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91. 发明申请

US20100113964A1 DETERMINING INTERCARDIAC IMPEDANCE 审中-公开
公开(公告)号：US20100113964A1
公开(公告)日：2010-05-06
申请号：US12263358
申请日：2008-10-31
申请人： John D. Wahlstrand , Timothy J. Denison , Wesley A. Santa
发明人： John D. Wahlstrand , Timothy J. Denison , Wesley A. Santa
IPC分类号： A61B5/05
CPC分类号： A61B5/053 , A61B5/6846 , A61B5/7217
摘要： A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.

92. 发明申请

US20100100153A1 STIMULATION ELECTRODE SELECTION 有权
标题翻译：刺激电极选择
公开(公告)号：US20100100153A1
公开(公告)日：2010-04-22
申请号：US12563845
申请日：2009-09-21
申请人： David Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott Stanslaski , William J. Marks
发明人： David Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott Stanslaski , William J. Marks
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/36185 , A61N1/37247
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.
摘要翻译：可以在具有多个感测电极组合的患者的脑内感测生物电信号。可以基于感测信号的频带特性来选择用于将刺激递送给患者以管理患者状况的刺激电极组合。在一些示例中，可以选择与检测到具有相对较高的相对β带功率水平的生物电脑信号的感测电极组合相关联的刺激电极组合，以向患者传递刺激治疗。也可以使用其他频带特性来选择刺激电极组合。

93. 发明申请

US20090105785A1 THERAPY PROGRAM SELECTION 有权
标题翻译：治疗方案选择
公开(公告)号：US20090105785A1
公开(公告)日：2009-04-23
申请号：US12238025
申请日：2008-09-25
申请人： Xuan Wei , Richard T. Stone , Timothy J. Denison , Gregory F. Molnar
发明人： Xuan Wei , Richard T. Stone , Timothy J. Denison , Gregory F. Molnar
IPC分类号： A61N1/02 , A61B5/00 , A61B5/0476 , G08B21/00 , A61M31/00 , A61B5/0488
CPC分类号： A61N1/36542 , A61N1/36132 , A61N1/36135 , A61N1/37 , G06F19/00 , G06F19/3481
摘要： A therapy program is selected based on a patient state, where the patient state comprises at least one of a movement state, sleep state or speech state. In this way, therapy delivery is tailored to the patient state, which may include specific patient symptoms. The therapy program is selected from a plurality of stored therapy programs that comprise therapy programs associated with a respective one at least two of the movement, sleep, and speech states. Techniques for determining a patient state include receiving volitional patient input or detecting biosignals generated within the patient's brain. The biosignals are nonsymptomatic and may be incidental to the movement, sleep, and speech states or generated in response to volitional patient input.
摘要翻译：基于患者状态选择治疗程序，其中患者状态包括运动状态，睡眠状态或语音状态中的至少一个。以这种方式，治疗递送是针对患者状态而定制的，其可以包括特定的患者症状。治疗程序选自包括与运动，睡眠和言语状态中的至少两个相关的治疗程序的多个存储的治疗程序。用于确定患者状态的技术包括接收患者输入或检测患者大脑内生成的生物信号。生物信号是无症状的，可能与运动，睡眠和言语状态有关，或者是响应于患者输入的意图产生的。

94. 发明申请

US20090099627A1 THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US20090099627A1
公开(公告)日：2009-04-16
申请号：US12237799
申请日：2008-09-25
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/36 , A61B5/0476 , A61M37/00
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已经成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

95. 发明申请

US20090079607A1 CHOPPER-STABILIZED ANALOG-TO-DIGITAL CONVERTER 有权
标题翻译： CHOPPER稳定的模拟数字转换器
公开(公告)号：US20090079607A1
公开(公告)日：2009-03-26
申请号：US11861939
申请日：2007-09-26
申请人： Timothy J. Denison , Joel A. Anderson , Michael W. Heinks
发明人： Timothy J. Denison , Joel A. Anderson , Michael W. Heinks
IPC分类号： H03M1/12 , H03M3/00
CPC分类号： A61B5/7203 , A61B5/04012 , A61B5/7217 , A61B5/7228 , A61B5/7242 , H03M3/34 , H03M3/39
摘要： This disclosure describes a chopper-stabilized sigma-delta analog-to-digital converter (ADC). The ADC is configured to provide accurate output at low frequency with relatively low power. The chopper-stabilized ADC substantially reduces or eliminates noise and offset from an output signal produced by the mixer amplifier. Dynamic limitations, i.e., glitching that result from chopper stabilization at low power are substantially eliminated or reduced through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the ADC operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. In this manner, the chopper-stabilized ADC can be used in a low power system, such as an implantable medical device (IMD), to provide a stable, low-noise output signal.
摘要翻译：本公开描述了斩波稳定的Σ-Δ模数转换器（ADC）。 ADC配置为以较低功率提供低频精确输出。斩波稳定的ADC大大减少或消除了由混频放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除或减少动态限制，即，在低功率下由斩波器稳定产生的啁啾。 ADC的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或进入信号通道的外部信号的最小混叠。以这种方式，斩波稳定的ADC可以用在诸如可植入医疗设备（IMD）的低功率系统中，以提供稳定的低噪声输出信号。

96. 发明申请

US20080269631A1 Seizure prediction 有权
标题翻译：缉获预测
公开(公告)号：US20080269631A1
公开(公告)日：2008-10-30
申请号：US11799051
申请日：2007-04-30
申请人： Timothy J. Denison , Wesley A. Santa
发明人： Timothy J. Denison , Wesley A. Santa
IPC分类号： A61B5/04
CPC分类号： A61B5/053 , A61B5/024 , A61B5/0402 , A61B5/0478 , A61B5/0488 , A61B5/4094 , A61B5/4839 , A61B5/7228 , A61B5/7275 , A61N1/08 , A61N1/36025 , A61N1/36082 , G06F19/00
摘要： Seizure prediction systems and methods include measuring impedance within a brain of a patient to determine whether the brain is in a state indicative of a possibility of an onset of a seizure. In some embodiments, the measured impedance is compared to a predetermined threshold in order to determine whether the brain is in a state indicative of a possibility of a seizure. In other embodiments, a trend of the impedance measurements is correlated to a template. In other embodiments, a frequency component of a waveform of the impedance measurement amplitudes over time is correlated to frequency components of a template waveform. Upon detecting a state in which a seizure is likely to occur, a seizure indicator may be generated, which, in some embodiments, may be used to activate therapy delivery to the patient or, in other embodiments, activate an alarm.
摘要翻译：癫痫发作预测系统和方法包括测量患者脑内的阻抗，以确定大脑是否处于指示癫痫发作可能性的状态。在一些实施例中，将测量的阻抗与预定阈值进行比较，以便确定大脑是否处于指示癫痫发作的可能性的状态。在其他实施例中，阻抗测量的趋势与模板相关。在其他实施例中，随时间的阻抗测量幅度的波形的频率分量与模板波形的频率分量相关。在检测到可能发生癫痫发作的状态时，可以产生咬合指示器，在一些实施例中，可以使用缉获指示器来激活对患者的治疗递送，或者在其他实施例中激活警报。

97. 发明申请

US20080183098A1 CHOPPER-STABILIZED INSTRUMENTATION AMPLIFIER FOR IMPEDANCE MEASUREMENT 有权
标题翻译：用于阻抗测量的CHOPPER-STABILIZED INSTRUMENTATION AMPLIFIER
公开(公告)号：US20080183098A1
公开(公告)日：2008-07-31
申请号：US12058066
申请日：2008-03-28
申请人： Timothy J. Denison , Wesley A. Santa
发明人： Timothy J. Denison , Wesley A. Santa
IPC分类号： A61B5/053 , H03F3/38 , A61N1/00
CPC分类号： H03F3/387 , A61B5/0002 , A61B5/04004 , A61B5/0428 , A61B5/053 , A61B5/103 , A61B5/7203 , A61B5/7217 , A61B5/7228 , A61B2560/0209 , A61N1/36521 , A61N1/3702 , A61N1/3704 , A61N2001/083 , H03F1/26 , H03F3/45183 , H03F3/45192 , H03F3/45475 , H03F3/45744 , H03F3/45968 , H03F2200/153 , H03F2200/252 , H03F2200/261 , H03F2200/271 , H03F2200/372 , H03F2200/375 , H03F2203/45028 , H03F2203/45138 , H03F2203/45212 , H03F2203/45264 , H03F2203/45396 , H03F2203/45512 , H03F2203/45534 , H03F2203/45551
摘要： This disclosure describes a chopper stabilized instrumentation amplifier. The amplifier is configured to achieve stable measurements at low frequency with very low power consumption. The instrumentation amplifier uses a differential architecture and a mixer amplifier to substantially eliminate noise and offset from an output signal produced by the amplifier. Dynamic limitations, i.e., glitching, that result from chopper stabilization at low power are substantially eliminated through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the amplifier operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. The amplifier can be used in a low power system, such as an implantable medical device, to provide a stable, low-noise output signal.
摘要翻译：本公开描述了一种斩波稳定仪表放大器。放大器被配置为以低功耗实现稳定的低频测量。仪表放大器使用差分架构和混频器放大器来基本上消除由放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除了在低功率下由斩波器稳定所产生的动态限制，即，短路。放大器的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或外部信号的最小混叠进入信号通路。该放大器可用于诸如可植入医疗设备的低功率系统中，以提供稳定的低噪声输出信号。

98. 发明授权

US06627067B1 Molecular and atomic scale evaluation of biopolymers 有权
标题翻译：生物聚合物的分子和原子尺度评估
公开(公告)号：US06627067B1
公开(公告)日：2003-09-30
申请号：US09602650
申请日：2000-06-22
申请人： Daniel Branton , Jene A. Golovchenko , Timothy J. Denison
发明人： Daniel Branton , Jene A. Golovchenko , Timothy J. Denison
IPC分类号： G01N27327
CPC分类号： C12Q1/6869 , B01L3/5027 , B24B37/013 , G01N33/48721 , H01L22/26 , H01L2924/0002 , H01L2924/00 , C12Q2523/305 , C12Q2565/607 , C12Q2565/631
摘要： A method for evaluating a polymer molecule including linearly connected monomer residues includes providing a polymer molecule in a liquid, contacting the liquid with an insulating solid-state membrane having a detector capable of detecting polymer molecule characteristics, and causing the polymer molecule to traverse a limited region of the solid-state membrane so that monomers of the polymer molecule traverse the limit region in sequential order, whereby the polymer molecule interacts linearly with the detector and data suitable to determine polymer molecule characteristics are obtained. The limited region may be defined by a nanometer-sized aperture in the membrane.
摘要翻译：包括线性连接的单体残基的聚合物分子的评估方法包括在液体中提供聚合物分子，使液体与具有能够检测聚合物分子特性的检测器的绝缘固态膜接触，并使聚合物分子穿过有限的区域，使得聚合物分子的单体按顺序横穿极限区域，由此聚合物分子与检测器线性相互作用，并获得适合于确定聚合物分子特性的数据。有限区域可以由膜中的纳米尺寸的孔限定。

99. 发明授权

US06611168B1 Differential parametric amplifier with physically-coupled electrically-isolated micromachined structures 有权
标题翻译：具有物理耦合电隔离微加工结构的差分参数放大器
公开(公告)号：US06611168B1
公开(公告)日：2003-08-26
申请号：US10024741
申请日：2001-12-19
申请人： Timothy J. Denison , Thomas W. Kelly
发明人： Timothy J. Denison , Thomas W. Kelly
IPC分类号： H03F700
CPC分类号： H01G5/16 , H03F3/38 , H03F7/04 , H03F2200/261
摘要： A micromachined variable capacitor structure is used as a modulation mechanism for a differential parametric amplifier. The capacitance of the capacitor structure is modulated by a control signal while a differential signal is applied to the capacitor structure. Modulation of the capacitance produces a signal representative of the input differential voltage. This signal is provided to an amplifier. Once the signal is amplified, a demodulator demodulates the amplified signal to provide an amplified version of the differential signal. The variable capacitor structure also allows for internal feedback, which permits the parametric amplifier to be used as a galvanically isolated differential measurement amplifier. A number of techniques are used to remove common mode and other errors from the modulated difference signal, thereby eliminating them from the amplified output.
摘要翻译：微机械可变电容器结构用作微分参量放大器的调制机制。电容器结构的电容由控制信号调制，同时将差分信号施加到电容器结构。电容的调制产生代表输入差分电压的信号。该信号被提供给放大器。一旦信号被放大，解调器解调放大的信号以提供差分信号的放大版本。可变电容器结构还允许内部反馈，这允许参数放大器用作电隔离差分测量放大器。许多技术用于从调制的差分信号中去除共模和其他误差，从而从放大的输出中消除它们。

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