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1. 发明授权

US08623079B2 Stents for prosthetic heart valves 有权
标题翻译：假体心脏瓣膜支架
公开(公告)号：US08623079B2
公开(公告)日：2014-01-07
申请号：US13093305
申请日：2011-04-25
申请人： Padraig Savage , Gianfranco Pellegrini , Finn Rinne , Matthew Rust , Michael Krivoruchko
发明人： Padraig Savage , Gianfranco Pellegrini , Finn Rinne , Matthew Rust , Michael Krivoruchko
IPC分类号： A61F2/24
CPC分类号： A61F2/24 , A61F2/2418 , A61F2/848 , A61F2002/8483 , A61F2220/0016 , A61F2230/0054 , A61F2230/008
摘要： A stented valve including a stent structure having a generally tubular body portion, an interior area, a longitudinal axis, an first end, an second end, and an outer surface; at least one outflow barb extending from the outer surface of the stent adjacent to the first end of the stent structure and toward the second end of the stent structure; at least one inflow barb extending from the outer surface of the stent adjacent to the second end of the stent structure and toward the first end of the stent structure; and a valve structure attached within the interior area of the stent structure.
摘要翻译：一种支架式阀，包括具有大致管状主体部分，内部区域，纵向轴线，第一端部，第二端部和外部表面的支架结构; 至少一个流出倒钩，其从所述支架的外表面邻近所述支架结构的所述第一端延伸并朝向所述支架结构的第二端; 至少一个流入倒钩，其从所述支架的外表面延伸到所述支架结构的第二端并朝向所述支架结构的第一端; 以及附接在支架结构的内部区域内的阀结构。

2. 发明申请

US20120198878A1 HEATING DEVICE WITH IRREVERSIBLE THERMODYNAMIC CYCLE FOR HEATING INSTALLATIONS HAVING HIGH DELIVERY TEMPERATURE 审中-公开
标题翻译：具有不可逆温度循环的加热装置，用于加热具有高输送温度的安装
公开(公告)号：US20120198878A1
公开(公告)日：2012-08-09
申请号：US13501505
申请日：2010-10-13
申请人： Gianfranco Pellegrini
发明人： Gianfranco Pellegrini
IPC分类号： F25B29/00
CPC分类号： F25B30/02 , F25B7/00 , F25B40/02 , F25B2339/047
摘要： The present invention relates to a heating device with irreversible thermodynamic cycle. The device comprises a low temperature circuit and a high temperature circuit in which respectively a first and a second operating fluid circulate. Each circuit comprises evaporating, compression, condensation and expansion means of the respective operating fluid. The low temperature circuit absorbs thermal energy from a supply water flow for evaporating the first operating fluid. The thermal energy deriving from the condensation of the first operating fluid is used for evaporating the second fluid. Instead, the thermal energy deriving from the condensation of the second fluid is used for heating a delivery water flow. According to the invention, the two operating circuits each comprise cooling means interposed between the corresponding condensation and expansion means. Such cooling means are in thermal contact with independent partial flows of the supply water flow so as to heat the latter overall by means of thermal energy removed from the operating fluids circulating in the two circuits.
摘要翻译：本发明涉及一种具有不可逆热循环的加热装置。该装置包括低温电路和高温电路，其中第一和第二工作流体分别循环。每个回路包括各个工作流体的蒸发，压缩，冷凝和膨胀装置。低温回路从供水流中吸收热能以蒸发第一工作流体。来自第一工作流体的冷凝的热能用于蒸发第二流体。相反，来自第二流体的冷凝的热能用于加热输送水流。根据本发明，两个操作电路各自包括插入在相应的冷凝和膨胀装置之间的冷却装置。这种冷却装置与供水流的独立部分流动热接触，以便通过从在两个回路中循环的工作流体移除的热能来加热后者。

3. 发明申请

US20110245782A1 Method of Using Catheter with Rotating Portion 有权
标题翻译：使用导管与旋转部分的方法
公开(公告)号：US20110245782A1
公开(公告)日：2011-10-06
申请号：US12754827
申请日：2010-04-06
申请人： William Berthiaume , Gianfranco Pellegrini , Scott Doig
发明人： William Berthiaume , Gianfranco Pellegrini , Scott Doig
IPC分类号： A61M25/01 , A61L29/14
CPC分类号： A61M25/01 , A61M25/0152
摘要： A catheter includes a proximal portion and a distal portion, the distal portion including an arcuate portion. The catheter further includes a rotating portion, the rotating portion connecting the proximal portion and distal portion, the rotating portion including a first piece and a second piece, wherein the first piece and second piece create a snap fit. Methods of using the catheter include threading the inserted catheter through the vasculature and allowing the distal portion to freely rotate about an axis defined by the rotating portion responsive to any tortuosity in the vasculature.
摘要翻译：导管包括近端部分和远端部分，远侧部分包括弓形部分。导管还包括旋转部分，旋转部分连接近端部分和远端部分，旋转部分包括第一部分和第二部分，其中第一部分和第二部分形成卡扣配合。使用导管的方法包括穿过脉管系统插入插入的导管，并允许远端部分响应于脉管系统中的任何曲折度而围绕由旋转部分限定的轴线自由旋转。

4. 发明申请

US20080319534A1 Stent With Improved Mechanical Properties 审中-公开
标题翻译：具有改善机械性能的支架
公开(公告)号：US20080319534A1
公开(公告)日：2008-12-25
申请号：US11767308
申请日：2007-06-22
申请人： Matthew J. Birdsall , Gianfranco Pellegrini , Justin Goshgarian , Jeffrey Allen
发明人： Matthew J. Birdsall , Gianfranco Pellegrini , Justin Goshgarian , Jeffrey Allen
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/915 , A61F2002/91508 , A61F2002/91558 , A61F2220/0058 , A61F2250/0036
摘要： A stent includes a central portion having a first waveform. The first waveform is wrapped around a longitudinal axis of the stent at a pitch to define a plurality of helical turns. The stent also includes an end segment connected to one end of the central portion. The end segment has a second waveform that includes a plurality of struts and a plurality of crowns. Each of the plurality of struts has a different length so that peaks of the crowns that define an end of the stent lie within a plane that is substantially perpendicular to the longitudinal axis. Cross-sectional areas of the struts having different lengths vary so that the struts move substantially uniformly during radial contraction and/or radial expansion of the stent.
摘要翻译：支架包括具有第一波形的中心部分。第一波形以间距缠绕在支架的纵向轴线上以限定多个螺旋形匝。支架还包括连接到中心部分的一端的端部段。端部段具有包括多个支柱和多个冠部的第二波形。多个支柱中的每一个具有不同的长度，使得限定支架的端部的冠部的顶点位于基本上垂直于纵向轴线的平面内。具有不同长度的支柱的横截面积变化，使得支柱在支架的径向收缩和/或径向膨胀期间基本均匀地移动。

5. 发明授权

US5894437A Concurrent read/write architecture for a flash memory 失效
标题翻译： Flash存储器的并发读/写架构
公开(公告)号：US5894437A
公开(公告)日：1999-04-13
申请号：US12268
申请日：1998-01-23
申请人： Gianfranco Pellegrini
发明人： Gianfranco Pellegrini
IPC分类号： G11C7/18 , G11C16/08 , G11C16/04
CPC分类号： G11C16/08 , G11C7/18 , G11C2216/22
摘要： A semiconductor device having an array of flash memory cells and for each column of cells, a global read bit line, a global write bit line, and a plurality of local bit lines, wherein the column of cells is divided into a plurality of subcolumns and each local bit line is electrically coupled to each of the cells in a subcolumn associated with the local bit line. The local bit line is coupled and decoupled to the global read bit line by a local read select transistor and is coupled and decoupled to the global write bit line by a local write select transistor. By coupling one local bit line for a column to the global read bit line and coupling another local bit line to the global write bit line, one cell can be written while another cell is read from, even though the cell being read and the cell being written are in the same column. A variation uses the two global bit lines as read lines or read/write lines instead of a global read bit line and a global write bit line for each column.
摘要翻译：一种半导体器件，具有闪存单元阵列和每列单元阵列，全局读位线，全局写位线和多个局部位线，其中该列单元被分成多个子列和每个本地位线电耦合到与局部位线相关联的子列中的每个单元。局部位线由本地读选晶体管耦合并去耦到全局读位线，并通过局部写选择晶体管与全局写位线耦合并去耦合。通过将列的一个局部位线耦合到全局读位线并将另一局部位线耦合到全局写位线，即使读取单元并且单元为写在同一列。变体使用两条全局位线作为读线或读/写线，而不是每列的全局读位线和全局写位线。

6. 发明授权

US09339630B2 Retractable drug delivery system and method 有权
标题翻译：伸缩药物输送系统及方法
公开(公告)号：US09339630B2
公开(公告)日：2016-05-17
申请号：US12389070
申请日：2009-02-19
申请人： Brian Cook , James Mitchell , Natividad Vasquez , Gianfranco Pellegrini
发明人： Brian Cook , James Mitchell , Natividad Vasquez , Gianfranco Pellegrini
IPC分类号： A61F2/95 , A61M25/00 , A61F2/966 , A61F2/91 , A61M25/06
CPC分类号： A61M25/0082 , A61F2/91 , A61F2/95 , A61F2/966 , A61F2002/9665 , A61F2250/0068 , A61M25/0068 , A61M2025/0057 , A61M2025/0681
摘要： A system for treating a vascular condition includes a catheter having an inner member and an outer member, the outer member concentrically arranged about the inner member and a retractable drug delivery device disposed at a distal end of the inner member. A coating disposed on at least a portion of an outer surface of the retractable drug delivery device includes at least one therapeutic agent.
摘要翻译：用于治疗血管病症的系统包括具有内部构件和外部构件的导管，所述外部构件围绕内部构件同心地布置，以及设置在内部构件的远端处的可伸缩药物输送装置。设置在可伸缩药物输送装置的外表面的至少一部分上的涂层包括至少一种治疗剂。

7. 发明授权

US09060889B2 Methods for forming an orthogonal end on a helical stent 有权
标题翻译：在螺旋支架上形成正交端的方法
公开(公告)号：US09060889B2
公开(公告)日：2015-06-23
申请号：US12693593
申请日：2010-01-26
申请人： Richard Bliss , Justin Goshgarian , Rui Lam , Padraig Savage , Erik Griswold , Gianfranco Pellegrini , Matthew Baldwin , Lance Ensign
发明人： Richard Bliss , Justin Goshgarian , Rui Lam , Padraig Savage , Erik Griswold , Gianfranco Pellegrini , Matthew Baldwin , Lance Ensign
IPC分类号： A61F2/06 , A61F2/88 , A61F2/915
CPC分类号： B21F45/008 , A61F2/88 , A61F2/915 , A61F2002/91508 , A61F2002/91525 , A61F2002/91558 , B21F1/04 , B21F3/02 , B23K31/027 , B23K2101/22 , B23K2201/22 , Y10T29/49826
摘要： A stent includes a continuous wave form having a plurality of struts and a plurality of crowns throughout the wave form. Each crown connects two adjacent struts. The wave form is wrapped around a longitudinal axis to define a central portion and two end portions located on opposite sides the central portion. The central portion includes a plurality of turns wrapped around the longitudinal axis and oriented at a first pitch angle relative to the longitudinal axis. The end portions each include a plurality of turns wrapped around the longitudinal axis and oriented at different pitch angles, and an end turn oriented at an angle relative to the longitudinal axis. The different pitch angles of the end portions are between the first pitch angle and the angle of the end turn relative to the longitudinal axis.
摘要翻译：支架包括具有整个波浪形状的多个支柱和多个冠部的连续波形。每个皇冠连接两个相邻的支柱。波形围绕纵向轴线包围以限定位于中心部分的相对侧上的中心部分和两个端部部分。中心部分包括围绕纵向轴线缠绕并相对于纵向轴线以第一俯仰角定向的多个匝。端部分别包括围绕纵向轴线缠绕并以不同的俯仰角定向的多个匝和相对于纵向轴线成一定角度定向的端匝。端部的不同桨距角位于第一桨距角和端匝相对于纵向轴线的角度之间。

8. 发明授权

US08034099B2 Stent prosthesis having select flared crowns 失效
标题翻译：具有选择扩张冠的支架假体
公开(公告)号：US08034099B2
公开(公告)日：2011-10-11
申请号：US12057032
申请日：2008-03-27
申请人： Gianfranco Pellegrini
发明人： Gianfranco Pellegrini
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/958 , A61F2002/821 , A61F2230/005 , A61F2230/0054
摘要： A generally tubular, cylindrical stent prosthesis has an unexpanded delivery configuration and an expanded configuration for contacting the vessel wall. The stent prosthesis has a plurality of adjacent stent struts, each stent strut having a wavelike or sinusoidal pattern of straight segments and crowns. A Y-shaped member is attached to one or more crowns to cause the crowns to flare outwardly at an angle from the cylindrical stent body when the stent is expanded. Upon expansion of the stent, the crown(s) having Y-shaped members attached thereto are angled with respect to the longitudinal axis and radially flare from the cylindrical stent body. The flared crowns anchor the stent within the vessel by protruding into the vessel wall and/or seating the stent within an ostium.
摘要翻译：通常管状的圆柱形支架假体具有未膨胀的输送构型和用于接触血管壁的扩张构型。支架假体具有多个相邻的支架支柱，每个支架支柱具有直段和冠部的波浪形或正弦曲线图案。当支架膨胀时，Y形构件附接到一个或多个冠部，以使冠部与圆柱形支架体成一定角度向外张开。在支架膨胀时，具有附接到其上的具有Y形构件的表冠相对于纵向轴线成角度，并且从圆柱形支架主体径向闪耀。扩张冠冠通过突出到血管壁和/或将支架置于口内而将支架锚定在血管内。

9. 发明申请

US20090287290A1 Delivery Systems and Methods of Implantation for Prosthetic Heart Valves 审中-公开
标题翻译：假体心脏瓣膜植入系统和方法
公开(公告)号：US20090287290A1
公开(公告)日：2009-11-19
申请号：US12358084
申请日：2009-01-22
申请人： Patrick E. Macaulay , Robert J. Murray , Trevor Greenan , Timothy R. Ryan , Charles Tabor , Matthew J. Birdsall , Gianfranco Pellegrini
发明人： Patrick E. Macaulay , Robert J. Murray , Trevor Greenan , Timothy R. Ryan , Charles Tabor , Matthew J. Birdsall , Gianfranco Pellegrini
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2002/9505 , A61F2002/9511 , A61F2002/9534 , A61F2002/9665 , A61F2250/0098
摘要： A delivery system for delivering a stented prosthetic heart valve to a lumen of a patient, the delivery system including a tubular body having a proximal end, a distal end, and a base portion with a plurality of extending elements, wherein each of the extending elements is engageable with a portion of a stent of a prosthetic heart valve. The delivery system further includes a sleeve having an inner area. The sheath is longitudinally moveable relative to the base portion from a first position where the inner area of the sleeve at least partially covers the extending elements of the base portion to a second position where the extending elements are not positioned within the inner area of the sleeve.
摘要翻译：一种用于将支架假体心脏瓣膜递送到患者的内腔的输送系统，所述输送系统包括具有近端，远端和具有多个延伸元件的基部的管状体，其中每个所述延伸元件可与假体心脏瓣膜的支架的一部分接合。输送系统还包括具有内部区域的套筒。护套从第一位置可相对于基部纵向移动，其中套筒的内部区域至少部分地将基部的延伸元件覆盖到第二位置，在第二位置，延伸元件不位于套筒的内部区域内。

10. 发明申请

US20090248139A1 Stent Prosthesis Having Select Flared Crowns 失效
标题翻译：支架假体具有选择喇叭冠
公开(公告)号：US20090248139A1
公开(公告)日：2009-10-01
申请号：US12057032
申请日：2008-03-27
申请人： Gianfranco Pellegrini
发明人： Gianfranco Pellegrini
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/958 , A61F2002/821 , A61F2230/005 , A61F2230/0054
摘要： A generally tubular, cylindrical stent prosthesis has an unexpanded delivery configuration and an expanded configuration for contacting the vessel wall. The stent prosthesis has a plurality of adjacent stent struts, each stent strut having a wavelike or sinusoidal pattern of straight segments and crowns. A Y-shaped member is attached to one or more crowns to cause the crowns to flare outwardly at an angle from the cylindrical stent body when the stent is expanded. Upon expansion of the stent, the crown(s) having Y-shaped members attached thereto are angled with respect to the longitudinal axis and radially flare from the cylindrical stent body. The flared crowns anchor the stent within the vessel by protruding into the vessel wall and/or seating the stent within an ostium.
摘要翻译：通常管状的圆柱形支架假体具有未膨胀的输送构型和用于接触血管壁的扩张构型。支架假体具有多个相邻的支架支柱，每个支架支柱具有直段和冠部的波浪形或正弦曲线图案。当支架膨胀时，Y形构件附接到一个或多个冠部，以使冠部与圆柱形支架体成一定角度向外张开。在支架膨胀时，具有附接到其上的具有Y形构件的表冠相对于纵向轴线成角度，并且从圆柱形支架体径向闪耀。扩张冠冠通过突出到血管壁和/或将支架置于口内而将支架锚定在血管内。

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