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    • 10. 发明授权
    • Apparatus and method for reproducibly modifying localized absorption and scattering coefficients at a tissue measurement site during optical sampling
    • 在光学采样期间在组织测量部位可重复地修改局部吸收和散射系数的装置和方法
    • US06534012B1
    • 2003-03-18
    • US09631440
    • 2000-08-02
    • Kevin H. HazenGeorge AcostaN. Alan Abul-HajRoxanne E. Abul-Haj
    • Kevin H. HazenGeorge AcostaN. Alan Abul-HajRoxanne E. Abul-Haj
    • G01N2147
    • A61B5/0059A61B5/14552A61B5/6824A61B5/6843
    • An apparatus for varying localized absorption and scattering coefficients at a tissue measurement site in a controlled and reproducible manner during optical sampling of a tissue volume by controlling the pressure applied to a tissue measurement site by a spectroscopic analyzer allows applied pressure to be maintained at a constant level, or the applied pressure may be varied in a controlled, reproducible manner as a function of time. A rest for receiving a body part holds the body part in a fixed position and at a fixed elevation. A mechanical system advances a fiber optic probe until it makes contact with the body part with a constant amount of pressure. The applied force is supplied by a counterweight on a single arm balance. A temperature control allows the temperature of the fiber optic probe to be equilibrated with the temperature in the immediate vicinity of the tissue measurement site. Alternate embodiments allow the fiber optic probe to be brought into direct contact with the tissue measurement site, and displaced a known distance into the tissue. The invention is also embodied as a method in which the absorption and scattering coefficients for successive spectral measurements are calculated to determine optimum depth of penetration for detection of a target analyte.
    • 一种用于通过控制通过光谱分析仪施加到组织测量部位的压力而在组织体积的光学取样期间以受控和可再现的方式在组织测量部位处改变局部吸收和散射系数的装置,使施加的压力保持恒定 水平或施加的压力可以以受控的,可再生的方式随时间变化。 用于接收身体部分的休息部将身体部分保持在固定位置并且固定高度。 机械系统推进光纤探针,直到其与身体部分以恒定的压力接触。 施加的力由一个平衡臂上的配重提供。 温度控制允许光纤探针的温度与组织测量位置附近的温度平衡。 替代实施例允许光纤探针与组织测量部位直接接触,并将已知距离移位到组织中。 本发明还被体现为其中计算连续光谱测量的吸收和散射系数以确定用于检测目标分析物的最佳穿透深度的方法。