mark T. Reed , Eric Williamson , Bryan Crane , Patrick Leung , Dale Buermann , Alexander P. Kindwall , Frederick Erie , Mark Pratt , Jason Harris , Andrew James Carson , Stanley S. Hong , Jason Bryant , Mark Wang , Drew Verkade
IPC分类号： C12M3/00 , B01L9/00 , B01L3/00
CPC分类号： B01L3/502715 , B01L7/52 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2300/022 , B01L2300/041 , B01L2300/043 , B01L2300/0816 , B01L2300/0877 , G01N21/05 , G01N2021/058 , Y10T436/25
摘要： A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.
摘要翻译：流体装置保持器，其构造成定向流体装置。装置保持器包括构造成接收流体装置的支撑结构。所述支撑结构包括在Z轴方向上面对并且被配置成具有定位在其上的流体装置的基面。装置保持器还包括沿着XY平面在各个方向上面对的多个参考表面。装置保持器还包括具有致动器和可操作地联接到致动器的可动定位臂的对准组件。定位臂具有接合端。致动器将定位臂移动到缩回位置和偏置位置之间，以使接合端远离参考表面移动。定位臂构造成当定位臂处于偏置位置时将流体装置保持在参考表面上。

2. 发明授权

US08759077B2 Apparatus for selective excitation of microparticles 有权
标题翻译：微粒选择性激发装置
公开(公告)号：US08759077B2
公开(公告)日：2014-06-24
申请号：US11846067
申请日：2007-08-28
申请人： Stanley S. Hong , Jekwan Ryu , Jong Buhm Park
发明人： Stanley S. Hong , Jekwan Ryu , Jong Buhm Park
IPC分类号： C12M1/34 , C12M3/00 , B01J19/00 , G01N33/543 , B01L7/00
CPC分类号： C12Q1/6869 , B01J19/0046 , B01L7/52 , G01N21/6452 , G01N33/54366 , G01N33/54373
摘要： Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an optical fiber delivering a first laser beam, and an interference pattern generation module coupled to the optical fiber. The interference pattern generation module splits the first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams.
摘要翻译：通过使用一种或多种试剂对微粒进行测序反应来对核酸微粒进行测序，选择性地以激发图案激发微粒，以不足以分辨单个微粒的分辨率光学成像微粒，并使用以下步骤处理微粒的光学图像关于激发模式的信息以确定光学特征的存在或不存在，其指示核酸的序列信息。用于微粒的光激发的装置包括传送第一激光束的光纤和耦合到光纤的干涉图案生成模块。干涉图案生成模块将第一激光束分割成第二和第三激光束，并产生用于通过第二和第三激光束之间的干涉选择性地激发微粒的激励图案。

3. 发明授权

US08222040B2 Nucleic acid sequencing by selective excitation of microparticles 有权
标题翻译：通过选择性激发微粒进行核酸测序
公开(公告)号：US08222040B2
公开(公告)日：2012-07-17
申请号：US11846049
申请日：2007-08-28
申请人： Stanley S. Hong , Jekwan Ryu , Jong Buhm Park
发明人： Stanley S. Hong , Jekwan Ryu , Jong Buhm Park
IPC分类号： G01N21/63 , G06K9/00 , C12Q1/68
CPC分类号： G06K9/00 , C12Q1/6869 , G01N21/6428 , G06K2209/07 , Y10T436/143333 , C12Q2563/107 , C12Q2563/149
摘要： Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more reagents, selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an optical fiber delivering a first laser beam, and an interference pattern generation module coupled to the optical fiber. The interference pattern generation module splits the first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams.
摘要翻译：通过使用一种或多种试剂对微粒进行测序反应来对核酸微粒进行测序，选择性地以激发图案激发微粒，以不足以分辨单个微粒的分辨率光学成像微粒，并使用以下步骤处理微粒的光学图像关于激发模式的信息以确定光学特征的存在或不存在，其指示核酸的序列信息。用于微粒的光激发的装置包括传送第一激光束的光纤和耦合到光纤的干涉图案生成模块。干涉图案生成模块将第一激光束分割成第二和第三激光束，并产生用于通过第二和第三激光束之间的干涉选择性地激发微粒的激励图案。

4. 发明申请

US20090061526A1 NUCLEIC ACID SEQUENCING BY SELECTIVE EXCITATION OF MICROPARTICLES 有权
标题翻译：通过选择性激活微阵列进行核酸序列测序
公开(公告)号：US20090061526A1
公开(公告)日：2009-03-05
申请号：US11846049
申请日：2007-08-28
申请人： Stanley S. Hong , Jekwan Ryu , Jong Buhm Park
发明人： Stanley S. Hong , Jekwan Ryu , Jong Buhm Park
IPC分类号： G01N33/00 , G06K9/74
CPC分类号： G06K9/00 , C12Q1/6869 , G01N21/6428 , G06K2209/07 , Y10T436/143333 , C12Q2563/107 , C12Q2563/149
摘要： Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more reagents, selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an optical fiber delivering a first laser beam, and an interference pattern generation module coupled to the optical fiber. The interference pattern generation module splits the first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams.
摘要翻译：通过使用一种或多种试剂对微粒进行测序反应来对核酸微粒进行测序，选择性地以激发图案激发微粒，以不足以分辨单个微粒的分辨率光学成像微粒，并使用以下步骤处理微粒的光学图像关于激发模式的信息以确定光学特征的存在或不存在，其指示核酸的序列信息。用于微粒的光激发的装置包括传送第一激光束的光纤和耦合到光纤的干涉图案生成模块。干涉图案生成模块将第一激光束分割成第二和第三激光束，并产生用于通过第二和第三激光束之间的干涉选择性地激发微粒的激励图案。

5. 发明申请

US20090061505A1 APPARATUS FOR SELECTIVE EXCITATION OF MICROPARTICLES 有权
标题翻译：选择性激活微波炉的装置
公开(公告)号：US20090061505A1
公开(公告)日：2009-03-05
申请号：US11846067
申请日：2007-08-28
申请人： Stanley S. Hong , Jekwan Ryu , Jong Buhm Park
发明人： Stanley S. Hong , Jekwan Ryu , Jong Buhm Park
IPC分类号： C12M1/00
CPC分类号： C12Q1/6869 , B01J19/0046 , B01L7/52 , G01N21/6452 , G01N33/54366 , G01N33/54373
摘要： Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation pattern to determine the presence or absence of the optical signature, which indicates the sequence information of the nucleic acid. An apparatus for optical excitation of the microparticles comprises an optical fiber delivering a first laser beam, and an interference pattern generation module coupled to the optical fiber. The interference pattern generation module splits the first laser beam into second and third laser beams and generates the excitation pattern for selectively exciting the microparticles by interference between the second and third laser beams.
摘要翻译：通过使用一种或多种试剂对微粒进行测序反应来对核酸微粒进行测序，选择性地以激发图案激发微粒，以不足以分辨单个微粒的分辨率光学成像微粒，并使用以下步骤处理微粒的光学图像关于激发模式的信息以确定光学特征的存在或不存在，其指示核酸的序列信息。用于微粒的光激发的装置包括传送第一激光束的光纤和耦合到光纤的干涉图案生成模块。干涉图案生成模块将第一激光束分割成第二和第三激光束，并产生用于通过第二和第三激光束之间的干涉选择性地激发微粒的激励图案。

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