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1. 发明申请

US20060232783A1 Methods and systems for reducing complex conjugat ambiguity in interferometric data 有权
标题翻译：用于降低干涉测量数据中复杂的共轭模糊度的方法和系统
公开(公告)号：US20060232783A1
公开(公告)日：2006-10-19
申请号：US11336652
申请日：2006-01-20
申请人： Michael Choma , Joseph Izatt , Anjul Davis
发明人： Michael Choma , Joseph Izatt , Anjul Davis
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02069 , G01B9/02078 , G01B9/02091
摘要： A complex conjugate ambiguity can be resolved in an Optical Coherence Tomography (OCT) interferogram. A reference light signal is propagated along a reference path. A sample light signal is impinged on a sample reflector. The reference light signal is frequency shifted with respect to the sample light signal to thereby separate a positive and a negative displacement of a complex conjugate component of the OCT interferogram.
摘要翻译：在光学相干断层扫描（OCT）干涉图中可以解决复共轭模糊度。参考光信号沿着参考路径传播。样品光信号撞击样品反射器。参考光信号相对于采样光信号被偏移，从而分离OCT干涉图的复共轭分量的正位移和负位移。

2. 发明授权

US10432871B2 Systems and methods for imaging using a random laser 有权
公开(公告)号：US10432871B2
公开(公告)日：2019-10-01
申请号：US14110937
申请日：2012-04-16
申请人： Hui Cao , Brandon Redding , Michael Choma
发明人： Hui Cao , Brandon Redding , Michael Choma
IPC分类号： G02B27/48 , H04N5/235 , H01S3/30 , H04N9/31 , H01S5/10 , H01S3/10 , H01S3/08 , H01S3/213 , H01S5/04
摘要： Systems and methods are provided for imaging using complex lasers. In general, a complex laser may be used as an electromagnetic source for an imaging application. The use of a lower spatial coherence configured complex laser in imaging applications may advantageously mitigate coherent artifacts in imaging such as cross-talk and speckle and improve overall image quality. Imaging applications where a complex laser may be useful include both incoherent imaging applications, such as digital light projectors and traditional microscopy, and coherent imaging applications, such as optical coherence tomography (OCT) and holography. The systems and methods provided also enable controlling the degree of spatial coherence of a complex laser.

3. 发明授权

US08077325B2 Methods, systems and computer program products for characterizing structures based on interferometric phase data 有权
标题翻译：基于干涉相位数据表征结构的方法，系统和计算机程序产品
公开(公告)号：US08077325B2
公开(公告)日：2011-12-13
申请号：US12634153
申请日：2009-12-09
申请人： Michael Choma , Joseph A. Izatt , Audrey Ellerbee , Marinko Sarunic
发明人： Michael Choma , Joseph A. Izatt , Audrey Ellerbee , Marinko Sarunic
IPC分类号： G01N21/41
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/0073 , A61B5/7257 , G01B9/02004 , G01B9/0203 , G01B9/02044 , G01B9/02057 , G01B9/02083 , G01B9/02091 , G01J3/2823 , G01J3/453 , G01N21/39 , G01N2021/1787
摘要： Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion of the structure is selected. Phase variations of the plurality of interferometric optical profiles are determined at the selected axial position. A physical displacement of the structure is identified based on the phase variations at the selected axial position.
摘要翻译：可以通过获得作为轴向方向上的结构深度的函数的结构的多个宽带干涉光学轮廓来识别来自光学干涉测量数据的结构轮廓。多个干涉光学轮廓中的每一个包括通过参考路径传播的参考信号和在轴向方向上从样本反射器反射的样本信号。选择对应于结构的至少一部分的轴向位置。在所选择的轴向位置处确定多个干涉光学轮廓的相位变化。基于所选轴向位置处的相位变化来识别结构的物理位移。

4. 发明授权

US07633627B2 Methods, systems and computer program products for characterizing structures based on interferometric phase data 有权
标题翻译：基于干涉相位数据表征结构的方法，系统和计算机程序产品
公开(公告)号：US07633627B2
公开(公告)日：2009-12-15
申请号：US11337166
申请日：2006-01-20
申请人： Michael Choma , Joseph A. Izatt , Audrey Ellerbee , Marinko Sarunic
发明人： Michael Choma , Joseph A. Izatt , Audrey Ellerbee , Marinko Sarunic
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/0073 , A61B5/7257 , G01B9/02004 , G01B9/0203 , G01B9/02044 , G01B9/02057 , G01B9/02083 , G01B9/02091 , G01J3/2823 , G01J3/453 , G01N21/39 , G01N2021/1787
摘要： Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion of the structure is selected. Phase variations of the plurality of interferometric optical profiles are determined at the selected axial position. A physical displacement of the structure is identified based on the phase variations at the selected axial position.
摘要翻译：可以通过获得作为轴向方向上的结构深度的函数的结构的多个宽带干涉光学轮廓来识别来自光学干涉测量数据的结构轮廓。多个干涉光学轮廓中的每一个包括通过参考路径传播的参考信号和在轴向方向上从样本反射器反射的样本信号。选择对应于结构的至少一部分的轴向位置。在所选择的轴向位置处确定多个干涉光学轮廓的相位变化。基于所选轴向位置处的相位变化来识别结构的物理位移。

5. 发明授权

US07336366B2 Methods and systems for reducing complex conjugate ambiguity in interferometric data 有权
标题翻译：用于降低干涉测量数据中复杂共轭模糊度的方法和系统
公开(公告)号：US07336366B2
公开(公告)日：2008-02-26
申请号：US11336652
申请日：2006-01-20
申请人： Michael Choma , Joseph A. Izatt , Anjul Davis
发明人： Michael Choma , Joseph A. Izatt , Anjul Davis
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02069 , G01B9/02078 , G01B9/02091
摘要： A complex conjugate ambiguity can be resolved in an Optical Coherence Tomography (OCT) interferogram. A reference light signal is propagated along a reference path. A sample light signal is impinged on a sample reflector. The reference light signal is frequency shifted with respect to the sample light signal to thereby separate a positive and a negative displacement of a complex conjugate component of the OCT interferogram.
摘要翻译：在光学相干断层扫描（OCT）干涉图中可以解决复共轭模糊度。参考光信号沿着参考路径传播。样品光信号撞击样品反射器。参考光信号相对于采样光信号被偏移，从而分离OCT干涉图的复共轭分量的正位移和负位移。

6. 发明申请

US20050036150A1 Method for optical coherence tomography imaging with molecular contrast 有权
标题翻译：光学相干层析成像与分子对比的方法
公开(公告)号：US20050036150A1
公开(公告)日：2005-02-17
申请号：US10765010
申请日：2004-01-26
申请人： Joseph Izatt , Divakar Rao , Changhuei Yang , Michael Choma , Siavash Yazdanfar , Andrew Rollins , Brian Applegate
发明人： Joseph Izatt , Divakar Rao , Changhuei Yang , Michael Choma , Siavash Yazdanfar , Andrew Rollins , Brian Applegate
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02007 , G01B9/02014 , G01B9/02044 , G01B9/02069 , G01B9/02091 , G01B2290/70
摘要： Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.
摘要翻译：关于特定分子造影剂的空间信息，例如浓度和位移可以通过刺激含有试剂的样品来确定，从而改变试剂的光学性质。可以获取多个光学相干断层摄影（OCT）图像，其中至少一些在不同的刺激强度下被获取。采集的图像用于分析样品的分子造影剂浓度分布。

7. 发明申请

US20060256343A1 Methods, systems and computer program products for characterizing structures based on interferometric phase data 有权
公开(公告)号：US20060256343A1
公开(公告)日：2006-11-16
申请号：US11337166
申请日：2006-01-20
申请人： Michael Choma , Joseph Izatt , Audrey Ellerbee , Marinko Sarunic
发明人： Michael Choma , Joseph Izatt , Audrey Ellerbee , Marinko Sarunic
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/0073 , A61B5/7257 , G01B9/02004 , G01B9/0203 , G01B9/02044 , G01B9/02057 , G01B9/02083 , G01B9/02091 , G01J3/2823 , G01J3/453 , G01N21/39 , G01N2021/1787
摘要： Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion of the structure is selected. Phase variations of the plurality of interferometric optical profiles are determined at the selected axial position. A physical displacement of the structure is identified based on the phase variations at the selected axial position.

8. 发明授权

US07019838B2 System and method for low coherence broadband quadrature interferometry 失效
标题翻译：低相干宽带正交干涉测量系统和方法
公开(公告)号：US07019838B2
公开(公告)日：2006-03-28
申请号：US10855652
申请日：2004-05-28
申请人： Joseph A. Izatt , Michael Choma , Changhuei Yang
发明人： Joseph A. Izatt , Michael Choma , Changhuei Yang
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02044 , G01B9/02081 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01N21/4795
摘要： A quadrature broadband interferometry system and method obtains a complete complex interferometric signal instantaneously in both homodyne and heterodyne systems in a simple, compact, and inexpensive setup. This is accomplished by separating interferometric components from non-interferometric components in each of at least two detector signals of an interferometer having a number of N×N couplers, scaling the interferometric components, and generating real and imaginary parts of a complex interferometric signal from the scaled interferometric components. The detector signals preferably derive from a broadband light source coupled to the interferometer, and the number of N×N couplers may be one or more, with N≧3.
摘要翻译：正交宽带干涉测量系统和方法在简单，紧凑且便宜的设置中在零差和外差系统中瞬时获得完整的复杂干涉信号。这是通过将具有多个N×N耦合器的干涉仪的至少两个检测器信号中的每一个中的干涉测量分量分离成干涉测量分量来实现的，缩放干涉测量分量，以及从经缩放的干涉测量中产生复干涉信号的实部和虚部组件。检测器信号优选地源自耦合到干涉仪的宽带光源，并且N×N个耦合器的数量可以是一个或多个，其中N≥3。

9. 发明申请

US20140111671A1 Systems and Methods for Imaging Using a Random Laser 审中-公开
标题翻译：使用随机激光成像的系统和方法
公开(公告)号：US20140111671A1
公开(公告)日：2014-04-24
申请号：US14110937
申请日：2012-04-16
申请人： Hui Cao , Brandon Redding , Michael Choma
发明人： Hui Cao , Brandon Redding , Michael Choma
IPC分类号： H04N5/235 , H01S3/10
摘要： Systems and methods are provided for imaging using complex lasers. In general, a complex laser may be used as an electromagnetic source for an imaging application. The use of a lower spatial coherence configured complex laser in imaging applications may advantageously mitigate coherent artifacts in imaging such as cross-talk and speckle and improve overall image quality. Imaging applications where a complex laser may be useful include both incoherent imaging applications, such as digital light projectors and traditional microscopy, and coherent imaging applications, such as optical coherence tomography (OCT) and holography. The systems and methods provided also enable controlling the degree of spatial coherence of a complex laser.
摘要翻译：提供了使用复合激光成像的系统和方法。通常，复合激光器可以用作成像应用的电磁源。在成像应用中使用配置复杂激光的较低的空间相干性可以有利地减轻成像中的相干伪影，例如串扰和散斑，并提高整体图像质量。复合激光器可能有用的成像应用包括非相干成像应用，如数字光投影仪和传统显微镜，以及相干成像应用，如光学相干断层扫描（OCT）和全息术。所提供的系统和方法还能够控制复杂激光器的空间相干性程度。

10. 发明申请

US20100201991A1 Methods, Systems and Computer Program Products for Characterizing Structures Based on Interferometric Phase Data 有权
标题翻译：基于干涉相位数据表征结构的方法，系统和计算机程序产品
公开(公告)号：US20100201991A1
公开(公告)日：2010-08-12
申请号：US12634153
申请日：2009-12-09
申请人： Michael Choma , Joseph A. Izatt , Audrey Ellerbee , Marinko Sarunic
发明人： Michael Choma , Joseph A. Izatt , Audrey Ellerbee , Marinko Sarunic
IPC分类号： G01B11/02
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/0073 , A61B5/7257 , G01B9/02004 , G01B9/0203 , G01B9/02044 , G01B9/02057 , G01B9/02083 , G01B9/02091 , G01J3/2823 , G01J3/453 , G01N21/39 , G01N2021/1787
摘要： Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical profiles include a reference signal propagated through a reference path and a sample signal reflected from a sample reflector in the axial direction. An axial position corresponding to at least a portion of the structure is selected. Phase variations of the plurality of interferometric optical profiles are determined at the selected axial position. A physical displacement of the structure is identified based on the phase variations at the selected axial position.
摘要翻译：可以通过获得作为轴向方向上的结构深度的函数的结构的多个宽带干涉光学轮廓来识别来自光学干涉测量数据的结构轮廓。多个干涉光学轮廓中的每一个包括通过参考路径传播的参考信号和在轴向方向上从样本反射器反射的样本信号。选择对应于结构的至少一部分的轴向位置。在所选择的轴向位置处确定多个干涉光学轮廓的相位变化。基于所选轴向位置处的相位变化来识别结构的物理位移。

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