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1. 发明授权

US06772642B2 High throughput mechanical property and bulge testing of materials libraries 失效
标题翻译：材料库的高通量机械性能和凸起试验
公开(公告)号：US06772642B2
公开(公告)日：2004-08-10
申请号：US09939404
申请日：2001-08-24
申请人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
发明人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
IPC分类号： G01N308
CPC分类号： G01N3/18 , B01J2219/00274 , G01N3/10 , G01N2203/0016 , G01N2203/0051 , G01N2203/0252 , G01N2203/0254 , G01N2203/0258 , G01N2203/0617 , G01N2203/0623 , G01N2203/0641
摘要： A method for high throughput mechanical property and bulge testing of materials libraries. A plurality of samples on a substrate are monitored for their response to a force from a fluid.
摘要翻译：一种材料库高通量机械性能和凸起试验方法。监测基板上的多个样品对来自流体的力的响应。

2. 发明授权

US06690179B2 High throughput mechanical property testing of materials libraries using capacitance 失效
标题翻译：使用电容的材料库的高通量机械性能测试
公开(公告)号：US06690179B2
公开(公告)日：2004-02-10
申请号：US09939263
申请日：2001-08-24
申请人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
发明人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
IPC分类号： G01R2726
CPC分类号： G01N3/10 , B01J2219/00274 , B01J2219/00315 , B01J2219/00364 , B01J2219/00373 , B01J2219/00477 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00653 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00707 , B01J2219/00716 , B01J2219/00722 , B01J2219/00745 , B01J2219/0075 , B01J2219/00754 , B82Y30/00 , C40B40/14 , C40B40/18 , C40B50/14 , C40B60/14 , G01N3/18 , G01N2203/0016 , G01N2203/0252 , G01N2203/0254 , G01N2203/0258 , G01N2203/0617 , G01N2203/0623 , G01N2203/0641
摘要： One aspect of the present invention provides instruments for measuring mechanical properties of a combinatorial library of materials. The instruments include at least one capacitor to which a member of a library of material samples is removably secured for testing; at least one voltage source for delivering one or more forces to each library member; and at least one sensing device for monitoring the response each library member to the one or more forces. Another aspect of the present invention provides methods of screening a combinatorial library of materials where the method monitors the responses of a plurality of samples on a substrate to a force induced by a capacitor.
摘要翻译：本发明的一个方面提供用于测量材料组合库的机械特性的仪器。这些仪器包括至少一个电容器，材料样品库的成员可拆卸地固定到其上进行测试; 至少一个电压源，用于将一个或多个力递送到每个库构件; 以及至少一个感测装置，用于监视每个库成员对一个或多个力的响应。本发明的另一方面提供了筛选材料的组合文库的方法，其中该方法将衬底上的多个样品的响应监测到由电容器引起的力。

3. 发明授权

US06650102B2 High throughput mechanical property testing of materials libraries using a piezoelectric 失效
标题翻译：使用压电材料库的高通量力学性能测试
公开(公告)号：US06650102B2
公开(公告)日：2003-11-18
申请号：US09938994
申请日：2001-08-24
申请人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
发明人： Damian A. Hajduk , Eric D. Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
IPC分类号： G01N2700
CPC分类号： B01J19/0046 , B01J2219/00315 , B01J2219/00364 , B01J2219/00369 , B01J2219/00376 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00659 , B01J2219/00677 , B01J2219/00689 , B01J2219/00691 , B01J2219/00698 , B01J2219/00704 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/00756 , G01N3/10 , G01N3/18 , G01N2203/0016 , G01N2203/0051 , G01N2203/0252 , G01N2203/0254 , G01N2203/0258 , G01N2203/0617 , G01N2203/0623 , G01N2203/0641
摘要： The present invention provides instruments and methods for screening combinatorial libraries that addresses many of the problems encountered when using conventional instruments. For example, the disclosed instruments can measure mechanical properties of library members in rapid serial or parallel test format, and can perform tests on small amounts of material, which are easily prepared or dispensed using art-disclosed liquid or solid handling techniques. Compared to conventional instruments, the disclosed instruments afford faster sample loading and unloading, for example, through the use of disposable libraries of material samples.
摘要翻译：本发明提供了用于筛选组合文库的仪器和方法，其解决了使用常规仪器时遇到的许多问题。例如，所公开的仪器可以以快速的串联或并行测试形式测量文库成员的机械性能，并且可以使用本领域公开的液体或固体处理技术容易地制备或分配的少量材料进行测试。与常规仪器相比，所公开的仪器例如通过使用材料样品的一次性库来提供更快的样品加载和卸载。

4. 发明授权

US06936471B2 Instrument for high throughput measurement of material physical properties and method of using same 失效
标题翻译：用于材料物理性能高通量测量的仪器及其使用方法
公开(公告)号：US06936471B2
公开(公告)日：2005-08-30
申请号：US09779149
申请日：2001-02-08
申请人： Damian Hajduk , Eric Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
发明人： Damian Hajduk , Eric Carlson , J. Christopher Freitag , Oleg Kolosov , James R. Engstrom , Adam Safir , Ravi Srinivasan , Leonid Matsiev
IPC分类号： G01N11/00 , B01L3/00 , G01N1/28 , G01N3/02 , G01N3/08 , G01N3/20 , G01N3/32 , G01N5/00 , G01N19/00 , G01N29/02 , G01N29/22 , G01N37/00 , G01N31/00 , G01N3/00
CPC分类号： B01L3/5085 , B01J2219/00707 , B01J2219/00718 , G01N5/00 , G01N11/00 , G01N19/00 , G01N29/02 , G01N29/222 , G01N2203/0286 , G01N2291/02466 , G01N2291/0255 , G01N2291/02818 , G01N2291/106 , Y10T436/12
摘要： An apparatus and method for screening combinatorial libraries of materials by measuring the response of individual library members to mechanical perturbations is described. The apparatus generally includes a sample holder for containing the library members, an array of probes for mechanically perturbing individual library members, and an array of sensors for measuring the response of each of the library members to the mechanical perturbations. Library members undergoing screening make up a sample array, and individual library members constitute elements of the sample array that are confined to specific locations on the sample holder. During screening, the apparatus mechanically perturbs individual library members by displacing the sample array (sample holder) and the array of probes. Typically, all of the elements of the sample array are perturbed simultaneously, but the apparatus also can also perturb individual or groups of sample array elements sequentially. The flexible apparatus and method can screen libraries of materials based on many different bulk physical properties, including Young's modulus (flexure, uniaxial extension, biaxial compression, and shear); hardness (indentation), failure (stress and strain at failure, toughness), adhesion (tack, loop tack), and flow (viscosity, melt flow indexing, and rheology), among others.
摘要翻译：描述了通过测量单个文库成员对机械扰动的响应来筛选材料组合文库的装置和方法。该装置通常包括用于容纳库构件的样本保持器，用于机械扰乱各个库构件的探针阵列，以及用于测量每个库构件对机械扰动的响应的传感器阵列。正在进行筛选的图书馆成员组成一个样本数组，单独的图书馆成员构成了样本数组的元素，它们限于样本持有者的特定位置。在筛选期间，设备通过移位样品阵列（样品架）和探针阵列来机械地干扰各个库成员。通常，样本阵列的所有元素都被同时扰动，但是该装置也可以顺序扰乱单个或组的样本阵列元素。灵活的装置和方法可以基于许多不同的体积物理性质（包括杨氏模量（挠曲，单轴延伸，双轴压缩和剪切））筛选材料库; 硬度（压痕），破坏（破坏时的应力和应变，韧性），粘附性（粘性，环粘性）和流动性（粘度，熔体流动指数和流变学）等。

5. 发明授权

US06701774B2 Parallel gas chromatograph with microdetector array 失效
公开(公告)号：US06701774B2
公开(公告)日：2004-03-09
申请号：US09801430
申请日：2001-03-07
申请人： Ravi Srinivasan , Daniel Meron Pinkas , Shenheng Guan , Michael Myslovaty , Michael Spitkovsky , James R. Engstrom , H. Sam Bergh
发明人： Ravi Srinivasan , Daniel Meron Pinkas , Shenheng Guan , Michael Myslovaty , Michael Spitkovsky , James R. Engstrom , H. Sam Bergh
IPC分类号： G01N3004
CPC分类号： G01N30/18 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00704 , G01N30/466 , G01N30/6004 , G01N30/6095 , G01N30/66 , G01N30/8631 , G01N2030/185 , G01N2030/208 , G01N2030/3084 , G01N2030/8881
摘要： Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.

6. 发明授权

US07281408B2 Parallel gas chromatograph with microdetector array 失效
标题翻译：具有微量检测器阵列的平行气相色谱仪
公开(公告)号：US07281408B2
公开(公告)日：2007-10-16
申请号：US10718196
申请日：2003-11-20
申请人： Ravi Srinivasan , Daniel M. Pinkas , Shenheng Guan , Michael Myslovaty , Mikhail Spitkovsy , James R. Engstrom , H. Sam Bergh
发明人： Ravi Srinivasan , Daniel M. Pinkas , Shenheng Guan , Michael Myslovaty , Mikhail Spitkovsy , James R. Engstrom , H. Sam Bergh
IPC分类号： G01N30/04
CPC分类号： G01N30/18 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00704 , G01N30/466 , G01N30/6004 , G01N30/6095 , G01N30/66 , G01N30/8631 , G01N2030/185 , G01N2030/208 , G01N2030/3084 , G01N2030/8881
摘要： Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.
摘要翻译：本发明的气相色谱通常包含四个或更多个分析通道。具体地说，四个或更多个气相色谱柱被配置用于并行分析四种或更多种气态样品，其中使用包含四个或更多微量检测器的微量检测器阵列进行检测。在一个实施例中，四个或更多个微检测器510是微制造的检测器，并且与基板或与安装在基板上的一个或多个微芯片体整体形成。在优选实施例中，微检测器阵列包括具有一个或多个薄膜检测丝的四个或更多个热导检测器。还公开了用于高度平行的气相色谱仪的优选的加热环境。

7. 发明申请

US20050166667A1 Rheometer for rapidly measuring small quantity samples 失效
标题翻译：用于快速测量小批量样品的流变仪
公开(公告)号：US20050166667A1
公开(公告)日：2005-08-04
申请号：US11090755
申请日：2005-03-25
申请人： Damian Hajduk , Eric Carlson , Ravi Srinivasan
发明人： Damian Hajduk , Eric Carlson , Ravi Srinivasan
IPC分类号： G01N19/00 , G01L1/16 , G01L1/24 , G01N3/02 , G01N3/24 , G01N11/14 , G01N11/16
CPC分类号： G01N3/24 , G01N11/16 , G01N2203/0051 , G01N2203/0286 , G01N2203/0623
摘要： The present invention relates to a miniature rheometer, a parallel rheometer, and improved force sensor elements which may advantageously be used in combination with the miniature rheometer and the parallel rheometer. The miniature rheometer is adapted to determine rheological characteristics of materials which are provided in the form of small quantity samples. The miniature rheometer comprises an actuating element, a sensing element and a feedback circuit to provide rebalance of the shear force applied by the sample to the sensing element, which insures an exceptional stiffness in determining the shear strain so as to allow measurements of high accuracy. The parallel rheometer of the present invention allows simultaneous measurements of a plurality of samples so as to allow of a plurality of samples within a short time period. The force sensor element according to the present invention allows simultaneous measurement of a shear force and a normal force applied to the sensor element. Moreover, a rheometer is provided which comprises a force sensor based on stress-optic material.
摘要翻译：本发明涉及微型流变仪，平行流变仪和改进的力传感器元件，其可有利地与微型流变仪和平行流变仪组合使用。微型流变仪适用于确定以少量样品形式提供的材料的流变特性。微型流变仪包括致动元件，感测元件和反馈电路，以提供由样品施加到感测元件的剪切力的重新平衡，这确保了确定剪切应变的特殊刚度，以便允许高精度的测量。本发明的并行流变仪允许多个样本的同时测量，以便在短时间内允许多个样本。根据本发明的力传感器元件允许同时测量施加到传感器元件的剪切力和法向力。此外，提供了一种流变仪，其包括基于应力光学材料的力传感器。

8. 发明授权

US06823507B1 Detection of memory-related errors in computer programs 失效
标题翻译：检测计算机程序中的内存相关错误
公开(公告)号：US06823507B1
公开(公告)日：2004-11-23
申请号：US09587924
申请日：2000-06-06
申请人： Ravi Srinivasan , Usha Kiran , Navin Kumar Sinha
发明人： Ravi Srinivasan , Usha Kiran , Navin Kumar Sinha
IPC分类号： G06F945
CPC分类号： G06F11/3604 , G06F8/443
摘要： A method, an apparatus, and a computer program product are disclosed for detecting memory-related errors in a computer program during compiling of the computer program. In the method, static analysis is performed upon a computer program. One or more conditions in the computer program are computed based on the static analysis. Each condition is a test for checking a memory access in the computer program and can be either a pre- or post-condition. The validity of each condition in the computer program is then evaluated. If the evaluation is determinate during compiling, the presence or absence of memory-related errors in the computer program is reported. A condition is determinate if the condition is valid or invalid during compiling. Otherwise, computer code based on the condition is generated for incorporation in the computer program for run-time detection of memory-related errors.
摘要翻译：公开了一种方法，装置和计算机程序产品，用于在计算机程序的编译期间检测计算机程序中的存储器相关错误。在该方法中，在计算机程序上执行静态分析。基于静态分析计算计算机程序中的一个或多个条件。每个条件都是用于检查计算机程序中的存储器访问的测试，可以是前一个或后一个条件。然后评估计算机程序中每个条件的有效性。如果评估在编译期间是确定的，则报告计算机程序中是否存在与内存有关的错误。条件在编译期间是否有效或无效。否则，生成基于条件的计算机代码，用于并入计算机程序中用于运行时检测与存储器相关的错误。

9. 发明授权

US06644101B2 Rheometer for rapidly measuring small quantity samples 失效
公开(公告)号：US06644101B2
公开(公告)日：2003-11-11
申请号：US10261945
申请日：2002-10-01
申请人： Damian Hajduk , Eric Carlson , Ravi Srinivasan
发明人： Damian Hajduk , Eric Carlson , Ravi Srinivasan
IPC分类号： G01N1110
CPC分类号： G01N3/24 , G01N11/16 , G01N2203/0051 , G01N2203/0286 , G01N2203/0623
摘要： The present invention relates to a miniature rheometer, a parallel rheometer, and improved force sensor elements which may advantageously be used in combination with the miniature rheometer and the parallel rheometer. The miniature rheometer is adapted to determine rheological characteristics of materials which are provided in the form of small quantity samples. The miniature rheometer comprises an actuating element, a sensing element and a feedback circuit to provide rebalance of the shear force applied by the sample to the sensing element, which insures an exceptional stiffness in determining the shear strain so as to allow measurements of high accuracy. The parallel rheometer of the present invention allows simultaneous measurements of a plurality of samples so as to allow of a plurality of samples within a short time period. The force sensor element according to the present invention allows simultaneous measurement of a shear force and a normal force applied to the sensor element. Moreover, a rheometer is provided which comprises a force sensor based on stress-optic material.

10. 发明授权

US06029082A Less-claustrophobic, quadrature, radio-frequency head coil for nuclear magnetic resonance 失效
标题翻译：用于核磁共振的不幽闭，正交，射频头线圈
公开(公告)号：US06029082A
公开(公告)日：2000-02-22
申请号：US976857
申请日：1997-11-24
申请人： Ravi Srinivasan , Haiying Liu , Robert A. Elek
发明人： Ravi Srinivasan , Haiying Liu , Robert A. Elek
IPC分类号： G01R33/34 , A61B5/055
CPC分类号： G01R33/34046 , G01R33/34084
摘要： A less-claustrophobic, quadrature, radio-frequency head coil (42) includes first and second broken end rings (90, 92) connected to each other in parallel by a plurality of leg conductors (94). At least two of the leg conductors are interconnected by a third arcuate conductor segment (98) axially displaced from planes of the first and second end rings to provide an opening (44) over a subject's face. The opening reduces patient claustrophobia and permits access to the patient for life-support devices or the practice of interventional medicine. The end rings have a fixed capacitance (C.sub.1, C.sub.2) between each pair of leg conductors. The fixed capacitance C.sub.1 between at least one pair of leg conductors and the fixed capacitance C.sub.2 between at least the pair of leg conductors adjacent the opening, where C.sub.2 >C.sub.1. A two-port feed (66, 68) circumferentially attached to the coil generally opposite the opening matches the individual linear modes. Thus, the radio frequency coil is able to maintain two preferred principal linear modes (A, B) across the open area of the coil.
摘要翻译：较不幽闭的正交射频头线圈（42）包括通过多个腿导体（94）并联连接的第一和第二断开端环（90,92）。至少两个腿导体通过从第一和第二端环的平面轴向移位的第三弓形导体段（98）互连，以在对象的表面上提供开口（44）。开幕式可减少患者幽闭恐惧症，并允许进入患者的生命支持设备或介入医学的实践。端环在每对腿导体之间具有固定电容（C1，C2）。在至少一对腿导体之间的固定电容C1和固定电容C2之间至少一对腿导体相邻开口，其中C2> C1。周向地连接到与开口相对的线圈的两端口馈送（66,68）与各个线性模式匹配。因此，射频线圈能够在线圈的开放区域上保持两个优选的主线性模式（A，B）。

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