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1. 发明授权

US07019838B2 System and method for low coherence broadband quadrature interferometry 失效
标题翻译：低相干宽带正交干涉测量系统和方法
公开(公告)号：US07019838B2
公开(公告)日：2006-03-28
申请号：US10855652
申请日：2004-05-28
申请人： Joseph A. Izatt , Michael Choma , Changhuei Yang
发明人： Joseph A. Izatt , Michael Choma , Changhuei Yang
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02044 , G01B9/02081 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01N21/4795
摘要： A quadrature broadband interferometry system and method obtains a complete complex interferometric signal instantaneously in both homodyne and heterodyne systems in a simple, compact, and inexpensive setup. This is accomplished by separating interferometric components from non-interferometric components in each of at least two detector signals of an interferometer having a number of N×N couplers, scaling the interferometric components, and generating real and imaginary parts of a complex interferometric signal from the scaled interferometric components. The detector signals preferably derive from a broadband light source coupled to the interferometer, and the number of N×N couplers may be one or more, with N≧3.
摘要翻译：正交宽带干涉测量系统和方法在简单，紧凑且便宜的设置中在零差和外差系统中瞬时获得完整的复杂干涉信号。这是通过将具有多个N×N耦合器的干涉仪的至少两个检测器信号中的每一个中的干涉测量分量分离成干涉测量分量来实现的，缩放干涉测量分量，以及从经缩放的干涉测量中产生复干涉信号的实部和虚部组件。检测器信号优选地源自耦合到干涉仪的宽带光源，并且N×N个耦合器的数量可以是一个或多个，其中N≥3。

2. 发明授权

US07075658B2 Method for optical coherence tomography imaging with molecular contrast 有权
标题翻译：光学相干层析成像与分子对比的方法
公开(公告)号：US07075658B2
公开(公告)日：2006-07-11
申请号：US10765010
申请日：2004-01-26
申请人： Joseph A. Izatt , Divakar K. Rao , Changhuei Yang , Michael A. Choma , Siavash Yazdanfar , Andrew M. Rollins , Brian E. Applegate
发明人： Joseph A. Izatt , Divakar K. Rao , Changhuei Yang , Michael A. Choma , Siavash Yazdanfar , Andrew M. Rollins , Brian E. Applegate
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02007 , G01B9/02014 , G01B9/02044 , G01B9/02069 , G01B9/02091 , G01B2290/70
摘要： Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.
摘要翻译：关于特定分子造影剂的空间信息，例如浓度和位移可以通过刺激含有试剂的样品来确定，从而改变试剂的光学性质。可以获取多个光学相干断层摄影（OCT）图像，其中至少一些在不同的刺激强度下被获取。采集的图像用于分析样品的分子造影剂浓度分布。

3. 发明申请

US20050036150A1 Method for optical coherence tomography imaging with molecular contrast 有权
标题翻译：光学相干层析成像与分子对比的方法
公开(公告)号：US20050036150A1
公开(公告)日：2005-02-17
申请号：US10765010
申请日：2004-01-26
申请人： Joseph Izatt , Divakar Rao , Changhuei Yang , Michael Choma , Siavash Yazdanfar , Andrew Rollins , Brian Applegate
发明人： Joseph Izatt , Divakar Rao , Changhuei Yang , Michael Choma , Siavash Yazdanfar , Andrew Rollins , Brian Applegate
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02007 , G01B9/02014 , G01B9/02044 , G01B9/02069 , G01B9/02091 , G01B2290/70
摘要： Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.
摘要翻译：关于特定分子造影剂的空间信息，例如浓度和位移可以通过刺激含有试剂的样品来确定，从而改变试剂的光学性质。可以获取多个光学相干断层摄影（OCT）图像，其中至少一些在不同的刺激强度下被获取。采集的图像用于分析样品的分子造影剂浓度分布。

4. 发明授权

US09041938B2 Surface wave assisted structures and systems 有权
标题翻译：表面波辅助结构和系统
公开(公告)号：US09041938B2
公开(公告)日：2015-05-26
申请号：US13344550
申请日：2012-01-05
申请人： Guoan Zheng , Xiquan Cui , Xin Heng , Changhuei Yang , Axel Scherer
发明人： Guoan Zheng , Xiquan Cui , Xin Heng , Changhuei Yang , Axel Scherer
IPC分类号： G01B9/02 , G02B6/122 , B82Y20/00 , G01N21/552 , G02B5/00 , G02B21/00 , G02B21/14 , G02B27/52
CPC分类号： G02B6/1226 , B82Y20/00 , G01N21/554 , G02B5/008 , G02B21/0032 , G02B21/004 , G02B21/0056 , G02B21/0068 , G02B21/14 , G02B27/52
摘要： A surface wave assisted system having an aperture layer with a surface and an aperture, and a plurality of grooves around the aperture. The plurality of grooves is configured to generate an optical transfer function at the aperture by inducing a surface wave for interfering with transmission of light of a range of spatial frequency.
摘要翻译：表面波辅助系统，具有具有表面和孔径的孔层，以及围绕孔的多个凹槽。多个槽被配置为通过诱导表面波来干扰空间频率范围的光的透射来在孔处产生光学传递函数。

5. 发明授权

US08946619B2 Talbot-illuminated imaging devices, systems, and methods for focal plane tuning 有权
标题翻译： Talbot照明成像设备，系统和焦平面调谐方法
公开(公告)号：US08946619B2
公开(公告)日：2015-02-03
申请号：US13451543
申请日：2012-04-20
申请人： Jigang Wu , Shuo Pang , Zheng Li , Guoan Zheng , Changhuei Yang
发明人： Jigang Wu , Shuo Pang , Zheng Li , Guoan Zheng , Changhuei Yang
IPC分类号： H01J5/16 , G02B21/08 , G02B21/00 , G02B21/24 , G02B21/36 , G02B27/42
CPC分类号： G02B21/086 , G02B21/0044 , G02B21/244 , G02B21/361 , G02B27/4227
摘要： A Talbot-illuminated imaging system for focal plane tuning, the device comprising a Talbot element, a tunable illumination source, a scanning mechanism, a light detector, and a processor. The element generate san array of focused light spots at a focal plane. The tunable illumination source shifts the focal plane to a plane of interest by adjusting a wavelength of light incident the Talbot element. The scanning mechanism scans an object across an array of focused light spots in a scanning direction. The light detector determines time-varying light data associated with the array of focused light spots as the object scans across the array of light spots. The processor constructs an image of the object based on the time-varying data.
摘要翻译：一种用于焦平面调谐的Talbot照明成像系统，该装置包括Talbot元件，可调谐照明源，扫描机构，光检测器和处理器。该元素在聚焦平面上产生聚焦光斑的圣阵列。可调谐照明源通过调节入射到Talbot元件的光的波长将焦平面移动到感兴趣的平面。扫描机构沿扫描方向扫描聚焦光点阵列上的物体。光检测器确定随着对象扫描光点阵列而与聚焦光点阵列相关联的时变光数据。处理器基于时变数据构建对象的图像。

6. 发明授权

US08767216B2 Holographically illuminated imaging devices 有权
标题翻译：全息照明成像装置
公开(公告)号：US08767216B2
公开(公告)日：2014-07-01
申请号：US12903650
申请日：2010-10-13
申请人： Changhuei Yang , Jigang Wu , Shuo Pang
发明人： Changhuei Yang , Jigang Wu , Shuo Pang
IPC分类号： G01B9/02 , G02B21/16 , G02B27/14 , G02B26/10 , G02B5/32 , G02B27/10 , G02B21/00 , G02B26/00
CPC分类号： G02B27/106 , G02B5/32 , G02B21/0076 , G02B21/16 , G02B26/004 , G02B26/10 , G02B27/1093 , G02B27/141
摘要： Embodiments of the present invention relate to holographically illuminated imaging devices including a holographic element for transforming an illumination beam into a focal array of light spots, a scanning mechanism for moving an object across one or more light spots in the focal array of light spots, and a light detector for detecting light associated with the focal array of light spots and generating light data associated with the received light.
摘要翻译：本发明的实施例涉及全息照明的成像装置，其包括用于将照明光束变换成光点的焦点阵列的全息元件，用于沿着光斑的焦点阵列中的一个或多个光点移动物体的扫描机构，以及光检测器，用于检测与光点的焦点阵列相关联的光并产生与所接收的光相关联的光数据。

7. 发明授权

US08633432B2 Reflective focusing and transmissive projection device 有权
标题翻译：反射聚焦和透射投影装置
公开(公告)号：US08633432B2
公开(公告)日：2014-01-21
申请号：US12886779
申请日：2010-09-21
申请人： Shuo Pang , Changhuei Yang
发明人： Shuo Pang , Changhuei Yang
IPC分类号： H01J3/14 , G01J3/50 , G01N15/06
CPC分类号： G01B9/04 , G02B5/10 , G02B17/002 , G02B19/0028 , G02B19/0076 , G02B21/0076 , G02B21/16 , G02B27/40
摘要： Embodiments of the present invention relate to a reflective focusing and transmissive projection device having a body, a set of reflective-focusing components and a light detector. The body has a surface layer with first and second surfaces, and a detecting layer outside the second surface. The set of reflective-focusing components is in the surface layer. Each reflective-focusing component has a contouring element and a curved reflective element conformed to the contouring element. The curved reflective element is configured to reflect light of a first type, transmit light of a second type and focus the light of the first type outside the first surface of the surface layer. The light detector is in the detecting layer, and is configured to receive light and generate light data associated with the received light. Also, the contouring element can be configured to focus the light of the second type on the light detector.
摘要翻译：本发明的实施例涉及一种具有主体，一组反射聚焦部件和光检测器的反射聚焦和透射投影装置。主体具有第一表面和第二表面的表面层，以及位于第二表面外部的检测层。该组反射聚焦组件位于表面层。每个反射聚焦部件具有轮廓元件和符合轮廓元件的弯曲反射元件。弯曲反射元件被配置为反射第一类型的光，透射第二类型的光并将第一类型的光聚焦在表面层的第一表面之外。光检测器在检测层中，并且被配置为接收光并产生与所接收的光相关联的光数据。此外，轮廓元件可以被配置为将第二类型的光聚焦在光检测器上。

8. 发明授权

US08334982B2 Systems and methods for phase measurements 有权
标题翻译：相位测量的系统和方法
公开(公告)号：US08334982B2
公开(公告)日：2012-12-18
申请号：US12494605
申请日：2009-06-30
申请人： Christopher Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra Dasari , Michael Feld
发明人： Christopher Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra Dasari , Michael Feld
IPC分类号： G01B11/02
CPC分类号： G01B9/02091 , A61B5/14532 , A61B5/1455 , A61B5/7232 , G01B9/02002 , G01B9/02007 , G01B9/02011 , G01B9/02057 , G01B9/02063 , G01B9/02067 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02078 , G01B9/02083 , G01B9/0209 , G01B2290/45 , G01B2290/60 , G01B2290/70 , G01J9/04 , G01N21/45
摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
摘要翻译：本发明的优选实施例涉及用于相位测量的系统，其使用多种策略的组合来解决相位噪声问题，包括但不限于公共路径干涉测量，相位参考，主动稳定和差分测量。实施例涉及用于用光成像小生物物体的光学装置。这些实施方案可以应用于例如细胞生理学和神经科学领域。这些优选实施例基于相位测量和成像技术的原理。使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学，其可以包括但不限于成像发育异常起源，细胞通讯，神经元传播和遗传密码的实现。亚细胞组分的结构和动力学目前不能使用现有的方法和技术（例如x射线和中子散射）在其天然状态下研究。相比之下，具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。因此，本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统，并且用于研究细胞生理学。这些系统包括使用光学干涉仪来测量相位的低相干干涉测量（LCI）原理，或使用其中使用细胞部件本身内部的干扰的光散射光谱（LSS），或者替代地，LCI和LSS的原理可以组合以产生在本发明的系统中。

9. 发明授权

US08314933B2 Optofluidic microscope device with photosensor array 有权
标题翻译：具有光电传感器阵列的光电显微镜装置
公开(公告)号：US08314933B2
公开(公告)日：2012-11-20
申请号：US12398050
申请日：2009-03-04
申请人： Xiquan Cui , Xin Heng , Lap Man Lee , Changhuei Yang
发明人： Xiquan Cui , Xin Heng , Lap Man Lee , Changhuei Yang
IPC分类号： G01N21/00
CPC分类号： G01N21/53 , G01N21/6458
摘要： Embodiments of the present invention relate to techniques for improving optofluidic microscope (OFM) devices. One technique which may be used eliminates the aperture layer covering the light detector layer. Other techniques retain the aperture layer, reversing the relative position of the light source and light detector such that light passes through the aperture layer before passing through the fluid channel to the light detector. Another technique adds an optical tweezer for controlling the movement of objects moving through the fluid channel. Another technique adds an optical fiber bundle to relay light from light transmissive regions to a remote light detector. Another technique adds two electrodes at ends of the fluid channel to generate an electrical field capable of moving objects through the fluid channel while suppressing rotation. These techniques can be employed separately or in combination to improve the capabilities of OFM devices.
摘要翻译：本发明的实施例涉及用于改进光流体显微镜（OFM）装置的技术。可以使用的一种技术消除了覆盖光检测器层的孔径层。其他技术保留孔径层，反转光源和光检测器的相对位置，使得光在通过流体通道之前通过孔层，到达光检测器。另一种技术增加了用于控制移动通过流体通道的物体运动的光学镊子。另一种技术增加了光纤束，以将来自光透射区域的光中继到远程光检测器。另一种技术在流体通道的端部添加两个电极，以产生能够通过流体通道移动物体同时抑制旋转的电场。这些技术可以单独使用或组合使用以提高OFM设备的能力。

10. 发明申请

US20120223217A1 E-PETRI DISHES, DEVICES, AND SYSTEMS 有权
标题翻译：电子PETRI DISHES，设备和系统
公开(公告)号：US20120223217A1
公开(公告)日：2012-09-06
申请号：US13411302
申请日：2012-03-02
申请人： Guoan Zheng , Samuel Yang , Seung Ah Lee , Shuo Pang , Changhuei Yang
发明人： Guoan Zheng , Samuel Yang , Seung Ah Lee , Shuo Pang , Changhuei Yang
IPC分类号： G01J1/02
CPC分类号： B01L3/508 , B01L3/502792 , B01L2300/0654 , C12M23/10 , G01N21/03 , G01N21/25 , G01N21/272 , G01N2201/10 , G02B21/0008 , G02B21/06 , G02B21/367 , G03H1/0443 , G03H1/0465 , G03H2001/0447 , G03H2222/34 , G03H2240/56
摘要： An e-Petri dish comprising a transparent layer having a specimen surface and a light detector configured to sample a sequence of sub-pixel shifted projection images of a specimen located on the specimen surface. The sub-pixel shifted projection images associated with light from a plurality of illumination angles provided by an illumination source.
摘要翻译：一种电子培养皿，包括具有样本表面的透明层和被配置为对位于样本表面上的样本的亚像素偏移的投影图像的序列进行采样的光检测器。子像素偏移与由照明源提供的多个照明角度的光相关联的投影图像。

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