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1. 发明申请

US20180250649A1 RADIOPHARMACEUTICAL LABELING DEVICE 审中-公开
公开(公告)号：US20180250649A1
公开(公告)日：2018-09-06
申请号：US15909000
申请日：2018-03-01
申请人： David ALEXOFF , Dohyun KIM , Hank KUNG
发明人： David ALEXOFF , Dohyun KIM , Hank KUNG
IPC分类号： B01J19/00 , G16H40/40
CPC分类号： B01J19/0006 , A61K51/0489 , A61K51/0497 , B01J19/004 , B01J19/0046 , B01J2219/00353 , B01J2219/00412 , B01J2219/00418 , B01J2219/0072 , C07B59/00 , G16H30/20 , G16H40/40 , G16H40/63 , G21G1/0005
摘要： An automated apparatus and method for producing a 68Ga radiopharmaceutical is provided. The apparatus can direct fluid flow through a radiopharmaceutical generator, a vessel in a temperature controlled reactor, and a solid phase extraction cartridge to produce a final radiopharmaceutical product without human intervention under a clean environment.

2. 发明授权

US09850460B2 Reactor system 有权
公开(公告)号：US09850460B2
公开(公告)日：2017-12-26
申请号：US14909141
申请日：2014-07-30
申请人： Anaero Technology Ltd
发明人： Ray Middleton , Edgar Blanco , Robin Proctor
IPC分类号： B01J4/00 , B01J19/00 , B01J19/18 , F04B9/00 , F04B9/02 , F04B23/00 , F04B23/04 , F04B23/06 , C12M1/00 , B01J19/24 , B01J4/02 , C12M1/107 , C12M1/02
CPC分类号： C12M29/00 , B01J4/007 , B01J4/02 , B01J19/0046 , B01J19/1856 , B01J19/24 , B01J19/2445 , B01J2219/00011 , B01J2219/00058 , B01J2219/00069 , B01J2219/00094 , B01J2219/00164 , B01J2219/00166 , B01J2219/00186 , B01J2219/00353 , B01J2219/00376 , B01J2219/24 , C12M21/04 , C12M23/36 , C12M27/00 , C12M41/18 , F04B9/02 , F04B23/06
摘要： An apparatus is described which includes at least one reactor, at least one linear piston pump, the or each piston pump including a tube, a piston and an arm coupled to the piston, the or each piston pump arranged to inject feedstock to a respective reactor, a beam or plate coupled to the arm(s) of the piston pump(s) configured to linearly drive the piston(s) and a linear actuator for driving the beam or plate. The piston pump has a volume of at least 50 milliliters and an output port having a diameter of at least 5 mm.

3. 发明申请

US20170354946A1 METHODS OF EVOLUTIONARY SYNTHESIS INCLUDING EMBODIED CHEMICAL SYNTHESES 有权
公开(公告)号：US20170354946A1
公开(公告)日：2017-12-14
申请号：US15669080
申请日：2017-08-04
申请人： The University Court of the University of Glasgow
发明人： Leroy CRONIN
IPC分类号： B01J19/00 , C40B50/04 , C40B60/08
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00353 , B01J2219/00479 , B01J2219/00495 , B01J2219/0059 , B01J2219/00599 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/007 , B01J2219/00702 , B01J2219/00704 , B01J2219/00738 , B01J2219/00747 , B01J2219/00756 , C40B50/04 , C40B60/08
摘要： The invention provides a method for preparing a compound or a product having one or more characteristics that meet or exceed a user specification, the process comprising the step of selecting a first combination of chemical inputs, optionally together with physical inputs, and supplying those inputs to a reaction space, thereby to generate a first product; analysing one or more characteristics of the product generated; comparing the one or more characteristics against a user specification; using a genetic algorithm selecting a second combination of chemical inputs, optionally together with physical inputs, wherein the second combination differs from the first combination, and supplying those inputs to the reaction space, thereby to generate a second product; analysing one or more characteristics of the second product generated; comparing the one or more characteristics generated against the user specification; repeating the selecting and analysing steps for further individual combinations of chemical and/or physical inputs, to provide an array of products wherein the flow chemistry system operates continuously to provide the first, second and further products, thereby to identify one or more products meeting or exceeding the user specification.

4. 发明申请

US20160194697A1 Apparatus, System, And Method Using Immiscible-Fluid-Discrete-Volumes 审中-公开
标题翻译：装置，系统和使用不混溶流体离散体的方法
公开(公告)号：US20160194697A1
公开(公告)日：2016-07-07
申请号：US14925656
申请日：2015-10-28
申请人： APPLIED BIOSYSTEMS, LLC
发明人： Linda G. Lee , Sam L. Woo , Congcong Ma , Richard T. Reel , Mark F. Oldham , David M. Cox , Benjamin G. Schroeder , Jon M. Sorenson , Willy Wiyatno
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575 , C12Q2535/101
摘要： Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
摘要翻译：本发明的各种实施方案涉及生物化学或分子生物学程序中用于样品制备或分析的系统或方法。样品制备可以涉及在离散部分或段或块中的小体积处理，在本文中称为离散体积。分子生物学程序可以是核酸分析。核酸分析可以是一个综合的DNA扩增/ DNA测序程序。

5. 发明申请

US20150298088A1 DEVICES AND SYSTEMS FOR CREATION OF DNA CLUSTER ARRAYS 有权
标题翻译：用于创建DNA集群阵列的设备和系统
公开(公告)号：US20150298088A1
公开(公告)日：2015-10-22
申请号：US14551232
申请日：2014-11-24
申请人： ILLUNINA, INC.
发明人： MARK T. REED , ANDREA SABOT
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00333 , B01J2219/00353 , B01J2219/00355 , B01J2219/00391 , B01J2219/00418 , B01J2219/00495 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00722 , C12Q1/6837 , C12Q2565/543 , C12Q2565/629
摘要： The present invention comprises systems and devices for isothermal amplification of polynucleotide sequences to produce DNA cluster arrays.
摘要翻译：本发明包括用于等位扩增多核苷酸序列以产生DNA簇阵列的系统和装置。

6. 发明申请

US20150246336A1 METHOD OF IN SITU SYNTHESIZING MICROARRAYS 审中-公开
标题翻译：微波合成的方法
公开(公告)号：US20150246336A1
公开(公告)日：2015-09-03
申请号：US14431222
申请日：2013-10-22
申请人： UNIVERSITÄT WIEN
发明人： Mark Somoza , Veronika Somoza
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00286 , B01J2219/00353 , B01J2219/00418 , B01J2219/00439 , B01J2219/00533 , B01J2219/00585 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C40B50/14
摘要： The invention provides a method of step-wise synthesizing copies of polymers of potentially different units on at least two solid carrier surfaces simultaneously in a preselected pattern, comprising providing a layered synthesis arrangement comprising a transparent first solid carrier and a second solid carrier, wherein said first and second carrier each contain an active surface to which polymer units can be applied dependent on reactions of photosensitive moieties, projecting light in a preselected pattern onto the first and second carrier surface, wherein the light passes through the transparent first solid carrier, whereby photons react with photosensitive moieties thereby activating the first surface, said pass-through light further projects onto the second carrier surface, whereby photons react with photosensitive moieties thereby activating the second surface, applying a fluid comprising a polymer unit to the first and second active surfaces and binding the polymer unit to the exposed sites of said pattern, repeating projecting and binding steps with optionally different patterns and/or polymer units, thereby synthesising polymers on said carrier surfaces; as well as means for performing said method.
摘要翻译：本发明提供了一种在预选图案中同时以至少两个固体载体表面逐步合成潜在不同单元的聚合物的方法的方法，包括提供包含透明的第一固体载体和第二固体载体的分层合成布置，其中所述第一和第二载体各自含有活性表面，根据感光部分的反应可以将聚合物单元施加到其上，以预选图案将光投射到第一和第二载体表面上，其中光通过透明的第一固体载体，由此光子与感光部分反应，从而激活第一表面，所述穿透光进一步突出到第二载体表面上，由此光子与感光部分反应，从而激活第二表面，将包含聚合物单元的流体施加到第一和第二活性表面，将聚合物单元结合到e 所述图案的裸露位置，重复突出和结合步骤，具有任选不同的图案和/或聚合物单元，从而在所述载体表面上合成聚合物; 以及用于执行所述方法的装置。

7. 发明授权

US09108177B2 Microfluidic droplet queuing network 有权
标题翻译：微流控液滴排队网络
公开(公告)号：US09108177B2
公开(公告)日：2015-08-18
申请号：US14057301
申请日：2013-10-18
申请人： STOKES BIO LIMITED
发明人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
IPC分类号： C12M1/34 , B01J19/00 , B01F13/00 , B01F15/02 , B01L3/00
CPC分类号： B01J19/0046 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01J2219/00313 , B01J2219/00353 , B01J2219/00479 , B01J2219/00587 , B01J2219/00608 , B01L3/5025 , B01L3/502784 , B01L2200/0673 , B01L2300/0829 , B01L2400/0487 , Y10T436/25
摘要： A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.
摘要翻译：多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。室（3）连接四个端口，在使用时永久充满油（11）。油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。这些阶段是密度匹配的，以创造引力几乎可忽略的环境。这导致当从毛细管尖端悬浮时，液滴（10）采用球形。此外，质量流量的相等性等于体积流量的相等。入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

8. 发明申请

US20150133306A1 METHODS OF EVOLUTIONARY SYNTHESIS INCLUDING EMBODIED CHEMICAL SYNTHESES 有权
标题翻译：包括化学合成的演化合成方法
公开(公告)号：US20150133306A1
公开(公告)日：2015-05-14
申请号：US14402943
申请日：2013-05-24
申请人： The University Court of the University of Glasgow
发明人： Leroy Cronin
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00286 , B01J2219/00353 , B01J2219/00479 , B01J2219/00495 , B01J2219/0059 , B01J2219/00599 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/007 , B01J2219/00702 , B01J2219/00704 , B01J2219/00738 , B01J2219/00747 , B01J2219/00756 , C40B50/04 , C40B60/08
摘要： The invention provides a method for preparing a compound or a product having one or more characteristics that meet or exceed a user specification, the process comprising the step of selecting a first combination of chemical inputs, optionally together with physical inputs, and supplying those inputs to a reaction space, thereby to generate a first product; analysing one or more characteristics of the product generated; comparing the one or more characteristics against a user specification; using a genetic algorithm selecting a second combination of chemical inputs, optionally together with physical inputs, wherein the second combination differs from the first combination, and supplying those inputs to the reaction space, thereby to generate a second product; analysing one or more characteristics of the second product generated; comparing the one or more characteristics generated against the user specification; repeating the selecting and analysing steps for further individual combinations of chemical and/or physical inputs, to provide an array of products wherein the flow chemistry system operates continuously to provide the first, second and further products, thereby to identify one or more products meeting or exceeding the user specification.
摘要翻译：本发明提供了一种制备具有满足或超过用户规格的一种或多种特性的化合物或产品的方法，该方法包括选择化学输入的第一组合，可选地与物理输入一起并将这些输入提供给反应空间，从而产生第一产物; 分析产生的产品的一个或多个特征; 将一个或多个特征与用户规范进行比较; 使用选择化学输入的第二组合的可选的物理输入的遗传算法，其中所述第二组合与所述第一组合不同，并且将所述输入提供给所述反应空间，从而产生第二乘积; 分析产生的第二产品的一个或多个特性; 比较生成的一个或多个特征与用户规范; 重复选择和分析步骤以用于进一步的化学和/或物理输入的单独组合，以提供产品阵列，其中流化学系统连续操作以提供第一，第二和其他产品，由此识别一个或多个产品会议或超过用户规格。

9. 发明授权

US08969257B1 Combinatorial flow system and method 有权
标题翻译：组合流系统和方法
公开(公告)号：US08969257B1
公开(公告)日：2015-03-03
申请号：US12074882
申请日：2008-03-06
申请人： Zachary Fresco , Rich Endo
发明人： Zachary Fresco , Rich Endo
IPC分类号： C40B50/14
CPC分类号： B01J19/0053 , B01J2219/00353 , B01J2219/00418 , B01J2219/00495 , H01L21/67023 , H01L21/67051 , H01L21/6708
摘要： A reactor assembly having a plurality of reaction chambers defined therein is provided. The reactor assembly includes a fluid flow module that provides a pressurized control flow of fluid from an open container. In another embodiment, the reactor block includes a plurality of passageways defined over a surface of a substrate to accommodate the combinatorial processing in order to obtain multiple data points from a single substrate.
摘要翻译：提供了一种其中限定有多个反应室的反应器组件。反应器组件包括流体流动模块，其提供来自开放容器的流体的加压控制流。在另一个实施例中，反应器块包括限定在衬底的表面上的多个通道，以适应组合处理，以便从单个衬底获得多个数据点。

10. 发明授权

US07993911B2 Microfluidic droplet queuing network 有权
标题翻译：微流控液滴排队网络
公开(公告)号：US07993911B2
公开(公告)日：2011-08-09
申请号：US12097455
申请日：2007-02-07
申请人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
发明人： Mark Davies , Tara Dalton , Julie Garvey , Kieran Curran , Damian Curtin
IPC分类号： C12M1/34
CPC分类号： B01J19/0046 , B01F13/0071 , B01F15/0201 , B01F15/0232 , B01J2219/00313 , B01J2219/00353 , B01J2219/00479 , B01J2219/00587 , B01J2219/00608 , B01L3/5025 , B01L3/502784 , B01L2200/0673 , B01L2300/0829 , B01L2400/0487 , Y10T436/25
摘要： A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.
摘要翻译：多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。室（3）连接四个端口，在使用时永久充满油（11）。油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。这些阶段是密度匹配的，以创造引力几乎可忽略的环境。这导致当从毛细管尖端悬浮时，液滴（10）采用球形。此外，质量流量的相等性等于体积流量的相等。入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

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