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1. 发明申请

US20080249599A1 Stent With Therapeutic Agent Delivery Structures in Low Strain Regions 审中-公开
标题翻译：在低应变区域中具有治疗剂递送结构的支架
公开(公告)号：US20080249599A1
公开(公告)日：2008-10-09
申请号：US11696816
申请日：2007-04-05
申请人： Jeffrey Allen , Scott Doig , Matthew J. Birdsall , Darrel Untereker
发明人： Jeffrey Allen , Scott Doig , Matthew J. Birdsall , Darrel Untereker
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91558 , A61F2250/0023 , A61F2250/0067
摘要： A system for treating abnormalities of the cardiovascular system includes a stent having a plurality of therapeutic agent-carrying regions and non therapeutic agent-carrying regions. The therapeutic agent-carrying regions are located within low strain regions of the stent and the non therapeutic agent-carrying regions are located within high strain regions of the stent. Another embodiment of the invention includes a method of manufacturing a therapeutic agent-carrying stent comprising forming a stent framework and applying a formulation containing one or more therapeutic agents to the stent framework while preventing the therapeutic agents from contacting the high strain regions of the stent framework.
摘要翻译：用于治疗心血管系统异常的系统包括具有多个治疗剂携带区域和非治疗剂携带区域的支架。治疗剂携带区域位于支架的低应变区域内，并且非治疗剂携带区域位于支架的高应变区域内。本发明的另一个实施方案包括制备治疗剂携带支架的方法，包括形成支架框架并将含有一种或多种治疗剂的制剂施用于支架框架，同时防止治疗剂接触支架框架的高应变区域。

2. 发明申请

US20090093871A1 Medical Implant With Internal Drug Delivery System 审中-公开
标题翻译：医疗植入物与内部药物输送系统
公开(公告)号：US20090093871A1
公开(公告)日：2009-04-09
申请号：US11868742
申请日：2007-10-08
申请人： Susan Rea , Feridun Ozdil , Robert Rajalingam , Noreen F. Moloney , Jeffrey Allen , Matthew J. Birdsall , Darrel Untereker , Jeffrey Gross , Mark Dolan
发明人： Susan Rea , Feridun Ozdil , Robert Rajalingam , Noreen F. Moloney , Jeffrey Allen , Matthew J. Birdsall , Darrel Untereker , Jeffrey Gross , Mark Dolan
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2250/0068
摘要： A system for treating a vascular condition includes a catheter and a stent disposed on the catheter. The stent includes tubing having a wall defining a central lumen and a plurality of holes. The system further includes a therapeutic agent disposed within the central lumen of the tubing. A method of manufacturing a therapeutic agent carrying stent includes inserting a therapeutic agent within a therapeutic agent delivery system into the central lumen of a hollow metal tube and forming a stent framework from the hollow tube.
摘要翻译：用于治疗血管状态的系统包括导管和设置在导管上的支架。支架包括具有限定中心腔和多个孔的壁的管。该系统还包括设置在管的中心腔内的治疗剂。制造治疗剂携带支架的方法包括将治疗剂递送系统内的治疗剂插入中空金属管的中心腔，并从中空管形成支架框架。

3. 发明授权

US07318837B2 Customized alloys for stents 有权
标题翻译：用于支架的定制合金
公开(公告)号：US07318837B2
公开(公告)日：2008-01-15
申请号：US11278052
申请日：2006-03-30
申请人： Michael Krivoruchko , Joseph Lessar , Richard Francis , Matthew Birdsall , Darrel Untereker , Jeffrey Allen
发明人： Michael Krivoruchko , Joseph Lessar , Richard Francis , Matthew Birdsall , Darrel Untereker , Jeffrey Allen
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91508 , A61F2002/91516 , A61F2002/91541 , A61F2002/91558 , A61F2230/0013 , A61L31/022
摘要： A balloon-expandable stent formed from a customized alloy formulation. The stent alloy has a either a high, variable or no work hardening rate, very high modulus of elasticity (Young's modulus), and a low yield point. A stent constructed of a material with this combination of properties undergoes significant plastic deformation upon deployment in vivo to its implantation diameter and exhibits minimum recoil for better sizing. The plastic deformation also raises the subsequent yield point of the stent material resulting in a stronger stent upon implantation that is more resistant to vascular loading.
摘要翻译：由定制的合金制剂形成的球囊扩张支架。支架合金具有高的，可变的或没有加工硬化率，非常高的弹性模量（杨氏模量）和低屈服点。由具有这种性质组合的材料构成的支架在体内部署到其植入直径时经历显着的塑性变形，并且显示出最小的反冲以获得更好的上浆。塑性变形也提高了支架材料的随后屈服点，从而导致植入时更坚固的支架，其更能抵抗血管负荷。

4. 发明申请

US20080319534A1 Stent With Improved Mechanical Properties 审中-公开
标题翻译：具有改善机械性能的支架
公开(公告)号：US20080319534A1
公开(公告)日：2008-12-25
申请号：US11767308
申请日：2007-06-22
申请人： Matthew J. Birdsall , Gianfranco Pellegrini , Justin Goshgarian , Jeffrey Allen
发明人： Matthew J. Birdsall , Gianfranco Pellegrini , Justin Goshgarian , Jeffrey Allen
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/915 , A61F2002/91508 , A61F2002/91558 , A61F2220/0058 , A61F2250/0036
摘要： A stent includes a central portion having a first waveform. The first waveform is wrapped around a longitudinal axis of the stent at a pitch to define a plurality of helical turns. The stent also includes an end segment connected to one end of the central portion. The end segment has a second waveform that includes a plurality of struts and a plurality of crowns. Each of the plurality of struts has a different length so that peaks of the crowns that define an end of the stent lie within a plane that is substantially perpendicular to the longitudinal axis. Cross-sectional areas of the struts having different lengths vary so that the struts move substantially uniformly during radial contraction and/or radial expansion of the stent.
摘要翻译：支架包括具有第一波形的中心部分。第一波形以间距缠绕在支架的纵向轴线上以限定多个螺旋形匝。支架还包括连接到中心部分的一端的端部段。端部段具有包括多个支柱和多个冠部的第二波形。多个支柱中的每一个具有不同的长度，使得限定支架的端部的冠部的顶点位于基本上垂直于纵向轴线的平面内。具有不同长度的支柱的横截面积变化，使得支柱在支架的径向收缩和/或径向膨胀期间基本均匀地移动。

5. 发明申请

US20090204203A1 Bioabsorbable Stent Having a Radiopaque Marker 审中-公开
标题翻译：具有不透射线标记的生物可吸收支架
公开(公告)号：US20090204203A1
公开(公告)日：2009-08-13
申请号：US12027715
申请日：2008-02-07
申请人： Jeffrey Allen , Matthew J. Birdsall
发明人： Jeffrey Allen , Matthew J. Birdsall
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2210/0004 , A61F2230/0013 , A61F2250/003 , A61F2250/0036 , A61F2250/0098
摘要： A bioabsorbable stent includes one or more radiopaque markers. The stent body may include a generally cylindrical body portion and a marker support for receiving the one or more marker(s). The marker support may be connected to an end of the body portion, or may be an integral portion of the body portion. By selectively controlling dissolution of the biodegradable material of the marker support, the marker support will remain intact for a sufficient time to allow for the marker to endothelialize and therefore prevent the marker from dislodging and embolizing. The controlled dissolution may be accomplished via one or more of the following mechanisms, including increasing the cross-sectional thickness of the marker support, passivating or oxidizing the marker support, utilizing a different, slower absorbing material for the marker support, utilizing a bioabsorbable polymeric coating on the marker support, or protecting the marker support with a sacrificial anode.
摘要翻译：生物可吸收支架包括一个或多个不透射线的标记。支架主体可以包括大致圆柱形主体部分和用于接收一个或多个标记的标记支撑件。标记支撑件可以连接到主体部分的端部，或者可以是主体部分的整体部分。通过选择性地控制标记载体的可生物降解材料的溶解，标记物载体将保持完整的足够的时间以允许标记物内皮化并因此防止标记物移出和栓塞。受控的溶解可以通过一种或多种以下机制来实现，包括使用生物可吸收聚合物的标记载体的不同的较慢的吸收材料来增加标记物载体的横截面厚度，钝化或氧化标记物载体涂覆在标记支撑件上，或用牺牲阳极保护标记支撑件。

6. 发明申请

US20080208352A1 Stent Having Controlled Porosity for Improved Ductility 审中-公开
标题翻译：具有控制孔隙度的支架以改善延展性
公开(公告)号：US20080208352A1
公开(公告)日：2008-08-28
申请号：US11679426
申请日：2007-02-27
申请人： Michael Krivoruchko , Jeffrey Allen , Matthew J. Birdsall
发明人： Michael Krivoruchko , Jeffrey Allen , Matthew J. Birdsall
IPC分类号： A61F2/86
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2230/0013 , A61F2250/0023 , A61L31/146
摘要： An endoluminal prosthesis for placement in a body lumen of a metallic material having controlled porosity for improved ductility. The metallic material may be formed into a stent structure or a wire or sheet, which may then be formed into the stent structure. The porous network of the stent includes pores that range from nanometer scale to micron scale. The controlled porosity accommodates volume changes as well as provides a barrier to crack propagation to allow alloy steels and amorphous metal materials, which would otherwise be considered too brittle for the demands of intraventional use, to be utilized in a stent.
摘要翻译：用于放置在具有受控孔隙度的金属材料的体腔中用于改善延展性的腔内假体。金属材料可以形成为可以形成支架结构的支架结构或线或片。支架的多孔网络包括范围从纳米级到微米级的孔。受控的孔隙率适应体积变化，并且提供裂纹扩展的障碍，以允许在支架中使用合金钢和非晶态金属材料，否则其将被认为对于常规使用的要求太脆。

7. 发明申请

US20090024200A1 Drug Eluting Medical Device and Method 有权
标题翻译：药物洗脱医疗器械及方法
公开(公告)号：US20090024200A1
公开(公告)日：2009-01-22
申请号：US11780572
申请日：2007-07-20
申请人： Josiah Wilcox , Jeffrey Allen , Scott Doig , Rafaelita Brown
发明人： Josiah Wilcox , Jeffrey Allen , Scott Doig , Rafaelita Brown
IPC分类号： A61F2/84 , A61F2/82
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/608 , A61L2420/08 , C08L5/02
摘要： A drug elution stent includes a stent framework and a drug elution portion disposed on the stent framework. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and a second sugar layer disposed on the at least one therapeutic agent layer. A method of manufacturing a drug elution stent includes the steps of providing a stent having a stent framework and coating at least a portion of the stent framework with a drug elution portion. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and a second sugar layer disposed on the at least one therapeutic agent layer
摘要翻译：药物洗脱支架包括支架框架和设置在支架框架上的药物洗脱部分。药物洗脱部分包括设置在支架框架上的第一糖层，设置在第一糖层上的至少一个治疗剂层和设置在至少一个治疗剂层上的第二糖层。制备药物洗脱支架的方法包括以下步骤：提供具有支架框架的支架，并用药物洗脱部分涂覆支架框架的至少一部分。药物洗脱部分包括设置在支架框架上的第一糖层，设置在第一糖层上的至少一个治疗剂层和设置在至少一个治疗剂层上的第二糖层

8. 发明授权

US08070798B2 Drug eluting medical device and method 有权
标题翻译：药物洗脱医疗器械及方法
公开(公告)号：US08070798B2
公开(公告)日：2011-12-06
申请号：US11780572
申请日：2007-07-20
申请人： Josiah Wilcox , Jeffrey Allen , Scott Doig , Rafaelita Brown
发明人： Josiah Wilcox , Jeffrey Allen , Scott Doig , Rafaelita Brown
IPC分类号： A61F2/82
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/608 , A61L2420/08 , C08L5/02
摘要： A drug elution stent includes a stent framework and a drug elution portion disposed on the stent framework. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and a second sugar layer disposed on the at least one therapeutic agent layer. A method of manufacturing a drug elution stent includes the steps of providing a stent having a stent framework and coating at least a portion of the stent framework with a drug elution portion. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and a second sugar layer disposed on the at least one therapeutic agent layer.
摘要翻译：药物洗脱支架包括支架框架和设置在支架框架上的药物洗脱部分。药物洗脱部分包括设置在支架框架上的第一糖层，设置在第一糖层上的至少一个治疗剂层和设置在至少一个治疗剂层上的第二糖层。制备药物洗脱支架的方法包括以下步骤：提供具有支架框架的支架，并用药物洗脱部分涂覆支架框架的至少一部分。药物洗脱部分包括设置在支架框架上的第一糖层，设置在第一糖层上的至少一个治疗剂层和设置在至少一个治疗剂层上的第二糖层。

9. 外观设计

USD714453S1 Hand held unit for diagnostics or measurement 有权
标题翻译：用于诊断或测量的手持单元
公开(公告)号：USD714453S1
公开(公告)日：2014-09-30
申请号：US29430814
申请日：2012-08-30
申请人： Jonathan David Mongin , David Farquhar , William W. Wells, Jr. , Richard L. Fowler , Jeffrey Allen , Devin Lee Moore , Brian Andrew Wong-Shui , Jesse Marie Newton
设计人： Jonathan David Mongin , David Farquhar , William W. Wells, Jr. , Richard L. Fowler , Jeffrey Allen , Devin Lee Moore , Brian Andrew Wong-Shui , Jesse Marie Newton

10. 发明授权

US08562673B2 Stented transcatheter prosthetic heart valve delivery system and method 有权
公开(公告)号：US08562673B2
公开(公告)日：2013-10-22
申请号：US12886975
申请日：2010-09-21
申请人： Hubert Yeung , John Shanahan , Joshua Dwork , Adam Shipley , Jeffrey Allen , Susheel Deshmukh , Kishore Udipi , Ya Guo
发明人： Hubert Yeung , John Shanahan , Joshua Dwork , Adam Shipley , Jeffrey Allen , Susheel Deshmukh , Kishore Udipi , Ya Guo
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/966 , A61F2002/9528 , A61F2002/9534 , A61F2220/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/008
摘要： A percutaneous stented valve delivery device including an inner shaft, a sheath, and a delivery capsule. The sheath slidably receives the inner shaft. A capsule proximal zone is attached to the sheath. A capsule distal zone is configured to transition between normal and flared states. A diameter of the distal zone is greater in the flared state, and the capsule includes a shape memory component that naturally assumes the normal state. The device is operable to perform a reversible partial deployment procedure in which a portion of the prosthesis is exposed distal the capsule and allowed to radially expand. Subsequently, with distal advancement of the capsule, the distal zone transitions to the flared state and imparts a collapsing force onto the prosthesis, causing the prosthesis to radially collapse and become recaptured within the delivery capsule. The capsule can include a laser cut tube encapsulated by a polymer.

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