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1. 发明授权

US10201305B2 Apparatus for data retention in an implantable medical device 有权
公开(公告)号：US10201305B2
公开(公告)日：2019-02-12
申请号：US11264887
申请日：2005-11-02
申请人： Touby A. Drew , Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , David L. Carlson
发明人： Touby A. Drew , Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , David L. Carlson
IPC分类号： A61B5/04 , A61B5/00 , A61N1/372 , G06F19/00 , G06F17/30 , A61B5/0205 , A61B5/0402 , A61B5/0476 , A61B5/11 , A61B5/16 , G16H10/60 , A61N1/36 , A61N1/365 , A61N1/37 , A61B5/021 , A61B5/024 , A61B5/03 , A61B5/08 , G16H40/63
摘要： An apparatus for storing data records associated with a medical monitoring event in a data structure. An implanted device obtains data and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.

2. 发明授权

US09014804B2 Implantable medical device for treating neurological conditions including ECG sensing 有权
标题翻译：用于治疗包括心电图感觉在内的神经病症的植入式医疗装置
公开(公告)号：US09014804B2
公开(公告)日：2015-04-21
申请号：US13158099
申请日：2011-06-10
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
IPC分类号： A61N1/365 , A61N1/375 , A61N1/36 , A61N1/37
CPC分类号： A61N1/375 , A61N1/36082 , A61N1/36114 , A61N1/36585 , A61N1/37 , A61N1/3756
摘要： An implantable medical device such as an implantable pulse generator that includes EEG sensing for monitoring and treating neurological conditions, and leadless ECG sensing for monitoring cardiac signals. The device includes a connector block with provisions for cardiac leads which may be used/enabled when needed. If significant co-morbid cardiac events are observed in patients via the leadless ECG monitoring, then cardiac leads may be subsequently connected for therapeutic use.
摘要翻译：可植入的医疗装置，例如植入式脉冲发生器，其包括用于监测和治疗神经病症的脑电图感测，以及用于监测心脏信号的无引导心电图感测。该装置包括具有用于心脏引线的装置的连接器块，其可以在需要时使用/启用。如果通过无引导心电图监测在患者中观察到显着的并发心脏事件，则心脏引线可以随后连接用于治疗用途。

3. 发明授权

US08332038B2 Detecting sleep to evaluate therapy 有权
标题翻译：检测睡眠以评估治疗
公开(公告)号：US08332038B2
公开(公告)日：2012-12-11
申请号：US13249862
申请日：2011-09-30
申请人： Kenneth T. Heruth , Keith A. Miesel , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Kenneth T. Heruth , Keith A. Miesel , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61N1/08
CPC分类号： A61M5/1723 , A61B5/0205 , A61B5/0476 , A61B5/4809 , A61B5/4815 , A61B5/4818 , A61M5/14276 , A61M2005/1726 , A61M2210/0693 , A61M2230/10 , A61M2230/40 , A61M2230/62 , A61M2230/63 , A61N1/36067 , A61N1/36082 , A61N1/36135 , A61N1/36585 , G06F19/00 , G06F19/3481 , G16H40/63
摘要： A system includes one or more sensors and a processor. Each of the sensors generates a signal as a function of at least one physiological parameter of a patient that may discernibly change when the patient is asleep. The processor monitors the physiological parameters, and determines whether the patient is asleep based on the parameters. In some embodiments, the processor determines plurality of sleep metric values, each of which indicates a probability of the patient being asleep, based on each of a plurality of physiological parameters. The processor may average or otherwise combine the plurality of sleep metric values to provide an overall sleep metric value that is compared to a threshold value in order to determine whether the patient is asleep. In addition, an electroencephalogram signal may be used to identify sleep states of the patient.
摘要翻译：系统包括一个或多个传感器和处理器。每个传感器产生作为患者的至少一个生理参数的函数的信号，当患者睡着时可以明显改变。处理器监视生理参数，并根据参数确定患者是否睡着了。在一些实施例中，处理器基于多个生理参数中的每一个来确定多个睡眠度量值，每个休眠度量值指示患者睡眠的概率。处理器可以平均或以其他方式组合多个睡眠度量值以提供与阈值进行比较的整体睡眠度量值，以便确定患者是否睡着了。此外，可以使用脑波信号来识别患者的睡眠状态。

4. 发明授权

US08108038B2 System and method for segmenting a cardiac signal based on brain activity 有权
标题翻译：基于脑活动分割心脏信号的系统和方法
公开(公告)号：US08108038B2
公开(公告)日：2012-01-31
申请号：US11380462
申请日：2006-04-27
申请人： Jonathon E. Giftakis , Jonathan C. Werder , Nina M. Graves , Eric J. Panken , David L. Carlson
发明人： Jonathon E. Giftakis , Jonathan C. Werder , Nina M. Graves , Eric J. Panken , David L. Carlson
IPC分类号： A61B5/0402
CPC分类号： A61B5/0402 , A61B5/0031 , A61B5/02 , A61B5/0245 , A61B5/0476 , A61B5/0816 , A61B5/1135 , A61B5/4094 , A61N1/36064 , A61N1/36082 , A61N1/3611 , A61N1/365 , A61N1/36521 , A61N1/36585 , A61N1/37288 , A61N1/3962
摘要： A medical device system that includes a brain monitoring element, cardiac monitoring element and a processor. The processor is configured to receive a brain signal from the brain monitoring element and a cardiac signal from the cardiac monitoring element. The processor is further configured to determine at least one reference point for a brain event time period by evaluation of the brain signal. The processor further identifies a first portion of the cardiac signal based on the at least one reference point of the brain event time period.
摘要翻译：一种包括脑部监测元件，心脏监测元件和处理器的医疗装置系统。处理器被配置为从脑监测元件接收脑信号和来自心脏监测元件的心脏信号。处理器还被配置为通过评估脑信号来确定大脑事件时间段的至少一个参考点。处理器还基于大脑事件时间段的至少一个参考点识别心脏信号的第一部分。

5. 发明授权

US07979130B2 Method and apparatus for detection of nervous system disorders 有权
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：US07979130B2
公开(公告)日：2011-07-12
申请号：US11677360
申请日：2007-02-21
申请人： David L Carlson , Eric J Panken , Touby A Drew , Jonathan C Werder
发明人： David L Carlson , Eric J Panken , Touby A Drew , Jonathan C Werder
IPC分类号： A61N1/36
CPC分类号： A61B5/02405 , A61B5/0456 , A61B5/0476 , A61B5/0482 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , A61N2/006 , G06F19/00 , G06K9/00543
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Further embodiments of the invention include preparing for the delivery of therapy by warming up therapy delivery components prior to the expected delivery of therapy.
摘要翻译：用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。本发明的其它实施方案包括通过在治疗的预期递送之前预热治疗递送成分来准备递送治疗。

6. 发明授权

US07881798B2 Controlling therapy based on sleep quality 有权
标题翻译：基于睡眠质量控制治疗
公开(公告)号：US07881798B2
公开(公告)日：2011-02-01
申请号：US11691430
申请日：2007-03-26
申请人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
发明人： Keith A. Miesel , Kenneth T. Heruth , Jonathan C. Werder , Steve R. LaPorte , Nina M. Graves
IPC分类号： A61N1/18
CPC分类号： A61N1/36082
摘要： A medical device, such as an implantable medical device (IMD), determines values for one or more metrics that indicate the quality of a patient's sleep, and controls delivery of a therapy based on the sleep quality metric values. For example, the medical device may compare a sleep quality metric value with one or more threshold values, and adjust the therapy based on the comparison. In some embodiments, the medical device adjusts the intensity of therapy based on the comparison, e.g., increases the therapy intensity when the comparison indicates that the patient's sleep quality is poor. In some embodiments, the medical device automatically selects one of a plurality of therapy parameter set available for use in delivering therapy based on a comparison sleep quality metric values associated with respective therapy parameter sets within the plurality of available therapy parameter sets.
摘要翻译：诸如可植入医疗装置（IMD）的医疗设备确定指示患者睡眠质量的一个或多个指标的值，并且基于睡眠质量量度值控制治疗的递送。例如，医疗设备可以将睡眠质量度量值与一个或多个阈值进行比较，并且基于比较来调整治疗。在一些实施例中，医疗装置基于比较来调整治疗的强度，例如当比较表明患者的睡眠质量差时，增加治疗强度。在一些实施例中，医疗设备基于与多个可用治疗参数组内的各个治疗参数组相关联的比较睡眠质量量度值，自动选择可用于递送治疗的多个治疗参数集中的一个。

7. 发明申请

US20100121214A1 SEIZURE DISORDER EVALUATION BASED ON INTRACRANIAL PRESSURE AND PATIENT MOTION 审中-公开
标题翻译：基于内分泌压力和患者运动的癫痫病症评估
公开(公告)号：US20100121214A1
公开(公告)日：2010-05-13
申请号：US12359055
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
IPC分类号： A61B5/0476 , A61B5/03 , A61B5/11 , A61B5/053
CPC分类号： A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.
摘要翻译：可以监测患者的颅内压，以评估癫痫发作障碍。在一些示例中，可以监测颅内压力随时间的趋势，例如以检测患者状况的变化。此外，在一些示例中，可以基于感测的颅内压力产生针对检测到的发作的发作量度。癫痫发作度数可以表示例如在癫痫发作期间观察到的平均值，中位数或最高相对颅内压值，在癫痫发作期间从基线值变化的百分比，或颅内压力回到基线状态的时间发生癫痫发作。除了或代替颅内压之外，可以监测患者的运动或姿势以评估患者的癫痫发作障碍。例如，可以基于在癫痫发作期间感测到的患者运动来确定癫痫发作类型或严重程度。

8. 发明申请

US20090083070A1 THERAPY ADJUSTMENT BASED ON PATIENT EVENT INDICATION 审中-公开
标题翻译：基于患者事件指征的治疗调整
公开(公告)号：US20090083070A1
公开(公告)日：2009-03-26
申请号：US12236260
申请日：2008-09-23
申请人： Jonathon E. Giftakis , Peter J. Kovach , Warren W. Ball , Jonathan C. Werder , Nina M. Graves , David C. Ullestad , Sarah B. Alme
发明人： Jonathon E. Giftakis , Peter J. Kovach , Warren W. Ball , Jonathan C. Werder , Nina M. Graves , David C. Ullestad , Sarah B. Alme
IPC分类号： G06Q50/00
摘要： An indication that a patient event occurred may be used to evaluate the efficacy of at least one therapy program and/or adjust therapy delivery to the patient. In some examples, the patient event indication includes patient input that may be received via an event indication button of a programming device. In some examples, therapy delivery may be adjusted by adjusting at least one therapy parameter value, switching therapy programs or therapy program groups or restarting a therapy cycle of a medical device.
摘要翻译：发生患者事件的指示可用于评估至少一个治疗程序的功效和/或调整对患者的治疗递送。在一些示例中，患者事件指示包括可经由编程设备的事件指示按钮接收的患者输入。在一些实例中，可以通过调整至少一个治疗参数值，切换治疗程序或治疗程序组或重新启动医疗装置的治疗周期来调整治疗递送。

9. 发明申请

US20070225674A1 Method and Apparatus for the Treatment of Movement Disorders 有权
标题翻译：用于治疗运动障碍的方法和装置
公开(公告)号：US20070225674A1
公开(公告)日：2007-09-27
申请号：US11565268
申请日：2006-11-30
申请人： Gregory F. Molnar , Gabriela C. Miyazawa , Keith A. Miesel , Jonathan C. Werder , David L. Carlson , Jonathon E. Giftakis
发明人： Gregory F. Molnar , Gabriela C. Miyazawa , Keith A. Miesel , Jonathan C. Werder , David L. Carlson , Jonathon E. Giftakis
IPC分类号： A61N1/00 , A61M31/00 , A61B5/00 , A61B5/04
CPC分类号： A61N1/36067 , A61B5/048 , A61B5/4082 , A61N1/36003
摘要： A method, apparatus, and system for treating patients suffering from movement disorders having the ability to determine one or more biomarkers indicative of a disease state. In some embodiments, the biomarker may be used as a closed-loop feedback signal to control the delivery of therapy (such as electrical stimulation or drug therapy), and which may also be used as an indication of therapy effectiveness. One embodiment uses electrodes placed in the brain to measure EEG or local field potential (LFP) signals, from which the one or more biomarkers may be determined.
摘要翻译：用于治疗患有运动障碍的患者的方法，装置和系统，其具有确定指示疾病状态的一种或多种生物标志物的能力。在一些实施方案中，生物标志物可以用作闭环反馈信号以控制治疗的递送（例如电刺激或药物治疗），并且其也可以用作治疗有效性的指示。一个实施例使用放置在脑中的电极来测量EEG或局部场电位（LFP）信号，从该信号可以确定一个或多个生物标志物。

10. 发明授权

US5095467A Target tracking system for determining bearing of a target 失效
标题翻译：用于确定目标的方位的目标跟踪系统
公开(公告)号：US5095467A
公开(公告)日：1992-03-10
申请号：US582571
申请日：1990-09-14
申请人： David P. Olson , Jonathan C. Werder
发明人： David P. Olson , Jonathan C. Werder
IPC分类号： G01S3/801 , G01S3/805
CPC分类号： G01S3/805 , G01S3/801
摘要： A passive acoustic target tracking system includes three microphones arrayed respectively at corners of an equilateral triangle for sensing acoustic energy emitted by a target, such as a heavy vehicle, and generating separate streams of analog signals representative of the acoustic energy sensed at the triangle corners. Hardware of the tracking system receives the separate streams of analog signals from the microphones and conditions and converts the separate streams of analog signals from analog to digital form and outputs the separate streams as digital signals. Software of the tracking system receives the separate streams of digital signals and provides the bearing to the target emitting the sensed acoustic energy. The software includes a minimum residual correlation algorithm and a two-state kalman filter algorithm. The minimum residual correlation algorithm receives the separate streams of digital signals, performs correlations on the separate streams from pairs of the microphones, and produces a raw azimuth signal as a result of the correlation. The two-state kalman filter algorithm receives the raw azimuth signal, performs a two-state kalman filtering of the raw azimuth signal, and produces a smooth azimuth signal constituting the bearing to the target emitting the sensed acoustic energy.
摘要翻译：无源声目标跟踪系统包括分别排列在等边三角形的拐角处的三个麦克风，用于感测由诸如重型车辆的目标发出的声能，并且产生代表在三角形拐角处感测到的声能的单独的模拟信号流。跟踪系统的硬件从麦克风接收单独的模拟信号流和条件，并将单独的模拟信号流从模拟形式转换为数字形式，并将单独的流作为数字信号输出。跟踪系统的软件接收单独的数字信号流，并向发射感测声能的目标提供支撑。该软件包括最小残差相关算法和双状态卡尔曼滤波算法。最小残差相关算法接收单独的数字信号流，在与麦克风对成对的单独流上执行相关性，并产生作为相关结果的原始方位信号。双状态卡尔曼滤波算法接收原始方位信号，对原始方位信号进行双状态卡尔曼滤波，并产生构成对发射感测声能的目标的方位角的平滑方位信号。

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