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1. 发明授权

US08420831B2 Intermediates of 1-O-acyl-2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranoses 有权
标题翻译： 1-O-酰基-2-脱氧-2-氟-4-硫代-β-D-阿拉伯呋喃糖苷的中间体
公开(公告)号：US08420831B2
公开(公告)日：2013-04-16
申请号：US13606746
申请日：2012-09-07
申请人： David Voigtländer , Michael Sander , Michael Harre
发明人： David Voigtländer , Michael Sander , Michael Harre
IPC分类号： C07D495/06
CPC分类号： C07D333/32 , C07H13/04
摘要： The present invention relates to a process for preparing 1-O-acyl-2-deoxy-2-fluoro-4-thio-β-D-arabinofuranoses having formula I and intermediates thereof: wherein R1 represents —C(O)—C1-C6-alkyl or —C(O)-aryl; and R2 represents C1-C6-alkyl, C1-C4-perfluoroalkyl or aryl.
摘要翻译：本发明涉及一种制备具有式I的1-O-酰基-2-脱氧-2-氟-4-硫代-β-阿拉伯呋喃糖的方法及其中间体：其中R1表示-C（O）-C1 -C 1-6 - 烷基或-C（O） - 芳基; 并且R 2表示C 1 -C 6烷基，C 1 -C 4全氟烷基或芳基。

2. 发明申请

US20130033397A1 METHODS FOR RECEIVING GPS INDOORS WITH HIGH PRECISION AND DEVICES THEREOF 审中-公开
标题翻译：用于接收具有高精度的GPS室的方法及其装置
公开(公告)号：US20130033397A1
公开(公告)日：2013-02-07
申请号：US13567688
申请日：2012-08-06
申请人： John Fischer , Gilles Boime , Denis Reilly , Michael Sander , David Sohn
发明人： John Fischer , Gilles Boime , Denis Reilly , Michael Sander , David Sohn
IPC分类号： G01S19/48 , G01S19/05
CPC分类号： G01S19/14 , G01S19/246 , G01S19/25
摘要： A method, non-transitory computer readable medium, and apparatus that determines a GPS location includes obtaining assisted GPS data of locations of a plurality of GPS satellites, current time, and initial location data of the receiver computing device. A GPS signal from one or more of the plurality of GPS satellites within a frequency range and time range is acquired based on the obtained assisted GPS data, current time, and initial location data of the receiver computing device. The one or more acquired GPS signals are integrated over a frame period of two or more seconds. A GPS location for the receiver computing device is determined based on the one or more integrated GPS signals.
摘要翻译：确定GPS位置的方法，非暂时计算机可读介质和装置包括获得多个GPS卫星的位置的辅助GPS数据，当前时间和接收机计算设备的初始位置数据。基于所获得的辅助GPS数据，当前时间和接收机计算设备的初始位置数据，获取在频率范围和时间范围内来自多个GPS卫星中的一个或多个GPS卫星的GPS信号。一个或多个获取的GPS信号在两秒或更多秒的帧周期内被积分。基于一个或多个集成GPS信号来确定用于接收机计算设备的GPS位置。

3. 发明授权

US07906678B2 Crystalline potassium salt of lipoxin A4 analogs 有权
公开(公告)号：US07906678B2
公开(公告)日：2011-03-15
申请号：US11999000
申请日：2007-12-03
申请人： Tilo Haag , Danja Grossbach , Gabriele Winter , Michael Sander , Wolfgang Beckmann , Klaus Bartel , Christian Dinter
发明人： Tilo Haag , Danja Grossbach , Gabriele Winter , Michael Sander , Wolfgang Beckmann , Klaus Bartel , Christian Dinter
IPC分类号： C07C59/00
CPC分类号： C07C59/70 , C07C51/412 , C07C57/04
摘要： This invention is directed to the crystalline potassium salt of a lipoxin A4 analog of Formula (I): processes for preparing the crystalline potassium salts, methods for using them to treat disease-states characterized by inflammation, and pharmaceutical compositions comprising such crystalline potassium salts.

4. 发明授权

US07500857B2 Arrangement with a contact element 失效
标题翻译：与接触元件的布置
公开(公告)号：US07500857B2
公开(公告)日：2009-03-10
申请号：US10599627
申请日：2005-03-26
申请人： Harald Schmid , Hermann Rappenecker , Wilhelm Weisser , Ralf-Michael Sander , Alexander Hahn
发明人： Harald Schmid , Hermann Rappenecker , Wilhelm Weisser , Ralf-Michael Sander , Alexander Hahn
IPC分类号： H01R12/00
CPC分类号： H01R12/58
摘要： A circuit board (20) is equipped with at least one conductor path (22) and a contact element (44). The latter is adapted to mechanically engage and electrically contact an electrical conductor (66). In the region of a conductor path (22), the circuit board (20) has passthrough orifices (24, 26, 28, 30, 32). The contact element (44) has a base part (46) and feet (34, 36, 38, 40, 42) which press-fit into the orifices (24 to 32) of the circuit board (20). The contact element (44) has a contact tongue (54) that is resiliently articulated on the base part (46) and clamps the electrical conductor (66). This makes possible a secure connection from the electrical conductor (66) to the circuit board (20), e.g. for connecting a device having a large current demand.
摘要翻译：电路板（20）配备有至少一个导体路径（22）和接触元件（44）。后者适于与电导体（66）机械接合和电接触。在导体路径（22）的区域中，电路板（20）具有通孔（24,26,28,30,32）。接触元件（44）具有压配合到电路板（20）的孔口（24至32）中的基部（46）和脚（34,36,38,40,42）。接触元件（44）具有在基部（46）上弹性铰接并夹持电导体（66）的接触舌片（54）。这使得可能从电导体（66）到电路板（20）的安全连接，例如。用于连接具有大电流需求的装置。

5. 发明授权

US06350911B1 Method for producing amines 有权
标题翻译：胺的制备方法
公开(公告)号：US06350911B1
公开(公告)日：2002-02-26
申请号：US09857903
申请日：2001-06-11
申请人： Michael Sander , Ulrich Penzel , Hans Volkmar Schwarz , Eckhard Ströfer , Dieter Stützer , Jörn Müller , Markus Maurer , Peter Zehner , Ekkehard Schwab , Ralf Böhling , Dominic Vanoppen
发明人： Michael Sander , Ulrich Penzel , Hans Volkmar Schwarz , Eckhard Ströfer , Dieter Stützer , Jörn Müller , Markus Maurer , Peter Zehner , Ekkehard Schwab , Ralf Böhling , Dominic Vanoppen
IPC分类号： C07C21100
CPC分类号： C07C209/36 , B01J4/002 , B01J10/002 , B01J19/006 , B01J19/246 , B01J19/2465 , B01J19/2475 , B01J2219/00078 , B01J2219/00081 , B01J2219/00085 , B01J2219/00094 , B01J2219/00777 , C07C211/51
摘要： The invention relates to a process for the preparation of amines by hydrogenation of nitro compounds, which comprises carrying out the hydrogenation in a vertical reactor whose length is greater than its diameter, having a downward-facing jet nozzle arranged in the upper region of the reactor through which the starting materials and the reaction mixture are fed in, and having an outlet at any desired point of the reactor, through which the reaction mixture is fed back to the jet nozzle in an external circuit by means of a conveying means, and having flow reversal in the lower region of the reactor.
摘要翻译：本发明涉及一种通过氢化硝基化合物制备胺的方法，其包括在其长度大于其直径的立式反应器中进行氢化，其具有布置在反应器的上部区域中的面向下的喷嘴原料和反应混合物通过该反应混合物进料，并在反应器的任何所需点处具有出口，反应混合物通过该反应混合物通过输送装置在外部回路中被反馈到喷嘴，并具有在反应器的下部区域的流动反转。

6. 发明授权

US08324412B2 Method for preparing 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil) 有权
标题翻译：制备4- [17β-甲氧基-17α-甲氧基甲基-3-氧代雌-4,9-二烯-11β-基]苯甲醛（E） - 肟（asoprisnil）的方法，
公开(公告)号：US08324412B2
公开(公告)日：2012-12-04
申请号：US12987850
申请日：2011-01-10
申请人： Detlef Grawe , Sabine Gliesing , Hagen Gerecke , Peter Hoesel , Uwe Mueller , Thomas Michel , Robert Eilers , Uwe Knabe , Bernd Erhart , Michael Mosebach , David Voigtlaender , Ulf Tilstam , Jürgen Jacke , Klaus Bahl , Ulf Bohlmann , Dieter Wehmeier , Michael Sander
发明人： Detlef Grawe , Sabine Gliesing , Hagen Gerecke , Peter Hoesel , Uwe Mueller , Thomas Michel , Robert Eilers , Uwe Knabe , Bernd Erhart , Michael Mosebach , David Voigtlaender , Ulf Tilstam , Jürgen Jacke , Klaus Bahl , Ulf Bohlmann , Dieter Wehmeier , Michael Sander
IPC分类号： C07J1/00
CPC分类号： C07J3/00 , Y10T428/2982
摘要： The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).
摘要翻译：本发明涉及一种可靠和可重复制备4- [17-甲氧基-17α-甲氧基甲基-3-氧代雌-4,9-二烯-11-基]苯甲醛（E） - 肟（asoprisnil）的方法，在试点和制造规模上。通过该方法制备的麻醉药具有非常好的物理稳定性，因此特别适用于制备固体药物形式（片剂，包衣片剂等）。

7. 发明申请

US20120157421A1 17Beta-Alkyl-17Alpha-oxy-estratrienes 审中-公开
标题翻译： 17β-烷基-17α-氧 - 雌三烯
公开(公告)号：US20120157421A1
公开(公告)日：2012-06-21
申请号：US13376194
申请日：2010-05-26
申请人： Rolf Bohlmann , Nikolaus Heinrich , Jan Hübner , Georg Kettschau , Hermann Künzer , Philip Lienau , Michael Gerisch , Silke Köhr , Dieter Lang , Karsten Denner , Michael Sander , Jens Hoffmann , Tim Wintermantel
发明人： Rolf Bohlmann , Nikolaus Heinrich , Jan Hübner , Georg Kettschau , Hermann Künzer , Philip Lienau , Michael Gerisch , Silke Köhr , Dieter Lang , Karsten Denner , Michael Sander , Jens Hoffmann , Tim Wintermantel
IPC分类号： A61K31/58 , A61K31/56 , C07J3/00 , A61P5/30 , C07J31/00 , C07J41/00 , C07J43/00
CPC分类号： A61K31/56 , C07J41/0072 , C07J43/003
摘要： The invention relates to 17β-alkyl-17α-oxy-oestratrienes of the formula (I), to processes for their preparation, to the use of the 17β-alkyl-17α-oxy-oestratrienes for preparing pharmaceuticals and to pharmaceutical preparations comprising these compounds.
摘要翻译：本发明涉及式（I）的17α-烷基-17α-氧 - 三亚甲基三醇，其制备方法，17α-烷基-17α-氧 - 二亚甲基三唑在制备药物中的用途以及药物制剂，其包含这些化合物。

8. 发明申请

US20120071662A1 PREPARING AMINOARYLALKYL COMPOUNDS 审中-公开
标题翻译：制备氨基胆碱化合物
公开(公告)号：US20120071662A1
公开(公告)日：2012-03-22
申请号：US13197046
申请日：2011-08-03
申请人： Michael Sander , Wolfgang Stirner , Frank Laschinski , Michael Konrad , Karsten Von Dem Bruch
发明人： Michael Sander , Wolfgang Stirner , Frank Laschinski , Michael Konrad , Karsten Von Dem Bruch
IPC分类号： C07D213/73 , C07D213/75
CPC分类号： C07D213/75
摘要： The invention relates to a process for preparing aminoarylalkyl compounds, more particularly 5-amino-2-isopropylpyridine.
摘要翻译：本发明涉及一种制备氨基芳基烷基化合物，更特别是5-氨基-2-异丙基吡啶的方法。

9. 发明申请

US20110257142A1 METHOD FOR PREPARING 4-[17BETA-METHOXY-17ALPHA-METHOXYMETHYL-3-OXOESTRA-4,9-DIEN-11-BETA-YL]BENZALDEHYDE (E)-OXIME (ASOPRISNIL) 有权
标题翻译：制备4- [17-甲氧基-17α-甲氧基甲基-3-氧杂环丙烷-4,9-二烯-11-β-YL]苯甲醛（E）-OXIME（ASOPRISNIL）
公开(公告)号：US20110257142A1
公开(公告)日：2011-10-20
申请号：US12987850
申请日：2011-01-10
申请人： Detlef Grawe , Sabine Gliesing , Hagen Gerecke , Peter Hoesel , Uwe Mueller , Thomas Michel , Robert Eilers , Uwe Knabe , Bernd Erhart , Michael Mosebach , David Voigtlaender , Ulf Tilstam , Jürgen Jacke , Klaus Bahl , Ulf Bohlmann , Dieter Wehmeier , Michael Sander
发明人： Detlef Grawe , Sabine Gliesing , Hagen Gerecke , Peter Hoesel , Uwe Mueller , Thomas Michel , Robert Eilers , Uwe Knabe , Bernd Erhart , Michael Mosebach , David Voigtlaender , Ulf Tilstam , Jürgen Jacke , Klaus Bahl , Ulf Bohlmann , Dieter Wehmeier , Michael Sander
IPC分类号： A61K31/56 , A61P43/00 , C07J3/00
CPC分类号： C07J3/00 , Y10T428/2982
摘要： The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).
摘要翻译：本发明涉及一种可靠和可重复制备4- [17-甲氧基-17α-甲氧基甲基-3-氧代雌-4,9-二烯-11-基]苯甲醛（E） - 肟（asoprisnil）的方法，在试点和制造规模上。通过该方法制备的麻醉药具有非常好的物理稳定性，因此特别适用于制备固体药物形式（片剂，包衣片剂等）。

10. 发明申请

US20080182901A1 Crystalline acid of lipoxin A4 analogs and method of making 审中-公开
标题翻译：脂氧素A4类似物的结晶酸及其制备方法
公开(公告)号：US20080182901A1
公开(公告)日：2008-07-31
申请号：US11999003
申请日：2007-12-03
申请人： Klaus Bartel , Danja Grossbach , William J. Guilford , Michael Sander , Gabriele Winter
发明人： Klaus Bartel , Danja Grossbach , William J. Guilford , Michael Sander , Gabriele Winter
IPC分类号： A61K31/192 , C07C59/64 , C07C51/367 , A61P11/00 , A61P29/00
CPC分类号： C07C59/70 , C07C51/09
摘要： This invention is directed to a crystalline acid of a lipoxin A4 analog of Formula (II): wherein: R1 is —O—, —S(O)t— (where t is 0, 1 or 2), or a straight or branched alkylene chain; and R2 is aryl (optionally substituted by one or more substituents selected from alkyl, alkoxy, halo, haloalkyl and haloalkoxy) or aralkyl (optionally substituted by one or more substituents selected from f alkyl, alkoxy, halo, haloalkyl and haloalkoxy); and wherein the compound of Formula (II) is a single stereoisomer or any mixture of stereoisomers. This crystalline acid is useful in treating disease-states characterized by inflammation, such as inflammatory and autoimmune disorders or pulmonary or respiratory tract inflammations in humans. Methods of preparing the crystalline acid are also described.
摘要翻译：本发明涉及式（II）的脂氧素A 4 H 4类似物的结晶酸：其中：R 1是-O - ， - S（O）（其中t为0,1或2）或直链或支链亚烷基链; 和R 2是芳基（任选被一个或多个选自烷基，烷氧基，卤素，卤代烷基和卤代烷氧基的取代基取代）或芳烷基（任选地被一个或多个选自F，烷基，烷氧基，卤素，卤代烷基和卤代烷氧基）; 并且其中式（II）的化合物是单一立体异构体或任何立体异构体的混合物。该结晶酸可用于治疗以炎症和自身免疫疾病为特征的疾病状态或人类肺或呼吸道炎症。还描述了制备结晶酸的方法。

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