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1. 发明公开

US20240369582A1 CLOTTING TIME COMPUTATION METHODS AND SYSTEMS INCLUDING ATTACHMENT DEVICES FOR SMARTPHONES 审中-公开
公开(公告)号：US20240369582A1
公开(公告)日：2024-11-07
申请号：US18557905
申请日：2022-05-20
申请人： University of Washington
发明人： Justin Chan , Shyamnath Gollakota , Kelly Michaelsen
IPC分类号： G01N33/86 , B01L3/00
CPC分类号： G01N33/86 , B01L3/508 , B01L2200/16 , B01L2300/0654 , B01L2400/0433 , G01N2333/7454
摘要： Example systems may include an electronic device (e.g., a smartphone) and an attachment member that may couple the electronic device to a cup. The cup may be positioned within a field of view (e.g., within a focal length) of a camera that is coupled to or integral to the electronic device. The cup may receive a sample of whole blood and/or plasma. The attachment member may convey vibration from the electronic device to the cup. The cup may include a particle positioned in the cup. The camera may capture images of the cup including the particle, and motion of the particle may be used by the electronic device to calculate a clotting time of the sample. For example, the particle may move freely responsive to vibration during a time the sample is in a non-clotted state, but may slow and/or stop motion when the sample has clotted.

2. 发明授权

US12128413B2 Test device 有权
公开(公告)号：US12128413B2
公开(公告)日：2024-10-29
申请号：US17877231
申请日：2022-07-29
申请人： Zhejiang Orient Gene Biotech Co.,Ltd
发明人： Jianqiu Fang , Jun Ling , Xiulong Ge , Fangzhou Xu
IPC分类号： B01L3/00
CPC分类号： B01L3/508 , B01L2300/041
摘要： A test device includes a housing and a carrier detachable from the housing. The housing includes a socket, and the carrier contains a testing element, and the carrier along with the testing element therein is capable of being inserted into the housing through the socket. The housing includes a blocking structure and a locking structure. The blocking structure and the locking structure are integrated to form a locking component. When the carrier is inserted into the housing, and a position of the carrier is locked by the locking structure, the carrier is abutted against the blocking structure. The carrier keeps stable after being inserted into the housing; and the carrier is located in the same position for each insertion.

3. 发明授权

US12090484B2 Detection device for a sample detection 有权
公开(公告)号：US12090484B2
公开(公告)日：2024-09-17
申请号：US17000685
申请日：2020-08-24
申请人： Hangzhou D2 Technology CO., LTD.
发明人： Jielin Dai
IPC分类号： B01L3/00
CPC分类号： B01L3/508 , B01L2200/025 , B01L2200/141 , B01L2200/145 , B01L2300/041 , B01L2300/0832
摘要： The present invention provides a detection device for sample detection, where the detection device includes a device body and a device cover, the device cover is configured to cover the device body, the device body is spirally connected to the device cover, a signal apparatus is disposed between the device body and the device cover, a completely screwed state exists between the device body and the device cover, and when the device body and the device cover are in the completely screwed state, the signal apparatus makes a sound. The detection device is provided with a two-stage sealing apparatus and the signal apparatus. As the device cover performs covering, a first sealing apparatus first seals the device body and the device cover, and the signal apparatus makes a first sound, to prompt an operator that the detection device has completed primary sealing, which is suitable for short-distance and gentle-vibration transportation after sampling is performed by using the detection device. As the device cover continues performing covering, a second sealing apparatus seals the device body and the device cover again, and the signal apparatus makes a second sound, to prompt the operator that the detection device has completed secondary sealing, and covering no longer needs to be continued.

4. 发明授权

US12076723B2 Glass container comprising a glass bottom with improved properties 有权
公开(公告)号：US12076723B2
公开(公告)日：2024-09-03
申请号：US17126618
申请日：2020-12-18
申请人： SCHOTT PHARMA AG & CO. KGAA , SCHOTT PHARMA SCHWEIZ AG
发明人： Alexander Humbertjean , Tobias Wetzel , Robert Frost , Jens Ulrich Thomas , Frank-Thomas Lentes , Andreas Langsdorf , Doris Moseler , Günter Weidmann , Roman Huhn
IPC分类号： B65D1/02 , A61J1/14 , B01L3/00 , B65D81/30 , C03B23/08 , C03B23/09 , C03B23/11 , A61J1/05
CPC分类号： B01L3/508 , A61J1/1468 , B65D1/0261 , B65D81/30 , C03B23/08 , C03B23/09 , C03B23/112 , A61J1/05 , B01L2300/0832 , B01L2300/0851
摘要： A glass container is provided that includes a tube, a circular bottom, and a longitudinal axis. A curved glass heel extends from an outer end the bottom to the first end of the tube. The outer surface has a topography defined by a function ĥ(x) that is an azimuthal average of a distance between a contact plane and the outer surface at any given position located on a circle having the centre and the radius |x|. The values ĥ for ĥ(x) are determined for a plurality of circles the radius of which increases stepwise by 500 μm starting with a circle around the centre having a radius of 500 μm. The values ĥ are determined in a range from x=−0.4×d2/2 to x=+0.4×d2/2, d2 having a size such that at least 4 values ĥ are determined and can be fitted with a curvature function

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5. 发明授权

US12075986B2 Sample collection system including valve assembly 有权
公开(公告)号：US12075986B2
公开(公告)日：2024-09-03
申请号：US18208980
申请日：2023-06-13
申请人： SPECTRUM SOLUTIONS, LLC
发明人： Neil Jeremy Johnson
IPC分类号： B01L3/00 , A61B10/02 , B65D51/28
CPC分类号： A61B10/02 , B01L3/502 , B01L3/508 , B01L3/50825 , B01L3/523 , B65D51/2864 , B65D51/2878 , B65D51/2892 , B01L2200/0689 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/047 , B01L2300/049 , B01L2300/0832
摘要： A biological sample collection system includes (i) a sample collection vessel having an opening for receiving a biological sample, (ii) a selectively movable valve comprising a core and a collar disposed about the core, and (iii) a sealing cap coupled to the collar and including a reagent chamber for storing a measure of sample preservation reagent. The sealing cap is configured to associate and form a fluid tight connection with the sample collection vessel. Associating the sealing cap with the sample collection vessel causes a physical rearrangement of the core relative to the collar such that a fluid vent associated with the core is placed into fluid communication with the reagent chamber, thereby permitting sample preservation reagent to pass from the regent chamber to the sample collection vessel.

6. 发明授权

US12066400B2 Active transport of charged molecules into, within, and/or from charged matrices 有权
公开(公告)号：US12066400B2
公开(公告)日：2024-08-20
申请号：US16549450
申请日：2019-08-23
申请人： Massachusetts Institute of Technology
发明人： Kwanghun Chung , Sung-Yon Kim , Kimberly Ohn , Evan Murray , Jae Hun Cho
IPC分类号： G01N27/447 , B01L3/00 , G01N1/31 , G01N27/26 , G01N33/561
CPC分类号： G01N27/44756 , B01L3/502 , B01L3/508 , G01N1/31 , G01N27/26 , G01N27/44704 , G01N27/44708 , G01N27/44713 , B01L2300/0609 , B01L2400/0421 , G01N33/561
摘要： Articles and methods for the active transport of molecules into, within, and/or from a matrix are generally described. In some embodiments, an electric field may be used to alter the position of the molecule with respect to the matrix. The electric field may be used to move the molecule to a new location within the matrix, remove the molecule from the matrix, or infuse the molecule into the matrix. For instance, the electric field may be used to move a molecule having a binding partner within the matrix into or away from the vicinity of the binding partner. In some embodiments, the position of the molecule may be altered by exposing the molecule to an electrodynamic field. In some such embodiments, the molecule exposed to the dynamic electric field may have enhanced mobility and minimal adverse matrix interactions relative to conventional molecular transport methods, and in some cases, a molecule exposed to an electrostatic field. The active transport methods and articles, described herein, may be particularly well-suited for a variety of applications including histological, biological, and pharmaceutical applications.

7. 发明授权

US12066368B2 Compact optical virus detection analyzer of nano- and micro-size bio particles using light scattering and fluorescence 有权
公开(公告)号：US12066368B2
公开(公告)日：2024-08-20
申请号：US17503086
申请日：2021-10-15
申请人： Robert R. Alfano , Lingyan Shi , Binlin Wu
发明人： Robert R. Alfano , Lingyan Shi , Binlin Wu
IPC分类号： G01N15/06 , B01L3/00 , G01N15/00 , G01N15/01 , G01N15/075
CPC分类号： G01N15/0612 , B01L3/508 , B01L2200/025 , B01L2300/0609 , B01L2300/0654 , B01L2300/0663 , B01L2300/168 , G01N15/01 , G01N15/075
摘要： A Compact Optical Virus Detection Analyzer (COVDA) uses light scattering and fluorescence to detect nanometer (nm) and micrometer (um) sized particles, such as biological particles and can be used to detect viruses such as coronavirus including SAR-CoV-2 responsible for COVID-19, pollen and bacteria. It can be used for prescreening, rapid detection of suspicious people. COVDA involves experimental and theoretical methods for particle and virus detection using Tryptophan as a key biomarker. Light sources in compact units include lamps such as Xenon (Xe) lamp with narrow band filters, LEDs (such as AlN) or laser diode, Q switched and mode lock Lasers for nanosecond and picosecond pulses (such as Nd Yag/Glass, Ti sapphire with Harmonic generator) in blue from 400 nm to 500 nm to generate second harmonic generation (SHG) in KDP/BBO crystals to produce 200 nm to 250 nm emission, or green laser pointers at about 530 nm to get emitters with harmonic crystals at about 270 nm or LEDS from 230 nm to 300 nm for pumping the samples at 230 nm to 289 nm to pump tryptophan and light scatter of nanometer particles of virus. The ultra high power ns and ps lasers in mJ to J can level can be used to locate Bio virus bacteria clouds in free space to image and destroy and kill virus.

8. 发明授权

US12053167B2 Sample collection system including plug assembly 有权
公开(公告)号：US12053167B2
公开(公告)日：2024-08-06
申请号：US18204120
申请日：2023-05-31
申请人： SPECTRUM SOLUTIONS, LLC
发明人： Neil Jeremy Johnson
IPC分类号： B01L3/00 , A61B10/02 , B65D51/24 , B65D51/28
CPC分类号： A61B10/02 , B01L3/502 , B01L3/508 , B01L3/50825 , B01L3/523 , B65D51/2864 , B65D51/2878 , B65D51/2892 , B01L2200/0689 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/047 , B01L2300/049 , B01L2300/0832
摘要： A biological sample collection system can include (i) a sample collection vessel having an opening for receiving a biological sample, (ii) a plug assembly that includes a post with a fluid vent therethrough, a collar disposed about the post, and a plug that initially obstructs the fluid vent, and (iii) a sealing cap coupled to the collar and comprising a reagent chamber for storing a sample preservation reagent. The sealing cap is configured to associate and form a fluid tight connection with the sample collection vessel such that associating the sealing cap with the sample collection vessel causes a physical rearrangement of the plug assembly such that the plug is detached from the post, thereby permitting sample preservation reagent to pass from the regent chamber to the sample collection vessel.

9. 发明公开

US20240226900A1 METHODS AND SYSTEMS FOR NUCLEIC ACID ANALYSIS 审中-公开
公开(公告)号：US20240226900A1
公开(公告)日：2024-07-11
申请号：US18391291
申请日：2023-12-20
申请人： Ultima Genomics, Inc.
发明人： Jose Martin SOSA , Joseph ANTHONY , Nathan BECKETT , Gilad ALMOGY , Chandan SHEE , Phillip You Fai LEE , Yuto WATANABE
IPC分类号： B01L7/00 , B01L3/00 , C12Q1/686
CPC分类号： B01L7/52 , B01L3/508 , B01L2200/0647 , B01L2300/1805 , B01L2400/0415 , C12Q1/686
摘要： The present disclosure provides methods and processes for increasing the efficiency and accuracy of nucleic acid sequencing using techniques such as polymerase chain reaction (PCR). Methods and systems provided herein may facilitate performing reactions such as emulsion PCR (ePCR) on samples comprising nucleic acids and beads. The methods provided herein may provide a higher throughput compared to existing technologies.

10. 发明公开

US20240216906A1 HUMIDIFIED SAMPLE PREPARATION STATION FOR SERIAL CRYSTALLOGRAPHY 审中-公开
公开(公告)号：US20240216906A1
公开(公告)日：2024-07-04
申请号：US18422738
申请日：2024-01-25
申请人： Mitegen, LLC
发明人： Richard Jayne , David Closs , Benjamin A. Apker , Robert E. Thorne
IPC分类号： B01L1/02 , B01L3/00 , B01L7/00 , G02B21/06 , G02B27/00
CPC分类号： B01L1/025 , B01L3/508 , B01L7/00 , G02B21/06 , G02B27/0006 , B01L2300/0663 , B01L2300/123 , B01L2300/18
摘要： Humidified sample preparation station for serial crystallography according to one embodiment is a humidified enclosure that delivers relative humidities above 95% and preferably above 97% in standard operation, and that can allow microscope observation of samples within. Humidified sample preparation station for serial crystallography can be used for preparation of protein crystal samples for examination using X-rays and for protein structure determination by X-ray crystallography, involving addition of liquid to the sample and removal of liquid from the sample using vacuum or suction.

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