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1. 发明授权

US08554325B2 Therapy control based on a patient movement state 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US08554325B2
公开(公告)日：2013-10-08
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/18
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

2. 发明申请

US20120108998A1 THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US20120108998A1
公开(公告)日：2012-05-03
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61B5/0476 , A61N1/36 , A61B5/048 , A61B5/0482
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

3. 发明申请

US20090099627A1 THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US20090099627A1
公开(公告)日：2009-04-16
申请号：US12237799
申请日：2008-09-25
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/36 , A61B5/0476 , A61M37/00
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已经成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

4. 发明授权

US08121694B2 Therapy control based on a patient movement state 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US08121694B2
公开(公告)日：2012-02-21
申请号：US12237799
申请日：2008-09-25
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/18
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

5. 发明授权

US07848817B2 Coupling module of a modular implantable medical device 有权
标题翻译：模块化可植入医疗器械的耦合模块
公开(公告)号：US07848817B2
公开(公告)日：2010-12-07
申请号：US10731699
申请日：2003-12-09
申请人： Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Mark S. Lent , Keith A. Miesel , James E. Cabak
发明人： Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Mark S. Lent , Keith A. Miesel , James E. Cabak
IPC分类号： A61N1/00
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： In an implantable medical device having individual modules, a coupling module couples the modules to one another. The coupling module supports electrical and/or mechanical coupling of the modules. The coupling module may assume a variety of shapes or configurations. The various embodiments of the coupling module may offer the modules varying degrees of freedom of movement relative to one another.
摘要翻译：在具有各个模块的可植入医疗装置中，耦合模块将模块彼此连接。联接模块支持模块的电气和/或机械耦合。联接模块可呈现各种形状或构型。联接模块的各种实施例可以提供模块相对于彼此的不同移动自由度。

6. 发明授权

US08666497B2 Coupling module of a modular implantable medical device 有权
标题翻译：模块化可植入医疗器械的耦合模块
公开(公告)号：US08666497B2
公开(公告)日：2014-03-04
申请号：US12942806
申请日：2010-11-09
申请人： Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Mark S. Lent , Keith A. Miesel , James E. Cabak
发明人： Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Mark S. Lent , Keith A. Miesel , James E. Cabak
IPC分类号： A61N1/372
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： In an implantable medical device having individual modules, a coupling module couples the modules to one another. The coupling module supports electrical and/or mechanical coupling of the modules. The coupling module may assume a variety of shapes or configurations. The various embodiments of the coupling module may offer the modules varying degrees of freedom of movement relative to one another.
摘要翻译：在具有各个模块的可植入医疗装置中，耦合模块将模块彼此连接。联接模块支持模块的电气和/或机械耦合。联接模块可呈现各种形状或构型。联接模块的各种实施例可以提供模块相对于彼此的不同移动自由度。

7. 发明申请

US20110054563A1 COUPLING MODULE OF A MODULAR IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：一种模块化植入式医疗装置的联接模块
公开(公告)号：US20110054563A1
公开(公告)日：2011-03-03
申请号：US12942806
申请日：2010-11-09
申请人： Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Mark S. Lent , Keith A. Miesel , James E. Cabak
发明人： Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Mark S. Lent , Keith A. Miesel , James E. Cabak
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： In an implantable medical device having individual modules, a coupling module couples the modules to one another. The coupling module supports electrical and/or mechanical coupling of the modules. The coupling module may assume a variety of shapes or configurations. The various embodiments of the coupling module may offer the modules varying degrees of freedom of movement relative to one another.
摘要翻译：在具有各个模块的可植入医疗装置中，耦合模块将模块彼此连接。联接模块支持模块的电气和/或机械耦合。联接模块可呈现各种形状或构型。联接模块的各种实施例可以提供模块相对于彼此的不同移动自由度。

8. 发明申请

US20120130444A1 INCONTINENCE THERAPY 有权
标题翻译：不良治疗
公开(公告)号：US20120130444A1
公开(公告)日：2012-05-24
申请号：US13265702
申请日：2010-04-09
申请人： Xuan K. Wei , Eric H. Bonde , Keith A. Miesel , Mark S. Lent , Gregory F. Molnar
发明人： Xuan K. Wei , Eric H. Bonde , Keith A. Miesel , Mark S. Lent , Gregory F. Molnar
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0514 , A61N1/0551 , A61N1/36128 , A61N1/36135 , A61N1/37235 , A61N1/37252
摘要： Techniques for managing urinary or fecal incontinence include delivering a first type of therapy to generate a first physiological response and, upon detecting a trigger event, delivering a second type of therapy to generate a second physiological response. The first type of therapy can be delivered on a substantially regular basis, while the second type of therapy is delivered as needed to provide an additional boost of therapy. The trigger event for activating the delivery of the second type of therapy may include input from a sensor that indicates a bladder condition, patient activity level or patient posture, or patient input. In some examples, the therapy is stimulation therapy.
摘要翻译：用于管理尿失禁或大便失禁的技术包括递送第一类型的治疗以产生第一生理反应，并且在检测到触发事件时，递送第二类型的治疗以产生第二生理反应。第一种类型的治疗可以基本上定期地递送，而第二种类型的治疗根据需要被递送以提供额外的治疗效果。用于激活第二类治疗的递送的触发事件可以包括来自传感器的输入，其指示膀胱状况，患者活动水平或患者姿势或患者输入。在一些例子中，治疗是刺激疗法。

9. 发明授权

US09155885B2 Incontinence therapy 有权
标题翻译：失禁治疗
公开(公告)号：US09155885B2
公开(公告)日：2015-10-13
申请号：US13265702
申请日：2010-04-09
申请人： Xuan K. Wei , Eric H. Bonde , Keith A. Miesel , Mark S. Lent , Gregory F. Molnar
发明人： Xuan K. Wei , Eric H. Bonde , Keith A. Miesel , Mark S. Lent , Gregory F. Molnar
IPC分类号： A61N1/00 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36007 , A61N1/0514 , A61N1/0551 , A61N1/36128 , A61N1/36135 , A61N1/37235 , A61N1/37252
摘要： Techniques for managing urinary or fecal incontinence include delivering a first type of therapy to generate a first physiological response and, upon detecting a trigger event, delivering a second type of therapy to generate a second physiological response. The first type of therapy can be delivered on a substantially regular basis, while the second type of therapy is delivered as needed to provide an additional boost of therapy. The trigger event for activating the delivery of the second type of therapy may include input from a sensor that indicates a bladder condition, patient activity level or patient posture, or patient input. In some examples, the therapy is stimulation therapy.
摘要翻译：用于管理尿失禁或大便失禁的技术包括递送第一类型的治疗以产生第一生理反应，并且在检测到触发事件时，递送第二类型的治疗以产生第二生理反应。第一种类型的治疗可以基本上定期地递送，而第二种类型的治疗根据需要被递送以提供额外的治疗效果。用于激活第二类治疗的递送的触发事件可以包括来自传感器的输入，其指示膀胱状况，患者活动水平或患者姿势或患者输入。在一些例子中，治疗是刺激疗法。

10. 发明授权

US08137334B2 Reduction of inflammatory mass with spinal catheters 有权
标题翻译：减少脊髓导管的炎症质量
公开(公告)号：US08137334B2
公开(公告)日：2012-03-20
申请号：US10745897
申请日：2003-12-23
申请人： Kenneth T. Heruth , Mark S. Lent
发明人： Kenneth T. Heruth , Mark S. Lent
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61M5/16827 , A61M25/007 , A61M2025/0007 , A61M2025/0057 , A61M2025/0073 , A61M2202/0464 , A61M2205/0244 , A61M2205/123 , A61M2205/128 , A61M2205/3331 , A61M2205/3523 , A61M2205/50 , A61M2210/0693 , A61M2210/1003
摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc. Methods for treating diseases, including pain and spasticity are also discussed, as well as methods for screening patients and optimizing therapies. In addition, methods for delivering a drug to a brain through a spinal canal are described.
摘要翻译：公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。在各个方面，系统和方法可以包括具有渗透膜的输注部分的导管，其具有显着的背压以增强药物在输注部分上的均匀递送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 还讨论了治疗疾病，包括疼痛和痉挛症的方法，以及筛选患者和优化疗法的方法。另外，描述了通过椎管将药物递送到脑的方法。

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