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1. 发明申请

US20180057444A1 AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS 审中-公开
公开(公告)号：US20180057444A1
公开(公告)日：2018-03-01
申请号：US15659320
申请日：2017-07-25
申请人： WILLIAM MARSH RICE UNIVERSITY
发明人： HONGYIN GAO , Zhe ZHOU , Laszlo KURTI
IPC分类号： C07C209/66 , C07C37/01 , C07D295/135 , C07D307/79 , C07D317/66 , C07D317/46 , C07C319/20 , C07D317/28 , C07D309/12 , C07D213/73 , C07D213/04 , C07D209/04 , C07D277/82 , C07D333/20 , C07D307/91 , C07D209/88 , C07J41/00 , C07D333/16 , C07C41/26 , C07D317/64 , C07D295/096 , C07D317/20 , C07B43/04 , C07B41/02
CPC分类号： C07C209/66 , C07B41/02 , C07B43/04 , C07C37/01 , C07C37/055 , C07C37/64 , C07C41/26 , C07C213/02 , C07C227/06 , C07C303/30 , C07C319/20 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2603/18 , C07C2603/26 , C07D209/04 , C07D209/88 , C07D213/04 , C07D213/73 , C07D215/38 , C07D277/82 , C07D295/096 , C07D295/135 , C07D307/79 , C07D307/91 , C07D309/12 , C07D311/58 , C07D317/20 , C07D317/28 , C07D317/46 , C07D317/64 , C07D317/66 , C07D333/16 , C07D333/20 , C07D333/36 , C07J41/0011 , C07C211/58 , C07C217/94 , C07C211/59 , C07C211/61 , C07C211/47 , C07C211/44 , C07C217/80 , C07C211/51 , C07C323/36 , C07C309/30 , C07C229/56 , C07C229/60 , C07C219/34 , C07C39/235 , C07C39/14 , C07C39/15 , C07C39/12 , C07C39/20 , C07C39/205 , C07C43/23
摘要： In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions.

2. 发明授权

US09656954B2 Synergistic compositions 有权
公开(公告)号：US09656954B2
公开(公告)日：2017-05-23
申请号：US14783336
申请日：2014-07-04
申请人： CADILA HEALTHCARE LIMITED
发明人： Mukul R. Jain , Suresh Giri , Himanshu M. Kothari , Kaushik Banerjee , Rashmikant Kachhiya
IPC分类号： C07D207/333 , A61K45/06 , C07C211/27 , C07C279/14 , C07C215/20 , C07C229/26 , C07D295/027 , C07D233/58 , C07C215/12 , C07C215/40 , C07C211/35 , C07C211/30 , C07C217/60 , A61K31/155 , A61K31/40 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K31/4015 , C07C211/11 , C07C211/51 , C07C215/10
CPC分类号： C07D207/333 , A61K31/155 , A61K31/40 , A61K31/4015 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K45/06 , A61K2300/00 , C07C211/11 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/51 , C07C215/10 , C07C215/12 , C07C215/40 , C07C217/60 , C07C229/26 , C07C279/14 , C07C2601/14 , C07D233/58 , C07D295/027
摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (Ia) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I), processes for the preparation of these novel salts and use thereof.

3. 发明申请

US20170062862A1 MULTI-ELECTRON REDOX ACTIVE MOLECULES FOR ENERGY STORAGE APPLICATIONS 有权
标题翻译：用于能源储存应用的多电子反应活性分子
公开(公告)号：US20170062862A1
公开(公告)日：2017-03-02
申请号：US14840853
申请日：2015-08-31
申请人： UChicago Argonne, LLC
发明人： Lu Zhang , Jinhua Huang , Zhengcheng Zhang , Anthony K. Burrell
IPC分类号： H01M8/18 , H01M8/02 , C07C211/52 , H01M8/20 , C07C211/54 , C07C211/51
CPC分类号： H01M8/188 , C07C211/51 , C07C211/52 , C07C211/54 , C07C217/08 , H01M8/18 , H01M2300/0025 , Y02E60/528
摘要： A non-aqueous redox flow battery includes a catholyte including a compound of formula (I) or a compound of formula (II): Where X1 is a moiety of formula I-A or I-B:

4. 发明申请

US20170057957A1 2,3,4,6-TETRA-SUBSTITUTED BENZENE-1,5-DIAMINE DERIVATIVES, PREPARATION METHOD THEREFOR AND MEDICINAL USE THEREOF 有权
标题翻译： 2,3,4,6-四取代的苯甲基-1,5-二胺衍生物，其制备方法及其药物用途
公开(公告)号：US20170057957A1
公开(公告)日：2017-03-02
申请号：US15303475
申请日：2015-04-13
申请人： SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. , YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD.
发明人： Jiong LAN , Yunzhou JIN , Fusheng ZHOU , Qi HE , Xiangyu HE , Qiang LV
IPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , C07D401/14 , C07D401/12 , A61K31/55 , C07D403/12
CPC分类号： C07D471/04 , A61K31/16 , A61K31/505 , A61K31/506 , A61K31/55 , A61K45/06 , C07C211/51 , C07C211/54 , C07D239/02 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to 2,3,4,6-tetra-substituted benzene-1,5-diamine derivatives, a preparation method therefor and a medicinal use thereof. Specifically, disclosed are compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details.
摘要翻译：本发明涉及2,3,4,6-四取代苯-1,5-二胺衍生物及其制备方法及其药用用途。具体地，公开了式（I）的化合物或其药学上可接受的盐，立体异构体，溶剂合物或前药，其制备方法和应用。公式中每个组的定义可以在规范中找到。

5. 发明申请

US20160068484A1 SYNERGISTIC COMPOSITIONS 有权
标题翻译：协同组合物
公开(公告)号：US20160068484A1
公开(公告)日：2016-03-10
申请号：US14783336
申请日：2014-07-04
申请人： CADILA HEALTHCARE LIMITED
发明人： Mukul R. JAIN , Suresh GIRI , Himanshu M. KOTHARI , Kaushik BANERJEE , Rashmikant KACHHIYA
IPC分类号： C07D207/333 , A61K45/06 , C07C211/27 , C07C279/14 , C07C215/10 , C07C229/26 , C07D295/027 , C07D233/58 , C07C215/12 , C07C215/40 , C07C211/35 , C07C211/30 , C07C217/60 , C07C211/51 , C07C211/11 , A61K31/4985 , A61K31/155 , A61K31/505 , A61K38/26 , A61K31/4015 , A61K31/40
CPC分类号： C07D207/333 , A61K31/155 , A61K31/40 , A61K31/4015 , A61K31/4985 , A61K31/505 , A61K31/64 , A61K38/26 , A61K45/06 , A61K2300/00 , C07C211/11 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/51 , C07C215/10 , C07C215/12 , C07C215/40 , C07C217/60 , C07C229/26 , C07C279/14 , C07C2601/14 , C07D233/58 , C07D295/027
摘要： The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or more biguanide antihyperglycaemic agent and a PPAR agonist of formula (Ia) for the treatment of diabetes, especially non-insulin dependent diabetes (NIDDM) or Type 2 diabetes and conditions associated with diabetes mellitus and to compositions suitable for use in such method. The invention also describes the preparation of such compositions. The present invention also relates to certain novel salts of the PPAR agonist of formula (I): processes for the preparation of these novel salts and use thereof.
摘要翻译：本发明描述了一种协同组合物，其包含一种或多种他汀类或一种或多种二肽基肽酶IV（DPP IV）抑制剂或一种或多种双胍抗高血糖药和式（Ia）的PPAR激动剂，用于治疗糖尿病， - 胰岛素依赖性糖尿病（NIDDM）或2型糖尿病和与糖尿病有关的病症以及适用于该方法的组合物。本发明还描述了这种组合物的制备。本发明还涉及式（I）的PPAR激动剂的某些新型盐：这些新型盐的制备方法及其用途。

6. 发明授权

US09072999B2 Aromatic amino compounds for carbon dioxide and sulfur dioxide removal 有权
标题翻译：用于二氧化碳和二氧化硫去除的芳香族氨基化合物
公开(公告)号：US09072999B2
公开(公告)日：2015-07-07
申请号：US13045674
申请日：2011-03-11
申请人： Mark A. Scialdone , James A. Schultz
发明人： Mark A. Scialdone , James A. Schultz
IPC分类号： B01D53/46 , B01D53/50 , B01D53/62 , B01D53/14 , B01D53/74 , B01D53/96 , B01D53/02 , B01D53/22 , B01D61/38 , C07C209/90
CPC分类号： B01D53/02 , B01D53/1475 , B01D53/1481 , B01D53/1493 , B01D53/228 , B01D53/507 , B01D53/62 , B01D61/38 , B01D2252/2041 , B01D2252/20436 , C07C209/90 , Y02A50/2349 , Y02C10/04 , Y02C10/06 , Y02C10/08 , Y02C10/10 , Y02P20/152 , C07C211/51
摘要： Described are aromatic amino compounds that are useful to methods of carbon dioxide and sulfur dioxide removal.
摘要翻译：描述了可用于二氧化碳和二氧化硫去除方法的芳族氨基化合物。

7. 发明授权

US09029425B2 Substituted dibenzo[FG,OP]tetracenes and formulations or electronic devices containing the same 有权
标题翻译：取代的二苯并[FG，OP]四环和含有它们的制剂或电子装置
公开(公告)号：US09029425B2
公开(公告)日：2015-05-12
申请号：US13984552
申请日：2012-01-18
申请人： Thomas Eberle , Rémi Manouk Anémian , Sigurd Hoeger , Vanessa Bobbe , Anna Jochemich
发明人： Thomas Eberle , Rémi Manouk Anémian , Sigurd Hoeger , Vanessa Bobbe , Anna Jochemich
IPC分类号： A61K31/015 , A61N5/06 , C07C13/62 , C07C13/72 , C07C211/51 , C07C211/54 , C07D209/86 , C07D209/92 , C07D251/24 , H01L51/00 , C07F15/00 , H01L51/50
CPC分类号： A61N5/062 , C07C13/62 , C07C13/72 , C07C211/51 , C07C211/54 , C07D209/86 , C07D209/92 , C07D251/24 , C07F15/0033 , H01L51/0056 , H01L51/0067 , H01L51/0072 , H01L51/0085 , H01L51/5012 , H01L51/5016 , Y02E10/549
摘要： The present invention is directed to a compound of the formula (2) and its uses thereof: wherein T, U, V and W is CR1; R1 is H; X, is CR2 and N with the proviso that at least one X is equal to CR2 and at least one R2 from CR2 is equal to Z; and n and m are 0, 1, 2, 3 to 4 and either n is at least 3 or m is at least 3.
摘要翻译：本发明涉及式（2）的化合物及其用途：其中T，U，V和W为CR 1; R1是H; X是CR 2和N，条件是至少一个X等于CR 2，并且来自CR 2的至少一个R 2等于Z; n和m分别为0,1,2,3〜4，n为3以上，m为3以上。

8. 发明申请

US20120289745A1 METHOD FOR PRODUCING AROMATIC AMINES IN THE LIQUID PHASE 有权
标题翻译：在液相中生产芳族氨基酸的方法
公开(公告)号：US20120289745A1
公开(公告)日：2012-11-15
申请号：US13521523
申请日：2011-01-10
申请人： Wolfgang Lorenz , Bernd Pennemann
发明人： Wolfgang Lorenz , Bernd Pennemann
IPC分类号： C07C209/00
CPC分类号： C07C209/36 , C07C211/51
摘要： The invention relates to a process for the preparation of aromatic amines in the liquid phase by catalytic hydrogenation of the corresponding nitroaromatic compounds in at least two reaction spaces connected in series, wherein at least one reaction space is operated isothermally and at least the reaction space connected downstream thereof is operated adiabatically, and in preferred embodiments the sudden adiabatic temperature change is used for monitoring the reaction.
摘要翻译：本发明涉及通过在至少两个串联连接的反应空间中对相应的硝基芳族化合物进行催化氢化在液相中制备芳族胺的方法，其中至少一个反应空间是等温运行的，并且至少连接的反应空间其下游绝热操作，在优选的实施方案中，突然的绝热温度变化用于监测反应。

9. 发明申请

US20120215029A1 PROCESS FOR PREPARING AROMATIC AMINES 有权
标题翻译：制备芳香胺的方法
公开(公告)号：US20120215029A1
公开(公告)日：2012-08-23
申请号：US13311371
申请日：2011-12-05
申请人： Stefanie Haase , Dusko Kadijevic , Anne-Kathrin Merten , Michael Zoellinger , Andreas Raichle , Alexander Schocker , Sandra Mühlbeyer , Olaf Wiedenhoff , Joana Coelho Tsou
发明人： Stefanie Haase , Dusko Kadijevic , Anne-Kathrin Merten , Michael Zoellinger , Andreas Raichle , Alexander Schocker , Sandra Mühlbeyer , Olaf Wiedenhoff , Joana Coelho Tsou
IPC分类号： C07C209/36 , B01J19/00
CPC分类号： C07C229/36 , B01J8/228 , B01J21/066 , B01J23/755 , B01J35/023 , B01J37/0036 , B01J2208/00132 , B01J2208/00752 , B01J2219/00202 , B01J2219/00231 , B01J2219/0024 , C07C209/34 , C07C209/36 , C07C211/58 , C07C211/51 , C07C211/46 , C07C211/47 , C07C211/27
摘要： A process for preparing aromatic amines by hydrogenation of nitroaromatics in the presence of catalysts, forming a fluid, amine-comprising reaction mixture in a reactor, wherein chromatographic analysis of the reaction mixture is carried out to determine the concentration of nitro and nitroso compounds in the reaction mixture.
摘要翻译：一种通过在催化剂存在下氢化硝基芳族化合物制备芳族胺的方法，在反应器中形成含流体的含胺反应混合物，其中进行反应混合物的色谱分析以测定硝基和亚硝基化合物的浓度反应混合物。

10. 发明授权

US08212078B2 Diimines and secondary diamines 有权
标题翻译：二亚胺和仲胺
公开(公告)号：US08212078B2
公开(公告)日：2012-07-03
申请号：US11909824
申请日：2005-12-30
申请人： John Y. Lee , Paul L. Wiggins , Judit Orgad , Mahmood Sabahi , Vernon O. Brandt , David W. Owens
发明人： John Y. Lee , Paul L. Wiggins , Judit Orgad , Mahmood Sabahi , Vernon O. Brandt , David W. Owens
IPC分类号： C07C211/00
CPC分类号： C07C211/12 , C07C211/51 , C08G18/10 , C08G18/3234 , C08G18/324 , C08G18/325 , C08G18/5024 , C08G18/6685 , C08G18/7671 , Y02P20/582
摘要： This invention provides aromatic diimines where the diimines have imino groups with at least two carbon atoms, and either are in the form of one benzene ring having two imino groups on the ring, which imino groups are meta or para relative to each other, and in which each position ortho to an imino group bears a hydrocarbyl group, or are in the form of two benzene rings connected by an alkylene bridge and having one imino group on each ring, and in which each position ortho to an imino group bears a hydrocarbyl group. This invention also provides aromatic secondary diamines where the diamines have amino hydrocarbyl groups with at least two carbon atoms, and either are in the form of one benzene ring having two amino groups on the ring, which amino groups are meta or para relative to each other, and in which each position ortho to an amino group bears a hydrocarbyl group, or are in the form of two benzene rings connected by an alkylene bridge and having one amino group on each ring, and in which each position ortho to an amino group bears a hydrocarbyl group. Also provided are processes for forming diimines and secondary diamines from primary diamines, including the aromatic diimines and aromatic secondary diamines of the invention.
摘要翻译：本发明提供芳族二亚胺，其中二亚胺具有至少两个碳原子的亚氨基，并且是环上具有两个亚氨基的一个苯环的形式，该亚氨基相对于彼此是间位或对位的，并且在其中每个位于亚氨基的邻位具有烃基，或者是由亚烷基桥连接并在每个环上具有一个亚氨基的两个苯环的形式，并且其中亚氨基的邻位各有一个烃基。本发明还提供芳族仲二胺，其中二胺具有至少两个碳原子的氨基烃基，并且是环上具有两个氨基的一个苯环的形式，该氨基相对于彼此是间位或对位的并且其中氨基的每个位置具有烃基，或者为两个苯环的形式，其通过亚烷基桥连接并且在每个环上具有一个氨基，并且其中氨基的邻位各自承载烃基。还提供了由伯二胺形成二亚胺和仲二胺的方法，包括本发明的芳族二亚胺和芳族仲二胺。

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