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1. 发明授权

US06208880B1 Blood parameter measurement device 有权
标题翻译：血液参数测量装置
公开(公告)号：US06208880B1
公开(公告)日：2001-03-27
申请号：US09455166
申请日：1999-12-06
申请人： James G. Bentsen , Stanley O. Heinemann , Gary W. Lee , Thomas G. Hacker , N. Alan Abul-Haj , Roxanne E. Abul-Haj
发明人： James G. Bentsen , Stanley O. Heinemann , Gary W. Lee , Thomas G. Hacker , N. Alan Abul-Haj , Roxanne E. Abul-Haj
IPC分类号： A61B500
CPC分类号： G01N21/05 , A61B5/14557
摘要： A blood parameter measurement device especially useful for surgical procedures includes a compact housing with a light source, light detector and signal converter contained within the housing. In use, the device is releasably coupled to a cassette that can be either used as an in-line cell in series with a cardiopulmonary by-pass circuit, or in another passageway that shunts the cardiopulmonary by-pass circuit. Preferably, the housing of the device has a longitudinal axis that extends in a direction generally parallel to the direction of blood flowing through the cassette.
摘要翻译：特别适用于外科手术的血液参数测量装置包括具有包含在壳体内的光源，光检测器和信号转换器的紧凑外壳。在使用中，该装置可释放地耦合到盒，其可以被用作与心肺旁路电路串联的直列电池，或者用于分流心肺旁路电路的另一通道。优选地，装置的壳体具有沿大致平行于流过盒的血液的方向的方向延伸的纵向轴线。

2. 发明授权

US6009339A Blood parameter measurement device 失效
标题翻译：血液参数测量装置
公开(公告)号：US6009339A
公开(公告)日：1999-12-28
申请号：US810955
申请日：1997-02-27
申请人： James G. Bentsen , Stanley O. Heinemann , Gary W. Lee , Thomas G. Hacker , N. Alan Abul-Haj , Roxanne E. Abul-Haj
发明人： James G. Bentsen , Stanley O. Heinemann , Gary W. Lee , Thomas G. Hacker , N. Alan Abul-Haj , Roxanne E. Abul-Haj
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1495 , G01N21/05
CPC分类号： G01N21/05 , A61B5/14557
摘要： A blood parameter measurement device especially useful for surgical procedures includes a compact housing with a light source, light detector and signal converter contained within the housing. In use, the device is releasably coupled to a cassette that can be either used as an in-line cell in series with a cardiopulmonary by-pass circuit, or in another passageway that shunts the cardiopulmonary by-pass circuit. Preferably, the housing of the device has a longitudinal axis that extends in a direction generally parallel to the direction of blood flowing through the cassette.
摘要翻译：特别适用于外科手术的血液参数测量装置包括具有包含在壳体内的光源，光检测器和信号转换器的紧凑外壳。在使用中，该装置可释放地耦合到盒，其可以被用作与心肺旁路电路串联的直列电池，或者用于分流心肺旁路电路的另一通道。优选地，装置的壳体具有沿大致平行于流过盒的血液的方向的方向延伸的纵向轴线。

3. 发明授权

US5822137A Assembly for retaining optical components 失效
标题翻译：用于保持光学部件的组件
公开(公告)号：US5822137A
公开(公告)日：1998-10-13
申请号：US806359
申请日：1997-02-27
申请人： Nagel A. Abul-Haj , Roxanne E. Abul-Haj , Thomas G. Hacker
发明人： Nagel A. Abul-Haj , Roxanne E. Abul-Haj , Thomas G. Hacker
IPC分类号： G02B6/36 , G02B7/00 , G02B7/02
CPC分类号： G02B7/00 , G02B7/02
摘要： An assembly useful for retaining optical components such as lenses, optical filters and the like includes a block having a cavity and a pair of retainers received in the cavity. In certain embodiments, the cavity is cylindrical and each retainer has a semi-cylindrical configuration. Each retainer preferably includes integrally molded deformable ribs that shift the optical components when the retainers are closed to a position such that the optical axis of each component is collinear with the central axis of the optical chamber and the retainer cavity.
摘要翻译：用于保持诸如透镜，滤光器等的光学部件的组件包括具有容纳在空腔中的空腔和一对保持器的块。在某些实施例中，空腔是圆柱形的，并且每个保持器具有半圆柱形构型。每个保持器优选地包括整体模制的可变形肋，当保持器闭合到使得每个部件的光轴与光学腔和保持器腔的中心轴线共线的位置时，偏移光学部件。

4. 外观设计

USD408918S Calibration cuvette assembly for blood gas measurement 失效
公开(公告)号：USD408918S
公开(公告)日：1999-04-27
申请号：US84336
申请日：1998-02-26
申请人： Thomas G. Hacker
设计人： Thomas G. Hacker

5. 发明授权

US4954318A Optical sensor 失效
标题翻译：光学传感器
公开(公告)号：US4954318A
公开(公告)日：1990-09-04
申请号：US91432
申请日：1987-08-31
申请人： Masao Yafuso , Cheng F. Yan , Thomas G. Hacker , Henry K. Hui , Thomas P. Maxwell , William W. Miller
发明人： Masao Yafuso , Cheng F. Yan , Thomas G. Hacker , Henry K. Hui , Thomas P. Maxwell , William W. Miller
IPC分类号： G01N21/77
CPC分类号： G01N21/7703 , G01N2021/772
摘要： An apparatus for measuring the concentration of a component in a medium comprising:an optical sensor including at least one optical indicator for providing an optical signal which varies in response to the presence of a component in a medium;an optical signal fiber capable of transmitting the optical signal from the optical sensor; anda supply reservoir associated with the optical sensor and acting to provide additional optical indicator to the optical sensor.
摘要翻译：一种用于测量介质中的组分的浓度的装置，包括：光学传感器，包括至少一个光学指示器，用于提供响应于介质中组分的存在而变化的光学信号; 能够从光学传感器发送光信号的光信号光纤; 以及与所述光学传感器相关联并用于向所述光学传感器提供附加光学指示器的供应储存器。

6. 外观设计

USD582044S1 Medical instrument module 有权
标题翻译：医疗仪器模块
公开(公告)号：USD582044S1
公开(公告)日：2008-12-02
申请号：US29250390
申请日：2006-11-13
申请人： Thomas G. Hacker , Brent William Allen
设计人： Thomas G. Hacker , Brent William Allen

7. 发明授权

US5175016A Method for making gas sensing element 失效
标题翻译：制造气体传感元件的方法
公开(公告)号：US5175016A
公开(公告)日：1992-12-29
申请号：US496560
申请日：1990-03-20
申请人： Masao Yafuso , Mark Z. Holody , Thomas P. Maxwell , Thomas G. Hacker
发明人： Masao Yafuso , Mark Z. Holody , Thomas P. Maxwell , Thomas G. Hacker
IPC分类号： G01N21/64 , G01N21/77 , G01N21/78 , G01N31/22 , G01N33/49
CPC分类号： G01N21/783 , G01N31/223 , Y10T436/204998
摘要： A method for making a sensing element, and an assembled sensing element, useful in sensing the concentration of a gas, e.g., carbon dioxide, in a medium, e. g. blood, are disclosed. In one embodiment, the method comprises placing a quantity of a sensing composition precursor between and in contact with a transparent, gas impermeable solid disc and an opaque, gas permeable film, the sensing composition precursor comprises a sensing component, a polymer precursor and a cross-linking agent; and forming a gas sensing composition from this quantity of sensing composition precursor.

8. 发明授权

US5006314A Sensor and method for sensing the concentration of a component in a medium 失效
标题翻译：用于感测介质中组分浓度的传感器和方法
公开(公告)号：US5006314A
公开(公告)日：1991-04-09
申请号：US206189
申请日：1988-06-13
申请人： Ted H. Gourley , Thomas P. Maxwell , Thomas G. Hacker , William W. Miller , Masao Yafuso
发明人： Ted H. Gourley , Thomas P. Maxwell , Thomas G. Hacker , William W. Miller , Masao Yafuso
IPC分类号： A61B5/00 , G01N21/64 , G01N21/80 , G01N21/81 , G01N31/22
CPC分类号： G01N21/7703 , A61B5/1459 , G01N31/223 , G01N2021/6434 , G01N2021/6439 , G01N2021/772 , G01N2021/773 , G01N2021/7786 , G01N21/80 , G01N21/81
摘要： An apparatus for sensing the concentration of a component such as oxygen in a medium such as blood. The apparatus includes an elongated signal transmitter and a sensing element at one end thereof. A substantially rigid sleeve is secured around such end to provide a pocket for the sensing element.
摘要翻译：用于感测诸如血液的介质中诸如氧的组分的浓度的装置。该装置包括细长的信号发射器和在其一端的感测元件。围绕该端部固定有基本刚性的套筒，以提供感测元件的口袋。

9. 发明授权

US4951669A Blood parameter measurement system 失效
标题翻译：血液参数测量系统
公开(公告)号：US4951669A
公开(公告)日：1990-08-28
申请号：US229703
申请日：1988-08-08
申请人： Thomas P. Maxwell , Thomas G. Hacker
发明人： Thomas P. Maxwell , Thomas G. Hacker
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1459 , A61M25/00
CPC分类号： A61B5/1459
摘要： A parameter of blood is sensed with a system which includes a catheter and a sensor and a volume oscillator element. The catheter has a lumen extending therethrough, a proximal end, a distal end and an opening, adapted to be placed in the blood vessel of a patient. The sensor senses a blood parameter and is adapted to be located outside the patient's body in fluid communication with the lumen. The volume oscillator element is in fluid communication with the lumen and is capable of acting to periodically cause blood to enter and exit the lumen. The system is structured so that a flush or anti-clotting solution flows into the patient when the volume oscillator element is inactive. With the volume oscillator activated, blood is moved back and forth in the lumen to expose the sensors to blood so that the blood parameter of interest can be sensed.
摘要翻译：用包括导管和传感器以及体积振荡器元件的系统检测血液的参数。导管具有延伸穿过其中的内腔，近端，远端和开口，适于放置在患者的血管中。传感器感测血液参数，并且适于位于患者身体外部与流体流体连通。体积振荡器元件与内腔流体连通，并且能够作用以周期性地使血液进入和离开管腔。该系统的结构使得当体积振荡器元件不活动时，冲洗或抗凝血溶液流入患者体内。当体积振荡器激活时，血液在内腔中来回移动以将传感器暴露于血液，使得可以感测感兴趣的血液参数。

10. 发明申请

US20080146902A1 Microsensor needle for pH measurement in tissue 有权
标题翻译：微量传感器针组织中的pH测量
公开(公告)号：US20080146902A1
公开(公告)日：2008-06-19
申请号：US11642036
申请日：2006-12-19
申请人： Thomas G. Hacker , Tetsuro Kawanishi
发明人： Thomas G. Hacker , Tetsuro Kawanishi
IPC分类号： A61B5/1459
CPC分类号： A61B5/14542 , A61B5/14539 , A61B5/14556 , A61B5/1459 , A61B5/6848 , Y10T29/49879
摘要： A sensor probe for in-situ measurement of pH in a human tissue (e.g., cardiovascular) environment comprises a hollow needle having a tip and a back end. The tip is insertable through tissue into the tissue environment. An optic cable comprises a light conduit surrounded by a cladding. A first end of the light conduit not covered by the cladding is inserted from the back end of the needle and extends to within a predetermined distance of the tip to define a cavity within the tip. A porous dye layer is contained within the cavity adjacent to the first end of the light conduit, wherein the dye layer has a response to excitation light delivered through the light conduit that varies according to the pH of the tissue environment. An overcoat layer is deposited on the dye layer, wherein the overcoat layer is ionically permeable and substantially opaque at a light wavelength corresponding to the variable response of the dye layer.
摘要翻译：用于在人体组织（例如心血管）环境中原位测量pH的传感器探针包括具有尖端和后端的空心针。尖端可通过组织插入到组织环境中。光缆包括由包层围绕的光导管。未被包层覆盖的光导管的第一端从针的后端插入并延伸到尖端的预定距离内以限定尖端内的空腔。多孔染料层包含在与光导管的第一端相邻的空腔内，其中染料层对根据组织环境的pH变化的通过光导管传递的激发光具有响应。在染料层上沉积外涂层，其中外涂层在对应于染料层的可变响应的光波长处是离子可渗透的并且基本上不透明。

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