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1. 发明申请

US20090024200A1 Drug Eluting Medical Device and Method 有权
标题翻译：药物洗脱医疗器械及方法
公开(公告)号：US20090024200A1
公开(公告)日：2009-01-22
申请号：US11780572
申请日：2007-07-20
申请人： Josiah Wilcox , Jeffrey Allen , Scott Doig , Rafaelita Brown
发明人： Josiah Wilcox , Jeffrey Allen , Scott Doig , Rafaelita Brown
IPC分类号： A61F2/84 , A61F2/82
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/608 , A61L2420/08 , C08L5/02
摘要： A drug elution stent includes a stent framework and a drug elution portion disposed on the stent framework. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and a second sugar layer disposed on the at least one therapeutic agent layer. A method of manufacturing a drug elution stent includes the steps of providing a stent having a stent framework and coating at least a portion of the stent framework with a drug elution portion. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and a second sugar layer disposed on the at least one therapeutic agent layer
摘要翻译：药物洗脱支架包括支架框架和设置在支架框架上的药物洗脱部分。药物洗脱部分包括设置在支架框架上的第一糖层，设置在第一糖层上的至少一个治疗剂层和设置在至少一个治疗剂层上的第二糖层。制备药物洗脱支架的方法包括以下步骤：提供具有支架框架的支架，并用药物洗脱部分涂覆支架框架的至少一部分。药物洗脱部分包括设置在支架框架上的第一糖层，设置在第一糖层上的至少一个治疗剂层和设置在至少一个治疗剂层上的第二糖层

2. 发明授权

US08070798B2 Drug eluting medical device and method 有权
标题翻译：药物洗脱医疗器械及方法
公开(公告)号：US08070798B2
公开(公告)日：2011-12-06
申请号：US11780572
申请日：2007-07-20
申请人： Josiah Wilcox , Jeffrey Allen , Scott Doig , Rafaelita Brown
发明人： Josiah Wilcox , Jeffrey Allen , Scott Doig , Rafaelita Brown
IPC分类号： A61F2/82
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/608 , A61L2420/08 , C08L5/02
摘要： A drug elution stent includes a stent framework and a drug elution portion disposed on the stent framework. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and a second sugar layer disposed on the at least one therapeutic agent layer. A method of manufacturing a drug elution stent includes the steps of providing a stent having a stent framework and coating at least a portion of the stent framework with a drug elution portion. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and a second sugar layer disposed on the at least one therapeutic agent layer.
摘要翻译：药物洗脱支架包括支架框架和设置在支架框架上的药物洗脱部分。药物洗脱部分包括设置在支架框架上的第一糖层，设置在第一糖层上的至少一个治疗剂层和设置在至少一个治疗剂层上的第二糖层。制备药物洗脱支架的方法包括以下步骤：提供具有支架框架的支架，并用药物洗脱部分涂覆支架框架的至少一部分。药物洗脱部分包括设置在支架框架上的第一糖层，设置在第一糖层上的至少一个治疗剂层和设置在至少一个治疗剂层上的第二糖层。

3. 发明申请

US20060136050A1 Autologous Growth Factors to Promote Tissue In-Growth in Vascular Device 审中-公开
标题翻译：自体生长因子促进组织生长在血管装置中
公开(公告)号：US20060136050A1
公开(公告)日：2006-06-22
申请号：US11276518
申请日：2006-03-03
申请人： Jack Chu , Scott Doig , Brian Fernandes , Trevor Huang , Josiah Wilcox
发明人： Jack Chu , Scott Doig , Brian Fernandes , Trevor Huang , Josiah Wilcox
IPC分类号： A61F2/06
CPC分类号： A61L27/3616 , A61L27/3641 , A61L27/3645 , A61L27/54 , A61L2300/414
摘要： Methods and devices for ameliorating stent graft migration and endoleak using treatment site-specific cell growth promoting compositions in combination with stent grafts are disclosed. Also disclosed is coating of autologous growth factor compositions onto stent grafts prior to stent graft implantation. Additional embodiments include stent grafts having autologous growth factor composition coatings useful for treating aneurysms.
摘要翻译：公开了使用处理位点特异性细胞生长促进组合物与支架移植物组合来改善支架移植物迁移和内漏的方法和装置。还公开了在支架移植物植入之前将自体生长因子组合物涂覆到覆膜支架上。另外的实施方案包括具有用于治疗动脉瘤的自体生长因子组合物涂层的支架移植物。

4. 发明申请

US20080249599A1 Stent With Therapeutic Agent Delivery Structures in Low Strain Regions 审中-公开
标题翻译：在低应变区域中具有治疗剂递送结构的支架
公开(公告)号：US20080249599A1
公开(公告)日：2008-10-09
申请号：US11696816
申请日：2007-04-05
申请人： Jeffrey Allen , Scott Doig , Matthew J. Birdsall , Darrel Untereker
发明人： Jeffrey Allen , Scott Doig , Matthew J. Birdsall , Darrel Untereker
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91558 , A61F2250/0023 , A61F2250/0067
摘要： A system for treating abnormalities of the cardiovascular system includes a stent having a plurality of therapeutic agent-carrying regions and non therapeutic agent-carrying regions. The therapeutic agent-carrying regions are located within low strain regions of the stent and the non therapeutic agent-carrying regions are located within high strain regions of the stent. Another embodiment of the invention includes a method of manufacturing a therapeutic agent-carrying stent comprising forming a stent framework and applying a formulation containing one or more therapeutic agents to the stent framework while preventing the therapeutic agents from contacting the high strain regions of the stent framework.
摘要翻译：用于治疗心血管系统异常的系统包括具有多个治疗剂携带区域和非治疗剂携带区域的支架。治疗剂携带区域位于支架的低应变区域内，并且非治疗剂携带区域位于支架的高应变区域内。本发明的另一个实施方案包括制备治疗剂携带支架的方法，包括形成支架框架并将含有一种或多种治疗剂的制剂施用于支架框架，同时防止治疗剂接触支架框架的高应变区域。

5. 发明申请

US20070202093A1 Systems and Methods to Reduce Gel Retraction 有权
标题翻译：减少凝胶收缩的系统和方法
公开(公告)号：US20070202093A1
公开(公告)日：2007-08-30
申请号：US11685257
申请日：2007-03-13
申请人： Dennis Brooks , Jack Chu , Scott Doig , Trevor Huang , Tessy Kanayinkal
发明人： Dennis Brooks , Jack Chu , Scott Doig , Trevor Huang , Tessy Kanayinkal
IPC分类号： A61F2/06 , A61K38/48 , C12P21/06
CPC分类号： A61L27/3616 , A61L27/3641 , A61L27/3645 , A61L27/54 , A61L2300/414
摘要： Methods for ameliorating stent graft migration and endoleak using treatment site-specific cell growth promoting compositions in combination with stent grafts are disclosed. Also disclosed are application of cell growth promoting compositions such as, but not limited to, autologous platelet gel compositions directly to treatment sites during or after stent graft implantation.
摘要翻译：公开了使用处理部位特异性细胞生长促进组合物与支架移植物组合来改善支架移植物迁移和内漏的方法。还公开了将细胞生长促进组合物（例如但不限于自体血小板凝胶组合物）直接施用于支架移植物植入期间或之后的治疗部位。

6. 发明授权

US08968391B2 Systems and methods to reduce gel retraction 有权
标题翻译：减少凝胶收缩的系统和方法
公开(公告)号：US08968391B2
公开(公告)日：2015-03-03
申请号：US11685257
申请日：2007-03-13
申请人： Dennis Brooks , Jack Chu , Scott Doig , Trevor Huang , Tessy Kanayinkal
发明人： Dennis Brooks , Jack Chu , Scott Doig , Trevor Huang , Tessy Kanayinkal
IPC分类号： A01N1/02 , A61K38/48 , A61F2/06 , A01N65/00 , A61L27/36 , A61L27/54
CPC分类号： A61L27/3616 , A61L27/3641 , A61L27/3645 , A61L27/54 , A61L2300/414
摘要： Methods for ameliorating stent graft migration and endoleak using treatment site-specific cell growth promoting compositions in combination with stent grafts are disclosed. Also disclosed are application of cell growth promoting compositions such as, but not limited to, autologous platelet gel compositions directly to treatment sites during or after stent graft implantation.
摘要翻译：公开了使用处理部位特异性细胞生长促进组合物与支架移植物组合来改善支架移植物迁移和内漏的方法。还公开了将细胞生长促进组合物（例如但不限于自体血小板凝胶组合物）直接施用于支架移植物植入期间或之后的治疗部位。

7. 发明授权

US07438721B2 Universal modular stent graft assembly to accommodate flow to collateral branches 有权
标题翻译：通用模块式支架移植组件，以适应流动到附属分支
公开(公告)号：US07438721B2
公开(公告)日：2008-10-21
申请号：US10423297
申请日：2003-04-25
申请人： Scott Doig , James Machek
发明人： Scott Doig , James Machek
IPC分类号： A61F2/04
CPC分类号： A61F2/90 , A61F2/07 , A61F2/852 , A61F2/856 , A61F2002/061 , A61F2002/075 , A61F2002/826 , A61F2220/0033 , A61F2250/0008 , A61F2250/006 , A61F2250/0065
摘要： Universal modular stented graft assemblies are assembled, on site, and often in a patient's parent artery, from at least two components; a first component and a second component. The first and second components each include a window, or fenestration. The second component couples with the first component by fitting at least partially in the first component to form the universal modular stent graft assembly with an adjustable collateral opening. As the first and second components are assembled, the first and second components are adjusted relative to each other so that the first and second component windows overlap to form a collateral opening whose size is selectable, depending on the overlap, with the desired position and dimensions in the universal modular stent graft assembly.
摘要翻译：通用模块化支架移植组件在现场并经常在患者的母体动脉中从至少两个组件组装; 第一组件和第二组件。第一和第二组件各自包括窗口或开窗。第二部件通过至少部分地配合在第一部件中而与第一部件联接以形成具有可调节的侧支开口的通用模块化支架移植物组件。当组装第一和第二部件时，第一和第二部件相对于彼此进行调节，使得第一和第二部件窗口重叠以形成侧面开口，其尺寸可根据重叠与期望的位置和尺寸可选择在通用模块化支架移植组件中。

8. 发明申请

US20050043786A1 Methods and apparatus for treatment of aneurysmal tissue 审中-公开
标题翻译：用于治疗动脉瘤组织的方法和装置
公开(公告)号：US20050043786A1
公开(公告)日：2005-02-24
申请号：US10643649
申请日：2003-08-18
申请人： Jack Chu , Scott Doig , David Brin
发明人： Jack Chu , Scott Doig , David Brin
IPC分类号： A61F2/00 , A61F2/06 , A61F2/88
CPC分类号： A61F2/88 , A61F2250/0067
摘要： Methods and apparatus for aiding aneurysm repair are provided. Such apparatus is constructed to support or bolster the aneurysmal site initially, while contracting if the aneurysmal site shrinks or contracts. The apparatus also supplies a pharmaceutical agent to aid in healing the surrounding aneurysmal tissue. The apparatus may comprise a drug eluting polymer or may have a passive coating which can be selectively deployed by adding an activation agent after deployment. The device can be used alone or in conjunction with a AAA stent graft that isolates the aneurysmal sac from the vascular system.
摘要翻译：提供了辅助动脉瘤修复的方法和装置。这种装置被构造成最初支撑或支撑动脉瘤部位，同时如果动脉瘤部位缩小或收缩则承包。该装置还提供药剂以帮助愈合周围的动脉瘤组织。该装置可以包括药物洗脱聚合物或可以具有被动涂层，其可以在部署之后通过添加活化剂来选择性地部署。该装置可以单独使用或与用于将动脉瘤囊与血管系统隔离的AAA支架移植物结合使用。

9. 发明申请

US20120007354A1 Wear Resistant Slurry Pipe Fitting 审中-公开
标题翻译：耐磨浆管配件
公开(公告)号：US20120007354A1
公开(公告)日：2012-01-12
申请号：US13185900
申请日：2011-07-19
申请人： Scott Doig
发明人： Scott Doig
IPC分类号： F16L57/06 , F16L55/24 , F16L43/00
CPC分类号： B65G53/523 , B65G2207/48 , F16L43/002
摘要： A wear resistant pipe fitting having an inlet end in fluid communication, in use, with a first linear pipe segment, and an outlet end in fluid communication, in use, with a second linear pipe segment is disclosed. The pipe fitting includes a first eccentric reducer arranged to receive a slurry or pipeline fluid from the first linear pipe section and deliver the slurry or pipeline fluid to a second eccentric reducer; the second eccentric reducer arranged to receive the slurry or fluid from the first eccentric reducer and deliver the slurry or pipeline fluid to the second linear pipe section; and, a flow interrupter device positioned within the first eccentric reducer for disrupting the flow of the slurry or pipeline fluid before the slurry or fluid enters the second eccentric reducer.
摘要翻译：公开了一种耐磨管件，其具有在使用中与第一直线管段流体连通的入口端和在使用中与第二直管段流体连通的出口端。管件包括第一偏心减速器，其布置成从第一直管段接收浆料或管道流体，并将浆液或管道流体输送到第二偏心减速器; 所述第二偏心减速器布置成从所述第一偏心减速器接收所述浆料或流体，并将所述浆料或管道流体输送到所述第二直管段; 以及定位在所述第一偏心减速器内的流动断路器装置，用于在所述浆料或流体进入所述第二偏心减速器之前破坏所述浆料或管道流体的流动。

10. 发明授权

US08052736B2 Universal modular stent graft assembly to accommodate flow to collateral branches 有权
标题翻译：通用模块式支架移植组件，以适应流动到附属分支
公开(公告)号：US08052736B2
公开(公告)日：2011-11-08
申请号：US12209291
申请日：2008-09-12
申请人： Scott Doig , James Machek
发明人： Scott Doig , James Machek
IPC分类号： A61F2/06
CPC分类号： A61F2/90 , A61F2/07 , A61F2/852 , A61F2/856 , A61F2002/061 , A61F2002/075 , A61F2002/826 , A61F2220/0033 , A61F2250/0008 , A61F2250/006 , A61F2250/0065
摘要： Universal modular stented graft assemblies are assembled, on site, and often in a patient's parent artery, from at least two components; a first component and a second component. The first and second components each include a window, or fenestration. The second component couples with the first component by fitting at least partially in the first component to form the universal modular stent graft assembly with an adjustable collateral opening. As the first and second components are assembled, the first and second components are adjusted relative to each other so that the first and second component windows overlap to form a collateral opening whose size is selectable, depending on the overlap, with the desired position and dimensions in the universal modular stent graft assembly.
摘要翻译：通用模块化支架移植组件在现场并经常在患者的母体动脉中从至少两个组件组装; 第一组件和第二组件。第一和第二组件各自包括窗口或开窗。第二部件通过至少部分地配合在第一部件中而与第一部件联接以形成具有可调节的侧支开口的通用模块化支架移植物组件。当组装第一和第二部件时，第一和第二部件相对于彼此进行调节，使得第一和第二部件窗口重叠以形成侧面开口，其尺寸可根据重叠与期望的位置和尺寸可选择在通用模块化支架移植组件中。

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