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1. 发明授权

US5075127A Sensor with overcoating and process for making same 失效
标题翻译：传感器具有外涂和制造过程
公开(公告)号：US5075127A
公开(公告)日：1991-12-24
申请号：US492550
申请日：1990-03-12
申请人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
发明人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
IPC分类号： A61B5/00 , G01N21/64 , G01N21/81 , G01N31/22
CPC分类号： G01N21/7703 , A61B5/1459 , G01N21/6428 , G01N31/223 , G01N2021/6434 , G01N2021/772 , G01N21/81
摘要： A sensor comprising a sensing element capable of sensing a component in an aqueous medium and an overcoating at least partially covering the sensing element. The overcoating comprises a water insoluble, component permeable, cross-linked cellulosic material and an effective amount of an opaque agent.
摘要翻译：传感器，其包括能够感测水性介质中的组分的感测元件和至少部分地覆盖感测元件的外涂层。外涂层包含不溶于水的组分可渗透的交联纤维素材料和有效量的不透明剂。

2. 发明授权

US4954318A Optical sensor 失效
标题翻译：光学传感器
公开(公告)号：US4954318A
公开(公告)日：1990-09-04
申请号：US91432
申请日：1987-08-31
申请人： Masao Yafuso , Cheng F. Yan , Thomas G. Hacker , Henry K. Hui , Thomas P. Maxwell , William W. Miller
发明人： Masao Yafuso , Cheng F. Yan , Thomas G. Hacker , Henry K. Hui , Thomas P. Maxwell , William W. Miller
IPC分类号： G01N21/77
CPC分类号： G01N21/7703 , G01N2021/772
摘要： An apparatus for measuring the concentration of a component in a medium comprising:an optical sensor including at least one optical indicator for providing an optical signal which varies in response to the presence of a component in a medium;an optical signal fiber capable of transmitting the optical signal from the optical sensor; anda supply reservoir associated with the optical sensor and acting to provide additional optical indicator to the optical sensor.
摘要翻译：一种用于测量介质中的组分的浓度的装置，包括：光学传感器，包括至少一个光学指示器，用于提供响应于介质中组分的存在而变化的光学信号; 能够从光学传感器发送光信号的光信号光纤; 以及与所述光学传感器相关联并用于向所述光学传感器提供附加光学指示器的供应储存器。

3. 发明授权

US5284775A Gas sensing element and method for making same 失效
标题翻译：气体传感元件及其制造方法
公开(公告)号：US5284775A
公开(公告)日：1994-02-08
申请号：US949771
申请日：1992-09-21
申请人： Masao Yafuso , Mark Z. Holody , Thomas P. Maxwell , Thomas G. Hacker
发明人： Masao Yafuso , Mark Z. Holody , Thomas P. Maxwell , Thomas G. Hacker
IPC分类号： G01N21/64 , G01N21/77 , G01N21/78 , G01N31/22 , G01N33/49 , G01N33/50
CPC分类号： G01N21/783 , G01N31/223 , Y10T436/204998
摘要： Sensing composition precursors and sensing compositions, useful in sensing the concentration of a gas, e.g., carbon dioxide, in a medium, e.g., blood, are disclosed. In one embodiment, the sensing composition precursor comprises a dispersed aqueous liquid including a sensing component dissolved therein, a polymer precursor, and a hydrophilic dispersing agent selected from hydroxyalkyl celluloses and mixtures thereof in an amount effective to facilitate maintaining the dispersed aqueous liquid.
摘要翻译：公开了感测组合物前体和感测组合物，其可用于感测介质（例如血液）中的二氧化碳气体的浓度。在一个实施方案中，感测组合物前体包含分散的水性液体，其包含溶解于其中的感测组分，聚合物前体和选自羟烷基纤维素及其混合物的亲水性分散剂，其量有助于维持分散的水性液体。

4. 发明授权

US4919891A Sensor with overcoating and process for making same 失效
标题翻译：传感器具有外涂和制造过程
公开(公告)号：US4919891A
公开(公告)日：1990-04-24
申请号：US49844
申请日：1987-05-15
申请人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
发明人： Masao Yafuso , Henry K. Hui , Cheng F. Yan , William W. Miller
IPC分类号： A61B5/00 , G01N21/64 , G01N21/80 , G01N21/81 , G01N31/22
CPC分类号： G01N21/643 , A61B5/1459 , G01N31/223 , G01N2021/6434 , G01N2021/6439 , G01N21/80 , G01N21/81
摘要： A sensor comprising a sensing element capable of sensing a component in an aqueous medium and an overcoating at least partially covering the sensing element. The overcoating comprises a water insoluble, component permeable, cross-linked cellulosic material and an effective amount of an opaque agent.
摘要翻译：传感器，其包括能够感测水性介质中的组分的感测元件和至少部分地覆盖感测元件的外涂层。外涂层包含不溶于水的组分可渗透的交联纤维素材料和有效量的不透明剂。

5. 发明授权

US5958782A Cation-sensing composite structure and compounds for use therein 失效
标题翻译：阳离子检测复合结构和其中使用的化合物
公开(公告)号：US5958782A
公开(公告)日：1999-09-28
申请号：US810969
申请日：1997-02-27
申请人： James G. Bentsen , Shih-Hung Chou , Elisa M. Cross , Kurt J. Halverson , John E. Trend , Cary A. Kipke , Masao Yafuso , Sanjay L. Patil
发明人： James G. Bentsen , Shih-Hung Chou , Elisa M. Cross , Kurt J. Halverson , John E. Trend , Cary A. Kipke , Masao Yafuso , Sanjay L. Patil
IPC分类号： G01N21/64 , C07D498/18 , C09B23/10 , G01N31/22 , G01N33/20 , G01N33/487
CPC分类号： C07D498/18 , C09B23/102 , G01N31/22 , G01N31/221
摘要： A fluorescent ionophoric compound is disclosed that includes a complexing moiety, such as a cryptand or crown-ether portion, and a fluorescing moiety such as a coumarin portion. The coumarin portion may be substituted at the 3-position with an electron withdrawing or polarizable group such as a substituted aromatic group or a substituted heterocyclic group having a heteroatom in at least one of its alpha positions. The compound, which exhibits good photostability, can be incorporated into cation-sensing composite structures by means of convenient points of covalent attachment.
摘要翻译：公开了一种荧光离子化合物，其包括络合部分，例如穴状或冠醚部分，以及荧光部分如香豆素部分。香豆素部分可以在3位被吸电子或可极化基团取代，例如取代的芳基或在其α位中的至少一个具有杂原子的取代的杂环基。具有良好的光稳定性的化合物可以通过方便的共价连接点并入阳离子感应复合结构中。

6. 发明授权

US5583213A Process to activate sulfated polysaccharides 失效
标题翻译：活化硫酸多糖的方法
公开(公告)号：US5583213A
公开(公告)日：1996-12-10
申请号：US439522
申请日：1995-05-12
申请人： Masao Yafuso , Robert J. Linhardt
发明人： Masao Yafuso , Robert J. Linhardt
IPC分类号： A61L33/00 , A61L33/08 , C08B37/00 , C08B37/02 , C08B37/08 , C08B37/10
CPC分类号： C08B37/0063 , A61L33/0023 , A61L33/0094 , A61L33/08
摘要： The present specification is directed to a novel process to prepare an activated sulfated polysaccharide which may then be used in subsequent reactions or processes to bind the reactive polysaccharide with a nucleophilic agent or an aminated surface. The activating process comprises the steps of initially forming a polysaccharide tetraalkylammonium salt by contacting an aqueous mixture of a sulfated polysaccharide salt with a cation exchange resin to give a polysaccharide free acid and then contacting the polysaccharide free acid with a tetraalkylammonium hydroxide to give the polysaccharide tetraalkylammonium salt, and subsequently forming an activated sulfated polysaccharide by contacting the polysaccharide tetraalkylammonium salt of step i) with a coupling reagent in an aprotic organic solvent at ambient temperatures for a period of time sufficient to form the activated sulfated polysaccharide.
摘要翻译：本说明书涉及制备活化的硫酸多糖的新方法，其可以随后用于随后的反应或将活性多糖与亲核试剂或胺化表面结合的方法。活化方法包括以下步骤：首先通过使硫酸化多糖盐的水性混合物与阳离子交换树脂接触而形成多糖四烷基铵盐，得到多糖游离酸，然后使多糖游离酸与四烷基氢氧化铵接触，得到多糖四烷基铵盐，随后通过使步骤i）的多糖四烷基铵盐与偶联剂在非质子有机溶剂中在环境温度下接触足以形成活化的硫酸化多糖的时间，形成活化的硫酸化多糖。

7. 发明授权

US5508509A Sensing elements and methods for uniformly making individual sensing elements 失效
标题翻译：用于均匀地制作各个感应元件的感测元件和方法
公开(公告)号：US5508509A
公开(公告)日：1996-04-16
申请号：US159799
申请日：1993-11-30
申请人： Masao Yafuso , Ronnie L. Pratt , Kathryn R. Bretscher , Kenneth B. Wood , John L. Dektar , James G. Bentsen
发明人： Masao Yafuso , Ronnie L. Pratt , Kathryn R. Bretscher , Kenneth B. Wood , John L. Dektar , James G. Bentsen
IPC分类号： G01N31/22 , G01N33/49 , G01N33/52 , G01N33/84 , G01N33/50
CPC分类号： G01N33/52 , G01N31/223 , G01N33/84 , Y10T436/207497
摘要： Sensing elements, useful in sensing the concentration of a gas, e.g., carbon dioxide, in a medium, e.g. blood, and methods for making such sensing elements are disclosed. In one embodiment, the method comprises continuously placing a sensing composition precursor in contact with a continuous web, forming a continuous sensing composition from the precursor, and applying a continuous opaque film to the sensing composition. A plurality of individual sensing elements are formed from this composite structure. These sensing elements, which each have very similar sensing characteristics, are placed in a sensor fixture for use.
摘要翻译：感测元件，可用于感测介质中气体（例如二氧化碳）的浓度，例如二氧化碳。血液和制造这种感测元件的方法被公开。在一个实施方案中，该方法包括将感测组合物前体连续地放置成与连续纤维网接触，从前体形成连续感测组合物，以及向感测组合物施加连续的不透明膜。从该复合结构形成多个单独的感测元件。这些感测元件（每个具有非常相似的感测特性）被放置在传感器夹具中以供使用。

8. 发明授权

US5296381A Sensing elements and methods for making and using same 失效
标题翻译：感应元件和制造和使用方法
公开(公告)号：US5296381A
公开(公告)日：1994-03-22
申请号：US742002
申请日：1991-08-08
申请人： Masao Yafuso , Paul F. Korkowski , Roger A. Mader , Cheng Yan , John T. Carlock
发明人： Masao Yafuso , Paul F. Korkowski , Roger A. Mader , Cheng Yan , John T. Carlock
IPC分类号： A61B5/00 , G01N21/62 , G01N21/64 , G01N21/77
CPC分类号： G01N21/7703 , A61B5/1459 , G01N2021/772 , G01N2021/773 , G01N2021/7786
摘要： A sensing element for sensing the concentration of an analyte in a medium is disclosed. The sensing element comprises a matrix material having at least one indicator component covalently bonded thereto. The indicator component is capable of providing a signal dependent on the concentration of a analyte in a medium. The indicator component is derived from at least one indicator compound having an aromatic ring to which is directly bonded a group including a functional portion which is conjugated relative to this aromatic ring.
摘要翻译：公开了用于感测介质中分析物浓度的感测元件。感测元件包括具有至少一个与其共价键合的指示剂组分的基质材料。指示剂组分能够提供依赖于介质中分析物浓度的信号。指示剂组分衍生自至少一种具有芳环的指示剂化合物，其直接键合到包含相对于该芳环共轭的官能部分的基团上。

9. 发明授权

US5175016A Method for making gas sensing element 失效
标题翻译：制造气体传感元件的方法
公开(公告)号：US5175016A
公开(公告)日：1992-12-29
申请号：US496560
申请日：1990-03-20
申请人： Masao Yafuso , Mark Z. Holody , Thomas P. Maxwell , Thomas G. Hacker
发明人： Masao Yafuso , Mark Z. Holody , Thomas P. Maxwell , Thomas G. Hacker
IPC分类号： G01N21/64 , G01N21/77 , G01N21/78 , G01N31/22 , G01N33/49
CPC分类号： G01N21/783 , G01N31/223 , Y10T436/204998
摘要： A method for making a sensing element, and an assembled sensing element, useful in sensing the concentration of a gas, e.g., carbon dioxide, in a medium, e. g. blood, are disclosed. In one embodiment, the method comprises placing a quantity of a sensing composition precursor between and in contact with a transparent, gas impermeable solid disc and an opaque, gas permeable film, the sensing composition precursor comprises a sensing component, a polymer precursor and a cross-linking agent; and forming a gas sensing composition from this quantity of sensing composition precursor.

10. 发明授权

US5006314A Sensor and method for sensing the concentration of a component in a medium 失效
标题翻译：用于感测介质中组分浓度的传感器和方法
公开(公告)号：US5006314A
公开(公告)日：1991-04-09
申请号：US206189
申请日：1988-06-13
申请人： Ted H. Gourley , Thomas P. Maxwell , Thomas G. Hacker , William W. Miller , Masao Yafuso
发明人： Ted H. Gourley , Thomas P. Maxwell , Thomas G. Hacker , William W. Miller , Masao Yafuso
IPC分类号： A61B5/00 , G01N21/64 , G01N21/80 , G01N21/81 , G01N31/22
CPC分类号： G01N21/7703 , A61B5/1459 , G01N31/223 , G01N2021/6434 , G01N2021/6439 , G01N2021/772 , G01N2021/773 , G01N2021/7786 , G01N21/80 , G01N21/81
摘要： An apparatus for sensing the concentration of a component such as oxygen in a medium such as blood. The apparatus includes an elongated signal transmitter and a sensing element at one end thereof. A substantially rigid sleeve is secured around such end to provide a pocket for the sensing element.
摘要翻译：用于感测诸如血液的介质中诸如氧的组分的浓度的装置。该装置包括细长的信号发射器和在其一端的感测元件。围绕该端部固定有基本刚性的套筒，以提供感测元件的口袋。

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