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1. 发明授权

US07714757B2 Chopper-stabilized analog-to-digital converter 有权
标题翻译：斩波稳定的模数转换器
公开(公告)号：US07714757B2
公开(公告)日：2010-05-11
申请号：US11861939
申请日：2007-09-26
申请人： Timothy J. Denison , Joel A. Anderson , Michael W. Heinks
发明人： Timothy J. Denison , Joel A. Anderson , Michael W. Heinks
IPC分类号： H03M3/00
CPC分类号： A61B5/7203 , A61B5/04012 , A61B5/7217 , A61B5/7228 , A61B5/7242 , H03M3/34 , H03M3/39
摘要： This disclosure describes a chopper-stabilized sigma-delta analog-to-digital converter (ADC). The ADC is configured to provide accurate output at low frequency with relatively low power. The chopper-stabilized ADC substantially reduces or eliminates noise and offset from an output signal produced by the mixer amplifier. Dynamic limitations, i.e., glitching that result from chopper stabilization at low power are substantially eliminated or reduced through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the ADC operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. In this manner, the chopper-stabilized ADC can be used in a low power system, such as an implantable medical device (IMD), to provide a stable, low-noise output signal.
摘要翻译：本公开描述了斩波稳定的Σ-Δ模数转换器（ADC）。 ADC配置为以较低功率提供低频精确输出。斩波稳定的ADC大大减少或消除了由混频放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除或减少动态限制，即，在低功率下由斩波器稳定产生的啁啾。 ADC的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或进入信号通道的外部信号的最小混叠。以这种方式，斩波稳定的ADC可以用在诸如可植入医疗设备（IMD）的低功率系统中，以提供稳定的低噪声输出信号。

2. 发明申请

US20090079607A1 CHOPPER-STABILIZED ANALOG-TO-DIGITAL CONVERTER 有权
标题翻译： CHOPPER稳定的模拟数字转换器
公开(公告)号：US20090079607A1
公开(公告)日：2009-03-26
申请号：US11861939
申请日：2007-09-26
申请人： Timothy J. Denison , Joel A. Anderson , Michael W. Heinks
发明人： Timothy J. Denison , Joel A. Anderson , Michael W. Heinks
IPC分类号： H03M1/12 , H03M3/00
CPC分类号： A61B5/7203 , A61B5/04012 , A61B5/7217 , A61B5/7228 , A61B5/7242 , H03M3/34 , H03M3/39
摘要： This disclosure describes a chopper-stabilized sigma-delta analog-to-digital converter (ADC). The ADC is configured to provide accurate output at low frequency with relatively low power. The chopper-stabilized ADC substantially reduces or eliminates noise and offset from an output signal produced by the mixer amplifier. Dynamic limitations, i.e., glitching that result from chopper stabilization at low power are substantially eliminated or reduced through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the ADC operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. In this manner, the chopper-stabilized ADC can be used in a low power system, such as an implantable medical device (IMD), to provide a stable, low-noise output signal.
摘要翻译：本公开描述了斩波稳定的Σ-Δ模数转换器（ADC）。 ADC配置为以较低功率提供低频精确输出。斩波稳定的ADC大大减少或消除了由混频放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除或减少动态限制，即，在低功率下由斩波器稳定产生的啁啾。 ADC的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或进入信号通道的外部信号的最小混叠。以这种方式，斩波稳定的ADC可以用在诸如可植入医疗设备（IMD）的低功率系统中，以提供稳定的低噪声输出信号。

3. 发明申请

US20120066534A1 POWER SOURCE COUPLING AND DECOUPLING IN MEDICAL DEVICE 有权
标题翻译：电源耦合和解耦在医疗设备中
公开(公告)号：US20120066534A1
公开(公告)日：2012-03-15
申请号：US12879164
申请日：2010-09-10
申请人： David A. Dinsmoor , Joel A. Anderson , Matthew J. Michaels , Timothy J. Denison , Michael E. Newell
发明人： David A. Dinsmoor , Joel A. Anderson , Matthew J. Michaels , Timothy J. Denison , Michael E. Newell
IPC分类号： G06F1/26 , H03K17/687
CPC分类号： G06F1/28 , G06F1/30
摘要： Aspects of this disclosure relate to coupling and decoupling a power source of a device with circuitry within the device. For example, in aspects of this disclosure, when a short develops within the device, a switch circuit may decouple the power source from the some of the circuitry within the device. Decoupling the power source when a short develops may extent the operational time of the power source, and may reduce thermal excursion.
摘要翻译：本公开的方面涉及将设备的电源与设备内的电路耦合和去耦合。例如，在本公开的方面中，当器件内发生短路时，开关电路可以将电源与器件内的一些电路分离。短路发生时的电源解耦可能会延长电源的工作时间，并可能减少热偏移。

4. 发明授权

US08583954B2 Power source coupling and decoupling in medical device 有权
标题翻译：医疗器械中的电源耦合和去耦
公开(公告)号：US08583954B2
公开(公告)日：2013-11-12
申请号：US12879164
申请日：2010-09-10
申请人： David A. Dinsmoor , Joel A. Anderson , Matthew J. Michaels , Timothy J. Denison , Michael E. Newell
发明人： David A. Dinsmoor , Joel A. Anderson , Matthew J. Michaels , Timothy J. Denison , Michael E. Newell
IPC分类号： G06F1/00 , H02H3/00 , H02H7/00
CPC分类号： G06F1/28 , G06F1/30
摘要： Aspects of this disclosure relate to coupling and decoupling a power source of a device with circuitry within the device. For example, in aspects of this disclosure, when a short develops within the device, a switch circuit may decouple the power source from the some of the circuitry within the device. Decoupling the power source when a short develops may extent the operational time of the power source, and may reduce thermal excursion.
摘要翻译：本公开的方面涉及将设备的电源与设备内的电路耦合和去耦合。例如，在本公开的方面中，当器件内发生短路时，开关电路可以将电源与器件内的一些电路分离。短路发生时的电源解耦可能会延长电源的工作时间，并可能减少热偏移。

5. 发明授权

US08271089B2 Hybrid rectification for recharging an implantable medical device 有权
标题翻译：用于为可植入医疗设备再充电的混合整流
公开(公告)号：US08271089B2
公开(公告)日：2012-09-18
申请号：US12418291
申请日：2009-04-03
申请人： David A. Dinsmoor , Todd A. Kallmyer , Joel A. Anderson , Timothy J. Denison
发明人： David A. Dinsmoor , Todd A. Kallmyer , Joel A. Anderson , Timothy J. Denison
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , H02J7/025 , H02J50/10
摘要： A charging system is disclosed. In one embodiment, the system includes a charging unit having a primary coil, and an implantable medical device comprising a secondary coil to receive charge from the primary coil. The implantable medical device further includes a half-wave voltage-doubling rectifier coupled to the secondary coil, a full-wave rectifier coupled to the secondary coil, and a rechargeable power source. Control logic is provided to periodically configure the rechargeable power source to receive charge from a selected one of the voltage-doubling circuit and the full-wave rectifier in a manner that increases rate at which charge is transferred from the secondary coil to the rechargeable power source. The control logic may configure the rechargeable power source to receive charge based on one or more monitored conditions which may include, for example, an indication of a current, a voltage, a coupling coefficient, back-scatter, and temperature.
摘要翻译：公开了一种充电系统。在一个实施例中，系统包括具有初级线圈的充电单元和包括用于接收来自初级线圈的电荷的次级线圈的可植入医疗装置。可植入医疗装置还包括耦合到次级线圈的半波倍压整流器，耦合到次级线圈的全波整流器和可再充电电源。提供控制逻辑以周期性地配置可再充电电源，以便以增加电荷从次级线圈传递到可再充电电源的速率的方式从所选倍压电路和全波整流器中接收电荷。控制逻辑可以配置可再充电电源以基于一个或多个监视的条件来接收电荷，这些状态可以包括例如电流，电压，耦合系数，反向散射和温度的指示。

6. 发明申请

US20100256710A1 HYBRID RECTIFICATION FOR RECHARGING AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：用于补充可植入医疗器械的混合整流器
公开(公告)号：US20100256710A1
公开(公告)日：2010-10-07
申请号：US12418291
申请日：2009-04-03
申请人： David A. Dinsmoor , Todd A. Kallmyer , Joel A. Anderson , Timothy J. Denison
发明人： David A. Dinsmoor , Todd A. Kallmyer , Joel A. Anderson , Timothy J. Denison
IPC分类号： A61N1/02 , H02J7/00
CPC分类号： A61N1/3787 , H02J7/025 , H02J50/10
摘要： A charging system is disclosed. In one embodiment, the system includes a charging unit having a primary coil, and an implantable medical device comprising a secondary coil to receive charge from the primary coil. The implantable medical device further includes a half-wave voltage-doubling rectifier coupled to the secondary coil, a full-wave rectifier coupled to the secondary coil, and a rechargeable power source. Control logic is provided to periodically configure the rechargeable power source to receive charge from a selected one of the voltage-doubling circuit and the full-wave rectifier in a manner that increases rate at which charge is transferred from the secondary coil to the rechargeable power source. The control logic may configure the rechargeable power source to receive charge based on one or more monitored conditions which may include, for example, an indication of a current, a voltage, a coupling coefficient, back-scatter, and temperature.
摘要翻译：公开了一种充电系统。在一个实施例中，系统包括具有初级线圈的充电单元和包括用于接收来自初级线圈的电荷的次级线圈的可植入医疗装置。可植入医疗装置还包括耦合到次级线圈的半波倍压整流器，耦合到次级线圈的全波整流器和可再充电电源。提供控制逻辑以周期性地配置可再充电电源，以便以增加电荷从次级线圈传递到可再充电电源的速率的方式从所选倍压电路和全波整流器中接收电荷。控制逻辑可以配置可再充电电源以基于一个或多个监视的条件来接收电荷，这些状态可以包括例如电流，电压，耦合系数，反向散射和温度的指示。

7. 发明授权

US10493281B2 Timing therapy evaluation trials 有权
公开(公告)号：US10493281B2
公开(公告)日：2019-12-03
申请号：US12425922
申请日：2009-04-17
申请人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
IPC分类号： A61N1/00 , A61N1/36 , A61N1/05 , A61N1/372
CPC分类号： A61N1/36135 , A61N1/36082 , A61N1/0534 , A61N1/37211 , A61N1/37247
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy delivery dissipates. Monitoring a washout period may be useful for timing the delivery of therapy according to different therapy programs during a therapy evaluation period. For example, at least one physiological signal of the patient may be monitored to automatically determine when a washout period has ended, e.g., when stimulation and carryover effects of therapy delivery according to a first therapy program have substantially dissipated, in order to determine when therapy delivery according to a second therapy program can be initiated.

8. 发明授权

US09333350B2 Psychiatric disorder therapy control 有权
标题翻译：精神障碍治疗控制
公开(公告)号：US09333350B2
公开(公告)日：2016-05-10
申请号：US12425903
申请日：2009-04-17
申请人： Mark T. Rise , Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Nathan A. Torgerson
发明人： Mark T. Rise , Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Nathan A. Torgerson
IPC分类号： A61N1/00 , A61N1/36 , A61B5/16 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/00
CPC分类号： A61N1/36082 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/0816 , A61B5/165 , A61B5/441 , A61B5/4836 , A61B5/7275 , G06F19/00 , G16H20/70 , G16H40/63
摘要： A therapy system for managing a psychiatric disorder of the patient may be controlled based on a patient mood state. Therapy may be delivered to a patient according to a therapy program, and a physiological parameter of the patient may be monitored during or after therapy delivery. The patient mood state may be determined based on the monitored physiological parameter, and the therapy delivery may be controlled based on the determined mood state. In some embodiments, the therapy delivery is stopped prior to determining the patient mood state and the therapy delivery is restarted upon detecting a negative mood state. In other embodiments, therapy delivery is delivered until a positive mood state is detected, at which point the therapy delivery may be stopped.
摘要翻译：可以基于患者情绪状态来控制用于管理患者精神障碍的治疗系统。治疗可以根据治疗程序递送到患者，并且可以在治疗递送期间或之后监测患者的生理参数。可以基于所监测的生理参数来确定患者情绪状态，并且可以基于所确定的情绪状态来控制治疗递送。在一些实施例中，在确定患者情绪状态之前停止治疗递送，并且在检测到负情绪状态时重新开始治疗递送。在其它实施方案中，递送治疗递送直到检测到正状态，此时可以停止治疗递送。

9. 发明授权

US09327070B2 Medical device therapy based on posture and timing 有权
标题翻译：基于姿势和时机的医疗器械治疗
公开(公告)号：US09327070B2
公开(公告)日：2016-05-03
申请号：US12433501
申请日：2009-04-30
申请人： Dennis M. Skelton , Jon P. Davis , Timothy J. Denison
发明人： Dennis M. Skelton , Jon P. Davis , Timothy J. Denison
IPC分类号： A61M5/142 , A61B5/00 , A61B5/11 , A61N1/36 , A61N1/372
CPC分类号： A61M5/14276 , A61B5/11 , A61B5/1116 , A61B5/7475 , A61B2562/0219 , A61M2005/14208 , A61M2210/0693 , A61M2210/1053 , A61M2210/1078 , A61M2230/62 , A61N1/36071 , A61N1/36139 , A61N1/37247
摘要： This disclosure describes techniques implemented by a medical device, such as an implantable medical device (IMD). The IMD may be configured to detect a posture state of a patient, and deliver posture-responsive therapy. In particular, the IMD not only detects the posture state of a patient, but also detects timing associated with the detected posture state, such as the time of day, the day of the week, or a specific time of day associated with a specific day. In this way, the posture-responsive therapy delivered by the IMD may be dependent not only on the posture state of the patient, but also on the timing associated with the posture state. The same posture state, therefore, may result in different types of therapy to the patient if the same posture occurs at different times of the day.
摘要翻译：本公开描述了由诸如可植入医疗装置（IMD）的医疗装置实现的技术。 IMD可以被配置为检测患者的姿势状态，并且提供姿势响应治疗。特别地，IMD不仅检测患者的姿势状态，而且检测与检测到的姿势状态相关联的定时，例如一天中的时间，一周中的一天或与特定日期相关联的特定时间。以这种方式，由IMD递送的姿势响应治疗不仅取决于患者的姿势状态，而且还取决于与姿势状态相关的时间。因此，如果在一天的不同时间发生相同的姿势，那么相同的姿势状态可能导致对患者的不同类型的治疗。

10. 发明授权

US09149635B2 Stimulation waveform generator for an implantable medical device 有权
标题翻译：用于植入式医疗设备的刺激波形发生器
公开(公告)号：US09149635B2
公开(公告)日：2015-10-06
申请号：US13458109
申请日：2012-04-27
申请人： Timothy J. Denison , Robert W. Hocken, Jr. , Gabriela C. Molnar , Wesley A. Santa , Jalpa S. Shah , Larry E. Tyler
发明人： Timothy J. Denison , Robert W. Hocken, Jr. , Gabriela C. Molnar , Wesley A. Santa , Jalpa S. Shah , Larry E. Tyler
IPC分类号： A61N1/36 , A61N1/378
CPC分类号： A61N1/36125 , A61N1/378 , A61N1/3787
摘要： This disclosure describes techniques for generating stimulation current pulses that have differing pulse shapes in a medical device. A circuit architecture is described that is configured to charge a capacitor to an initial amount of charge, modulate the amount of charge stored in the capacitor based on a control signal, and generate a stimulation current pulse that has an amplitude based on the amount charge stored in the capacitor. The circuit architecture may be configured to generate complex pulse shapes, such as, e.g., steps, ramps, bursts, and combinations thereof.
摘要翻译：本公开描述了用于在医疗装置中产生具有不同脉冲形状的刺激电流脉冲的技术。描述了一种电路架构，其被配置为基于控制信号对电容器充电至初始电荷量，并且基于控制信号调制存储在电容器中的电荷量，并且产生具有基于存储的电荷量的幅度的刺激电流脉冲在电容器中。电路架构可以被配置为产生复数脉冲形状，例如步骤，斜坡，脉冲串及其组合。

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