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1. 发明授权

US08562673B2 Stented transcatheter prosthetic heart valve delivery system and method 有权
公开(公告)号：US08562673B2
公开(公告)日：2013-10-22
申请号：US12886975
申请日：2010-09-21
申请人： Hubert Yeung , John Shanahan , Joshua Dwork , Adam Shipley , Jeffrey Allen , Susheel Deshmukh , Kishore Udipi , Ya Guo
发明人： Hubert Yeung , John Shanahan , Joshua Dwork , Adam Shipley , Jeffrey Allen , Susheel Deshmukh , Kishore Udipi , Ya Guo
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/966 , A61F2002/9528 , A61F2002/9534 , A61F2220/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/008
摘要： A percutaneous stented valve delivery device including an inner shaft, a sheath, and a delivery capsule. The sheath slidably receives the inner shaft. A capsule proximal zone is attached to the sheath. A capsule distal zone is configured to transition between normal and flared states. A diameter of the distal zone is greater in the flared state, and the capsule includes a shape memory component that naturally assumes the normal state. The device is operable to perform a reversible partial deployment procedure in which a portion of the prosthesis is exposed distal the capsule and allowed to radially expand. Subsequently, with distal advancement of the capsule, the distal zone transitions to the flared state and imparts a collapsing force onto the prosthesis, causing the prosthesis to radially collapse and become recaptured within the delivery capsule. The capsule can include a laser cut tube encapsulated by a polymer.

2. 发明申请

US20120301403A1 POLYETHYLENE GLYCOLATED SUPEROXIDE DISMUTASE MIMETICS 审中-公开
标题翻译：聚乙烯甘油超氧化物歧化酶
公开(公告)号：US20120301403A1
公开(公告)日：2012-11-29
申请号：US13526111
申请日：2012-06-18
申请人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
发明人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
IPC分类号： A61K31/28 , A61P29/00 , A61P1/00 , A61P19/02 , A61P9/12 , A61P17/06 , A61P37/06 , A61P7/02 , A61P37/00 , A61P11/00 , A61P25/00 , A61P25/04 , A61P31/00 , A61K49/00 , C12Q1/18 , A61P9/10
CPC分类号： C12N9/0089 , A61K47/60 , C12Q1/26 , C12Q1/28 , G01N33/5014
摘要： Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds are also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
摘要翻译：用于利用包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物的化合物和方法。还提供了制备与聚乙二醇共价连接的超氧化物歧化酶模拟物的方法，所述方法包括使活化的聚乙二醇与超氧化物歧化酶模拟物反应，或者使超氧化物歧化酶模拟物与活化的聚乙二醇反应。还提供了一种用于预防或治疗涉及超氧化物阴离子的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物。还提供了确定化合物的安全性和功效的方法。确定安全性和功效的方法可以包括实验动物和人类的方法。

3. 发明授权

US08217166B2 Polyethylene glycolated superoxide dismutase mimetics 有权
标题翻译：聚乙烯甘氨酸超氧化物歧化酶模拟物
公开(公告)号：US08217166B2
公开(公告)日：2012-07-10
申请号：US11766221
申请日：2007-06-21
申请人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
发明人： Daniela Salvemini , William L. Neumann , Samuel Tremont , Kishore Udipi , Amruta Reddy Poreddy
IPC分类号： C07B47/00 , C07D487/22
CPC分类号： A61K47/60
摘要： Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds ere also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
摘要翻译：用于利用包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物的化合物和方法。还提供了制备与聚乙二醇共价连接的超氧化物歧化酶模拟物的方法，所述方法包括使活化的聚乙二醇与超氧化物歧化酶模拟物反应，或者使超氧化物歧化酶模拟物与活化的聚乙二醇反应。还提供了一种用于预防或治疗涉及超氧化物阴离子的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的包含与聚乙二醇共价连接的超氧化物歧化酶模拟物的化合物。还提供了确定化合物的安全性和功效的方法。确定安全性和功效的方法可以包括实验动物和人类的方法。

4. 发明申请

US20110150966A1 DEGRADABLE POLYMERS INCORPORATING GAMMA-BUTYROLACTONE 审中-公开
标题翻译：掺入γ-丁内酯的可降解聚合物
公开(公告)号：US20110150966A1
公开(公告)日：2011-06-23
申请号：US13037154
申请日：2011-02-28
申请人： Mingfei Chen , Peiwen Cheng , Ya Guo , Kishore Udipi
发明人： Mingfei Chen , Peiwen Cheng , Ya Guo , Kishore Udipi
IPC分类号： A61K47/34 , A61F2/00 , A61K39/395 , A61K31/436 , A61K31/565
CPC分类号： A61L31/148 , A61F2210/0004 , A61L27/18 , A61L27/34 , A61L27/54 , A61L27/58 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/252 , A61L2300/258 , A61L2300/402 , A61L2300/414 , A61L2300/432 , C08G63/08 , C08G63/823 , C09D167/04 , C08L67/04
摘要： Disclosed herein are implantable medical devices having controlled release biodegradable polymer coatings thereon wherein the polymer is formed from ring opening of γ-butyrolactone and at least one additional monomer selected from the group consisting of trimethylene carbonate, lactide, polyethylene glycol, glycolide, the monomers formed from ring opening of ε-caprolactone, 4-tert-butyl caprolactone, and N-acetyl caprolactone, and combinations thereof, and at least one drug releasable from the biodegradable polymer. Also disclosed are implantable medical devices form of the biodegradable polymers and processes for forming the polymers.
摘要翻译：本文公开了其上具有可控释放的可生物降解的聚合物涂层的可植入医疗装置，其中所述聚合物由γ-丁内酯的开环和至少一种选自三亚甲基碳酸酯，丙交酯，聚乙二醇，乙交酯的另外的单体形成，所形成的单体由ε-己内酯，4-叔丁基己内酯和N-乙酰基己内酯的开环及其组合，以及可从生物可降解聚合物中释放的至少一种药物。还公开了可生物降解聚合物的可植入医疗装置形式和形成聚合物的方法。

5. 发明申请

US20100262228A1 Implantable Medical Devices Having Bioabsorbable Primer Polymer Coatings 有权
标题翻译：具有生物可吸收底漆聚合物涂层的植入式医疗器械
公开(公告)号：US20100262228A1
公开(公告)日：2010-10-14
申请号：US12422018
申请日：2009-04-10
申请人： Kishore Udipi , Ya Guo
发明人： Kishore Udipi , Ya Guo
IPC分类号： A61F2/02 , A61F2/06
CPC分类号： A61L31/022 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L67/04
摘要： The present disclosure generally relates to implantable medical devices having a metallic surface coated with a bioabsorbable primer polymer layer under a bioabsorbable drug polymer layer. Thus, in addition to the degradation of the drug polymer layer, there is degradation of the primer layer. The underlying metallic framework may or may not degrade depending on whether bioabsorbable or biostable metals are chosen.
摘要翻译：本公开一般涉及具有在生物可吸收的药物聚合物层下方涂覆有生物可吸收底漆聚合物层的金属表面的可植入医疗装置。因此，除了药物聚合物层的降解之外，还有底漆层的降解。根据是否选择生物可吸收或生物稳定金属，底层金属框架可能降解或不降解。

6. 发明授权

US07811600B2 Nitric oxide donating medical devices and methods of making same 失效
标题翻译：一氧化氮捐赠医疗器械及其制造方法
公开(公告)号：US07811600B2
公开(公告)日：2010-10-12
申请号：US11683885
申请日：2007-03-08
申请人： Peiwen Cheng , Mingfei Chen , Kishore Udipi
发明人： Peiwen Cheng , Mingfei Chen , Kishore Udipi
IPC分类号： A61F2/00 , A61K31/74
CPC分类号： A61L27/14 , A61L17/145 , A61L27/34 , A61L29/04 , A61L29/085 , A61L31/04 , A61L31/10
摘要： Disclosed are implantable medical devices comprising nitric oxide (NO) donating polymers comprising polymer backbones having at least one cyclic amine disposed thereon. Methods are further disclosed for providing nitric oxide-donating polymers.
摘要翻译：公开了包含一氧化氮（NO）供体聚合物的植入式医疗装置，其包含其上布置有至少一个环状胺的聚合物主链。进一步公开了提供一氧化氮供体聚合物的方法。

7. 发明申请

US20100152831A1 Implantable Medical Devices Having Multiblock Copolymers 审中-公开
标题翻译：具有多嵌段共聚物的植入式医疗器械
公开(公告)号：US20100152831A1
公开(公告)日：2010-06-17
申请号：US12333642
申请日：2008-12-12
申请人： Ya Guo , Kishore Udipi
发明人： Ya Guo , Kishore Udipi
IPC分类号： A61F2/82 , A61F2/00 , A61F2/06 , A61F2/92 , A61B17/04 , A61F2/24 , A61M1/00 , A61N1/36 , A61B17/58 , A61P43/00
CPC分类号： A61L31/16 , A61L31/06 , A61L31/10 , A61L2300/416 , C08L67/04
摘要： Provided herein are implantable medical devices comprising a biodegradable multiblock copolymer comprising at least three blocks; wherein the at least three blocks includes at least one inner block and two end blocks; further wherein each of the at least one inner block comprises monomers selected from the group consisting of e-caprolactone, r-butylactone, trimethylene carbonate, caprolactone derivatives, P-Dioxanone, and combinations thereof; and further wherein each of the end blocks comprises monomers selected from the group consisting of l-lactide, D-lactide, glycolide, L,D-lactide, and combinations thereof.
摘要翻译：本文提供了可植入医疗装置，其包括至少三个块的可生物降解的多嵌段共聚物; 其中所述至少三个块包括至少一个内部块和两个端块; 进一步其中所述至少一个内部块中的每一个包括选自由ε-己内酯，γ-丁内酯，三亚甲基碳酸酯，己内酯衍生物，对二恶烷酮及其组合组成的组的单体; 并且其中每个末端嵌段包含选自1-丙交酯，D-丙交酯，乙交酯，L，D-丙交酯及其组合的单体。

8. 发明申请

US20050084515A1 Biocompatible controlled release coatings for medical devices and related methods 有权
标题翻译：用于医疗器械和相关方法的生物相容性控释涂层
公开(公告)号：US20050084515A1
公开(公告)日：2005-04-21
申请号：US11005463
申请日：2004-12-06
申请人： Kishore Udipi , Peiwen Cheng , Mingfei Chen , Su-Ping Lyu
发明人： Kishore Udipi , Peiwen Cheng , Mingfei Chen , Su-Ping Lyu
IPC分类号： A61F2/00 , A61K7/06 , A61K7/11
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/406 , A61L2300/416 , A61L2300/602
摘要： Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of bioactive agents from medical devices in vivo are disclosed wherein the solubility parameters of polymers and drugs are closely matched to control elute rate profiles. The present application also discloses providing vascular stents with controlled release coatings and related methods for making these coatings.
摘要翻译：公开了用于医疗装置的生物相容性涂层。具体地，公开了设计用于在体内控制生物活性剂从医疗装置释放的聚合物涂层，其中聚合物和药物的溶解度参数与控制洗脱速率曲线紧密匹配。本申请还公开了提供具有控制释放涂层的血管支架和用于制备这些涂层的相关方法。

9. 发明授权

US5346959A Functionalized ethylene oxide antistatic agents for ABS/SMA blends 失效
标题翻译： ABS / SMA共混物的功能化环氧乙烷抗静电剂
公开(公告)号：US5346959A
公开(公告)日：1994-09-13
申请号：US95291
申请日：1993-07-21
申请人： Goman (Gomez) Peter M. , Kishore Udipi , Lionel R. Stebbins
发明人： Goman (Gomez) Peter M. , Kishore Udipi , Lionel R. Stebbins
IPC分类号： C09K3/16 , C08G65/32 , C08G77/46 , C08K3/24 , C08K5/42 , C08L25/12 , C08L55/02 , C08L71/02 , C08L77/00 , C08L83/04 , C08L83/12 , C08L101/00 , C08L25/08
CPC分类号： C08L71/02 , C08L101/00 , C08L25/12 , C08L77/00 , C08L83/12 , C08L2201/04 , C08L55/02 , Y10S524/91 , Y10S524/912
摘要： An antistatic agent for thermoplastic polymers is provided wherein the antistatic agent is comprised of a functionalized alkylene oxide polymer and optionally a minor amount of an alkali or alkaline earth metal salt capable of complexing with the functionalized alkylene oxide polymer and wherein the thermoplastic polymers include styrenic polymers such as ABS; blends of an ABS copolymer and a styrene-maleic anhydride copolymer; or nylon 6.
摘要翻译：提供了一种用于热塑性聚合物的抗静电剂，其中抗静电剂由官能化的环氧烷聚合物和任选的少量能够与官能化烯化氧聚合物络合的碱金属或碱土金属盐组成，其中热塑性聚合物包括苯乙烯聚合物如ABS; ABS共聚物与苯乙烯 - 马来酸酐共聚物的共混物; 或尼龙6。

10. 发明授权

US5130370A Molding compositions of polyvinylbutyral blend 失效
标题翻译：聚乙烯醇缩丁醛共混物的成型组合物
公开(公告)号：US5130370A
公开(公告)日：1992-07-14
申请号：US795574
申请日：1991-11-21
申请人： Kishore Udipi , Lionel R. Stebbins
发明人： Kishore Udipi , Lionel R. Stebbins
IPC分类号： C08L29/14 , C08L33/12
CPC分类号： C08L29/14 , C08L33/12 , B29K2029/00 , B29L2031/778
摘要： A melt blended thermoplastic molding composition consisting essentially of, on a weight basis: (A) 40 to 70 parts plasticized polyvinyl butyral; (B) 60 to 30 parts poly(methylmethacrylate); (C) 0 to 15 parts filler; (D) 0 to 30 parts elastomeric graft polymer; and 0 to 30 parts thermoplastic polyurethane; provided that at least 10 parts of (D) or (E) or mixtures of (D) and (E) is present; and the sum of (A)+(B)+(C)+(D)+(E) is always 100.

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