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1. 发明申请

US20160187240A1 MICROFLUIDIC SYSTEM 有权
标题翻译：微流体系
公开(公告)号：US20160187240A1
公开(公告)日：2016-06-30
申请号：US14978341
申请日：2015-12-22
申请人： University of Chicago
发明人： Rustem F. Ismagilov , Bo Zheng , Cory John Gerdts
IPC分类号： G01N1/38
CPC分类号： G05D7/0694 , B01F5/0471 , B01F13/0071 , B01J19/0046 , B01J2219/00522 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01L3/0293 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , G01N1/38 , G01N35/08 , G01N2035/1034 , Y10T137/0318
摘要： The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
摘要翻译：本发明提供了微流体技术，其能够快速和经济地操作在瞳孔上的反应到微量级。

2. 发明授权

US08193336B2 Method and apparatus for combinatorial chemistry 有权
标题翻译：组合化学方法与装置
公开(公告)号：US08193336B2
公开(公告)日：2012-06-05
申请号：US12488242
申请日：2009-06-19
申请人： Robert S. Foote
发明人： Robert S. Foote
IPC分类号： C07H21/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/00306 , B01J2219/00369 , B01J2219/00427 , B01J2219/00432 , B01J2219/00511 , B01J2219/0052 , B01J2219/00522 , B01J2219/00524 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00664 , B01J2219/00675 , B01J2219/00711 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07H19/06 , C07H21/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14
摘要： A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be photoactivated within a subset of channels at the site of immobilized substrate molecules or at a light-addressable site upstream from the substrate molecules. The method and apparatus of the invention find particularly utility in the synthesis of biopolymer arrays, e.g., oligonucleotides, peptides and carbohydrates, and in the combinatorial synthesis of small molecule arrays for drug discovery.
摘要翻译：提供了一种用于在多个通道内的空间可寻址通道中执行光导反应的方法和装置。本发明的一个方面在溶于空间可寻址的流动流中的溶液中使用可光活化试剂，以控制固定在通道内的分子的平行合成。试剂可以在固定化的底物分子的位置处的通道子集中或在底物分子上游的可光寻址位点处光活化。本发明的方法和装置特别适用于生物聚合物阵列的合成，例如寡核苷酸，肽和碳水化合物，以及用于药物发现的小分子阵列的组合合成。

3. 发明申请

US20040058391A1 Three-dimensional array of supports for solid-phase parallel synthesis and method of use 审中-公开
标题翻译：用于固相平行合成的三维支撑阵列及其使用方法
公开(公告)号：US20040058391A1
公开(公告)日：2004-03-25
申请号：US10671341
申请日：2003-09-25
申请人： Aventis Pharmaceuticals Inc.
发明人： Stephen A. Baum
IPC分类号： G01N033/53 , C12M001/34
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00286 , B01J2219/0031 , B01J2219/00317 , B01J2219/00319 , B01J2219/00322 , B01J2219/00461 , B01J2219/00468 , B01J2219/00475 , B01J2219/00497 , B01J2219/005 , B01J2219/00502 , B01J2219/00522 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00668 , B01J2219/00675 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L2300/0819 , B01L2300/0829 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/543
摘要： A three-dimensional (3D) array of solid-phase supports is adapted to provide parallel synthesis of a library of molecules with 3D diversity. Individual locations in the 3D array may be assigned to selected molecules in the library such that molecules may be synthesized at and retrieved from such locations. Also, the supports include aperture walls in stacked plates; the supports may be suspended within stacked plate apertures; the 3D array include discrete supports arranged in columns in one or more wells; the supports include tube inner walls or be suspended in tubes, the tubes being secured in stacked, two-dimensional (2D) frameworks; or the supports include beads contained in porous enclosures having non-porous side walls and being secured in stacked, 2D frameworks. A support transfer device enables transfer of solid-phase supports used in a 3D array. Such apparatus includes: a rack of rods sized to be inserted through supports and a mechanism to prevent supports from coming off the rack; tubes connected to a vacuum manifold to suction supports one Z plane at a time; or a transfer block having recesses to receive one or more support and at least one gate withholding supports from passing through the gate when in a closed position. A method of 3D synthesis includes: a) functionalizing solid-phase supports; b) placing supports in a 3D array; and c) performing parallel synthesis with 3D diversity. At least one unique R1 group member may be assigned to each Z plane.
摘要翻译：三维（3D）固相支架阵列适用于提供具有3D多样性的分子库的并行合成。 3D阵列中的各个位置可以分配给文库中的选定分子，使得分子可以在这些位置合成并从这些位置检索。此外，支撑件包括堆叠板中的孔壁; 支撑件可以悬挂在堆叠的板孔内; 3D阵列包括以一个或多个孔中的列布置的离散支撑件; 支撑件包括管内壁或悬挂在管中，管被固定在堆叠的二维（2D）框架中; 或者支撑体包括包含在具有无孔侧壁并且被固定在堆叠的2D框架中的多孔封壳中的珠子。支撑转移装置能够传送在3D阵列中使用的固相支撑。这种装置包括：尺寸适于插入通过支撑件的杆状杆状物和防止支架从架子上脱落的机构; 连接到真空歧管以抽吸的管一次支撑一个Z平面; 或具有用于接收一个或多个支撑件的凹部的传递块和当处于关闭位置时至少一个闸门预扣支撑件不经过闸门。一种3D合成方法包括：a）将固相载体官能化; b）将支撑放置在3D阵列中; 和c）使用3D分集进行并行合成。可以将至少一个唯一的R1组成员分配给每个Z平面。

4. 发明申请

US20030096220A1 Capillary array-based sample screening 审中-公开
公开(公告)号：US20030096220A1
公开(公告)日：2003-05-22
申请号：US10156878
申请日：2002-05-28
申请人： Diversa Corporation, a Delaware corporation
发明人： William Michael Lafferty , Jay M. Short , Martin Keller
IPC分类号： C12Q001/00 , C12Q001/68 , G01N033/53 , G01N033/542
CPC分类号： C40B40/02 , B01J19/0046 , B01J2219/00351 , B01J2219/00367 , B01J2219/00416 , B01J2219/00479 , B01J2219/00481 , B01J2219/00522 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/5085 , B01L3/50857 , B82Y30/00 , C12N15/1037 , C12N15/1055 , C12Q1/6811 , C12Q1/6837 , C40B40/06 , C40B60/14
摘要： Provided are methods of screening and identification of bioactivities and bioactive molecules of interest using a capillary array system. More specifically, disclosed are methods of using optical detection and capillary array-based techniques for screening libraries and recovering bioactive molecules having a desired activity or a nucleic acid sequence encoding such bioactive molecules.

5. 发明申请

US20030036084A1 Nucleic acid detection method employing oligonucleotide probes affixed to particles and related compositions 审中-公开
标题翻译：使用固定在颗粒和相关组合物上的寡核苷酸探针的核酸检测方法
公开(公告)号：US20030036084A1
公开(公告)日：2003-02-20
申请号：US10200723
申请日：2002-07-22
发明人： Brian Hauser , Joerg Baier , Radoje T. Drmanac
IPC分类号： C12Q001/68 , C12P019/34
CPC分类号： C12Q1/6874 , B01J19/0046 , B01J2219/00317 , B01J2219/005 , B01J2219/00511 , B01J2219/00513 , B01J2219/0052 , B01J2219/00522 , B01J2219/00572 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00664 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01L3/5085 , C40B40/06 , C40B40/10 , C40B60/14 , C40B70/00 , C12Q2525/107 , C12Q2525/205 , C12Q2565/518
摘要： The invention relates to oligonucleotide probes attached to discrete particles wherein the particles can be grouped into a plurality of sets based on a physical property. A different probe is attached to the discrete particles of each set, and the identity of the probe is determined by identifying the discrete particles from their physical property. The physical property includes any that can be used to differentiate the discrete particles, and includes, for example, relative or absolute location, size, flourescence, radioactivity, electromagnetic charge, or absorbance, or label(s) may be attached to the particle such as a dye, a radionuclide, or an EML. The invention also relates to methods using the probes complexed with the discrete particles to analyze target nucleic acids.
摘要翻译：本发明涉及附着于离散颗粒的寡核苷酸探针，其中基于物理性质将颗粒分成多组。不同的探针连接到每组的离散颗粒，并且通过从其物理性质识别离散粒子来确定探针的身份。物理性质包括可用于区分离散颗粒的任何物质，并且包括例如相对或绝对位置，大小，荧光，放射性，电磁电荷或吸光度，或标记可附着于颗粒，例如作为染料，放射性核素或EML。本发明还涉及使用与离散颗粒复合的探针来分析靶核酸的方法。

6. 发明申请

US20030003500A1 Capillary array-based sample screening 审中-公开
公开(公告)号：US20030003500A1
公开(公告)日：2003-01-02
申请号：US10232869
申请日：2002-08-30
申请人： Diversa Coporation
发明人： William Michael Lafferty
IPC分类号： C12Q001/68 , C12M001/34
CPC分类号： G01N21/0303 , B01J19/0046 , B01J2219/00351 , B01J2219/00367 , B01J2219/00416 , B01J2219/00479 , B01J2219/00481 , B01J2219/00522 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/5085 , B01L3/50857 , B82Y30/00 , C12N15/1037 , C12N15/1055 , C12Q1/6811 , C12Q1/6837 , C40B40/02 , C40B40/06 , C40B60/14
摘要： A sample screening platform, system and method for screening and recovery of detectable samples. The platform includes a capillary array including a plurality of capillaries. Each capillary includes at least one wall defining a lumen for retaining the detectable sample. The detectable sample is introduced to and retained in the lumen by capillary forces. In a method of incubating the sample, a second liquid is introduced into the capillary containing the sample. A detection and recovery system includes an optical system for detecting the sample, and a recovery mechanism adapted to contact a capillary containing the sample. The recovery mechanism is further adapted to recover the sample from the capillary, and expel the recovered sample for analysis.

7. 发明申请

US20020055111A1 Three-dimensional probe carriers 审中-公开
标题翻译：三维探头载体
公开(公告)号：US20020055111A1
公开(公告)日：2002-05-09
申请号：US09938798
申请日：2001-08-24
发明人： Shiping Chen , Anthony Chen , Yuling Luo
IPC分类号： C12Q001/68 , C12M001/34
CPC分类号： G01N21/7703 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00351 , B01J2219/00509 , B01J2219/00522 , B01J2219/00524 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00641 , B01J2219/00659 , B01J2219/00664 , B01J2219/00673 , B01J2219/00675 , B01J2219/00677 , B01J2219/00704 , B01J2219/0072 , B01L3/5025 , B01L3/5085 , B01L2400/0475 , B01L2400/0487 , B82Y30/00 , C03B37/01413 , C03B37/01807 , C03B37/0756 , C03B2201/20 , C03B2201/31 , C03B2203/16 , C40B50/14 , G01N21/645 , G01N21/648 , G01N2021/6484 , G01N2021/7786 , G02B6/06
摘要： The inventions disclosed herein provide a novel 3-dimensional arrangement of probes on a probe carrier with concomitant increases in the economy of reagents, compactness and readability of the probe carriers. Novel methods of fabricating probe carriers are also disclosed. Techniques for hybridization assays and reading results of such assays are also presented.
摘要翻译：本文公开的发明提供了探针载体上的探针的新颖的三维布置，伴随着试剂的经济性的增加，探针载体的紧凑性和可读性。还公开了制造探针载体的新方法。还提供了用于杂交测定和这些测定的阅读结果的技术。

8. 发明授权

US06361958B1 Biochannel assay for hybridization with biomaterial 有权
公开(公告)号：US06361958B1
公开(公告)日：2002-03-26
申请号：US09438600
申请日：1999-11-12
申请人： Chan-Long Shieh , Barbara Foley , Huinan Yu , Vi-En Choong
发明人： Chan-Long Shieh , Barbara Foley , Huinan Yu , Vi-En Choong
IPC分类号： G01N33543
CPC分类号： B01L3/5027 , B01J2219/00317 , B01J2219/00351 , B01J2219/00416 , B01J2219/00418 , B01J2219/00421 , B01J2219/00432 , B01J2219/0052 , B01J2219/00522 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L7/525 , B01L2300/0636 , B01L2300/0816 , B01L2300/087 , B01L2400/0415 , B01L2400/043 , B01L2400/049 , B82Y30/00 , C12Q1/6834 , C40B40/06 , C40B40/10 , C40B60/14 , Y10S366/02 , Y10S435/81 , C12Q2565/629
摘要： The invention relates to a microfluidic device with microchannels that have separated regions which have a member of a specific binding pair member such as DNA or RNA bound to porous polymer, beads or structures fabricated into the microchannel. The microchannels of the invention are fabricated from plastic and are operatively associated with a fluid propelling component and detector.

9. 发明授权

US12097475B2 Microfluidic system 有权
公开(公告)号：US12097475B2
公开(公告)日：2024-09-24
申请号：US18412395
申请日：2024-01-12
申请人： The University of Chicago
发明人： Rustem F. Ismagilov , Bo Zheng , Cory John Gerdts
IPC分类号： B01L99/00 , B01F25/314 , B01F33/302 , B01J19/00 , B01L3/00 , B01L3/02 , C30B7/00 , C30B29/58 , G01N1/38 , G05D7/06 , B01L3/06 , G01N35/08 , G01N35/10
CPC分类号： B01F33/3021 , B01F25/314 , B01J19/0046 , B01L3/0293 , B01L3/502784 , B01L3/527 , C30B7/00 , C30B29/58 , G01N1/38 , G05D7/0694 , B01J2219/00522 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01L3/06 , B01L3/502723 , B01L3/502746 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0433 , B01L2400/0487 , G01N35/08 , G01N2035/1034 , Y10T137/0318 , Y10T436/12
摘要： The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.

10. 发明授权

US11717819B2 High-throughput crystallographic screening device and method for crystalizing membrane proteins using a sub physiological resting membrane potential across a lipid matrix of variable composition 有权
公开(公告)号：US11717819B2
公开(公告)日：2023-08-08
申请号：US17741595
申请日：2022-05-11
申请人： UNIVERSITY OF PUERTO RICO
发明人： Jose Lasalde-Dominicci , Orestes Quesada-Gonzalez , Josue Rodriguez-Cordero , Carlos Baez-Pagan , Martin Montoya-Zavala
IPC分类号： C30B7/12 , B01L3/06 , B01J19/00 , C40B40/10 , C07K1/30 , C30B29/58 , B01J19/18 , B01L3/00
CPC分类号： B01L3/06 , B01J19/0046 , B01J19/1893 , B01L3/5085 , C07K1/306 , C30B7/12 , C30B29/58 , C40B40/10 , B01J2219/00317 , B01J2219/00522 , B01J2219/00585 , B01J2219/00639 , B01J2219/00725 , B01J2219/00745 , B01J2219/00756 , B01L2300/069
摘要： The invention is a high-throughput voltage screening crystallographic device and methodology that uses multiple micro wells and electric circuits capable of assaying different crystallization condition for the same or different proteins of interest at the same of different voltages under a humidity and temperature controlled environment. The protein is solubilized in a lipid matrix similar to the lipid composition of the protein in the native environment to ensure stability of the protein during crystallization. The invention provides a system and method where the protein is transferred to a lipid matrix that holds a resting membrane potential, which reduces the degree of conformational freedom of the protein. The invention overcomes the majority of the difficulties associated with vapor diffusion techniques and essentially reconstitutes the protein in its native lipid environment under “cuasi” physiological conditions.

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