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1. 发明申请

US20090093871A1 Medical Implant With Internal Drug Delivery System 审中-公开
标题翻译：医疗植入物与内部药物输送系统
公开(公告)号：US20090093871A1
公开(公告)日：2009-04-09
申请号：US11868742
申请日：2007-10-08
申请人： Susan Rea , Feridun Ozdil , Robert Rajalingam , Noreen F. Moloney , Jeffrey Allen , Matthew J. Birdsall , Darrel Untereker , Jeffrey Gross , Mark Dolan
发明人： Susan Rea , Feridun Ozdil , Robert Rajalingam , Noreen F. Moloney , Jeffrey Allen , Matthew J. Birdsall , Darrel Untereker , Jeffrey Gross , Mark Dolan
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2250/0068
摘要： A system for treating a vascular condition includes a catheter and a stent disposed on the catheter. The stent includes tubing having a wall defining a central lumen and a plurality of holes. The system further includes a therapeutic agent disposed within the central lumen of the tubing. A method of manufacturing a therapeutic agent carrying stent includes inserting a therapeutic agent within a therapeutic agent delivery system into the central lumen of a hollow metal tube and forming a stent framework from the hollow tube.
摘要翻译：用于治疗血管状态的系统包括导管和设置在导管上的支架。支架包括具有限定中心腔和多个孔的壁的管。该系统还包括设置在管的中心腔内的治疗剂。制造治疗剂携带支架的方法包括将治疗剂递送系统内的治疗剂插入中空金属管的中心腔，并从中空管形成支架框架。

2. 发明申请

US20080249599A1 Stent With Therapeutic Agent Delivery Structures in Low Strain Regions 审中-公开
标题翻译：在低应变区域中具有治疗剂递送结构的支架
公开(公告)号：US20080249599A1
公开(公告)日：2008-10-09
申请号：US11696816
申请日：2007-04-05
申请人： Jeffrey Allen , Scott Doig , Matthew J. Birdsall , Darrel Untereker
发明人： Jeffrey Allen , Scott Doig , Matthew J. Birdsall , Darrel Untereker
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91558 , A61F2250/0023 , A61F2250/0067
摘要： A system for treating abnormalities of the cardiovascular system includes a stent having a plurality of therapeutic agent-carrying regions and non therapeutic agent-carrying regions. The therapeutic agent-carrying regions are located within low strain regions of the stent and the non therapeutic agent-carrying regions are located within high strain regions of the stent. Another embodiment of the invention includes a method of manufacturing a therapeutic agent-carrying stent comprising forming a stent framework and applying a formulation containing one or more therapeutic agents to the stent framework while preventing the therapeutic agents from contacting the high strain regions of the stent framework.
摘要翻译：用于治疗心血管系统异常的系统包括具有多个治疗剂携带区域和非治疗剂携带区域的支架。治疗剂携带区域位于支架的低应变区域内，并且非治疗剂携带区域位于支架的高应变区域内。本发明的另一个实施方案包括制备治疗剂携带支架的方法，包括形成支架框架并将含有一种或多种治疗剂的制剂施用于支架框架，同时防止治疗剂接触支架框架的高应变区域。

3. 发明申请

US20090196899A1 Controlled Alloy Stent 审中-公开
标题翻译：受控合金支架
公开(公告)号：US20090196899A1
公开(公告)日：2009-08-06
申请号：US12023268
申请日：2008-01-31
申请人： Matthew J. Birdsall , Jeffrey W. Allen , Darrel Untereker
发明人： Matthew J. Birdsall , Jeffrey W. Allen , Darrel Untereker
IPC分类号： A61F2/84 , A61F2/82 , A61F2/06
CPC分类号： B22F3/1121 , A61F2/82 , A61F2250/0023 , A61F2250/0067 , A61L31/022 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B22F3/1146 , B22F2999/00 , B22F1/0007
摘要： A method of manufacturing a stent includes determining a porosity characteristic and combining at least two predetermined alloy constituents based on the porosity characteristic. The method further determines a solidification profile based on the porosity characteristic and combined alloy constituents and solidifies the combined alloy constituents based on the solidification profile. In addition, the method includes forming a stent framework from the solidified alloy constituents, removing at least a portion of at least one of the alloy constituents, and forming pores within the stent framework based on the removal and consistent with the porosity characteristic.
摘要翻译：制造支架的方法包括确定孔隙率特性，并且基于孔隙率特性组合至少两个预定的合金成分。该方法还基于孔隙率特性和组合的合金成分进一步确定凝固曲线，并基于固化曲线固化组合的合金成分。此外，该方法包括从固化的合金成分形成支架框架，去除合金成分中的至少一种的至少一部分，并且基于去除并与孔隙特性一致，在支架框架内形成孔。

4. 发明授权

US08303639B2 Releasable polymer on drug elution stent and method 有权
标题翻译：药物洗脱支架上的可释放聚合物和方法
公开(公告)号：US08303639B2
公开(公告)日：2012-11-06
申请号：US11689733
申请日：2007-03-22
申请人： Mark Dolan , Matthew J. Birdsall , Eugene Tedeschi , Joseph Berglund , Raffy Brown
发明人： Mark Dolan , Matthew J. Birdsall , Eugene Tedeschi , Joseph Berglund , Raffy Brown
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/91 , A61F2250/0067
摘要： A method for treating a vascular condition is disclosed, the method comprising delivering a stent to a target region of a vessel, the stent including a drug polymer coating including an elution portion and a remaining portion, eluting the elution portion from the delivered stent for an elution period, heating the delivered stent after the elution period; and removing the remaining portion based on the heating.
摘要翻译：公开了一种用于治疗血管病症的方法，所述方法包括将支架输送到血管的靶区域，所述支架包括药物聚合物涂层，其包括洗脱部分和剩余部分，从所述输送的支架洗脱洗脱部分，洗脱期后，在洗脱期后加热输送的支架; 并且基于加热去除剩余部分。

5. 发明申请

US20080234808A1 Releasable Polymer on Drug Elution Stent and Method 有权
标题翻译：可释放聚合物对药物洗脱支架和方法的影响
公开(公告)号：US20080234808A1
公开(公告)日：2008-09-25
申请号：US11689733
申请日：2007-03-22
申请人： Mark Dolan , Matthew J. Birdsall , Eugene Tedeschi , Joseph Berglund , Raffy Brown
发明人： Mark Dolan , Matthew J. Birdsall , Eugene Tedeschi , Joseph Berglund , Raffy Brown
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/91 , A61F2250/0067
摘要： A method for treating a vascular condition is disclosed, the method comprising delivering a stent to a target region of a vessel, the stent including a drug polymer coating including an elution portion and a remaining portion, eluting the elution portion from the delivered stent for an elution period, heating the delivered stent after the elution period; and removing the remaining portion based on the heating.
摘要翻译：公开了一种用于治疗血管病症的方法，所述方法包括将支架输送到血管的靶区域，所述支架包括药物聚合物涂层，其包括洗脱部分和剩余部分，从所述输送的支架洗脱洗脱部分，洗脱期后，在洗脱期后加热输送的支架; 并且基于加热去除剩余部分。

6. 发明申请

US20080319534A1 Stent With Improved Mechanical Properties 审中-公开
标题翻译：具有改善机械性能的支架
公开(公告)号：US20080319534A1
公开(公告)日：2008-12-25
申请号：US11767308
申请日：2007-06-22
申请人： Matthew J. Birdsall , Gianfranco Pellegrini , Justin Goshgarian , Jeffrey Allen
发明人： Matthew J. Birdsall , Gianfranco Pellegrini , Justin Goshgarian , Jeffrey Allen
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/915 , A61F2002/91508 , A61F2002/91558 , A61F2220/0058 , A61F2250/0036
摘要： A stent includes a central portion having a first waveform. The first waveform is wrapped around a longitudinal axis of the stent at a pitch to define a plurality of helical turns. The stent also includes an end segment connected to one end of the central portion. The end segment has a second waveform that includes a plurality of struts and a plurality of crowns. Each of the plurality of struts has a different length so that peaks of the crowns that define an end of the stent lie within a plane that is substantially perpendicular to the longitudinal axis. Cross-sectional areas of the struts having different lengths vary so that the struts move substantially uniformly during radial contraction and/or radial expansion of the stent.
摘要翻译：支架包括具有第一波形的中心部分。第一波形以间距缠绕在支架的纵向轴线上以限定多个螺旋形匝。支架还包括连接到中心部分的一端的端部段。端部段具有包括多个支柱和多个冠部的第二波形。多个支柱中的每一个具有不同的长度，使得限定支架的端部的冠部的顶点位于基本上垂直于纵向轴线的平面内。具有不同长度的支柱的横截面积变化，使得支柱在支架的径向收缩和/或径向膨胀期间基本均匀地移动。

7. 发明申请

US20080208352A1 Stent Having Controlled Porosity for Improved Ductility 审中-公开
标题翻译：具有控制孔隙度的支架以改善延展性
公开(公告)号：US20080208352A1
公开(公告)日：2008-08-28
申请号：US11679426
申请日：2007-02-27
申请人： Michael Krivoruchko , Jeffrey Allen , Matthew J. Birdsall
发明人： Michael Krivoruchko , Jeffrey Allen , Matthew J. Birdsall
IPC分类号： A61F2/86
CPC分类号： A61L31/022 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2230/0013 , A61F2250/0023 , A61L31/146
摘要： An endoluminal prosthesis for placement in a body lumen of a metallic material having controlled porosity for improved ductility. The metallic material may be formed into a stent structure or a wire or sheet, which may then be formed into the stent structure. The porous network of the stent includes pores that range from nanometer scale to micron scale. The controlled porosity accommodates volume changes as well as provides a barrier to crack propagation to allow alloy steels and amorphous metal materials, which would otherwise be considered too brittle for the demands of intraventional use, to be utilized in a stent.
摘要翻译：用于放置在具有受控孔隙度的金属材料的体腔中用于改善延展性的腔内假体。金属材料可以形成为可以形成支架结构的支架结构或线或片。支架的多孔网络包括范围从纳米级到微米级的孔。受控的孔隙率适应体积变化，并且提供裂纹扩展的障碍，以允许在支架中使用合金钢和非晶态金属材料，否则其将被认为对于常规使用的要求太脆。

8. 发明申请

US20090204203A1 Bioabsorbable Stent Having a Radiopaque Marker 审中-公开
标题翻译：具有不透射线标记的生物可吸收支架
公开(公告)号：US20090204203A1
公开(公告)日：2009-08-13
申请号：US12027715
申请日：2008-02-07
申请人： Jeffrey Allen , Matthew J. Birdsall
发明人： Jeffrey Allen , Matthew J. Birdsall
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2210/0004 , A61F2230/0013 , A61F2250/003 , A61F2250/0036 , A61F2250/0098
摘要： A bioabsorbable stent includes one or more radiopaque markers. The stent body may include a generally cylindrical body portion and a marker support for receiving the one or more marker(s). The marker support may be connected to an end of the body portion, or may be an integral portion of the body portion. By selectively controlling dissolution of the biodegradable material of the marker support, the marker support will remain intact for a sufficient time to allow for the marker to endothelialize and therefore prevent the marker from dislodging and embolizing. The controlled dissolution may be accomplished via one or more of the following mechanisms, including increasing the cross-sectional thickness of the marker support, passivating or oxidizing the marker support, utilizing a different, slower absorbing material for the marker support, utilizing a bioabsorbable polymeric coating on the marker support, or protecting the marker support with a sacrificial anode.
摘要翻译：生物可吸收支架包括一个或多个不透射线的标记。支架主体可以包括大致圆柱形主体部分和用于接收一个或多个标记的标记支撑件。标记支撑件可以连接到主体部分的端部，或者可以是主体部分的整体部分。通过选择性地控制标记载体的可生物降解材料的溶解，标记物载体将保持完整的足够的时间以允许标记物内皮化并因此防止标记物移出和栓塞。受控的溶解可以通过一种或多种以下机制来实现，包括使用生物可吸收聚合物的标记载体的不同的较慢的吸收材料来增加标记物载体的横截面厚度，钝化或氧化标记物载体涂覆在标记支撑件上，或用牺牲阳极保护标记支撑件。

9. 发明申请

US20100125323A1 Coil Stent Delivery System and Method of Use 审中-公开
标题翻译：线圈支架输送系统及使用方法
公开(公告)号：US20100125323A1
公开(公告)日：2010-05-20
申请号：US12271465
申请日：2008-11-14
申请人： Joseph Berglund , Matthew J. Birdsall , Lesley Crookall
发明人： Joseph Berglund , Matthew J. Birdsall , Lesley Crookall
IPC分类号： A61F2/06
CPC分类号： A61L31/148 , A61F2/88 , A61F2/95 , A61F2002/9517 , A61F2002/9665 , A61F2220/0016
摘要： The coil stent delivery system and method of use includes a stent delivery system including a coil stent; a housing, the housing having a receiver defining a receiver chamber and a sheath defining a sheath lumen, the receiver chamber being in communication with the sheath lumen; and a screw assembly, the screw assembly having a shaft, a helical screw disposed about a distal portion of the shaft, and a drive operably coupled to the shaft. The shaft is disposed in the receiver chamber and the sheath lumen, the helical screw is disposed in the sheath, and the coil stent is disposed about the shaft in the receiver chamber and engages the helical screw. Rotation of the drive moves the coil stent through the sheath lumen.
摘要翻译：线圈支架输送系统和使用方法包括支架输送系统，其包括线圈支架; 壳体，其具有限定了接收器室的接收器和限定护套管腔的护套，所述接收器腔室与鞘管腔连通; 和螺钉组件，所述螺钉组件具有轴，设置在所述轴的远侧部分周围的螺旋形螺钉以及可操作地联接到所述轴的驱动器。轴设置在接收器腔室和护套管腔中，螺旋形螺钉设置在护套中，线圈支架围绕接收器腔室中的轴设置并与螺旋形螺钉接合。驱动器的旋转将线圈支架移动通过鞘管。

10. 发明申请

US20110008405A1 Hollow Tubular Drug Eluting Medical Devices 有权
标题翻译：中空管状药物洗脱医疗器械
公开(公告)号：US20110008405A1
公开(公告)日：2011-01-13
申请号：US12500359
申请日：2009-07-09
申请人： Matthew J. Birdsall , Christopher Storment , D.H. Perkins , Dustin Thompson
发明人： Matthew J. Birdsall , Christopher Storment , D.H. Perkins , Dustin Thompson
IPC分类号： A61L27/54 , B44C1/22
CPC分类号： A61M25/0015 , A61B2017/00526 , A61L31/022 , A61L31/16 , A61M25/0012 , A61N1/0587
摘要： A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from the lumen of the outer member without harming the outer member, leaving a hollow tubular member already formed into the desired pattern. The lumen of the outer member is filled with a therapeutic substance.
摘要翻译：形成中空药物洗脱医疗装置的方法包括提供具有外部构件和设置在外部构件的内腔内的芯构件的复合构件。复合构件成形为图案。通过复合构件的外部构件形成开口。处理复合构件以从外部构件的内腔移除芯构件而不损害外部构件，留下已经形成为期望图案的中空管状构件。外部构件的内腔填充有治疗物质。

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