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1. 发明授权

US07075658B2 Method for optical coherence tomography imaging with molecular contrast 有权
标题翻译：光学相干层析成像与分子对比的方法
公开(公告)号：US07075658B2
公开(公告)日：2006-07-11
申请号：US10765010
申请日：2004-01-26
申请人： Joseph A. Izatt , Divakar K. Rao , Changhuei Yang , Michael A. Choma , Siavash Yazdanfar , Andrew M. Rollins , Brian E. Applegate
发明人： Joseph A. Izatt , Divakar K. Rao , Changhuei Yang , Michael A. Choma , Siavash Yazdanfar , Andrew M. Rollins , Brian E. Applegate
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02007 , G01B9/02014 , G01B9/02044 , G01B9/02069 , G01B9/02091 , G01B2290/70
摘要： Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.
摘要翻译：关于特定分子造影剂的空间信息，例如浓度和位移可以通过刺激含有试剂的样品来确定，从而改变试剂的光学性质。可以获取多个光学相干断层摄影（OCT）图像，其中至少一些在不同的刺激强度下被获取。采集的图像用于分析样品的分子造影剂浓度分布。

2. 发明授权

US07006232B2 Phase-referenced doppler optical coherence tomography 有权
公开(公告)号：US07006232B2
公开(公告)日：2006-02-28
申请号：US10408745
申请日：2003-04-07
申请人： Andrew M. Rollins , Joseph A. Izatt , Volker Westphal , Cameron J. Pedersen , Siavash Yazdanfar
发明人： Andrew M. Rollins , Joseph A. Izatt , Volker Westphal , Cameron J. Pedersen , Siavash Yazdanfar
IPC分类号： G01B9/02
CPC分类号： G01B9/02045 , G01B9/02007 , G01B9/02076 , G01B9/02083 , G01B9/02091 , G01B2290/45
摘要： A phase-referenced Doppler optical coherence tomography (OCT) system includes a low-coherence optical radiation source and a reference source co-propagated to a sample arm and a reference arm. The low-coherence and reference optical radiation reflected from the reference and arms is detected by a pair of detectors, yielding OCT and reference interferometric data output signals. The reference interferometric data output signal can be used to correct the OCT interferometric to yield velocity-indicating images that are free from defects due to sample motion and/or interferometer jitter.

3. 发明授权

US07061622B2 Aspects of basic OCT engine technologies for high speed optical coherence tomography and light source and other improvements in optical coherence tomography 有权
公开(公告)号：US07061622B2
公开(公告)日：2006-06-13
申请号：US10213326
申请日：2002-08-05
申请人： Andrew M. Rollins , Joseph A. Izatt , Volker Westphal , Siavash Yazdanfar
发明人： Andrew M. Rollins , Joseph A. Izatt , Volker Westphal , Siavash Yazdanfar
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , A61B5/0066 , G01B11/2441
摘要： An optical coherence tomography (OCT) system including an interferometer provides illuminating light along a first optical path to a sample and an optical delay line and collects light from the sample along a second optical path remitted at several scattering angles to a detector. In one embodiment, illuminating light is directed along a number of incident light paths through a focusing lens to a sample. The light paths and focusing lens are related to the sample and to both the incident light source and the detector. In another embodiment, a focusing system directs light to a location in the sample. A transmission grating or acousto-optic modulator directs light from the sample at an angle representative of the wavelength of the incident light on the transmission grating or acousto-optic modulator.

4. 发明授权

US6006128A Doppler flow imaging using optical coherence tomography 失效
标题翻译：多普勒血流成像使用光学相干断层扫描
公开(公告)号：US6006128A
公开(公告)日：1999-12-21
申请号：US88562
申请日：1998-06-02
申请人： Joseph A. Izatt , Manish D. Kulkarni , Siavash Yazdanfar , Andrew Rollins , Michael V. Sivak
发明人： Joseph A. Izatt , Manish D. Kulkarni , Siavash Yazdanfar , Andrew Rollins , Michael V. Sivak
IPC分类号： A61B5/00 , A61B5/026 , A61B5/0285 , A61B10/00 , G01B9/02 , G01N21/17 , A61B5/02
CPC分类号： A61B5/0073 , A61B5/0066 , G01B9/02045 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02083 , G01B9/02091 , A61B5/7257 , G01B2290/35 , G01B2290/60
摘要： A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.
摘要翻译：一种用于在光学相干断层摄影系统中产生样本的速度指示断层图像的方法包括以下步骤：（a）从干涉仪获取互相关数据; （b）从指示样品中散射体的深度相关位置的互相关数据中生成灰度图像; （c）处理互相关数据以产生样品中运动散射体的速度值和位置; （d）为速度值分配颜色; 以及（f）在指示运动散射体的位置的灰度图像中将颜色合并成灰度图像，以产生速度指示的断层图像。优选地，将第一颜色分配给正速度值，并且将第二颜色分配给负速度值。

5. 发明授权

US06735463B2 Doppler flow imaging using optical coherence tomography 有权
标题翻译：多普勒血流成像使用光学相干断层扫描
公开(公告)号：US06735463B2
公开(公告)日：2004-05-11
申请号：US09468674
申请日：1999-12-21
申请人： Joseph A. Izatt , Manish D. Kulkarni , Siavash Yazdanfar , Andrew Rollins , Michael V. Sivak
发明人： Joseph A. Izatt , Manish D. Kulkarni , Siavash Yazdanfar , Andrew Rollins , Michael V. Sivak
IPC分类号： A61B502
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/7257 , G01B9/02045 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02083 , G01B9/02091 , G01B2290/35 , G01B2290/60
摘要： A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.
摘要翻译：一种用于在光学相干断层摄影系统中产生样本的速度指示断层图像的方法包括以下步骤：（a）从干涉仪获取互相关数据; （b）从指示样品中散射体的深度相关位置的互相关数据中生成灰度图像; （c）处理互相关数据以产生样品中运动散射体的速度值和位置; （d）为速度值分配颜色; 以及（f）在指示运动散射体位置的灰度图像中将颜色合并成灰度图像，以产生速度指示的断层图像。优选地，将第一颜色分配给正速度值，并且将第二颜色分配给负速度值。

6. 发明授权

US07362444B2 Interferometers for optical coherence domain reflectometry 有权
标题翻译：用于光学相干畴反射测量的干涉仪
公开(公告)号：US07362444B2
公开(公告)日：2008-04-22
申请号：US11470079
申请日：2006-09-05
申请人： Joseph A. Izatt , Andrew M. Rollins
发明人： Joseph A. Izatt , Andrew M. Rollins
IPC分类号： G01B11/02 , G01B9/02
CPC分类号： G01B9/02091 , G01B9/02022 , G01B2290/35 , G01B2290/70 , G01N21/4795
摘要： An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves the steps of: (a) producing low coherence optical radiation; (b) directing at least some of the low coherence optical radiation through an optical circulator to the sample; (c) reflecting at least some of the low coherence optical radiation off of the sample; and (d) detecting at least some of the reflected low coherence optical radiation and producing an electrical signal corresponding thereto.
摘要翻译：干涉仪系统包括光辐射源，连接在光辐射源和用于将光辐射从光辐射源传送到采样位置的采样位置之间的光循环器，连接到直接光辐射的光循环器的输出到光学探测器。这种系统的各种实施例是可能的。执行样本的OCDR或OCT成像的方法，其包括以下步骤：（a）产生低相干光辐射; （b）将至少一些低相干光辐射通过光循环器引导到样品; （c）反射离开样品的至少一些低相干光辐射; 和（d）检测至少一些反射的低相干光辐射并产生与其对应的电信号。

7. 发明授权

US07903256B2 Methods, systems, and computer program products for performing real-time quadrature projection based Fourier domain optical coherence tomography 有权
标题翻译：用于执行基于傅里叶域光学相干断层扫描的实时正交投影的方法，系统和计算机程序产品
公开(公告)号：US07903256B2
公开(公告)日：2011-03-08
申请号：US11725167
申请日：2007-03-16
申请人： Marinko V. Sarunic , Brian E. Applegate , Joseph A. Izatt
发明人： Marinko V. Sarunic , Brian E. Applegate , Joseph A. Izatt
IPC分类号： G01B11/02
CPC分类号： G01B9/02081 , A61B3/102 , A61B3/12 , G01B9/02004 , G01B9/02091 , G01B2290/45
摘要： Methods, systems, and computer program products for performing real-time quadrature projection based FDOCT are disclosed. According to one method, a plurality of interferogram signals is phase shifted. A Fourier transform is applied to each of the plurality of interferogram signals. Depth dependence of the plurality of transformed interferogram signals is then removed. A real quadrature component and an imaginary quadrature component for each of the plurality of transformed interferogram signals are subsequently calculated. The real quadrature components of the transformed interferogram signals are combined to obtain a derived real component and the imaginary quadrature components of the transformed interferogram signals are combined to obtain a derived imaginary component. A full-range depth profile of the object is constructed by adding the derived real component to the product of the derived imaginary component and a scaling factor. A full-range depth image of the object is then generated using the full-range depth profile.
摘要翻译：公开了用于执行基于实时正交投影的FDOCT的方法，系统和计算机程序产品。根据一种方法，多个干涉图信号被相移。对多个干涉图信号中的每一个进行傅立叶变换。然后去除多个变换干涉图信号的深度依赖性。随后计算多个变换干涉图信号中的每一个的真正正交分量和虚数正交分量。将变换的干涉图信号的真正正交分量组合以获得导出的实分量，并且将经变换的干涉图信号的虚数正交分量组合以获得衍生的虚分量。通过将派生的实数分量与派生的虚分量和缩放因子的乘积相加来构建对象的全范围深度分布。然后使用全范围深度轮廓生成对象的全范围深度图像。

8. 发明申请

US20080170219A1 Methods, systems, and computer program products for performing real-time quadrature projection based Fourier domain optical coherence tomography 有权
标题翻译：用于执行基于傅里叶域光学相干断层扫描的实时正交投影的方法，系统和计算机程序产品
公开(公告)号：US20080170219A1
公开(公告)日：2008-07-17
申请号：US11725167
申请日：2007-03-16
申请人： Marinko V. Sarunic , Brian E. Applegate , Joseph A. Izatt
发明人： Marinko V. Sarunic , Brian E. Applegate , Joseph A. Izatt
IPC分类号： G01N21/00 , G06F17/14 , G01B11/02
CPC分类号： G01B9/02081 , A61B3/102 , A61B3/12 , G01B9/02004 , G01B9/02091 , G01B2290/45
摘要： Methods, systems, and computer program products for performing real-time quadrature projection based FDOCT are disclosed. According to one method, a plurality of interferogram signals is phase shifted. A Fourier transform is applied to each of the plurality of interferogram signals. Depth dependence of the plurality of transformed interferogram signals is then removed. A real quadrature component and an imaginary quadrature component for each of the plurality of transformed interferogram signals are subsequently calculated. The real quadrature components of the transformed interferogram signals are combined to obtain a derived real component and the imaginary quadrature components of the transformed interferogram signals are combined to obtain a derived imaginary component. A full-range depth profile of the object is constructed by adding the derived real component to the product of the derived imaginary component and a scaling factor. A full-range depth image of the object is then generated using the full-range depth profile.
摘要翻译：公开了用于执行基于实时正交投影的FDOCT的方法，系统和计算机程序产品。根据一种方法，多个干涉图信号被相移。对多个干涉图信号中的每一个进行傅立叶变换。然后去除多个变换干涉图信号的深度依赖性。随后计算多个变换干涉图信号中的每一个的真正正交分量和虚数正交分量。将变换的干涉图信号的真正正交分量组合以获得导出的实分量，并且将经变换的干涉图信号的虚数正交分量组合以获得衍生的虚分量。通过将派生的实数分量与派生的虚分量和缩放因子的乘积相加来构建对象的全范围深度分布。然后使用全范围深度轮廓生成对象的全范围深度图像。

9. 发明授权

US07826059B2 Method and apparatus for polarization-sensitive optical coherence tomography 有权
标题翻译：用于偏振敏感光学相干断层扫描的方法和装置
公开(公告)号：US07826059B2
公开(公告)日：2010-11-02
申请号：US10055282
申请日：2002-01-22
申请人： Jonathan E. Roth , Joseph A. Izatt , Andrew M. Rollins
发明人： Jonathan E. Roth , Joseph A. Izatt , Andrew M. Rollins
IPC分类号： G01B9/02
CPC分类号： A61B5/0066 , A61B5/0073 , G01B9/02011 , G01B9/02072 , G01B9/02091 , G01B9/04 , G01B2290/70 , G01N21/4795 , Y10T29/49716
摘要： A method and apparatus for extracting the vector optical properties of biological samples with micron-scale resolution in three dimensions, using polarization-sensitive optical coherence tomography (PS-OCT). The method measures net retardance, net fast axis, and reflectivity. Polarization sensing is accomplished by illuminating the sample with at least three separate polarization states, using consecutive acquisitions of the same pixel, A-scan, or B-scan. The method can be implemented using non-polarization-maintaining fiber and a single detector. This PS-OCT method reported measures fast axis explicitly. In a calibration test of the system, net retardance was measured with an average error of 7.5° (standard deviation 2.2°) over the retardance range 0° to 180°, and fast axis with average error of 4.8° over the range 0° to 180°.
摘要翻译：一种使用偏振光敏光学相干断层扫描（PS-OCT）三维提取微尺度分辨率的生物样品的矢量光学性质的方法和装置。该方法测量净延迟，净快轴和反射率。通过使用相同像素，A扫描或B扫描的连续采集，以至少三个单独的极化状态照射样本来实现极化感测。该方法可以使用非偏振维持光纤和单个检测器来实现。这种PS-OCT方法报道了快轴测量。在系统的校准测试中，在0°至180°的延迟范围内测量平均误差为7.5°（标准偏差2.2°）的净延迟，平均误差为4.8°的快轴在0°至 180°。

10. 发明授权

US07102756B2 Interferometers for optical coherence tomography and reflectometry 有权
标题翻译：用于光学相干断层扫描和反射测量的干涉仪
公开(公告)号：US07102756B2
公开(公告)日：2006-09-05
申请号：US10646202
申请日：2003-08-22
申请人： Joseph A. Izatt , Andrew M. Rollins
发明人： Joseph A. Izatt , Andrew M. Rollins
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , G01B9/02022 , G01B2290/35 , G01B2290/70 , G01N21/4795
摘要： An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves the steps of: (a) producing low coherence optical radiation; (b) directing at least some of the low coherence optical radiation through an optical circulator to the sample; (c) reflecting at least some of the low coherence optical radiation off of the sample; and (d) detecting at least some of the reflected low coherence optical radiation and producing an electrical signal corresponding thereto.
摘要翻译：干涉仪系统包括光辐射源，连接在光辐射源和用于将光辐射从光辐射源传送到采样位置的采样位置之间的光循环器，连接到直接光辐射的光循环器的输出到光学探测器。这种系统的各种实施例是可能的。执行样本的OCDR或OCT成像的方法，其包括以下步骤：（a）产生低相干光辐射; （b）将至少一些低相干光辐射通过光循环器引导到样品; （c）反射离开样品的至少一些低相干光辐射; 和（d）检测至少一些反射的低相干光辐射并产生与其对应的电信号。

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