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1. 发明申请

US20110072914A1 Flow Cells And Manifolds Having An Electroosmotic Pump 有权
标题翻译：具有电渗泵的流动池和歧管
公开(公告)号：US20110072914A1
公开(公告)日：2011-03-31
申请号：US12031054
申请日：2008-02-14
申请人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
发明人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
IPC分类号： G01N1/14 , F04B37/10 , B01L3/02
CPC分类号： F04B19/006 , B01L3/502715 , B01L3/50273 , B01L7/00 , B01L2300/0816 , B01L2300/0877 , B01L2400/0418 , G01N35/00613 , G01N35/1095 , Y10T436/2575
摘要： A flows cell for use in a microfluidic detection system is provided. The flow cell includes a flows cell body having a channel that is configured to convey a solution through the flows cell body. The flow cell also includes a bottom surface and a top surface. The bottom surface is configured to be removably held by the detection system and the top surface is transparent and permits light to pass therethrough. The flow cell body also includes fluidic inlet and outlet ports that are in fluid communication with the channel. A pump cavity is also provided in the flow cell body. The pump cavity fluidly communicates with, and is interposed between, an end of the channel and one of the fluidic inlet and outlet ports. An electroosmotic (EO) pump is held in the pump cavity. The EO pump induces flow of the solution through the EO pump and channel between the fluidic inlet and outlet ports.
摘要翻译：提供了一种用于微流体检测系统的流通池。流动池包括具有通道的流动池主体，该通道被配置为将溶液输送通过流动池主体。流动池还包括底面和顶面。底表面被构造成由检测系统可移除地保持，并且顶表面是透明的并且允许光通过。流动池体还包括与通道流体连通的流体入口和出口。在流动池主体中还设有泵腔。泵腔与通道的端部和流体入口和出口之一流体连通并且介于其间。电渗（EO）泵保持在泵腔中。 EO泵通过EO泵和流体入口和出口之间的通道引起溶液的流动。

2. 发明授权

US09347440B2 Flow cells and manifolds having an electroosmotic pump 有权
标题翻译：具有电渗泵的流通池和歧管
公开(公告)号：US09347440B2
公开(公告)日：2016-05-24
申请号：US13442013
申请日：2012-04-09
申请人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
发明人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
IPC分类号： G01N33/48 , B01L3/00 , F04B19/00 , G01N35/00 , G01N35/10 , B01L7/00
CPC分类号： F04B19/006 , B01L3/502715 , B01L3/50273 , B01L7/00 , B01L2300/0816 , B01L2300/0877 , B01L2400/0418 , G01N35/00613 , G01N35/1095 , Y10T436/2575
摘要： A flow cell for use in a microfluidic detection system. The flow cell includes a flow cell body having a channel that extends along the flow cell body. The flow cell body has a substrate material that extends along the channel and that is transparent to at least one of excitation light or light emissions. The channel has a functionalized channel surface that includes reactive groups configured to attach to molecules for biochemical analysis. The flow cell also includes fluidic inlet and fluidic outlet ports provided on the flow cell body and an electroosmotic (EO) pump held within the flow cell body in fluid communication with the channel. The EO pump is operable to induce flow of a solution from the inlet port to the outlet port and along the functionalized channel surface.
摘要翻译：用于微流体检测系统的流动池。流动池包括具有沿着流动池体延伸的通道的流动池主体。流动池体具有沿着通道延伸并且对于激发光或光发射中的至少一种是透明的基底材料。通道具有功能化的通道表面，其包括配置成附着于分子用于生物化学分析的反应性基团。流动池还包括设置在流动池主体上的流体入口和流体出口以及保持在流动池主体内与通道流体连通的电渗（EO）泵。 EO泵可操作地引导溶液从入口流到出口并沿着官能化通道表面流动。

3. 发明申请

US20120195794A1 FLOW CELLS AND MANIFOLDS HAVING AN ELECTROOSMOTIC PUMP 有权
标题翻译：流动电池和具有电动泵的流量计
公开(公告)号：US20120195794A1
公开(公告)日：2012-08-02
申请号：US13442013
申请日：2012-04-09
申请人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
发明人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
IPC分类号： G01N33/48 , B01L3/00
CPC分类号： F04B19/006 , B01L3/502715 , B01L3/50273 , B01L7/00 , B01L2300/0816 , B01L2300/0877 , B01L2400/0418 , G01N35/00613 , G01N35/1095 , Y10T436/2575
摘要： A flow cell for use in a microfluidic detection system is provided. The flow cell includes a flow cell body having a channel that is configured to convey a solution through the flow cell body. The flow cell also includes a bottom surface and a top surface. The bottom surface is configured to be removably held by the detection system, and the top surface is transparent and permits light to pass therethrough. The flow cell body also includes fluidic inlet and outlet ports that are in fluid communication with the channel. A pump cavity is also provided in the flow cell body. The pump cavity fluidly communicates with, and is interposed between, an end of the channel and one of the fluidic inlet and outlet ports. An electroosmotic (EO) pump is held in the pump cavity. The EO pump induces flow of the solution through the EO pump and channel between the fluidic inlet and outlet ports.
摘要翻译：提供了一种用于微流体检测系统的流通池。流动池包括具有通道的流动池主体，该通道被配置为将溶液输送通过流动池主体。流动池还包括底面和顶面。底表面被构造成由检测系统可移除地保持，并且顶表面是透明的并且允许光通过。流动池体还包括与通道流体连通的流体入口和出口。在流动池主体中还设有泵腔。泵腔与通道的端部和流体入口和出口之一流体连通并且介于其间。电渗（EO）泵保持在泵腔中。 EO泵通过EO泵和流体入口和出口之间的通道引起溶液的流动。

4. 发明授权

US08173080B2 Flow cells and manifolds having an electroosmotic pump 有权
标题翻译：具有电渗泵的流通池和歧管
公开(公告)号：US08173080B2
公开(公告)日：2012-05-08
申请号：US12031054
申请日：2008-02-14
申请人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
发明人： Michal Lebl , Dale Buermann , Mark T. Reed , David L. Heiner , Alexander Triener
IPC分类号： B01L3/00
CPC分类号： F04B19/006 , B01L3/502715 , B01L3/50273 , B01L7/00 , B01L2300/0816 , B01L2300/0877 , B01L2400/0418 , G01N35/00613 , G01N35/1095 , Y10T436/2575
摘要： A flows cell for use in a microfluidic detection system is provided. The flow cell includes a flows cell body having a channel that is configured to convey a solution through the flows cell body. The flow cell also includes a bottom surface and a top surface. The bottom surface is configured to be removably held by the detection system, and the top surface is transparent and permits light to pass therethrough. The flow cell body also includes fluidic inlet and outlet ports that are in fluid communication with the channel. A pump cavity is also provided in the flow cell body. The pump cavity fluidly communicates with, and is interposed between, an end of the channel and one of the fluidic inlet and outlet ports. An electroosmotic (EO) pump is held in the pump cavity. The EO pump induces flow of the solution through the EO pump and channel between the fluidic inlet and outlet ports.
摘要翻译：提供了一种用于微流体检测系统的流通池。流动池包括具有通道的流动池主体，该通道被配置为将溶液输送通过流动池主体。流动池还包括底面和顶面。底表面被构造成由检测系统可移除地保持，并且顶表面是透明的并且允许光通过。流动池体还包括与通道流体连通的流体入口和出口。在流动池主体中还设有泵腔。泵腔与通道的端部和流体入口和出口之一流体连通并且介于其间。电渗（EO）泵保持在泵腔中。 EO泵通过EO泵和流体入口和出口之间的通道引起溶液的流动。

5. 发明授权

US08597594B2 Apparatus for fragmenting nucleic acids 有权
标题翻译：破碎核酸的装置
公开(公告)号：US08597594B2
公开(公告)日：2013-12-03
申请号：US13551704
申请日：2012-07-18
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain , Michael Schroeder
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain , Michael Schroeder
IPC分类号： B01L3/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.
摘要翻译：核酸分裂装置。该装置包括包含具有核酸的流体的样品储存器。该装置还可以包括位于样品容器内的剪切壁。剪切壁包括多孔芯介质，其具有尺寸允许核酸流过其中的孔。该装置还包括被剪力墙隔开的第一和第二室。第一和第二腔室通过剪切壁的多孔纤维介质彼此流体连通。此外，该装置可以包括分别位于第一和第二室内的第一和第二电极。第一和第二电极被配置成产生诱发样品流体流动的电场。核酸通过剪切壁移动，从而使核酸分裂。

6. 发明申请

US20120292190A1 APPARATUS FOR FRAGMENTING NUCLEIC ACIDS 有权
标题翻译：装备核酸的装置
公开(公告)号：US20120292190A1
公开(公告)日：2012-11-22
申请号：US13551704
申请日：2012-07-18
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
IPC分类号： C25B7/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.
摘要翻译：核酸分裂装置。该装置包括包含具有核酸的流体的样品储存器。该装置还可以包括位于样品容器内的剪切壁。剪切壁包括多孔芯介质，其具有尺寸允许核酸流过其中的孔。该装置还包括被剪力墙隔开的第一和第二室。第一和第二腔室通过剪切壁的多孔纤维介质彼此流体连通。此外，该装置可以包括分别位于第一和第二室内的第一和第二电极。第一和第二电极被配置成产生诱发样品流体流动的电场。核酸通过剪切壁移动，从而使核酸分裂。

7. 发明申请

US20100187115A1 ELECTROOSMOTIC PUMP WITH IMPROVED GAS MANAGEMENT 有权
标题翻译：具有改进气体管理的电动泵
公开(公告)号：US20100187115A1
公开(公告)日：2010-07-29
申请号：US12626353
申请日：2009-11-25
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
IPC分类号： B01D57/02 , F04B19/00 , B01D61/46 , B81B7/02 , C12Q1/68 , B01J19/00 , G01N27/447
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.
摘要翻译：提供一种电渗（EO）泵，其包括具有泵腔的壳体，多孔芯介质和电极。多孔芯介质定位在泵腔内以形成至少部分地围绕多孔芯介质的外表面延伸的外部储存器。多孔芯介质具有设置在其中的开放内室。内室表示内部储存器。电极定位在内室中并且位于外表面附近。电极通过多孔芯介质在内部和外部储存器之间引导流体流动，其中当电极引起流体流动时产生气体。壳体具有用于将流体输送到内部储存器和外部储存器中的一个的流体入口。壳体具有流体出口，以从另一个内部储存器和外部储存器排出流体。壳体具有用于从泵腔去除气体的气体去除装置。

8. 发明授权

US08252250B2 Electroosmotic pump with improved gas management 有权
标题翻译：电渗泵具有改进的气体管理
公开(公告)号：US08252250B2
公开(公告)日：2012-08-28
申请号：US12626353
申请日：2009-11-25
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
IPC分类号： B01L3/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.
摘要翻译：提供一种电渗（EO）泵，其包括具有泵腔的壳体，多孔芯介质和电极。多孔芯介质定位在泵腔内以形成至少部分地围绕多孔芯介质的外表面延伸的外部储存器。多孔芯介质具有设置在其中的开放内室。内室表示内部储存器。电极定位在内室中并且位于外表面附近。电极通过多孔芯介质在内部和外部储存器之间引导流体流动，其中当电极引起流体流动时产生气体。壳体具有用于将流体输送到内部储存器和外部储存器中的一个的流体入口。壳体具有流体出口，以从另一个内部储存器和外部储存器排出流体。壳体具有用于从泵腔去除气体的气体去除装置。

9. 发明授权

US08481903B2 Systems, methods, and apparatuses including a moveable optical component for detecting optical signals from a sample 有权
标题翻译：包括用于检测来自样品的光信号的可移动光学部件的系统，方法和装置
公开(公告)号：US08481903B2
公开(公告)日：2013-07-09
申请号：US13041194
申请日：2011-03-04
申请人： Alexander Triener , Erik Allegoren , Wenyi Feng , Dale Buermann , Erik Olson , James Osmus
发明人： Alexander Triener , Erik Allegoren , Wenyi Feng , Dale Buermann , Erik Olson , James Osmus
IPC分类号： G02B7/04
CPC分类号： C12Q1/6874 , C12Q1/6837 , G01N21/6428 , G01N21/645 , G01N21/6456
摘要： An optical system configured to detect optical signals during imaging sessions. The optical system includes an objective lens that has a collecting end that is positioned proximate to a sample and configured to receive optical signals therefrom. The optical system also includes a removable path compensator that is configured to be located at an imaging position between the collecting end of the objective lens and the sample. The path compensator adjusts an optical path of the light emissions when in the imaging position. Also, the optical system includes a transfer device that is configured to move the path compensator. The transfer device locates the path compensator at the imaging position for a first imaging session and removes the path compensator from the imaging position for a second imaging session.
摘要翻译：一种配置成在成像会话期间检测光信号的光学系统。光学系统包括物镜，该物镜具有位于样品附近并被配置为从其接收光信号的收集端。光学系统还包括被配置为位于物镜的收集端和样品之间的成像位置处的可移除路径补偿器。路径补偿器在成像位置调整光发射的光路。此外，光学系统包括被配置为移动路径补偿器的传送装置。传送装置将路径补偿器定位在用于第一成像会话的成像位置处，并从第二成像会话的成像位置移除路径补偿器。

10. 发明授权

US08951781B2 Systems, methods, and apparatuses to image a sample for biological or chemical analysis 有权
标题翻译：用于对样品进行成像以进行生物或化学分析的系统，方法和装置
公开(公告)号：US08951781B2
公开(公告)日：2015-02-10
申请号：US13273666
申请日：2011-10-14
申请人： Mark T. Reed , Eric Williamson , Bryan Crane , Patrick Leung , Dale Buermann , Alexander P. Kindwall , Frederick Erie , Mark Pratt , Jason Harris , Andrew James Carson , Stanley S. Hong , Jason Bryant , Mark Wang , Drew Verkade
发明人： Mark T. Reed , Eric Williamson , Bryan Crane , Patrick Leung , Dale Buermann , Alexander P. Kindwall , Frederick Erie , Mark Pratt , Jason Harris , Andrew James Carson , Stanley S. Hong , Jason Bryant , Mark Wang , Drew Verkade
IPC分类号： C12M3/00 , B01L9/00 , B01L3/00
CPC分类号： B01L3/502715 , B01L7/52 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/04 , B01L2200/0689 , B01L2300/022 , B01L2300/041 , B01L2300/043 , B01L2300/0816 , B01L2300/0877 , G01N21/05 , G01N2021/058 , Y10T436/25
摘要： A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.
摘要翻译：流体装置保持器，其构造成定向流体装置。装置保持器包括构造成接收流体装置的支撑结构。所述支撑结构包括在Z轴方向上面对并且被配置成具有定位在其上的流体装置的基面。装置保持器还包括沿着XY平面在各个方向上面对的多个参考表面。装置保持器还包括具有致动器和可操作地联接到致动器的可动定位臂的对准组件。定位臂具有接合端。致动器将定位臂移动到缩回位置和偏置位置之间，以使接合端远离参考表面移动。定位臂构造成当定位臂处于偏置位置时将流体装置保持在参考表面上。

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