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1. 发明授权

US06451255B1 Dry booster 失效
标题翻译：干加强器
公开(公告)号：US06451255B1
公开(公告)日：2002-09-17
申请号：US09472319
申请日：1999-12-23
申请人： Harold R. Williams , Hans Strobel , Henry K. Hui , Leslie A. Feldman , Szu-Min Lin
发明人： Harold R. Williams , Hans Strobel , Henry K. Hui , Leslie A. Feldman , Szu-Min Lin
IPC分类号： A61L200
CPC分类号： A61L2/186 , A61L2/208 , A61L2202/122 , A61L2202/24
摘要： A method for sterilizing the interior of the lumen, where a dry booster which does not contain liquid and which has a volume at least 2 times the volume of the lumen is attached to the end of the lumen. The lumen and dry booster are placed in a sterilization chamber, and germicide is introduced into the chamber. A higher pressure is created outside the booster than inside the booster. The empty dry booster draws germicide into the lumen, sterilizing the interior of the lumen. The method can be enhanced by reducing the pressure in the chamber before introducing the germicide.
摘要翻译：用于对内腔内部进行灭菌的方法，其中不含液体的干燥助推器具有至少体积的体积的2倍体积的体积附着到管腔的端部。管腔和干增强器放置在灭菌室中，并将杀菌剂引入室中。在增压器外部产生的压力高于助力器。空的干燥助剂将杀菌剂吸入管腔，对内腔内部进行消毒。在引入杀菌剂之前，可以通过降低室内的压力来增强该方法。

2. 发明授权

US5942438A Chemical indicator for oxidation-type sterilization processes using bleachable dyes 失效
标题翻译：使用可漂白染料的氧化型灭菌方法的化学指示剂
公开(公告)号：US5942438A
公开(公告)日：1999-08-24
申请号：US966397
申请日：1997-11-07
申请人： Patricia A. Antonoplos , Henry K. Hui , Alireza Ebrahim , Leslie A. Feldman , Nitu Kohli
发明人： Patricia A. Antonoplos , Henry K. Hui , Alireza Ebrahim , Leslie A. Feldman , Nitu Kohli
IPC分类号： G01N21/78 , A61L2/28 , C12Q1/22 , G01N31/22 , G01N31/12
CPC分类号： A61L2/28 , C12Q1/22 , G01N31/226
摘要： A method and apparatus for detecting exposure to an oxidation-type sterilant using a chemical indicator comprising bleachable dye is disclosed. Using the method and apparatus disclosed, a bleachable azo dye is incorporated with an anodized aluminum or chromate conversion coated surface and exposed to an oxidation-type sterilant, such as hydrogen peroxide, and inspected upon completion of the sterilization process for color change. If exposed to sterilant for an appropriate amount of time the bleachable dye changes color thereby indicating adequate sterilization. The surface incorporating bleachable dye may be made to change color after a predetermined number of exposures to a oxidation-type sterilant.
摘要翻译：公开了一种使用包含可漂白染料的化学指示剂检测暴露于氧化型杀菌剂的方法和装置。使用所公开的方法和装置，将可漂白的偶氮染料与阳极氧化的铝或铬酸盐转化涂覆的表面结合并暴露于氧化型灭菌剂如过氧化氢，并且在完成用于颜色变化的灭菌过程后检查。如果将杀菌剂暴露于适当的时间，则可漂白染料会改变颜色，从而指示适当的灭菌。包含可漂白染料的表面可以在预定数量的暴露于氧化型杀菌剂之后变色。

3. 发明授权

US5204265A Method of stabilizing a carbon dioxide sensor 失效
标题翻译：稳定二氧化碳传感器的方法
公开(公告)号：US5204265A
公开(公告)日：1993-04-20
申请号：US933884
申请日：1992-08-21
申请人： Alan Nelson , Henry K. Hui , Monte Bennett , Soonkap Hahn , Charles S. Bankert
发明人： Alan Nelson , Henry K. Hui , Monte Bennett , Soonkap Hahn , Charles S. Bankert
IPC分类号： A61B5/00 , G01N21/77 , G01N33/00
CPC分类号： G01N21/7703 , A61B5/1455 , A61B5/1495 , G01N33/0006 , G01N2201/127 , Y10T436/10 , Y10T436/102499
摘要： The method of stabilizing a carbon dioxide sensor involves treatment of the sensor to reduce the instability that may occur in carbon dioxide sensors when such sensors are exposed to either very low or very high carbon dioxide levels for extended periods of time. This is accomplished by storing the sensor in an aqueous solution containing at least 2 weight percent carbon dioxide, for from several days to several months. The solution may be prepared in advance, or may be dynamically infused with carbon dioxide to provide the desired carbon dioxide content.
摘要翻译：稳定二氧化碳传感器的方法包括处理传感器以减少在二氧化碳传感器中长时间暴露于非常低或非常高的二氧化碳水平时可能发生的不稳定性。这通过将传感器储存在含有至少2重量％二氧化碳的水溶液中来实现，从几天到几个月。该溶液可以预先制备，或者可以动态地注入二氧化碳以提供所需的二氧化碳含量。

4. 发明授权

US4919891A Sensor with overcoating and process for making same 失效
标题翻译：传感器具有外涂和制造过程
公开(公告)号：US4919891A
公开(公告)日：1990-04-24
申请号：US49844
申请日：1987-05-15
申请人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
发明人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
IPC分类号： A61B5/00 , G01N21/64 , G01N21/80 , G01N21/81 , G01N31/22
CPC分类号： G01N21/643 , A61B5/1459 , G01N31/223 , G01N2021/6434 , G01N2021/6439 , G01N21/80 , G01N21/81
摘要： A sensor comprising a sensing element capable of sensing a component in an aqueous medium and an overcoating at least partially covering the sensing element. The overcoating comprises a water insoluble, component permeable, cross-linked cellulosic material and an effective amount of an opaque agent.
摘要翻译：传感器，其包括能够感测水性介质中的组分的感测元件和至少部分地覆盖感测元件的外涂层。外涂层包含不溶于水的组分可渗透的交联纤维素材料和有效量的不透明剂。

5. 发明授权

US06936223B2 Chemical indicator 失效
标题翻译：化学指标
公开(公告)号：US06936223B2
公开(公告)日：2005-08-30
申请号：US10112187
申请日：2002-03-28
申请人： Thomas G. Lippold , Nitu Kohli , Pascale D. Endo , Henry K. Hui , Szu-Min Lin
发明人： Thomas G. Lippold , Nitu Kohli , Pascale D. Endo , Henry K. Hui , Szu-Min Lin
IPC分类号： A61L2/26 , A61L2/28 , C09K3/00 , G01N21/78 , G01N31/22 , A61L9/00
CPC分类号： A61L2/28 , G01N31/22 , G01N31/223 , G01N31/225 , G01N31/228
摘要： A chemical indicator of an aurin moiety in a substrate to detect the presence of an oxidizing agent.
摘要翻译：底物中aurin部分的化学指示剂，以检测氧化剂的存在。

6. 发明授权

US06787179B2 Sterilization of bioactive coatings 失效
标题翻译：生物活性涂料的灭菌
公开(公告)号：US06787179B2
公开(公告)日：2004-09-07
申请号：US09897657
申请日：2001-06-29
申请人： Debra A. Timm , Henry K. Hui , Mark B. Roller , Mora C. Melican , Syed Hossainy
发明人： Debra A. Timm , Henry K. Hui , Mark B. Roller , Mora C. Melican , Syed Hossainy
IPC分类号： A61L2700
CPC分类号： A61L27/34 , A61L2/14 , A61L29/085 , A61L31/10 , A61M25/0009 , A61M25/0045
摘要： The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.
摘要翻译：本发明提供了用于医疗装置（例如导管，组织工程支架或药物递送载体材料）中的材料和生物材料上的生物活性涂层的单步表面改性，接枝和灭菌的方法。这可以包括可以从改进的抗血栓形成和生物相容性表面受益的任何医疗装置或植入物。其他相关装置实例可包括用于减少凝血和再狭窄的肝素或尿激酶涂层的支架，牙科或眼科植入物。这些材料可以由多种聚合物组合物，如聚氨酯，聚酯，聚四氟乙烯，聚乙烯，聚甲基丙烯酸甲酯，聚乙烯醇，聚乙烯醇，聚硅氧烷，聚乳酸或乙醇酸，聚己内酯等组成。基材也可以是金属，陶瓷或生物学衍生材料。

7. 发明授权

US06551555B2 Apparatus with a chemical indicator for indicating exposure to an oxidative sterilant or disinfectant 有权
公开(公告)号：US06551555B2
公开(公告)日：2003-04-22
申请号：US09741633
申请日：2000-12-19
申请人： Patricia A. Antonoplos , Henry K. Hui , Alireza Ebrahim , Leslie A. Feldman , Nitu Kohli
发明人： Patricia A. Antonoplos , Henry K. Hui , Alireza Ebrahim , Leslie A. Feldman , Nitu Kohli
IPC分类号： G01N3112
CPC分类号： A61L2/28 , C12Q1/22 , G01N31/226
摘要： An apparatus for determining exposure to an oxidative sterilant is described. The apparatus includes a chemical indicator for indicating exposure to the oxidative sterilant and a biological indicator for determining the effectiveness of the exposure to the oxidative sterilant. The chemical indicator has a metallic surface with a non-pH sensitive permanent indicator on the surface for indicating exposure to the oxidative sterilant. The chemical indicator may be on a self-contained biological indicator. The biological indicator and chemical indicator may be inside a test pack, where the test pack restricts sterilant flow to the indicators.

8. 发明授权

US06218189B1 Method for indicating exposure to an oxidative sterilant or disinfectant 有权
标题翻译：指示暴露于氧化灭菌剂或消毒剂的方法
公开(公告)号：US06218189B1
公开(公告)日：2001-04-17
申请号：US09290592
申请日：1999-04-13
申请人： Patricia A. Antonoplos , Henry K. Hui , Alireza Ebrahim , Leslie A. Feldman , Nitu Kohli
发明人： Patricia A. Antonoplos , Henry K. Hui , Alireza Ebrahim , Leslie A. Feldman , Nitu Kohli
IPC分类号： G01N3112
CPC分类号： A61L2/28 , C12Q1/22 , G01N31/226
摘要： A method and apparatus detect exposure to an oxidation-type sterilant using a non-PH-sensitive bleachable dye as a chemical indicator. A change in color indicates exposure to oxidation-type sterilant.
摘要翻译：一种方法和装置使用非PH敏感性可漂洗染料作为化学指示剂检测对氧化型杀菌剂的暴露。颜色变化表示暴露于氧化型杀菌剂。

9. 发明授权

US5330718A Sensor element and method for making the same 失效
标题翻译：传感器元件及其制作方法
公开(公告)号：US5330718A
公开(公告)日：1994-07-19
申请号：US960903
申请日：1992-10-14
申请人： Henry K. Hui , Charles S. Bankert
发明人： Henry K. Hui , Charles S. Bankert
IPC分类号： G01N21/77 , G01N21/64 , G01N31/22
CPC分类号： G01N21/643 , G01N21/6428 , G01N21/7703 , G01N31/223 , G01N2021/174 , G01N2021/6434 , G01N2021/772 , G01N2021/773 , G01N2021/775 , G01N2021/7786 , G01N2021/7796
摘要： A sensor element includes an analyte-permeable matrix which supports and maintains an emulsion of a sensing solution containing an analyte-sensitive indicator substance in a plurality of tiny vesicles. The sensing solution is immiscible with the matrix material, and contains a dye indicator which dissociates into two different species. The sensing solution is initially mixed with an agent which modifies the equilibrium of dissociation of the dye indicator for optimal sensitivity. The liquid matrix preferably includes a curing inhibitor to allow the matrix to remain liquid until applied to a sensing surface, such as the tip of an optical fiber. The sensing solution remains suspended in these homogeneously dispersed vesicles after the matrix solidifies.
摘要翻译：传感器元件包括分析物可渗透基质，其支持并保持含有多个微小囊泡中的分析物敏感指示物质的感测溶液的乳液。感测溶液与基质材料不混溶，并含有分解成两种不同物质的染料指示剂。感测溶液最初与改变染料指示剂的解离平衡的试剂混合以获得最佳灵敏度。液体基质优选包括固化抑制剂，以允许基质保持液体，直到施加到诸如光纤的尖端的感测表面。基体凝固后，感应溶液保持悬浮在这些均匀分散的囊泡中。

10. 发明授权

US5166990A Multiple optical fiber event sensor and method of manufacture 失效
标题翻译：多光纤事件传感器及其制造方法
公开(公告)号：US5166990A
公开(公告)日：1992-11-24
申请号：US751818
申请日：1991-08-29
申请人： Samuel D. Riccitelli , Thomas A. Shern , Richard Homick , Alan Nelson , Charles S. Bankert , Henry K. Hui
发明人： Samuel D. Riccitelli , Thomas A. Shern , Richard Homick , Alan Nelson , Charles S. Bankert , Henry K. Hui
IPC分类号： A61B5/00 , G01N21/77 , G01N21/78
CPC分类号： A61B5/14539 , A61B5/0084 , A61B5/1459 , G01N21/7703 , G01N2021/773 , G01N21/783
摘要： The multiple optical fiber event sensor apparatus includes a semipermeable generally cylindrical shaft, one or more optical fiber gas sensor modules within the shaft, and an optical fiber pH sensor module extending beyond the distal end of the shaft, with the sensor modules arranged in an axially staggered relationship. The shaft contains a potting matrix for axially fixing the position of the optical fibers, and includes a gas permeable portion surrounding the one or more gas sensor modules, and a hydrophilic portion covering at least part of the pH sensor module. A hemodynamically shaped, rounded distal end is also provided on the distal end of the shaft. The device provides for a multiplicity of individual sensors incorporated in a single shaft which minimizes cross-interference and thrombus formation when used as an intravascular multi-sensor.
摘要翻译：多光纤事件传感器设备包括半透明的圆柱形轴，轴内的一个或多个光纤气体传感器模块，以及延伸超过轴远端的光纤pH传感器模块，传感器模块布置在轴向交错的关系轴包含用于轴向固定光纤位置的灌封基体，并且包括围绕一个或多个气体传感器模块的透气部分和覆盖至少部分pH传感器模块的亲水部分。血液动力学形状的圆形远端也设置在轴的远端上。该装置提供多个独立的传感器，其结合在单个轴中，当用作血管内多传感器时，可最大限度地减少交叉干扰和血栓形成。

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