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1. 发明申请

US20100100153A1 STIMULATION ELECTRODE SELECTION 有权
标题翻译：刺激电极选择
公开(公告)号：US20100100153A1
公开(公告)日：2010-04-22
申请号：US12563845
申请日：2009-09-21
申请人： David Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott Stanslaski , William J. Marks
发明人： David Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott Stanslaski , William J. Marks
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/36185 , A61N1/37247
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.
摘要翻译：可以在具有多个感测电极组合的患者的脑内感测生物电信号。可以基于感测信号的频带特性来选择用于将刺激递送给患者以管理患者状况的刺激电极组合。在一些示例中，可以选择与检测到具有相对较高的相对β带功率水平的生物电脑信号的感测电极组合相关联的刺激电极组合，以向患者传递刺激治疗。也可以使用其他频带特性来选择刺激电极组合。

2. 发明授权

US08428733B2 Stimulation electrode selection 有权
标题翻译：刺激电极选择
公开(公告)号：US08428733B2
公开(公告)日：2013-04-23
申请号：US12563845
申请日：2009-09-21
申请人： David L. Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott R. Stanslaski , William J. Marks, Jr.
发明人： David L. Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott R. Stanslaski , William J. Marks, Jr.
IPC分类号： A61N1/18
CPC分类号： A61N1/36067 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/36185 , A61N1/37247
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.
摘要翻译：可以在具有多个感测电极组合的患者的脑内感测生物电信号。可以基于感测信号的频带特性来选择用于将刺激递送给患者以管理患者状况的刺激电极组合。在一些示例中，可以选择与检测到具有相对较高的相对β带功率水平的生物电脑信号的感测电极组合相关联的刺激电极组合，以向患者传递刺激治疗。也可以使用其他频带特性来选择刺激电极组合。

3. 发明申请

US20110144521A1 STIMULATION ELECTRODE SELECTION 有权
公开(公告)号：US20110144521A1
公开(公告)日：2011-06-16
申请号：US12639678
申请日：2009-12-16
申请人： Gabriela C. Molnar , Jianping Wu
发明人： Gabriela C. Molnar , Jianping Wu
IPC分类号： A61B5/04
CPC分类号： A61B5/048 , A61B5/4082 , A61N1/0534 , A61N1/36139 , A61N1/36171 , A61N1/36185
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition can be selected based on a frequency domain characteristic of the sensed bioelectrical signals. In some examples, a stimulation electrode combination is selected based on a determination of which of the sense electrodes are located closest to a target tissue site, as indicated by the one or more sense electrodes that sensed a bioelectrical brain signal with a relatively highest value of the frequency domain characteristic. In some examples, determining which of the sense electrodes are located closest to the target tissue site may include executing an algorithm using relative values of the frequency domain characteristic.

4. 发明授权

US08538513B2 Stimulation electrode selection 有权
公开(公告)号：US08538513B2
公开(公告)日：2013-09-17
申请号：US12639678
申请日：2009-12-16
申请人： Gabriela C. Molnar , Jianping Wu
发明人： Gabriela C. Molnar , Jianping Wu
IPC分类号： A61B5/04
CPC分类号： A61B5/048 , A61B5/4082 , A61N1/0534 , A61N1/36139 , A61N1/36171 , A61N1/36185
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition can be selected based on a frequency domain characteristic of the sensed bioelectrical signals. In some examples, a stimulation electrode combination is selected based on a determination of which of the sense electrodes are located closest to a target tissue site, as indicated by the one or more sense electrodes that sensed a bioelectrical brain signal with a relatively highest value of the frequency domain characteristic. In some examples, determining which of the sense electrodes are located closest to the target tissue site may include executing an algorithm using relative values of the frequency domain characteristic.

5. 发明授权

US08532757B2 Stimulation electrode selection 有权
标题翻译：刺激电极选择
公开(公告)号：US08532757B2
公开(公告)日：2013-09-10
申请号：US12639717
申请日：2009-12-16
申请人： Gabriela C. Molnar , Jianping Wu
发明人： Gabriela C. Molnar , Jianping Wu
IPC分类号： A61B5/04
CPC分类号： A61N1/372 , A61N1/0534 , A61N1/36082 , A61N1/36185
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition can be selected based on a frequency domain characteristic of the sensed bioelectrical signals. In some examples, a stimulation electrode combination is selected based on a determination of which of the sense electrodes are located closest to a target tissue site, as indicated by the one or more sense electrodes that sensed a bioelectrical brain signal with a relatively highest value of the frequency domain characteristic. In some examples, determining which of the sense electrodes are located closest to the target tissue site may include executing an algorithm using relative values of the frequency domain characteristic.
摘要翻译：可以在具有多个感测电极组合的患者的脑内感测生物电信号。可以基于感测的生物电信号的频域特性来选择用于将刺激递送到患者以管理患者状况的刺激电极组合。在一些示例中，基于确定哪个感测电极位于最靠近目标组织位置的位置来选择刺激电极组合，如感测出具有相对较高值的生物电脑信号的一个或多个感测电极所示频域特性。在一些示例中，确定哪个感测电极位于最靠近目标组织位置的位置可以包括使用频域特性的相对值来执行算法。

6. 发明申请

US20110144715A1 STIMULATION ELECTRODE SELECTION 有权
标题翻译：刺激电极选择
公开(公告)号：US20110144715A1
公开(公告)日：2011-06-16
申请号：US12639717
申请日：2009-12-16
申请人： Gabriela C. Molnar , Jianping Wu
发明人： Gabriela C. Molnar , Jianping Wu
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/372 , A61N1/0534 , A61N1/36082 , A61N1/36185
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition can be selected based on a frequency domain characteristic of the sensed bioelectrical signals. In some examples, a stimulation electrode combination is selected based on a determination of which of the sense electrodes are located closest to a target tissue site, as indicated by the one or more sense electrodes that sensed a bioelectrical brain signal with a relatively highest value of the frequency domain characteristic. In some examples, determining which of the sense electrodes are located closest to the target tissue site may include executing an algorithm using relative values of the frequency domain characteristic.
摘要翻译：可以在具有多个感测电极组合的患者的脑内感测生物电信号。可以基于感测的生物电信号的频域特性来选择用于将刺激递送到患者以管理患者状况的刺激电极组合。在一些示例中，基于确定哪个感测电极位于最靠近目标组织位置的位置来选择刺激电极组合，如感测出具有相对较高值的生物电脑信号的一个或多个感测电极所示频域特性。在一些示例中，确定哪个感测电极位于最靠近目标组织位置的位置可以包括使用频域特性的相对值来执行算法。

7. 发明申请

US20090192556A1 SLEEP STAGE DETECTION 有权
标题翻译：睡眠阶段检测
公开(公告)号：US20090192556A1
公开(公告)日：2009-07-30
申请号：US12238105
申请日：2008-09-25
申请人： Jianping Wu , Gregory F. Molnar , Gabriela C. Miyazawa , Timothy J. Denison
发明人： Jianping Wu , Gregory F. Molnar , Gabriela C. Miyazawa , Timothy J. Denison
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61B5/4812 , A61B5/0031 , A61B5/01 , A61B5/02055 , A61B5/024 , A61B5/04014 , A61B5/04015 , A61B5/0402 , A61B5/0478 , A61B5/048 , A61B5/1116 , A61B5/1118 , A61B5/4082 , A61B5/4839 , A61M5/1723 , A61M21/02 , A61M2005/1726 , A61M2021/0072 , A61M2205/3523 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/52 , A61M2230/005 , A61M2230/04 , A61M2230/08 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/42 , A61M2230/50 , A61M2230/60 , A61M2230/63 , A61M2230/65 , A61N1/36078 , A61N1/36139 , G06F19/3481 , G16H40/63
摘要： Therapy delivery to a patient may be controlled based on a determined sleep stage of the patient. In examples, the sleep stage may be determined based on a frequency characteristic of a biosignal indicative of brain activity of the patient. A frequency characteristic may include, for example, a power level within one or more frequency bands of the biosignal, a ratio of the power level in two or more frequency bands, or a pattern in the power level of one or more frequency bands over time. A therapy program may be selected or modified based on the sleep stage determination. Therapy may be delivered during the sleep stage according to the selected or modified therapy program. In some examples, therapy delivery may be controlled after making separate determinations of a sleep stage based on the biosignal and another physiological parameter, and confirming that the sleep stage determinations are consistent.
摘要翻译：可以基于患者的确定的睡眠阶段来控制对患者的治疗递送。在实施例中，睡眠阶段可以基于指示患者的大脑活动的生物信号的频率特性来确定。频率特性可以包括例如生物信号的一个或多个频带内的功率电平，两个或更多个频带中的功率电平的比率，或者一个或多个频带的功率电平中的模式随时间的变化。可以基于睡眠阶段确定来选择或修改治疗程序。根据所选择或修改的治疗方案，治疗可以在睡眠阶段期间递送。在一些实例中，可以在基于生物信号和另一生理参数进行睡眠阶段的单独测定以及确认睡眠阶段确定是一致的之后控制治疗递送。

8. 发明授权

US09072870B2 Sleep stage detection 有权
标题翻译：睡眠阶段检测
公开(公告)号：US09072870B2
公开(公告)日：2015-07-07
申请号：US12238105
申请日：2008-09-25
申请人： Jianping Wu , Gregory F. Molnar , Gabriela C. Miyazawa , Timothy J. Denison
发明人： Jianping Wu , Gregory F. Molnar , Gabriela C. Miyazawa , Timothy J. Denison
IPC分类号： A61N1/00 , A61N1/08 , A61M21/02 , A61B5/00 , A61B5/04 , A61B5/048 , A61M21/00 , G06F19/00
CPC分类号： A61B5/4812 , A61B5/0031 , A61B5/01 , A61B5/02055 , A61B5/024 , A61B5/04014 , A61B5/04015 , A61B5/0402 , A61B5/0478 , A61B5/048 , A61B5/1116 , A61B5/1118 , A61B5/4082 , A61B5/4839 , A61M5/1723 , A61M21/02 , A61M2005/1726 , A61M2021/0072 , A61M2205/3523 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/50 , A61M2205/52 , A61M2230/005 , A61M2230/04 , A61M2230/08 , A61M2230/10 , A61M2230/205 , A61M2230/30 , A61M2230/42 , A61M2230/50 , A61M2230/60 , A61M2230/63 , A61M2230/65 , A61N1/36078 , A61N1/36139 , G06F19/3481 , G16H40/63
摘要： Therapy delivery to a patient may be controlled based on a determined sleep stage of the patient. In examples, the sleep stage may be determined based on a frequency characteristic of a biosignal indicative of brain activity of the patient. A frequency characteristic may include, for example, a power level within one or more frequency bands of the biosignal, a ratio of the power level in two or more frequency bands, or a pattern in the power level of one or more frequency bands over time. A therapy program may be selected or modified based on the sleep stage determination. Therapy may be delivered during the sleep stage according to the selected or modified therapy program. In some examples, therapy delivery may be controlled after making separate determinations of a sleep stage based on the biosignal and another physiological parameter, and confirming that the sleep stage determinations are consistent.
摘要翻译：可以基于患者的确定的睡眠阶段来控制对患者的治疗递送。在实施例中，睡眠阶段可以基于指示患者的大脑活动的生物信号的频率特性来确定。频率特性可以包括例如生物信号的一个或多个频带内的功率电平，两个或更多个频带中的功率电平的比率，或者一个或多个频带的功率电平中的模式随时间的变化。可以基于睡眠阶段确定来选择或修改治疗程序。根据所选择或修改的治疗方案，治疗可以在睡眠阶段期间递送。在一些实例中，可以在基于生物信号和另一生理参数进行睡眠阶段的单独测定以及确认睡眠阶段确定是一致的之后控制治疗递送。

9. 发明授权

US09878161B2 Entrainment of bioelectrical brain signals 有权
公开(公告)号：US09878161B2
公开(公告)日：2018-01-30
申请号：US13446801
申请日：2012-04-13
申请人： Jianping Wu , Steven L. Jensen , Dwight E. Nelson
发明人： Jianping Wu , Steven L. Jensen , Dwight E. Nelson
IPC分类号： A61N1/00 , A61N1/36
CPC分类号： A61N1/36171 , A61N1/36067 , A61N1/36139
摘要： The disclosure relates to the delivery of electrical stimulation therapy to the brain of a patient, e.g., to treat or otherwise manage a patient disorder. In one example, the disclosure relates to a method comprising generating electrical stimulation via a medical device; delivering the electrical stimulation at a first frequency to a brain of a patient when the bioelectrical brain signals of the patient oscillate at a second frequency, where the second frequency corresponds to pathological brain signals of the patient, where the electrical stimulation is selected to entrain the bioeiectrical brain signals of the patient; and adjusting the delivered electrical stimulation from the first frequency to a third frequency, where adjusting the delivered electrical stimulation changes the bioelectrical brain signal oscillations to a fourth frequency different from the second frequency. The fourth frequency may correspond to an oscillation frequency of non-pathological brain signals of the patient.

10. 发明授权

US09211411B2 Therapy for rapid eye movement behavior disorder (RBD) 有权
标题翻译：治疗快速眼球运动障碍（RBD）
公开(公告)号：US09211411B2
公开(公告)日：2015-12-15
申请号：US13211904
申请日：2011-08-17
申请人： Jianping Wu , Dwight E. Nelson
发明人： Jianping Wu , Dwight E. Nelson
IPC分类号： A61N1/36 , A61B5/04 , A61B5/0476 , A61B5/00 , A61B5/11 , A61B5/0488
CPC分类号： A61N1/36067 , A61B5/04001 , A61B5/0476 , A61B5/0488 , A61B5/1104 , A61B5/1116 , A61B5/4812 , A61B5/4815 , A61B5/4836 , A61B5/6868 , A61B2562/0219 , A61N1/36003 , A61N1/36078
摘要： Examples for delivering electrical stimulation to a patient via a medical device to manage or treat rapid eye movement behavior disorder (RBD) are described. In one example, a method comprises determining a patient is in a rapid eye movement (REM) sleep stage, and delivering electrical stimulation therapy to the patient based on the determination that the patient is in the REM sleep stage, where the electrical stimulation therapy is delivered to inhibit movement of the patient during the REM sleep stage. In some examples, the electrical stimulation therapy may be delivered to the brain of the patient.
摘要翻译：描述了通过医疗装置向患者传送电刺激以管理或治疗快速眼睛运动行为障碍（RBD）的实例。在一个示例中，一种方法包括确定患者处于快速眼动（REM）睡眠阶段，并且基于确定患者处于REM睡眠阶段中的电刺激疗法，其中电刺激治疗是输送以在REM睡眠阶段期间抑制患者的运动。在一些实例中，电刺激治疗可以递送到患者的大脑。

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