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    • 5. 发明申请
    • Method and device for coating pharmaceutical products
    • 制药产品涂敷方法及装置
    • US20040247776A1
    • 2004-12-09
    • US10483139
    • 2004-07-21
    • Staffan FolestadIngela Niklasson BjornDaniel Strom
    • B05D003/00
    • B05B17/0607A61K9/2893B01J2/006B01J2/16B05B7/0012
    • The present invention relates to a method for coating of a pharmaceutical product. The method comprises the step of producing discrete droplets (7) of controlled size, shape and composition with at least one micro dispenser (1) and distributing droplets (7) with controlled velocity, time of flight. Also, the method comprises the step of controlling the production frequency and modulation of the droplets (7). Further, the method comprises the step of controlling the flow rate, temperature and composition of the carrier gas and directing droplets (7) towards particles (10) subjected to coating. The present invention also relates to a device for coating of a pharmaceutical product. The device comprises a droplet producing unit (1) and a droplet-directing unit (8). The droplet producing unit (1) is a piezo-actuated micro dispenser (1) for producing discrete droplets (7) and controlling the size, shape and composition of said droplets (7).
    • 本发明涉及药物包衣的方法。 该方法包括用至少一个微分配器(1)产生具有受控尺寸,形状和组成的离散液滴(7)的步骤,并以受控的速度,飞行时间分布液滴(7)。 此外,该方法包括控制液滴的生产频率和调制的步骤(7)。 此外,该方法包括控制载气的流速,温度和组成并将液滴(7)引向经受涂覆的颗粒(10)的步骤。 本发明还涉及一种用于涂覆药物的装置。 该装置包括液滴产生单元(1)和液滴引导单元(8)。 液滴产生单元(1)是用于产生离散液滴(7)并控制所述液滴(7)的尺寸,形状和组成的压电致动微型分配器(1)。
    • 7. 发明申请
    • Immobilization method and kit therefor
    • 固定方法和试剂盒
    • US20040241724A1
    • 2004-12-02
    • US10806028
    • 2004-03-22
    • Biacore AB
    • Robert KarlssonAnders Sjodin
    • C12Q001/68C12M001/34B05D003/00
    • G01N33/5432G01N33/548
    • A method of immobilizing a target molecule to a solid support surface capable of interacting with the target molecule is disclosed. The method comprises the steps of complexing the target molecule with a vesicular structure capable of forming a dissociable complex with the target molecule, contacting the complex formed with the solid support surface to thereby bind the target molecule to the surface, dissociating the complex, and removing the vesicular structure from the solid support surface to leave the target molecule immobilized on the surface. A method of sensitizing a solid support surface, the use of the sensitized solid support surface for analyzing analytes, and a reagent kit for carrying out the method are also disclosed.
    • 公开了将目标分子固定在能够与靶分子相互作用的固体支持体表面上的方法。 该方法包括以下步骤:使目标分子与能够与靶分子形成可离解复合物的囊泡结构相接触,使与固体支持物表面形成的复合物接触,从而将靶分子结合到表面,解离复合物,并除去 来自固体支持体表面的水泡结构,使靶分子固定在表面上。 还公开了使固体支持体表面敏化的方法,使用敏化固体支持体表面分析分析物,以及用于实施该方法的试剂盒。
    • 10. 发明申请
    • Method and composition for controlling galling
    • 控制磨损的方法和组成
    • US20040224857A1
    • 2004-11-11
    • US10805400
    • 2004-03-19
    • Hendrik John
    • C10M125/00A61L002/00B05D003/00
    • F16L15/001C08K3/16C09D5/033C09D5/448C09D7/61E21B17/042F16L58/182
    • A method for controlling galling including applying a composition of about 3.5 to about 36 wt %, based upon the total weight of the composition of a fluoridic or oxidic compound of a transition of alkaline earth metal; about 4 to about 96.5 wt %, based upon the total weight of the composition, of an adherent and about 0 to about 65 wt %, based upon the total weight of the composition, of a solvent contact area of a member. An antigalling coating composition having about 3.5 to about 36 wt %, based upon the total weight of the composition, of a fluoridic or oxidic compound of a transition or alkaline earth metal; about 4 to about 96.5 wt %, based upon the total weight of the composition, of an adherent and about 0 to about 65 wt %, based upon the total weight of the composition, of a solvent.
    • 用于控制磨损的方法,包括施用约3.5至约36重量%的组合物,基于组合物的总重量,碱土金属的过渡的氟化物或氧化化合物; 基于组合物的总重量,约4至约96.5重量%的粘合剂和约0至约65重量%,基于组合物的总重量,构件的溶剂接触面积。 基于组合物的总重量,具有约3.5至约36重量%的抗过氧化涂料组合物的过渡金属或碱土金属的氟化物或氧化化合物; 基于组合物的总重量,约4至约96.5重量%的粘合剂和约0至约65重量%,基于组合物的总重量,溶剂。