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1. 发明授权

US08750615B2 Segmentation and quantification for intravascular optical coherence tomography images 有权
标题翻译：血管内光学相干断层扫描图像的分割和定量
公开(公告)号：US08750615B2
公开(公告)日：2014-06-10
申请号：US13196845
申请日：2011-08-02
申请人： Andrew Rollins , David Wilson , Marco Costa , Hiram Bezerra , Zhao Wang
发明人： Andrew Rollins , David Wilson , Marco Costa , Hiram Bezerra , Zhao Wang
IPC分类号： G06K9/34 , G06K9/00
CPC分类号： G06T7/0012 , A61B1/00009 , A61B1/3137 , A61B5/0066 , A61B5/0084 , A61B5/02007 , A61B5/06 , G01B9/02091 , G06T7/12 , G06T7/62 , G06T2200/24 , G06T2207/10101 , G06T2207/20116 , G06T2207/20161 , G06T2207/30021 , G06T2207/30101
摘要： A system and related methods for automatic or semi-automatic segmentation and quantification of blood vessel structure and physiology, including segmentation and quantification of lumen, guide wire, vessel wall, calcified plaques, fibrous caps, macrophages, metallic and bioresorbable stents are described, and including visualization of results. Calcified plaque segmentation can be used to estimate the distribution of superficial calcification and inform strategies stenting. Volumetric segmentation and quantification of fibrous caps can provide more comprehensive information of the mechanisms behind plaque rupture. Quantification of macrophages can aid diagnosis and prediction of unstable plaque and associated acute coronary events. Automated detection and quantification of metallic and bioresorbable stents can greatly reduce the analysis time and facilitate timely decision making for intervention procedures.
摘要翻译：描述了用于血管结构和生理学的自动或半自动分割和定量的系统和相关方法，包括内腔，导丝，血管壁，钙化斑块，纤维帽，巨噬细胞，金属和生物可吸收支架的分割和定量，以及包括结果的可视化。钙化斑块分割可以用于估计浅层钙化的分布，并通知策略支架。纤维帽的体积分割和定量可以提供斑块破裂背后机制的更全面的信息。巨噬细胞的定量可以帮助诊断和预测不稳定斑块和相关的急性冠状动脉事件。金属和生物可吸收支架的自动检测和定量可大大减少分析时间，便于及时决策干预措施。

2. 发明授权

US08190244B2 Gated optical coherence tomography (OCT) environmental chamber 有权
标题翻译：门式光学相干断层扫描（OCT）环境室
公开(公告)号：US08190244B2
公开(公告)日：2012-05-29
申请号：US12009992
申请日：2008-01-23
申请人： Andrew Rollins , Michael Jenkins , Osman Chughtai
发明人： Andrew Rollins , Michael Jenkins , Osman Chughtai
IPC分类号： A61B6/00
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/7285
摘要： Systems, methods, and other embodiments associated with gated optical coherence tomography (OCT) are described. One example method includes generating an image control signal to control an OCT apparatus to acquire an image of an embryonic heart at a specified point in time during a cardiac cycle of the embryonic heart. The method may also include controlling the OCT apparatus to acquire the image based on the image control signal. In different examples, the image may be acquired in vivo or from an excised heart that is paced. The OCT apparatus and the embryonic heart may be housed in an environmental chamber having a set of controllable environmental factors. Therefore, the method may include detecting and controlling the set of controllable environmental factors.
摘要翻译：描述了与门控光学相干断层摄影（OCT）相关联的系统，方法和其他实施例。一个示例性方法包括产生图像控制信号以控制OCT装置以在胚胎心脏的心动周期期间的指定时间点获取胚胎心脏的图像。该方法还可以包括控制OCT装置以基于图像控制信号获取图像。在不同的实施例中，可以在体内或从起搏的切除的心脏获得图像。 OCT设备和胚胎心脏可以容纳在具有一组可控环境因素的环境室中。因此，该方法可以包括检测和控制一组可控环境因素。

3. 发明申请

US20120265063A1 GATED OPTICAL COHERENCE TOMOGRAPHY (OCT) 有权
标题翻译：门式光学相干（OCT）
公开(公告)号：US20120265063A1
公开(公告)日：2012-10-18
申请号：US13481936
申请日：2012-05-28
申请人： Andrew ROLLINS , Michael JENKINS , Osman CHUGHTAI
发明人： Andrew ROLLINS , Michael JENKINS , Osman CHUGHTAI
IPC分类号： A61B6/02
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/7285
摘要： Systems, methods, and other embodiments associated with gated optical coherence tomography (OCT) are described. One example method includes generating an image control signal to control an OCT apparatus to acquire an image of an embryonic heart at a specified point in time during a cardiac cycle of the embryonic heart. The method may also include controlling the OCT apparatus to acquire the image based on the image control signal. In different examples, the image may be acquired in vivo or from an excised heart that is paced. The OCT apparatus and the embryonic heart may be housed in an environmental chamber having a set of controllable environmental factors. Therefore, the method may include detecting and controlling the set of controllable environmental factors.
摘要翻译：描述了与门控光学相干断层摄影（OCT）相关联的系统，方法和其他实施例。一个示例性方法包括产生图像控制信号以控制OCT装置以在胚胎心脏的心动周期期间的指定时间点获取胚胎心脏的图像。该方法还可以包括控制OCT装置以基于图像控制信号获取图像。在不同的实施例中，可以在体内或从起搏的切除的心脏获得图像。 OCT设备和胚胎心脏可以容纳在具有一组可控环境因素的环境室中。因此，该方法可以包括检测和控制一组可控环境因素。

4. 发明授权

US06615072B1 Optical imaging device 有权
标题翻译：光学成像装置
公开(公告)号：US06615072B1
公开(公告)日：2003-09-02
申请号：US09315982
申请日：1999-05-21
申请人： Joseph A. Izatt , Michael V. Sivak , Andrew Rollins , Akihiro Horii , Tadashi Hirata , Shuhei Iizuka , Jiro Narita
发明人： Joseph A. Izatt , Michael V. Sivak , Andrew Rollins , Akihiro Horii , Tadashi Hirata , Shuhei Iizuka , Jiro Narita
IPC分类号： A61B600
CPC分类号： A61B5/6852 , A61B5/0066 , G01B9/02002 , G01B9/0205 , G01B9/02061 , G01B9/02069 , G01B9/02091 , G01B2290/65 , G01B2290/70
摘要： An Optical Coherence Tomography (OCT) device irradiates a biological tissue with low coherence light, obtains a high resolution tomogram of the inside of the tissue by low-coherent interference with scattered light from the tissue, and is provided with an optical probe which includes an optical fiber having a flexible and thin insertion part for introducing the low coherent light. When the optical probe is inserted into a blood vessel or a patient's body cavity, the OCT enables the doctor to observe a high resolution tomogram. In a optical probe, generally, a fluctuation of a birefringence occurs depending on a bend of the optical fiber, and this an interference contrast varies depending on the condition of the insertion. The OCT of the present invention is provided with polarization compensation means such as a Faraday rotator on the side of the light emission of the optical probe, so that the OCT can obtain the stabilized interference output regardless of the state of the bend.
摘要翻译：光学相干断层扫描（OCT）装置以低相干光照射生物组织，通过与来自组织的散射光的低相干干涉获得组织内部的高分辨率断层图像，并且设置有包括光纤具有用于引入低相干光的柔性和薄的插入部分。当光学探针插入血管或患者的体腔时，OCT使医生能够观察高分辨率的断层图像。在光学探针中，通常根据光纤的弯曲发生双折射的波动，并且这种干涉对比度根据插入的条件而变化。本发明的OCT在光学探针的发光侧设置有诸如法拉第旋转器的偏振补偿装置，使得OCT可以获得稳定的干涉输出，而不管弯曲的状态如何。

5. 发明授权

US08812089B2 Gated optical coherence tomography (OCT) 有权
标题翻译：门式光学相干断层扫描（OCT）
公开(公告)号：US08812089B2
公开(公告)日：2014-08-19
申请号：US13481936
申请日：2012-05-28
申请人： Andrew Rollins , Michael Jenkins , Osman Chughtai
发明人： Andrew Rollins , Michael Jenkins , Osman Chughtai
IPC分类号： A61B6/00
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/7285
摘要： Systems, methods, and other embodiments associated with gated optical coherence tomography (OCT) are described. One example method includes generating an image control signal to control an OCT apparatus to acquire an image of an embryonic heart at a specified point in time during a cardiac cycle of the embryonic heart. The method may also include controlling the OCT apparatus to acquire the image based on the image control signal. In different examples, the image may be acquired in vivo or from an excised heart that is paced. The OCT apparatus and the embryonic heart may be housed in an environmental chamber having a set of controllable environmental factors. Therefore, the method may include detecting and controlling the set of controllable environmental factors.
摘要翻译：描述了与门控光学相干断层摄影（OCT）相关联的系统，方法和其他实施例。一个示例性方法包括产生图像控制信号以控制OCT装置以在胚胎心脏的心动周期期间的指定时间点获取胚胎心脏的图像。该方法还可以包括控制OCT装置以基于图像控制信号获取图像。在不同的实施例中，可以在体内或从起搏的切除的心脏获得图像。 OCT设备和胚胎心脏可以容纳在具有一组可控环境因素的环境室中。因此，该方法可以包括检测和控制一组可控环境因素。

6. 发明申请

US20080221445A1 Gated optical coherence tomography (OCT) environmental chamber 有权
标题翻译：门式光学相干断层扫描（OCT）环境室
公开(公告)号：US20080221445A1
公开(公告)日：2008-09-11
申请号：US12009992
申请日：2008-01-23
申请人： Andrew Rollins , Michael Jenkins , Osman Chughtai
发明人： Andrew Rollins , Michael Jenkins , Osman Chughtai
IPC分类号： A61B5/05
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/7285
摘要： Systems, methods, and other embodiments associated with gated optical coherence tomography (OCT) are described. One example method includes generating an image control signal to control an OCT apparatus to acquire an image of an embryonic heart at a specified point in time during a cardiac cycle of the embryonic heart. The method may also include controlling the OCT apparatus to acquire the image based on the image control signal. In different examples, the image may be acquired in vivo or from an excised heart that is paced. The OCT apparatus and the embryonic heart may be housed in an environmental chamber having a set of controllable environmental factors. Therefore, the method may include detecting and controlling the set of controllable environmental factors.
摘要翻译：描述了与门控光学相干断层摄影（OCT）相关联的系统，方法和其他实施例。一个示例性方法包括产生图像控制信号以控制OCT装置以在胚胎心脏的心动周期期间的指定时间点获取胚胎心脏的图像。该方法还可以包括控制OCT装置以基于图像控制信号获取图像。在不同的实施例中，可以在体内或从起搏的切除的心脏获得图像。 OCT设备和胚胎心脏可以容纳在具有一组可控环境因素的环境室中。因此，该方法可以包括检测和控制一组可控环境因素。

7. 发明申请

US20050036150A1 Method for optical coherence tomography imaging with molecular contrast 有权
标题翻译：光学相干层析成像与分子对比的方法
公开(公告)号：US20050036150A1
公开(公告)日：2005-02-17
申请号：US10765010
申请日：2004-01-26
申请人： Joseph Izatt , Divakar Rao , Changhuei Yang , Michael Choma , Siavash Yazdanfar , Andrew Rollins , Brian Applegate
发明人： Joseph Izatt , Divakar Rao , Changhuei Yang , Michael Choma , Siavash Yazdanfar , Andrew Rollins , Brian Applegate
IPC分类号： G01B9/02
CPC分类号： G01B9/02004 , G01B9/02002 , G01B9/02007 , G01B9/02014 , G01B9/02044 , G01B9/02069 , G01B9/02091 , G01B2290/70
摘要： Spatial information, such as concentration and displacement, about a specific molecular contrast agent, may be determined by stimulating a sample containing the agent, thereby altering an optical property of the agent. A plurality of optical coherence tomography (OCT) images may be acquired, at least some of which are acquired at different stimulus intensities. The acquired images are used to profile the molecular contrast agent concentration distribution of the sample.
摘要翻译：关于特定分子造影剂的空间信息，例如浓度和位移可以通过刺激含有试剂的样品来确定，从而改变试剂的光学性质。可以获取多个光学相干断层摄影（OCT）图像，其中至少一些在不同的刺激强度下被获取。采集的图像用于分析样品的分子造影剂浓度分布。

8. 发明授权

US6006128A Doppler flow imaging using optical coherence tomography 失效
标题翻译：多普勒血流成像使用光学相干断层扫描
公开(公告)号：US6006128A
公开(公告)日：1999-12-21
申请号：US88562
申请日：1998-06-02
申请人： Joseph A. Izatt , Manish D. Kulkarni , Siavash Yazdanfar , Andrew Rollins , Michael V. Sivak
发明人： Joseph A. Izatt , Manish D. Kulkarni , Siavash Yazdanfar , Andrew Rollins , Michael V. Sivak
IPC分类号： A61B5/00 , A61B5/026 , A61B5/0285 , A61B10/00 , G01B9/02 , G01N21/17 , A61B5/02
CPC分类号： A61B5/0073 , A61B5/0066 , G01B9/02045 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02083 , G01B9/02091 , A61B5/7257 , G01B2290/35 , G01B2290/60
摘要： A method for generating a velocity-indicating, tomographic image of a sample in an optical coherence tomography system includes the steps of (a) acquiring cross-correlation data from the interferometer; (b) generating a grayscale image from the cross-correlation data indicative of a depth-dependent positions of scatterers in the sample; (c) processing the cross-correlation data to produce a velocity value and location of a moving scatterer in the sample; (d) assigning a color to the velocity value; and (f) merging the color into the grayscale image, at a point in the grayscale image indicative of the moving scatterer's location, to produce a velocity-indicating, tomographic image. Preferably a first color is assigned for a positive velocity value and a second color is assigned for a negative velocity value.
摘要翻译：一种用于在光学相干断层摄影系统中产生样本的速度指示断层图像的方法包括以下步骤：（a）从干涉仪获取互相关数据; （b）从指示样品中散射体的深度相关位置的互相关数据中生成灰度图像; （c）处理互相关数据以产生样品中运动散射体的速度值和位置; （d）为速度值分配颜色; 以及（f）在指示运动散射体的位置的灰度图像中将颜色合并成灰度图像，以产生速度指示的断层图像。优选地，将第一颜色分配给正速度值，并且将第二颜色分配给负速度值。

9. 发明申请

US20120075638A1 SEGMENTATION AND QUANTIFICATION FOR INTRAVASCULAR OPTICAL COHERENCE TOMOGRAPHY IMAGES 有权
标题翻译：血管光学相干图像图像分割与定量
公开(公告)号：US20120075638A1
公开(公告)日：2012-03-29
申请号：US13196845
申请日：2011-08-02
申请人： Andrew Rollins , David Wilson , Marco Costa , Hiram Bezerra , Zhao Wang
发明人： Andrew Rollins , David Wilson , Marco Costa , Hiram Bezerra , Zhao Wang
IPC分类号： G01B9/02 , G06K9/00
CPC分类号： G06T7/0012 , A61B1/00009 , A61B1/3137 , A61B5/0066 , A61B5/0084 , A61B5/02007 , A61B5/06 , G01B9/02091 , G06T7/12 , G06T7/62 , G06T2200/24 , G06T2207/10101 , G06T2207/20116 , G06T2207/20161 , G06T2207/30021 , G06T2207/30101
摘要： A system and related methods for automatic or semi-automatic segmentation and quantification of blood vessel structure and physiology, including segmentation and quantification of lumen, guide wire, vessel wall, calcified plaques, fibrous caps, macrophages, metallic and bioresorbable stents are described, and including visualization of results. Calcified plaque segmentation can be used to estimate the distribution of superficial calcification and inform strategies stenting. Volumetric segmentation and quantification of fibrous caps can provide more comprehensive information of the mechanisms behind plaque rupture. Quantification of macrophages can aid diagnosis and prediction of unstable plaque and associated acute coronary events. Automated detection and quantification of metallic and bioresorbable stents can greatly reduce the analysis time and facilitate timely decision making for intervention procedures.
摘要翻译：描述了用于血管结构和生理学的自动或半自动分割和定量的系统和相关方法，包括内腔，导丝，血管壁，钙化斑块，纤维帽，巨噬细胞，金属和生物可吸收支架的分割和定量，以及包括结果的可视化。钙化斑块分割可以用于估计浅层钙化的分布，并通知策略支架。纤维帽的体积分割和定量可以提供斑块破裂背后机制的更全面的信息。巨噬细胞的定量可以帮助诊断和预测不稳定斑块和相关的急性冠状动脉事件。金属和生物可吸收支架的自动检测和定量可大大减少分析时间，便于及时决策干预措施。

10. 发明申请

US20080086048A1 Method for measuring biomechanical properties in an eye 有权
标题翻译：测量眼睛生物力学性质的方法
公开(公告)号：US20080086048A1
公开(公告)日：2008-04-10
申请号：US11807079
申请日：2007-05-25
申请人： William Dupps , Andrew Rollins , Matthew Ford
发明人： William Dupps , Andrew Rollins , Matthew Ford
IPC分类号： A61B3/10 , A61B3/107
CPC分类号： A61B3/10 , A61B3/165
摘要： Systems and methods are provided for characterizing biomechanical properties of tissue within an eye. A perturbation component introduces a stress to the eye tissue. An imaging component is operative to obtain an image of the eye tissue. A first image of the tissue can be obtained prior to the introduction of the stress and a second image of the tissue can be obtained after the introduction of the stress. An image analysis component compares the first image and the second image as to determine at least one biomechanical property of the tissue.
摘要翻译：提供了用于表征眼睛内组织的生物力学性质的系统和方法。扰动成分引起眼睛组织的压力。成像组件用于获得眼组织的图像。在引入应力之前可以获得组织的第一图像，并且可以在引入应力之后获得组织的第二图像。图像分析部件比较第一图像和第二图像，以确定组织的至少一个生物力学性质。

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