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91. 发明授权

US06738529B1 Analysis of chemical data from images 有权
标题翻译：图像化学数据分析
公开(公告)号：US06738529B1
公开(公告)日：2004-05-18
申请号：US09415772
申请日：1999-10-08
申请人： Thomas Crevier , William B. Archibald , Marc Hornbostel , Dieter Schaefer , Thomas Boussie
发明人： Thomas Crevier , William B. Archibald , Marc Hornbostel , Dieter Schaefer , Thomas Boussie
IPC分类号： G06K936
CPC分类号： G01N35/085 , B01J19/0046 , B01J19/26 , B01J2219/00274 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00317 , B01J2219/00335 , B01J2219/00337 , B01J2219/00344 , B01J2219/00351 , B01J2219/00364 , B01J2219/00378 , B01J2219/0043 , B01J2219/00443 , B01J2219/00452 , B01J2219/00495 , B01J2219/00497 , B01J2219/005 , B01J2219/00511 , B01J2219/00515 , B01J2219/0052 , B01J2219/00527 , B01J2219/00536 , B01J2219/00583 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00691 , B01J2219/00702 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00738 , B01J2219/00745 , B01J2219/00747 , B01J2219/0075 , B01J2219/00754 , B82Y30/00 , C07F15/0066 , C07F15/045 , C40B30/08 , C40B40/14 , C40B40/18 , C40B50/14 , G01J4/00 , G01N15/0205 , G01N21/253 , G01N21/64 , G01N29/036 , G01N29/2425 , G01N29/348 , G01N29/4427 , G01N33/44 , G01N2015/0288 , G01N2015/0294 , G01N2291/106 , Y10T436/112499 , Y10T436/113332 , Y10T436/115831
摘要： Computer programs and computer-implemented methods are disclosed for extracting and analyzing combinatorial chemical data from images. The invention receives a stream of data, identifies a plurality of regions of interest and determines a series of values for one or more regions of interest. The library includes a plurality of members. The data stream includes a series of images of the library. Each region of interest corresponds to a location in each of the images and to a location in the library. The series of values for each region includes a value for each of the images. Particular embodiments have the following features. The invention calculates a figure of merit for a library member from each series of values. The stream of data comprises a series of images generated at a frequency of greater than about 1, 6, 12 or 30 frames per second. The series of images is captured from a beginning of a combinatorial experiment to an end of a commercial experiment. The regions of interest are identified after the series of images has been captured. The images are infrared images. The figure of merit is an emittance change, a phase transition point or a thermoelectric figure of merit for a library member. Regions of interest are identified by a user and have a user-defined shape. The series of values for each region is determined based on a user-defined computation. A graphical representation of the figures of merit is displayed.
摘要翻译：公开了用于从图像中提取和分析组合化学数据的计算机程序和计算机实现的方法。本发明接收数据流，识别多个感兴趣区域并确定一个或多个感兴趣区域的一系列值。图书馆包括多个成员。数据流包括图书馆的一系列图像。每个感兴趣区域对应于每个图像中的位置和库中的位置。每个区域的一系列值包括每个图像的值。具体实施例具有以下特征。本发明根据每一系列值计算库成员的品质因数。数据流包括以大于每秒大约1,6,12或30帧的频率生成的一系列图像。从组合实验的开始到商业实验的结束捕获一系列图像。在捕获一系列图像之后识别感兴趣的区域。图像是红外图像。品质因数是库成员的发射变化，相变点或热电优值。感兴趣区域由用户识别并具有用户定义的形状。基于用户定义的计算来确定每个区域的一系列值。显示品质因数的图形表示。

92. 发明授权

US06690179B2 High throughput mechanical property testing of materials libraries using capacitance 失效
标题翻译：使用电容的材料库的高通量机械性能测试
公开(公告)号：US06690179B2
公开(公告)日：2004-02-10
申请号：US09939263
申请日：2001-08-24
申请人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
发明人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
IPC分类号： G01R2726
CPC分类号： G01N3/10 , B01J2219/00274 , B01J2219/00315 , B01J2219/00364 , B01J2219/00373 , B01J2219/00477 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00653 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00707 , B01J2219/00716 , B01J2219/00722 , B01J2219/00745 , B01J2219/0075 , B01J2219/00754 , B82Y30/00 , C40B40/14 , C40B40/18 , C40B50/14 , C40B60/14 , G01N3/18 , G01N2203/0016 , G01N2203/0252 , G01N2203/0254 , G01N2203/0258 , G01N2203/0617 , G01N2203/0623 , G01N2203/0641
摘要： One aspect of the present invention provides instruments for measuring mechanical properties of a combinatorial library of materials. The instruments include at least one capacitor to which a member of a library of material samples is removably secured for testing; at least one voltage source for delivering one or more forces to each library member; and at least one sensing device for monitoring the response each library member to the one or more forces. Another aspect of the present invention provides methods of screening a combinatorial library of materials where the method monitors the responses of a plurality of samples on a substrate to a force induced by a capacitor.
摘要翻译：本发明的一个方面提供用于测量材料组合库的机械特性的仪器。这些仪器包括至少一个电容器，材料样品库的成员可拆卸地固定到其上进行测试; 至少一个电压源，用于将一个或多个力递送到每个库构件; 以及至少一个感测装置，用于监视每个库成员对一个或多个力的响应。本发明的另一方面提供了筛选材料的组合文库的方法，其中该方法将衬底上的多个样品的响应监测到由电容器引起的力。

93. 发明申请

US20030214611A1 Programmable mask and method for fabricating biomolecule array using the same 审中-公开
标题翻译：可编程掩模和使用其制造生物分子阵列的方法
公开(公告)号：US20030214611A1
公开(公告)日：2003-11-20
申请号：US10246593
申请日：2002-09-18
发明人： Moon Youn Jung , Hae Sik Yang , Chi Hoon Jun , Yun Tae Kim , Young Shin Kim , Dong Ho Shin
IPC分类号： G02F001/13
CPC分类号： B01J19/0046 , B01J2219/00434 , B01J2219/00527 , B01J2219/00529 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B40/06 , C40B60/14 , G02F1/133528 , G02F1/13454 , G02F1/13725 , G02F1/216 , G02F2203/12 , G03F7/70291 , G03F7/7035 , H01L27/146
摘要： A programmable mask used in a photolithography process for fabricating a biomolecule array and a method for fabricating a biomolecule array using the same are disclosed. Particularly, a TFT-LCD type programmable mask for selectively transmitting incident light in accordance with an electrical signal applied thereto and a method for fabricating a biomolecule array using the same are provided. The ultraviolet light is selectively illuminated to a sample substrate so that the biomolecule array having high density can be fabricated.
摘要翻译：公开了用于制造生物分子阵列的光刻工艺中使用的可编程掩模和使用其的生物分子阵列的制造方法。特别地，提供了根据施加到其上的电信号选择性地透射入射光的TFT-LCD型可编程掩模和使用其的制造生物分子阵列的方法。紫外光被选择性地照射到样品基底上，使得可以制造具有高密度的生物分子阵列。

94. 发明授权

US06649404B1 Method for using and making a fiber array 有权
标题翻译：使用和制作光纤阵列的方法
公开(公告)号：US06649404B1
公开(公告)日：2003-11-18
申请号：US09590761
申请日：2000-06-08
申请人： Charles S. Vann , Tim Geiser , Andrew J. Blasband
发明人： Charles S. Vann , Tim Geiser , Andrew J. Blasband
IPC分类号： C12M134
CPC分类号： B01L3/5023 , B01J19/0046 , B01J2219/00326 , B01J2219/0043 , B01J2219/00495 , B01J2219/00515 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00657 , B01J2219/00675 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6816 , C40B40/06 , C40B50/14 , C40B60/14 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N21/7703 , G01N2021/6484 , G01N2021/7786 , Y10T436/143333 , C12Q2565/607
摘要： The invention provides a method for contacting at least two chemical species by immobilizing an immobilized chemical species on a fiber, placing the fiber on a support having a channel, and disposing a mobile chemical species into the channel such that the immobilized chemical species contacts the fiber. The invention also provides methods for analyzing the contact between at least two chemical species, detecting the binding of two chemical species, making a microchip, and synthesizing a chemical species on a fiber.
摘要翻译：本发明提供一种通过将固定的化学物质固定在纤维上来将至少两种化学物质接触的方法，将纤维放置在具有通道的载体上，并将可移动的化学物质置于通道中，使得固定的化学物质与纤维接触。本发明还提供了用于分析至少两种化学物质之间的接触，检测两种化学物质的结合，制造微芯片以及在纤维上合成化学物质的方法。

95. 发明申请

US20030143756A1 Multi-directional deposition in array fabrication 失效
标题翻译：阵列制造中的多向沉积
公开(公告)号：US20030143756A1
公开(公告)日：2003-07-31
申请号：US10066518
申请日：2002-01-30
发明人： William D. Fisher , Peter G. Webb , Svetlana V. Shchegrova , Michael P. Caren
IPC分类号： B05D003/00 , C12Q001/68 , C12M001/34 , G01N033/543
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00378 , B01J2219/00497 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00693 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/0241 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14 , G01N35/109 , G01N2035/1041
摘要： A method, apparatus, and computer program products for fabricating multiple chemical arrays on a substrate, each array having multiple rows of feature locations with arrays of different sets being arranged in a sideways orientation with respect to the rows. The method includes dispensing drops from a drop dispensing head onto the substrate while maintaining a gap between the head and substrate and moving them relative to one another along a path so as to fabricate the arrays. The path for the relative moving includes moving the head in a direction along the rows of a first array set then moving the head in an opposite direction along the rows of a second array set. This pattern is repeated with the second array set of an earlier cycle being the first array set of a later cycle.
摘要翻译：一种用于在衬底上制造多个化学阵列的方法，装置和计算机程序产品，每个阵列具有多行特征位置，其中不同组的阵列相对于行被排列成侧向取向。该方法包括将液滴从液滴分配头分配到基底上，同时保持头部和基底之间的间隙并且沿着路径相对于彼此移动它们以便制造阵列。相对移动的路径包括沿着第一阵列组的行的方向移动头部，然后沿着与第二阵列组的行相反的方向移动头部。重复该模式，其中较早周期的第二阵列集合是稍后循环的第一阵列集。

96. 发明申请

US20030143630A1 Apparatus and method for synthesizing 审中-公开
标题翻译：用于合成的装置和方法
公开(公告)号：US20030143630A1
公开(公告)日：2003-07-31
申请号：US10317178
申请日：2002-12-11
申请人： Selecticide Corporation
发明人： Marcel Patek , Safar Pavel , Martin Smrcina , Eric Wegrzyniak , Peter Strop , Gary A. Flynn , Stephen A. Baum
IPC分类号： G01N033/53 , B32B005/02 , G01N033/543
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/0031 , B01J2219/00313 , B01J2219/00315 , B01J2219/00317 , B01J2219/00319 , B01J2219/00322 , B01J2219/00328 , B01J2219/00459 , B01J2219/00461 , B01J2219/00468 , B01J2219/00472 , B01J2219/00475 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/00522 , B01J2219/00527 , B01J2219/00565 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00659 , B01J2219/00664 , B01J2219/00668 , B01J2219/00675 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/0819 , B01L2300/0829 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , C40B70/00 , G01N33/543 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： An apparatus and method for synthesizing a combinatorial library comprising a plurality of chemical compounds such that the chemical composition of each compound is easily tracked. The library compounds are synthesized on solid-phase supports, which are spatially arranged in frames during synthesis according to a predetermined protocol, such that each solid-phase support passes through a series of unique spatial 2D or 3D addresses by which the chemical composition of each compound may be determined at any point during synthesis. Solid-phase supports include hollow tubular-shaped lanterns and gears.
摘要翻译：一种用于合成包含多种化学化合物的组合文库的装置和方法，使得容易追踪每种化合物的化学组成。文库化合物在固相载体上合成，根据预定的方案在合成过程中在空间上排列成帧，使得每个固相载体通过一系列独特的空间2D或3D地址，通过这些独特的空间2D或3D地址，化合物可以在合成过程中的任何时间点确定。固相支架包括中空的管状灯笼和齿轮。

97. 发明申请

US20030143132A1 Reduced length kaleidoscopic light homogenizer 失效
标题翻译：减速千分尺光均化器
公开(公告)号：US20030143132A1
公开(公告)日：2003-07-31
申请号：US10277530
申请日：2002-10-21
发明人： Francesco Cerrina , Wei Huang
IPC分类号： B01J019/08
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/00353 , B01J2219/00439 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00675 , B01J2219/00689 , B01J2219/00693 , B01J2219/00711 , B01J2219/00722 , C07B2200/11 , C40B40/06 , C40B50/14 , C40B60/14
摘要： The present invention provides an apparatus for constructing arrays of DNA sequences using the image of a micromirror array projected on a reaction site using a highly uniform beam of light produced by a homogenizer formed of a prismatic refractive element followed by a kaleidoscopic element.
摘要翻译：本发明提供了使用由棱镜折射元件后面是万花筒形元件形成的均质器产生的高度均匀的光束，使用投影在反应位置上的微镜阵列的图像来构造DNA序列的装置。

98. 发明申请

US20030118717A1 Fluid exit in reaction chambers 失效
标题翻译：反应室中的流体出口
公开(公告)号：US20030118717A1
公开(公告)日：2003-06-26
申请号：US10035789
申请日：2001-12-24
发明人： Bill J. Peck
IPC分类号： B32B027/12 , B05D003/00 , B32B005/02
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/00337 , B01J2219/0036 , B01J2219/00378 , B01J2219/00389 , B01J2219/00477 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/5027 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： Apparatus and methods are disclosed for controlling flow of fluid inside a chamber. A device comprises a chamber comprising at least one wall, a first opening for introducing a fluid into the interior of the chamber, and a second opening opposite the first opening. The at least one wall of the chamber is designed to provide a contracting section, a section having substantially constant cross-sectional area and a diffusing section through the chamber from the first opening to the second opening. The device may be employed as a gas outlet in a reaction chamber for conducting reactions where it is desired to control the internal atmosphere of the reaction chamber. The apparatus may be employed in the manufacture of biopolymers on the surface of a support such as an array of biopolymer features on the support. Also disclosed is a holding element for a support wherein the holding element is a low drag body.
摘要翻译：公开了用于控制腔室内的流体流动的装置和方法。一种装置包括：室，包括至少一个壁，用于将流体引入室的内部的第一开口和与第一开口相对的第二开口。腔室的至少一个壁被设计成提供收缩部分，具有基本上恒定的横截面面积的部分和通过从第一开口到第二开口的腔室的扩散部分。该装置可以用作反应室中的气体出口，用于在需要控制反应室内部气氛的地方进行反应。该装置可以用于在载体的表面上制造生物聚合物，例如载体上生物聚合物特征的阵列。还公开了用于支撑件的保持元件，其中保持元件是低阻力体。

99. 发明申请

US20030104486A1 Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs 审中-公开
标题翻译：用光学生物仪器检测和定量淋巴细胞的方法和装置
公开(公告)号：US20030104486A1
公开(公告)日：2003-06-05
申请号：US09988728
申请日：2001-11-20
发明人： Gowri Pyapali Selvan
IPC分类号： G01N033/53 , G01N033/567 , G06F019/00 , G01N033/48 , G01N033/50
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/00702 , B01J2219/00707 , B01J2219/00722 , B01L3/5025 , B01L3/5027 , B01L3/502761 , B01L2300/0636 , B01L2300/0806 , B01L2300/168 , B01L2400/0409 , C40B40/06 , C40B50/14 , C40B60/14 , G01N15/1475 , G01N21/07 , G01N33/54306 , G01N33/54353 , G01N33/54386 , G01N33/56972 , G01N35/00069 , G01N2015/1486
摘要： A clinical diagnostic assay is performed on an optical bio disc and is read with a disc drive. A method for determining the quantity of a specific type of blood cell in a biological sample includes binding an antibody to a capture zone on the disc, providing a sample to the capture zone, remove portions of the sample that are not bound in the capture zone, and counting bound cells.
摘要翻译：在光学生物盘上进行临床诊断测定，并用盘驱动器读取。用于确定生物样品中特定类型的血细胞的量的方法包括将抗体结合到盘上的捕获区，向捕获区提供样品，除去未结合在捕获区中的样品部分，并计数结合的细胞。

100. 发明申请

US20030068644A1 THREE-DIMENSIONAL ARRAY OF SUPPORTS FOR SOLID-PHASE PARALLEL SYNTHESIS AND METHOD OF USE 失效
标题翻译：用于固相平行合成的三维阵列支持和使用方法
公开(公告)号：US20030068644A1
公开(公告)日：2003-04-10
申请号：US09082038
申请日：1998-05-20
发明人： STEPHEN A. BAUM
IPC分类号： G01N033/53 , C12M001/22 , C12M003/00 , G01N033/543
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/0031 , B01J2219/00317 , B01J2219/00319 , B01J2219/00322 , B01J2219/00461 , B01J2219/00468 , B01J2219/00475 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/00522 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00668 , B01J2219/00675 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/0819 , B01L2300/0829 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/543
摘要： A three-dimensional (3D) array of solid-phase supports is adapted to provide parallel synthesis of a library of molecules with 3D diversity. Individual locations in the 3D array may be assigned to selected molecules in the library such that molecules may be synthesized at and retrieved from such locations. Also, the supports include aperture walls in stacked plates; the supports may be suspended within stacked plate apertures; the 3D array include discrete supports arranged in columns in one or more wells; the supports include tube inner walls or be suspended in tubes, the tubes being secured in stacked, two-dimensional (2D) frameworks; or the supports include beads contained in porous enclosures having non-porous side walls and being secured in stacked, 2D frameworks. A support transfer device enables transfer of solid-phase supports used in a 3D array. Such apparatus includes: a rack of rods sized to be inserted through supports and a mechanism to prevent supports from coming off the rack; tubes connected to a vacuum manifold to suction supports one Z plane at a time; or a transfer block having recesses to receive one or more support and at least one gate withholding supports from passing through the gate when in a closed position. A method of 3D synthesis includes: a) functionalizing solid-phase supports; b) placing supports in a 3D array; and c) performing parallel synthesis with 3D diversity. At least one unique R1 group member may be assigned to each Z plane.
摘要翻译：三维（3D）固相支架阵列适用于提供具有3D多样性的分子库的并行合成。 3D阵列中的各个位置可以分配给文库中的选定分子，使得分子可以在这些位置合成并从这些位置检索。此外，支撑件包括堆叠板中的孔壁; 支撑件可以悬挂在堆叠的板孔内; 3D阵列包括以一个或多个孔中的列布置的离散支撑件; 支撑件包括管内壁或悬挂在管中，管被固定在堆叠的二维（2D）框架中; 或者支撑体包括包含在具有无孔侧壁并且被固定在堆叠的2D框架中的多孔封壳中的珠子。支撑转移装置能够传送在3D阵列中使用的固相支撑。这种装置包括：尺寸适于插入通过支撑件的杆状杆状物和防止支架从架子上脱落的机构; 连接到真空歧管以抽吸的管一次支撑一个Z平面; 或具有用于接收一个或多个支撑件的凹部的传递块和当处于关闭位置时至少一个闸门预扣支撑件不经过闸门。一种3D合成方法包括：a）将固相载体官能化; b）将支撑放置在3D阵列中; 和c）使用3D分集进行并行合成。可以将至少一个唯一的R1组成员分配给每个Z平面。

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