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1. 发明授权

US06781015B2 Aminobenzophenones and photopolymerizable compositions including the same 失效
标题翻译：氨基二苯甲酮和包含它们的光聚合组合物
公开(公告)号：US06781015B2
公开(公告)日：2004-08-24
申请号：US10261352
申请日：2002-10-01
申请人： John Gabriel Santobianco , Rajamani Nagarajan , August John Muller , Joseph Stanton Bowers, Jr.
发明人： John Gabriel Santobianco , Rajamani Nagarajan , August John Muller , Joseph Stanton Bowers, Jr.
IPC分类号： C07C21100
CPC分类号： C07C225/22 , C08F2/50 , G03F7/029 , G03F7/031 , G03F7/038
摘要： Novel benzophenone derivatives and methods of making and using the same are disclosed. The novel compounds can display highly active photoinitiation and photopolymerization properties.
摘要翻译：公开了新的二苯甲酮衍生物及其制备和使用方法。新型化合物可显示高度活性的光引发和光聚合性质。

2. 发明授权

US06713653B2 Polyamines and polymers made therewith 失效
标题翻译：多胺和聚合物
公开(公告)号：US06713653B2
公开(公告)日：2004-03-30
申请号：US09938696
申请日：2001-08-24
申请人： David P. Higley
发明人： David P. Higley
IPC分类号： C07C21100
CPC分类号： C08G69/26 , C07C211/14
摘要： A polyamine having the formula: H2N—A[NR—B]aNH2 or salt thereof, wherein A and B, which may be the same or different, are selected from aliphatic or aromatic substituents provided that at least four carbon atoms separate any two nitrogen groups, R is an aliphatic or aromatic group, and a is 2 to 5. In addition, a polymer having the formula: or salt thereof, wherein A, B and Q, which may be the same or different, are selected from aliphatic or aromatic substituents provided that at least four carbon atoms separate any two nitrogen groups, R is an aliphatic or aromatic group, a is greater than 1 to about 5, and n is 3 to about 1,000. The polymers are useful for improving acid-dyeability of polymer compositions, fibers, fabrics, films and other articles.
摘要翻译：具有下式的多胺或其盐，其中A和B可以相同或不同，选自脂族或芳族取代基，条件是至少四个碳原子分开任何两个氮基团，R是脂族或芳族基团，并且a为2至5.另外，具有下式的聚合物或其盐，其中A，B和Q可以相同或不同，选自脂族或芳族取代基，条件是至少四个碳原子分离任何两个氮基团，R是脂族或芳族基团，a大于1至约5，n为3至约1,000。聚合物可用于改善聚合物组合物，纤维，织物，薄膜和其它制品的酸 - 染色性。

3. 发明授权

US06670508B2 Process for manufacturing the chloride of 1,3-bis- (dimethylbenzylammonium) isopropyl, acrylate alone or mixed with other monomers, and corresponding (co) polymers 失效
公开(公告)号：US06670508B2
公开(公告)日：2003-12-30
申请号：US10132691
申请日：2002-04-26
申请人： Alain Riondel
发明人： Alain Riondel
IPC分类号： C07C21100
CPC分类号： C07C213/08 , C08F20/34 , C07C219/08
摘要： A compound of formula (I) is prepared alone or in combination with at least one monomer of formula (II): the quaternizing agents benzyl chloride is introduced into a solution, in a solvent selected from compounds of the formulae (I) and (II) and mixtures of these, of the compound of formula (III) at a temperature of from 35 to 60° C., and then water is added and the reaction is allowed to proceed to complete or substantially complete conversion of the compound (III), an aqueous solution of desired compound (I) is isolated where appropriate with at least one compound (II), if this or these have/has been used as solvent, and the water is removed where appropriate.

4. 发明授权

US06552227B2 Process for preparing (+)-cis-sertraline 有权
标题翻译：制备（+） - 顺式 - 舍曲林的方法
公开(公告)号：US06552227B2
公开(公告)日：2003-04-22
申请号：US09805829
申请日：2001-03-14
申请人： Marioara Mendelovici , Tamar Nidam , Gideon Pilarsky , Neomi Gershon
发明人： Marioara Mendelovici , Tamar Nidam , Gideon Pilarsky , Neomi Gershon
IPC分类号： C07C21100
CPC分类号： C07C209/52 , C07B2200/09 , C07C2602/10 , C07C211/42
摘要： The present invention is directed to (+)-cis-sertraline hydrochloride and methods of preparation. The present invention also includes processes for making sertraline having a cis/trans ratio greater than 3:1, greater than or equal to 8:1, or between about 8:1 and about 12:1, from the Schiff base of sertralone, sertraline-1-imine.
摘要翻译：本发明涉及（+） - 顺式 - 舍曲林盐酸盐及其制备方法。本发明还包括从舍曲林的席夫碱，舍曲林制备顺式/反式比大于3:1，大于或等于8:1或约8:1至约12:1的舍曲林的方法 -1亚胺。

5. 发明授权

US06541669B1 &bgr;2-adrenergic receptor agonists 有权
标题翻译： β2-肾上腺素能受体激动剂
公开(公告)号：US06541669B1
公开(公告)日：2003-04-01
申请号：US09323943
申请日：1999-06-02
申请人： Edmund J. Moran , Seok-Ki Choi
发明人： Edmund J. Moran , Seok-Ki Choi
IPC分类号： C07C21100
CPC分类号： C07D213/74 , A61K47/55 , C07B2200/11 , C07C215/60 , C07C217/08 , C07C323/62 , C07D211/42 , C07D211/56 , C07D213/80 , C07D263/32 , C07D263/34 , C07D265/32 , C07D277/24 , C07D277/28 , C07D277/34 , C07D401/12 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/12 , C07K1/047 , C40B40/00 , G01N33/9406 , G01N2333/62 , G01N2333/70578 , G01N2333/726 , G01N2500/00
摘要： Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.
摘要翻译：公开了作为β2肾上腺素能受体激动剂的多重联结化合物，并且可用于治疗和预防呼吸系统疾病如哮喘，支气管炎。它们也可用于治疗神经系统损伤和早产。

6. 发明授权

US06452054B2 Sertraline hydrochloride polymorphs, processes for preparing them, compositions containing them and methods of using them 有权
标题翻译：舍曲林盐酸盐多晶型物，其制备方法，含有它们的组合物和使用它们的方法
公开(公告)号：US06452054B2
公开(公告)日：2002-09-17
申请号：US09746320
申请日：2000-12-21
申请人： Judith Aronhime , Marioara Mendelovici , Tamar Nidam , Claude Singer
发明人： Judith Aronhime , Marioara Mendelovici , Tamar Nidam , Claude Singer
IPC分类号： C07C21100
CPC分类号： C07C211/42 , C07C2602/10
摘要： The present invention is directed to novel polymorphic Forms XI, XII, XIII, XIV, XV and XVI of sertraline hydrochloride, to processes for preparing them, methods of using them to treat disease, methods of using them to make other sertraline hydrochloride forms, and to pharmaceutical dosages containing the novel forms.
摘要翻译：本发明涉及盐酸舍曲林的新型多态性XI，XII，XIII，XIV，XV和XVI，其制备方法，使用它们治疗疾病的方法，使用它们制备其他舍曲林盐酸盐形式的方法，以及含有新型形式的药物剂量。

7. 发明授权

US06410792B1 Amide derivatives and methods for using the same as selective neuropeptide Y receptor antagonists 失效
标题翻译：酰胺衍生物和使用它们作为选择性神经肽Y受体拮抗剂的方法
公开(公告)号：US06410792B1
公开(公告)日：2002-06-25
申请号：US09294961
申请日：1999-04-20
申请人： Richard D. Connell , Timothy G. Lease , Gaetan H. Ladouceur , Martin H. Osterhout
发明人： Richard D. Connell , Timothy G. Lease , Gaetan H. Ladouceur , Martin H. Osterhout
IPC分类号： C07C21100
CPC分类号： A61K31/00
摘要： Amide derivatives and methods of administering the compositions to mammals to treat disorders such as obesity that are mediated by NPY and especially those mediated by NPY via the Y5 receptor.
摘要翻译：酰胺衍生物和将组合物施用于哺乳动物以治疗由NPY介导的疾病如肥胖的方法，特别是通过Y5受体由NPY介导的那些。

8. 发明授权

US06410789B1 Process for preparing aromatic polyamine mixtures 失效
标题翻译：制备芳族聚胺混合物的方法
公开(公告)号：US06410789B1
公开(公告)日：2002-06-25
申请号：US09367971
申请日：1999-08-24
申请人： Rainer Becker , Karsten Eller , Hans-Werner Langensiepen , Michael Hesse
发明人： Rainer Becker , Karsten Eller , Hans-Werner Langensiepen , Michael Hesse
IPC分类号： C07C21100
CPC分类号： C07C209/54 , B01J21/16 , C07C209/78 , C07C211/50 , C07C211/54
摘要： In a process for preparing aromatic polyamine mixtures which contain compounds of the formula (I), H2N—A—CH2—B—NH2 (I) where A and B are 1,4-phenylene radicals each of which independently of one another can have 1 to 4 substituents selected from C1-20 alkyls and halogens, a compound of the formula (IV) H—A—NH—CH2—HN—B—H (IV) and/or a compound of the formula (V) H—A—NH—CH2—B—NH2 (V) where A and B are substituted as above, are reacted at from 20° C. to 200° C. in the presence of a heterogeneous inorganic catalyst selected from the group consisting of a) one or more oxides of elements of group 3 to group 10 of the Periodic Table of the Elements, which can be acid-activated, b) a clay which is doped with at least one oxide of elements of groups 2 to 13 or the lanthanides of the Periodic Table of the Elements and can be acid-activated or c) a catalyst comprising one or more sheet silicates which may be acid-activated and have an acidity below pKa=1.5 of more than 0.05 mmol/g of catalyst.
摘要翻译：在制备含有式（I）化合物的芳族多胺混合物的方法中，其中A和B为1,4-亚苯基，其各自独立地可以具有1至4个选自C 1-20烷基和卤素的取代基，在异种无机催化剂的存在下，在20℃至200℃下使式（Ⅳ）化合物和/或其中A和B如上所述被取代的式（Ⅴ）化合物反应选自由以下组成的组：a）元素周期表第3族至第10族元素的一种或多种元素，其可被酸活化，b）掺杂有至少一种基团元素氧化物的粘土 2至13或元素周期表的镧系元素，并且可以是酸活化的）c）催化剂，其包含一种或多种可以被酸活化且酸度低于pKa = 1.5的片状硅酸盐超过0.05mmol / g 的催化剂。

9. 发明授权

US06403832B1 Process for producing optically active 3,3,3-Trifluoro-2-Hydroxy-2-Methylpropionic acid, and salt thereof 失效
标题翻译：光学活性3,3,3-三氟-2-羟基-2-甲基丙酸的制备方法及其盐
公开(公告)号：US06403832B1
公开(公告)日：2002-06-11
申请号：US09632804
申请日：2000-08-04
申请人： Miyuki Oikawa , Hideki Ushio , Isao Kurimoto , Takayuki Higashii
发明人： Miyuki Oikawa , Hideki Ushio , Isao Kurimoto , Takayuki Higashii
IPC分类号： C07C21100
CPC分类号： C07C251/24 , C07B2200/07 , C07C51/412 , C07C51/43 , C07C59/115 , C07C211/27 , C07C211/29 , C07C217/58
摘要： There are disclosed are a diastereomer salt of formula (1): a process for producing the same, a process for producing optically active 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid of formula (2′): a novel optically active amine compound of formula (4): a novel optically active amine compound of formula (8): an imine compound of formula (7) or (11):
摘要翻译：公开了式（1）的区域非对映体盐：其制备方法，式（2'）的光学活性3,3,3-三氟-2-羟基-2-甲基丙酸的制备方法：一种新颖的式（4）的光学活性胺化合物：式（8）的新型光学活性胺化合物：式（7）或（11）的亚胺化合物：

10. 发明授权

US06395932B1 1,2-diphenyl-2-propen-1-one derivatives 失效
标题翻译： 1,2-二苯基-2-丙烯-1-酮衍生物
公开(公告)号：US06395932B1
公开(公告)日：2002-05-28
申请号：US09889140
申请日：2001-07-12
申请人： Eiichi Shirasawa , Masaki Ichikawa , Hiroshi Suhara
发明人： Eiichi Shirasawa , Masaki Ichikawa , Hiroshi Suhara
IPC分类号： C07C21100
CPC分类号： C07C225/16 , C07C215/30 , C07C233/17 , C07C233/22 , C07C233/31 , Y02P20/55
摘要： The present invention provides compounds represented by the following formula [I] or salts thereof which lower intraocular pressure by causing morphological change in trabecular meshwork cells. In the formula, R1 is H, lower alkyl, hydroxy, lower alkoxy or halogen, R2, R3 and R4 are H or lower alkyl, and . . . is a single bond or a double bond. When R3 and/or R4 is hydrogen, the amino can be protected by a protecting group.
摘要翻译：本发明提供由下式[I]表示的化合物或其盐，其通过引起小梁网细胞的形态学变化降低眼内压。在该式中，R 1为H，低级烷基，羟基，低级烷氧基或卤素，R 2，R 3和R 4为H或低级烷基。。。是单键或双键。当R3和/或R4为氢时，氨基可被保护基保护。

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