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1. 发明授权

US08597594B2 Apparatus for fragmenting nucleic acids 有权
标题翻译：破碎核酸的装置
公开(公告)号：US08597594B2
公开(公告)日：2013-12-03
申请号：US13551704
申请日：2012-07-18
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain , Michael Schroeder
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain , Michael Schroeder
IPC分类号： B01L3/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.
摘要翻译：核酸分裂装置。该装置包括包含具有核酸的流体的样品储存器。该装置还可以包括位于样品容器内的剪切壁。剪切壁包括多孔芯介质，其具有尺寸允许核酸流过其中的孔。该装置还包括被剪力墙隔开的第一和第二室。第一和第二腔室通过剪切壁的多孔纤维介质彼此流体连通。此外，该装置可以包括分别位于第一和第二室内的第一和第二电极。第一和第二电极被配置成产生诱发样品流体流动的电场。核酸通过剪切壁移动，从而使核酸分裂。

2. 发明申请

US20120292190A1 APPARATUS FOR FRAGMENTING NUCLEIC ACIDS 有权
标题翻译：装备核酸的装置
公开(公告)号：US20120292190A1
公开(公告)日：2012-11-22
申请号：US13551704
申请日：2012-07-18
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
IPC分类号： C25B7/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An apparatus for fragmenting nucleic acid. The apparatus includes a sample reservoir that comprises a fluid having nucleic acids. The apparatus can also include a shear wall that is positioned within the sample reservoir. The shear wall includes a porous core medium that has pores that are sized to permit nucleic acids to flow therethrough. The apparatus also includes first and second chambers that are separated by the shear wall. The first and second chambers are in fluid communication with each other through the porous core medium of the shear wall. Also, the apparatus may include first and second electrodes that are located within the first and second chambers, respectively. The first and second electrodes are configured to generate an electric field that induces a flow of the sample fluid. The nucleic acids move through the shear wall thereby fragmenting the nucleic acids.
摘要翻译：核酸分裂装置。该装置包括包含具有核酸的流体的样品储存器。该装置还可以包括位于样品容器内的剪切壁。剪切壁包括多孔芯介质，其具有尺寸允许核酸流过其中的孔。该装置还包括被剪力墙隔开的第一和第二室。第一和第二腔室通过剪切壁的多孔纤维介质彼此流体连通。此外，该装置可以包括分别位于第一和第二室内的第一和第二电极。第一和第二电极被配置成产生诱发样品流体流动的电场。核酸通过剪切壁移动，从而使核酸分裂。

3. 发明授权

US08252250B2 Electroosmotic pump with improved gas management 有权
标题翻译：电渗泵具有改进的气体管理
公开(公告)号：US08252250B2
公开(公告)日：2012-08-28
申请号：US12626353
申请日：2009-11-25
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
IPC分类号： B01L3/00
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.
摘要翻译：提供一种电渗（EO）泵，其包括具有泵腔的壳体，多孔芯介质和电极。多孔芯介质定位在泵腔内以形成至少部分地围绕多孔芯介质的外表面延伸的外部储存器。多孔芯介质具有设置在其中的开放内室。内室表示内部储存器。电极定位在内室中并且位于外表面附近。电极通过多孔芯介质在内部和外部储存器之间引导流体流动，其中当电极引起流体流动时产生气体。壳体具有用于将流体输送到内部储存器和外部储存器中的一个的流体入口。壳体具有流体出口，以从另一个内部储存器和外部储存器排出流体。壳体具有用于从泵腔去除气体的气体去除装置。

4. 发明申请

US20100187115A1 ELECTROOSMOTIC PUMP WITH IMPROVED GAS MANAGEMENT 有权
标题翻译：具有改进气体管理的电动泵
公开(公告)号：US20100187115A1
公开(公告)日：2010-07-29
申请号：US12626353
申请日：2009-11-25
申请人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
发明人： Jonathan Posner , Kamil Salloum , Michal Lebl , Mark Reed , Dale Buermann , Matthew Hage , Bryan Crane , David Heiner , Robert Kain
IPC分类号： B01D57/02 , F04B19/00 , B01D61/46 , B81B7/02 , C12Q1/68 , B01J19/00 , G01N27/447
CPC分类号： F04B37/10 , F04B19/00 , Y10T436/2575
摘要： An electroosmotic (EO) pump is provided that includes a housing having a pump cavity, a porous core medium and electrodes. The porous core medium is positioned within the pump cavity to form an exterior reservoir that extends at least partially about an exterior surface of the porous core medium. The porous core medium has an open inner chamber provided therein. The inner chamber represents an interior reservoir. The electrodes are positioned in the inner chamber and are positioned proximate the exterior surface. The electrodes induce flow of a fluid through the porous core medium between the interior and exterior reservoirs, wherein a gas is generated when the electrodes induce flow of the fluid. The housing has a fluid inlet to convey the fluid to one of the interior reservoir and the exterior reservoir. The housing has a fluid outlet to discharge the fluid from another of the interior reservoir and the exterior reservoir. The housing has a gas removal device to remove the gas from the pump cavity.
摘要翻译：提供一种电渗（EO）泵，其包括具有泵腔的壳体，多孔芯介质和电极。多孔芯介质定位在泵腔内以形成至少部分地围绕多孔芯介质的外表面延伸的外部储存器。多孔芯介质具有设置在其中的开放内室。内室表示内部储存器。电极定位在内室中并且位于外表面附近。电极通过多孔芯介质在内部和外部储存器之间引导流体流动，其中当电极引起流体流动时产生气体。壳体具有用于将流体输送到内部储存器和外部储存器中的一个的流体入口。壳体具有流体出口，以从另一个内部储存器和外部储存器排出流体。壳体具有用于从泵腔去除气体的气体去除装置。

5. 发明申请

US20100111768A1 SYSTEMS AND DEVICES FOR SEQUENCE BY SYNTHESIS ANALYSIS 有权
标题翻译：通过合成分析进行序列的系统和设备
公开(公告)号：US20100111768A1
公开(公告)日：2010-05-06
申请号：US12295337
申请日：2007-03-30
申请人： Saibal Banerjee , Colin Barnes , Kevin Benson , John Bridgham , Jason Bryant , Dale Buermann , Sergey Etchin , Jonny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Isabelle Rasolonjatovo , Mark Reed , Chiara Rodighiero , Subra Sankar , Gary Schroth , Ning Sizto , Harold Swerdlow , Eric Vermaas
发明人： Saibal Banerjee , Colin Barnes , Kevin Benson , John Bridgham , Jason Bryant , Dale Buermann , Sergey Etchin , Jonny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Isabelle Rasolonjatovo , Mark Reed , Chiara Rodighiero , Subra Sankar , Gary Schroth , Ning Sizto , Harold Swerdlow , Eric Vermaas
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： C12Q1/6869 , C12Q2535/122 , C12Q2565/60 , G01N21/6456
摘要： The present invention comprises systems and devices for sequencing of nucleic acid, such as short DNA sequences from clonally amplified single-molecule arrays.
摘要翻译：本发明包括用于核酸测序的系统和装置，例如来自克隆扩增的单分子阵列的短DNA序列。

6. 发明授权

US08241573B2 Systems and devices for sequence by synthesis analysis 有权
标题翻译：通过合成分析进行序列的系统和装置
公开(公告)号：US08241573B2
公开(公告)日：2012-08-14
申请号：US12295337
申请日：2007-03-30
申请人： Saibal Banerjee , Colin Barnes , Kevin Benson , Jason Bryant , Dale Buermann , Sergey Etchin , Johnny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Mark Reed , Chiara Rodighiero , Subra Sankar , Harold Swerdlow , Eric Vermaas
发明人： Saibal Banerjee , Colin Barnes , Kevin Benson , Jason Bryant , Dale Buermann , Sergey Etchin , Johnny Ho , Xavier Lee , Peter Lundberg , Klaus Maisinger , Bojan Obradovic , Mark Pratt , Mark Reed , Chiara Rodighiero , Subra Sankar , Harold Swerdlow , Eric Vermaas
IPC分类号： G01N21/64 , G06K9/00 , C12M1/36
CPC分类号： C12Q1/6869 , C12Q2535/122 , C12Q2565/60 , G01N21/6456
摘要： The present invention comprises systems and devices for sequencing of nucleic acid, such as short DNA sequences from clonally amplified single-molecule arrays.
摘要翻译：本发明包括用于核酸测序的系统和装置，例如来自克隆扩增的单分子阵列的短DNA序列。

7. 发明申请

US20080077582A1 System and method of ad-hoc analysis of data 有权
标题翻译：数据临时分析的系统和方法
公开(公告)号：US20080077582A1
公开(公告)日：2008-03-27
申请号：US11897984
申请日：2007-08-31
申请人： Mark Reed
发明人： Mark Reed
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30613
摘要： It is a first aspect of the present invention to provide a computer implemented method of performing ad-hoc analysis including the steps of: generating a text index of the textual information items, generating a metadata lookup structure based, at least in part, on the text index, searching the text index using a search query, compiling results of the text index search into aggregate information related to characteristics of the search results from the metadata items associated with the textual information items in the search results from the metadata lookup structure, and reporting the aggregate information.
摘要翻译：本发明的第一方面是提供一种执行临时分析的计算机实现方法，包括以下步骤：生成文本信息项的文本索引，至少部分地基于文本信息项生成元数据查找结构文本索引，使用搜索查询搜索文本索引，将来自与来自元数据查找结构的搜索结果中的文本信息项相关联的元数据项的搜索结果的特征相关的文本索引搜索的结果编译成聚合信息;以及报告汇总信息。

8. 发明申请

US20070014694A1 High density plate filler 审中-公开
标题翻译：高密度板填料
公开(公告)号：US20070014694A1
公开(公告)日：2007-01-18
申请号：US11086800
申请日：2005-03-22
申请人： Nigel Beard , Albert Carrillo , Ian Harding , Mark Reed
发明人： Nigel Beard , Albert Carrillo , Ian Harding , Mark Reed
IPC分类号： B01L3/02
CPC分类号： B01L3/50853 , B01L3/0293 , B01L3/5025 , B01L3/50851 , B01L3/563 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2200/0684 , B01L2300/0829 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , G01N35/1074
摘要： A filling apparatus for filling a microplate. The microplate having a plurality of wells each sized to receive an assay. The filling apparatus can comprise an assay input layer having a first surface and an opposing second surface. The assay input layer can comprise an assay input port extending from the first surface to the second surface and at least one pressure nodule extending from the second surface. An output layer can comprise a plurality of staging capillaries each having an inlet and an outlet. A intermediate layer can be disposed between the assay input layer and the output layer. The intermediate layer can be flexible and comprise a plurality of microfluidic channels and a flow aperture being in fluid communication with the assay input port and the plurality of microfluidic channels. The assay input layer can be moveable relative to the intermediate layer such that the at least one pressure nodule engages the intermediate layer to apply a clamping force on at least a portion of one of the plurality of microfluidic channels to reduce flow of the assay therethrough.
摘要翻译：一种用于填充微板的填充装置。微量培养板具有多个孔，每个孔的大小用于接受测定。填充装置可以包括具有第一表面和相对的第二表面的测定输入层。测定输入层可以包括从第一表面延伸到第二表面的测定输入端口和从第二表面延伸的至少一个压力结节。输出层可以包括多个具有入口和出口的分段毛细管。中间层可以设置在测定输入层和输出层之间。中间层可以是柔性的并且包括多个微流体通道，并且流动孔与测定输入端口和多个微流体通道流体连通。测定输入层可以相对于中间层移动，使得至少一个压力结节接合中间层，以在多个微流体通道之一的至少一部分上施加夹紧力，以减少测定的流动。

9. 发明申请

US20060233673A1 High density plate filler 审中-公开
标题翻译：高密度板填料
公开(公告)号：US20060233673A1
公开(公告)日：2006-10-19
申请号：US11393083
申请日：2006-03-30
申请人： Nigel Beard , Mark Reed
发明人： Nigel Beard , Mark Reed
IPC分类号： B01L3/00 , G01N35/00
CPC分类号： G01N35/1074 , B01L3/0293 , B01L3/5025 , B01L3/50851 , B01L3/50853 , B01L3/563 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2200/0684 , B01L2300/0829 , B01L2300/0864 , B01L2300/1805 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487
摘要： A filling apparatus for filling a microplate. The microplate can comprise a plurality of wells each sized to receive an assay. A substrate can comprise a first surface and an opposing second surface, a first assay input port for receiving the assay disposed on the first surface, a plurality of staging capillaries extending through the substrate, a fluid interconnect system fluidly coupling the first assay input port with at least one of the plurality of staging capillaries, and an overflow retention system receiving and retaining excess assay from said fluid interconnect system. Each of the plurality of staging capillaries can comprise an inlet and an outlet and be sized to receive the assay.
摘要翻译：一种用于填充微板的填充装置。微量培养板可以包括多个孔，每个孔的尺寸适于接受测定。基底可以包括第一表面和相对的第二表面，用于接收设置在第一表面上的测定的第一测定输入端口，延伸穿过基底的多个分期毛细血管，将第一测定输入端口与所述多个分级毛细管中的至少一个，以及从所述流体互连系统接收和保留多余测定的溢流保持系统。多个分级毛细管中的每一个可以包括入口和出口，并且其大小适于接收测定。

10. 发明申请

US20050285060A1 Liquid level measurement 有权
标题翻译：液位测量
公开(公告)号：US20050285060A1
公开(公告)日：2005-12-29
申请号：US11130606
申请日：2005-05-16
申请人： Douwe Haga , Michael Flatbush , Michael Mosseau , Tony Yan , Willy Wiyatno , Mark Reed
发明人： Douwe Haga , Michael Flatbush , Michael Mosseau , Tony Yan , Willy Wiyatno , Mark Reed
IPC分类号： G01F23/00 , G01F23/292 , G01N9/04 , G01N15/06 , G01N21/49 , G01N35/02 , G01N35/10
CPC分类号： G01F23/292 , G01F23/0061 , G01F23/2928 , G01N9/04 , G01N35/028 , G01N2035/1025
摘要： The present application relates to an apparatus and method for measuring liquid levels in small-volume wells.
摘要翻译：本申请涉及用于测量小容量井中的液面的装置和方法。

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