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1. 发明申请

US20130109985A1 FAULT-TOLERANT SENSING IN AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：在可植入医疗器械中的容错感测
公开(公告)号：US20130109985A1
公开(公告)日：2013-05-02
申请号：US13285872
申请日：2011-10-31
申请人： Jeffrey M. Gillberg , Scott A. Hareland , Leonard P. Radtke , David G. Schaenzer , John D. Wahlstrand
发明人： Jeffrey M. Gillberg , Scott A. Hareland , Leonard P. Radtke , David G. Schaenzer , John D. Wahlstrand
IPC分类号： A61B5/0402
CPC分类号： A61B5/7221 , A61B5/0464 , A61B5/7203 , A61B2560/0266
摘要： A system includes a memory and a processing module. The memory includes a primary sensing vector and N alternate sensing vectors. The processing module determines a ranking value for each of the N alternate sensing vectors. Each ranking value is indicative of the integrity of a cardiac electrical signal acquired via the corresponding alternate sensing vector. The processing module senses cardiac events using the primary sensing vector, detects a reduction in the integrity of a cardiac electrical signal acquired via the primary sensing vector, and selects one of the N alternate sensing vectors in response to detecting a reduction in the integrity of the cardiac electrical signal acquired via the primary sensing vector. The selection is based on the ranking value associated with the one of the N alternate sensing vectors. The processing module then senses cardiac events using the selected one of the N alternate sensing vectors.
摘要翻译：系统包括存储器和处理模块。存储器包括主感测矢量和N个备选感测矢量。处理模块确定N个备选感测向量中的每一个的排序值。每个排序值表示通过相应的替代感测矢量获取的心脏电信号的完整性。处理模块使用主感测向量感测心脏事件，检测通过主感测向量获取的心电信号的完整性的降低，并且响应于检测到所述N个备选感测向量的完整性的降低而选择N个备选感测向量中的一个通过主感测矢量获得的心电信号。选择是基于与N个备选感测向量之一相关联的排名值。处理模块然后使用所选择的N个备选感测向量之一来感测心脏事件。

2. 发明申请

US20120101545A1 IMPLANTABLE MEDICAL DEVICE IMPEDANCE MEASUREMENT MODULE FOR COMMUNICATION WITH ONE OR MORE LEAD-BORNE DEVICES 有权
标题翻译：用于与一个或多个引线装置通信的可植入医疗装置阻抗测量模块
公开(公告)号：US20120101545A1
公开(公告)日：2012-04-26
申请号：US12912317
申请日：2010-10-26
申请人： John D. Wahlstrand , James J. St. Martin
发明人： John D. Wahlstrand , James J. St. Martin
IPC分类号： A61N1/08
CPC分类号： A61N1/05 , A61N1/36521 , A61N1/37288 , A61N2001/083
摘要： Example techniques for communicating between two medical devices are described. One medical device may be an implantable medical device. Another medical device may be a lead-borne implantable medical device. The lead-borne implantable medical device may be referred to as a satellite. The implantable medical device may measure impedance of a path including at least two electrodes, at least one of which is on the lead, using an impedance measurement module. In some example implementations of this disclosure, the implantable medical device may also use the impedance measurement module to communicate with the satellite on the lead.
摘要翻译：描述用于在两个医疗设备之间通信的示例技术。一种医疗装置可以是可植入医疗装置。另一种医疗装置可以是铅笔可植入医疗装置。铅笔可植入医疗器械可以称为卫星。可植入医疗装置可以使用阻抗测量模块来测量包括至少两个电极的路径的阻抗，其中至少一个电极在引线上。在本公开的一些示例性实施方案中，可植入医疗装置还可以使用阻抗测量模块与导线上的卫星通信。

3. 发明授权

US07797047B2 Implantable lead functional status monitor and method 有权
标题翻译：可植入式铅功能状态监测和方法
公开(公告)号：US07797047B2
公开(公告)日：2010-09-14
申请号：US10781426
申请日：2004-02-18
申请人： David J. Jorgenson , Ross O. Starkson , Rick D. McVenes , Charles D. Trautmann , John D. Wahlstrand , Bradley C. Peck
发明人： David J. Jorgenson , Ross O. Starkson , Rick D. McVenes , Charles D. Trautmann , John D. Wahlstrand , Bradley C. Peck
IPC分类号： A61N1/362
CPC分类号： A61N1/3925 , A61N1/3706 , A61N2001/083
摘要： An implantable medical device (IMD) includes a lead status monitoring system. The lead status monitoring system employs a method including the steps of: collecting data sets from a lead impedance source, a stimulation threshold source, and at least one additional source included in the IMD; and processing the data sets to determine if a lead status event has occurred.
摘要翻译：可植入医疗装置（IMD）包括引导状态监测系统。引导状态监视系统采用的方法包括以下步骤：从引线阻抗源，刺激阈值源和IMD中包括的至少一个附加源收集数据集; 并处理数据集以确定是否发生了引导状态事件。

4. 发明授权

US06681135B1 System and method for employing temperature measurements to control the operation of an implantable medical device 有权
标题翻译：用于采用温度测量来控制可植入医疗装置的操作的系统和方法
公开(公告)号：US06681135B1
公开(公告)日：2004-01-20
申请号：US09725329
申请日：2000-11-22
申请人： Timothy J. Davis , James D. Reinke , David W. Graden , John D. Wahlstrand
发明人： Timothy J. Davis , James D. Reinke , David W. Graden , John D. Wahlstrand
IPC分类号： A61N118
CPC分类号： A61N1/08 , A61N1/3655
摘要： A medical implantable device that includes a temperature sensor circuit and a control circuit coupled to the temperature sensor circuit to control non-therapy operation of the medical implantable device in response to temperature measurements obtained by the temperature sensor circuit.
摘要翻译：一种医疗可植入装置，其包括温度传感器电路和耦合到所述温度传感器电路的控制电路，以响应于所述温度传感器电路获得的温度测量来控制所述医学可植入装置的非治疗操作。

5. 发明授权

US5899927A Detection of pressure waves transmitted through catheter/lead body 失效
标题翻译：检测通过导管/铅体传输的压力波
公开(公告)号：US5899927A
公开(公告)日：1999-05-04
申请号：US953092
申请日：1997-10-17
申请人： Robert M. Ecker , Lawrence C. McClure , John D. Wahlstrand
发明人： Robert M. Ecker , Lawrence C. McClure , John D. Wahlstrand
IPC分类号： A61B5/0215 , A61B5/08 , A61N1/365 , A61N1/37 , A61B5/00
CPC分类号： A61N1/3702 , A61N1/36514
摘要： In an implanted medical device, a method and apparatus for detecting pressure waves caused by movement of a body organ, muscle group, limb or the like and transmitted through a catheter or lead body to the implanted medical device employing a pressure wave transducer mounted in relation to the proximal end of the catheter or lead to detect the transmitted pressure waves. The system may also include a reference transducer having the same pressure wave response characteristics as the pressure wave transducer but isolated from the proximal connector end for providing a reference signal including common mode pressure wave noise that both transducers are simultaneously subjected to. The pressure wave signal and the reference signal are preferably amplified, bandpass filtered to the body pressure wave of interest and stored, telemetered out or used to trigger a device operation. The pressure and reference wave transducers preferably are piezoelectric crystal transducers or accelerometers in direct or indirect mechanical contact with the proximal connector end of the catheter and is encapsulated from the body within a device connector assembly. Preferably, the catheter is a lead extending into direct or indirect contact with the patient's heart. Cardiac pressure waves and respiration pressure waves are both transmitted proximally through the lead body to the pressure wave transducer. Pressure wave signals may be derived in parallel to detect particular characteristics of the cardiac and/or respiratory cycle to provide timing signal(s) for controlling the device operations.
摘要翻译：在植入式医疗装置中，一种用于检测由身体器官，肌肉群，肢体等的运动引起的透射通过导管或引线体引起的植入医疗装置的压力波的方法和装置，所述压力波换能器安装在关系上到导管的近端或导致检测传输的压力波。该系统还可以包括具有与压力波传感器相同的压力波响应特性但与近端连接器端隔离的参考换能器，用于提供包括两个换能器同时经受的共模压力波噪声的参考信号。压力波信号和参考信号优选被放大，带通滤波到感兴趣的体压波，并被存储，遥测或用于触发装置操作。压力和参考波传感器优选地是与导管的近端连接器端直接或间接机械接触的压电晶体换能器或加速度计，并且在设备连接器组件内从主体封装。优选地，导管是延伸成与患者心脏直接或间接接触的导线。心脏压力波和呼吸压力波都通过引导体向近端传递到压力波传感器。可以并行导出压力波信号以检测心脏和/或呼吸周期的特定特征，以提供用于控制装置操作的定时信号。

6. 发明授权

US5702427A Verification of capture using pressure waves transmitted through a pacing lead 失效
标题翻译：使用通过起搏引线传输的压力波进行捕获验证
公开(公告)号：US5702427A
公开(公告)日：1997-12-30
申请号：US623443
申请日：1996-03-28
申请人： Robert M. Ecker , Lawrence C. McClure , John D. Wahlstrand
发明人： Robert M. Ecker , Lawrence C. McClure , John D. Wahlstrand
IPC分类号： A61N1/365 , A61N1/37 , A61N1/375
CPC分类号： A61N1/3702 , A61N1/36542 , A61N1/3712 , A61N1/36578
摘要： A capture verification system for a cardiac pacemaker comprising an implantable pulse generator (IPG) and one or more pacing leads having a proximal end coupled to the IPG and a distal end in contact with a patient's heart. The capture verification system employs a pressure wave sensor mounted in the IPG in relation to the proximal end of the pacing lead for sensing pressure waves transmitted from the distal end of the pacing lead to the proximal end thereof. The pressure waves include characteristic sounds of heart contraction and/or distal end lead motion caused by the contraction motion of the patient's heart that are transmitted along the lead body to the active sensor. A further isolated, reference sensor is also incorporated into the IPG in a similar fashion. Signal processors are coupled to the pressure wave and reference sensors for nulling out common mode noise.
摘要翻译：一种用于心脏起搏器的捕获验证系统，包括可植入脉冲发生器（IPG）和一个或多个起搏引线，其具有耦合到IPG的近端和与患者心脏接触的远端。捕获验证系统使用安装在IPG中的压力波传感器相对于起搏引线的近端，用于感测从起搏引线的远端传递到其近端的压力波。压力波包括由沿着引导体传递到有源传感器的患者心脏的收缩运动引起的心脏收缩和/或远端引导运动的特征性声音。另一个隔离的参考传感器也以类似的方式并入到IPG中。信号处理器耦合到压力波和参考传感器，以消除共模噪声。

7. 发明授权

US08688223B2 Implantable medical device impedance measurement module for communication with one or more lead-borne devices 有权
标题翻译：可植入医疗器械阻抗测量模块，用于与一个或多个引线传导器件通信
公开(公告)号：US08688223B2
公开(公告)日：2014-04-01
申请号：US12912317
申请日：2010-10-26
申请人： John D. Wahlstrand , James J. St. Martin
发明人： John D. Wahlstrand , James J. St. Martin
IPC分类号： A61N1/08
CPC分类号： A61N1/05 , A61N1/36521 , A61N1/37288 , A61N2001/083
摘要： Example techniques for communicating between two medical devices are described. One medical device may be an implantable medical device. Another medical device may be a lead-borne implantable medical device. The lead-borne implantable medical device may be referred to as a satellite. The implantable medical device may measure impedance of a path including at least two electrodes, at least one of which is on the lead, using an impedance measurement module. In some example implementations of this disclosure, the implantable medical device may also use the impedance measurement module to communicate with the satellite on the lead.
摘要翻译：描述用于在两个医疗设备之间通信的示例技术。一种医疗装置可以是可植入医疗装置。另一种医疗装置可以是铅笔可植入医疗装置。铅笔可植入医疗器械可以称为卫星。可植入医疗装置可以使用阻抗测量模块来测量包括至少两个电极的路径的阻抗，其中至少一个电极在引线上。在本公开的一些示例性实施方案中，可植入医疗装置还可以使用阻抗测量模块与导线上的卫星通信。

8. 发明授权

US07729770B2 Isolation circuitry and method for gradient field safety in an implantable medical device 失效
标题翻译：可植入式医疗设备中梯度场安全的隔离电路和方法
公开(公告)号：US07729770B2
公开(公告)日：2010-06-01
申请号：US11380241
申请日：2006-04-26
申请人： Lonny V. Cabelka , David E. Manahan , Forrest C. M. Pape , John D. Wahlstrand
发明人： Lonny V. Cabelka , David E. Manahan , Forrest C. M. Pape , John D. Wahlstrand
IPC分类号： A61N1/372
CPC分类号： A61N1/3752 , A61N1/3718
摘要： An implantable medical device is provided for isolating an elongated medical lead from internal device circuitry in the presence of a gradient magnetic or electrical field. The device includes an isolation circuit adapted to operatively connect an internal circuit to the medical lead in a first operative state and to electrically isolate the medical lead from the internal circuit in a second operative state.
摘要翻译：提供了可植入医疗装置，用于在梯度磁场或电场的存在下将细长的医疗引线与内部装置电路隔离。该装置包括隔离电路，其适于在第一操作状态下将内部电路可操作地连接到医疗引线，并且在第二操作状态下将医疗引线与内部电路电隔离。

9. 发明申请

US20100114223A1 DETERMINING INTERCARDIAC IMPEDANCE 有权
标题翻译：确定干扰素阻力
公开(公告)号：US20100114223A1
公开(公告)日：2010-05-06
申请号：US12263346
申请日：2008-10-31
申请人： John D. Wahlstrand , Timothy J. Denison , Wesley A. Santa
发明人： John D. Wahlstrand , Timothy J. Denison , Wesley A. Santa
IPC分类号： A61N1/39 , A61N1/365 , A61B5/053
CPC分类号： A61B5/053 , A61B5/026 , A61B5/0538 , A61B5/6846 , A61B5/7217 , A61N1/36521
摘要： A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.
摘要翻译：公开了一种用于确定复杂心脏阻抗以检测各种心脏功能的系统和方法，其涉及用于提供可调节直流电流信号的信号发生器装置，用于调制可调节直流电流信号以产生调制信号的调制器，用于传播的至少一个电极跨越心肌的调制信号，用于检测来自心肌的输出的调制信号的至少一个传感器，以及至少一个电路，以减少输出的调制信号中的过程噪声（侵略者）的影响。所述至少一个电路包括放大器，解调器和积分器。最终输出的调制信号的振幅和相位表示心肌的复阻抗。心肌复合阻抗模式的变化提供氧气和血液流向心肌的指示。该装置可用于可植入装置，包括心脏起搏器和可植入的心律转复除颤器。

10. 发明申请

US20100113964A1 DETERMINING INTERCARDIAC IMPEDANCE 审中-公开
公开(公告)号：US20100113964A1
公开(公告)日：2010-05-06
申请号：US12263358
申请日：2008-10-31
申请人： John D. Wahlstrand , Timothy J. Denison , Wesley A. Santa
发明人： John D. Wahlstrand , Timothy J. Denison , Wesley A. Santa
IPC分类号： A61B5/05
CPC分类号： A61B5/053 , A61B5/6846 , A61B5/7217
摘要： A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.

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