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1. 发明申请

US20100114237A1 MOOD CIRCUIT MONITORING TO CONTROL THERAPY DELIVERY 审中-公开
标题翻译： MOOD电路监控以控制治疗
公开(公告)号：US20100114237A1
公开(公告)日：2010-05-06
申请号：US12608815
申请日：2009-10-29
申请人： Jonathon E. Giftakis , Mark T. Rise , David L. Carlson , Paul H. Stypulkowski , Scott R. Stanslaski , Randy M. Jensen , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , David L. Carlson , Paul H. Stypulkowski , Scott R. Stanslaski , Randy M. Jensen , Timothy J. Denison
IPC分类号： A61N1/00
CPC分类号： A61B5/0476 , A61B5/0205 , A61B5/024 , A61B5/0488 , A61B5/16 , A61B5/165 , A61B5/4076 , A61B5/4839 , A61B5/486 , A61M21/00 , A61M2021/0072 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36082
摘要： Brain signals may be monitored at different locations of a mood circuit in order to determine a mood state of the patient. A relationship (e.g., a ratio) between frequency band characteristics of the monitored brain signals may be indicative of a particular mood state. In some examples, therapy parameter values that define the therapy delivered to the patient may be selected to maintain a target relationship (e.g., a target ratio) between the frequency band characteristics of the brain signals monitored within the mood circuit. In addition, in some examples, therapy delivery to the patient may be controlled based on the frequency band characteristics of brain signals sensed at different portions of the mood circuit.
摘要翻译：可以在心情电路的不同位置监测脑信号，以便确定患者的情绪状态。所监视的脑信号的频带特性之间的关系（例如，比率）可以指示特定的情绪状态。在一些示例中，可以选择限定递送给患者的治疗的治疗参数值，以在心情电路内监测的脑信号的频带特性之间维持目标关系（例如，目标比率）。此外，在一些示例中，可以基于在心情电路的不同部分感测到的脑信号的频带特性来控制对患者的治疗递送。

2. 发明授权

US08428733B2 Stimulation electrode selection 有权
标题翻译：刺激电极选择
公开(公告)号：US08428733B2
公开(公告)日：2013-04-23
申请号：US12563845
申请日：2009-09-21
申请人： David L. Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott R. Stanslaski , William J. Marks, Jr.
发明人： David L. Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott R. Stanslaski , William J. Marks, Jr.
IPC分类号： A61N1/18
CPC分类号： A61N1/36067 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/36185 , A61N1/37247
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.
摘要翻译：可以在具有多个感测电极组合的患者的脑内感测生物电信号。可以基于感测信号的频带特性来选择用于将刺激递送给患者以管理患者状况的刺激电极组合。在一些示例中，可以选择与检测到具有相对较高的相对β带功率水平的生物电脑信号的感测电极组合相关联的刺激电极组合，以向患者传递刺激治疗。也可以使用其他频带特性来选择刺激电极组合。

3. 发明申请

US20100274115A1 LEAD EXTENSION WITH PHYSIOLOGICAL DATA RECORDER 审中-公开
标题翻译：引导延伸与生理数据记录器
公开(公告)号：US20100274115A1
公开(公告)日：2010-10-28
申请号：US12429921
申请日：2009-04-24
申请人： Jonathan C. Werder , Randy M. Jensen , Donald L. Deyo
发明人： Jonathan C. Werder , Randy M. Jensen , Donald L. Deyo
IPC分类号： A61B5/0476
CPC分类号： A61N1/0551 , A61B5/0031 , A61N1/0531 , A61N1/0534
摘要： A lead extension is provided that includes a physiological data recorder configured to store physiological data from the patient. A first extension segment may electrically and physically couple an implantable medical lead to the physiological data recorder, and a second extension segment may electrically and physically couple an implantable medical device (IMD) or a secondary lead extension to the physiological data recorder. The physiological data recorder may include a processor that collects the physiological data derived from sensed electrical signals from the medical lead and a memory to store the physiological data. The physiological data recorder may also wirelessly transmit the physiological data to an external programmer, or be explanted for data retrieval. In some examples, the physiological data recorder may be powered by electrical signals generated by the IMD, which may be either signals intended solely for charging, or signals intended for stimulation therapy.
摘要翻译：提供引线扩展，其包括被配置为存储来自患者的生理数据的生理数据记录器。第一延伸段可以电和物理地将可植入医疗引线耦合到生理数据记录器，并且第二延伸段可以将可植入医疗设备（IMD）或次级引线延伸部分电气和物理耦合到生理数据记录器。生理数据记录器可以包括收集来自医疗引线的感测电信号的生理数据的处理器和用于存储生理数据的存储器。生理数据记录器也可以将生理数据无线地传输到外部编程器，或者被移植用于数据检索。在一些示例中，生理数据记录器可以由IMD产生的电信号供电，IMD可以是仅用于充电的信号或用于刺激治疗的信号。

4. 发明申请

US20100100153A1 STIMULATION ELECTRODE SELECTION 有权
标题翻译：刺激电极选择
公开(公告)号：US20100100153A1
公开(公告)日：2010-04-22
申请号：US12563845
申请日：2009-09-21
申请人： David Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott Stanslaski , William J. Marks
发明人： David Carlson , Randy M. Jensen , Timothy J. Denison , Jianping Wu , Gabriela C. Molnar , Scott Stanslaski , William J. Marks
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/0529 , A61N1/0534 , A61N1/36082 , A61N1/36185 , A61N1/37247
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.
摘要翻译：可以在具有多个感测电极组合的患者的脑内感测生物电信号。可以基于感测信号的频带特性来选择用于将刺激递送给患者以管理患者状况的刺激电极组合。在一些示例中，可以选择与检测到具有相对较高的相对β带功率水平的生物电脑信号的感测电极组合相关联的刺激电极组合，以向患者传递刺激治疗。也可以使用其他频带特性来选择刺激电极组合。

5. 发明授权

US5007032A Acoustic alert sensor 失效
标题翻译：声警报传感器
公开(公告)号：US5007032A
公开(公告)日：1991-04-09
申请号：US535267
申请日：1990-06-08
申请人： Randy M. Jensen
发明人： Randy M. Jensen
IPC分类号： F42C13/06 , G01S11/14 , G01V1/00
CPC分类号： G01V1/001 , F42C13/06 , G01S11/14
摘要： An acoustic detector for detecting acoustic signals produced by vehicles. The detector comprises an acoustic sensor which senses an acoustic signal which is provided to a zero crossing detector. The zero crossing detector provides a digital signal representing the frequency of the incoming acoustic signal. The zero crossing detector's providing this digital signal to a first counter, the first counter's counting each zero crossing, and the first counter's reaching a predetermined count of zero crossings in a predetermined time for a predetermined number of times results in an acoustic alert provided to a secondary device which is put on alert of a vehicle in its vicinity. This secondary device may be a mine.

6. 发明授权

US08543214B2 Configuring and testing treatment therapy parameters for a medical device system 有权
标题翻译：配置和测试医疗器械系统的治疗治疗参数
公开(公告)号：US08543214B2
公开(公告)日：2013-09-24
申请号：US10687135
申请日：2003-10-15
申请人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Randy M. Jensen
发明人： Ivan Osorio , Mark G. Frei , Naresh C. Bhavaraju , Thomas E. Peters , Randy M. Jensen
IPC分类号： A61N1/00
CPC分类号： A61N1/36132 , A61N1/08
摘要： Apparatus and method support the configuration and testing of therapy parameters for a medical device system in the treatment of nervous system disorders. With the embodiment, the medical device system operates in a manual treatment therapy mode, in which the medical device system evaluates a set of information that is indicative of a system configuration. The medical device system determines if the set of information is acceptable. During the manual treatment therapy mode, the medical device system applies therapeutic treatment to a patient in accordance with the set of information. If the patient cannot tolerate the therapeutic treatment, the user indicates so through a user interface. The medical device system may associate the patient's intolerance to therapeutic treatments that equal or exceed the patient's level of tolerance. Moreover, the medical device system may use this information to prevent a delivery of therapeutic treatment that exceeds the patient's level of tolerance during a run mode.
摘要翻译：装置和方法支持用于治疗神经系统疾病的医疗装置系统的治疗参数的配置和测试。在该实施例中，医疗设备系统以手动治疗治疗模式操作，其中医疗设备系统评估指示系统配置的一组信息。医疗设备系统确定该组信息是否可接受。在手动治疗治疗模式期间，医疗装置系统根据该组信息向患者施加治疗。如果患者不能耐受治疗，则用户通过用户界面来表示。医疗装置系统可以将患者的不耐受性与等于或超过患者的耐受水平的治疗性治疗联系起来。此外，医疗装置系统可以使用该信息来防止在运行模式期间超过患者的容忍度的治疗性治疗的递送。

7. 发明申请

US20090082691A1 FREQUENCY SELECTIVE MONITORING OF PHYSIOLOGICAL SIGNALS 审中-公开
标题翻译：频率选择性监测生理信号
公开(公告)号：US20090082691A1
公开(公告)日：2009-03-26
申请号：US12237868
申请日：2008-09-25
申请人： Timothy J. Denison , Randy M. Jensen , Wesley A. Santa
发明人： Timothy J. Denison , Randy M. Jensen , Wesley A. Santa
IPC分类号： A61B5/04
CPC分类号： A61B5/04004 , A61B5/04018 , A61B5/048 , A61B5/4082 , A61B5/4094
摘要： In general, the disclosure is directed to a frequency selective monitor and methods for monitoring physiological signals in one or more selected frequency bands. A frequency selective monitor may utilize a heterodyning, chopper-stabilized amplifier architecture to convert a selected frequency band to a baseband for analysis. The frequency selective monitor may be useful in a variety of therapeutic and/or diagnostic applications. As examples, a frequency selective signal monitor may be provided within a medical device or within a sensor coupled to a medical device. The physiological signal may be analyzed in one or more selected frequency bands to trigger delivery of patient therapy and/or recording of diagnostic information.
摘要翻译：通常，本发明涉及一种频率选择性监测器和用于监测一个或多个所选频带中的生理信号的方法。频率选择性监视器可以利用外差斩波稳定的放大器架构将所选择的频带转换为基带用于分析。频率选择性监测器可用于各种治疗和/或诊断应用。作为示例，可以在医疗装置内或耦合到医疗装置的传感器内提供频率选择信号监视器。可以在一个或多个所选频带中分析生理信号以触发患者治疗的传递和/或记录诊断信息。

8. 发明授权

US07242983B2 Channel-selective blanking for a medical device system 有权
标题翻译：用于医疗设备系统的通道选择性消隐
公开(公告)号：US07242983B2
公开(公告)日：2007-07-10
申请号：US10687133
申请日：2003-10-15
申请人： Mark G. Frei , Ivan Osorio , Mark T. Rise , Jonathon E. Giftakis , Nina M. Graves , David L. Carlson , Randy M. Jensen
发明人： Mark G. Frei , Ivan Osorio , Mark T. Rise , Jonathon E. Giftakis , Nina M. Graves , David L. Carlson , Randy M. Jensen
IPC分类号： A61N1/00
CPC分类号： A61N1/37264 , A61N1/36146 , A61N2/00
摘要： Apparatuses and methods selectively blank a neurological channel of a medical device system in the treatment of a nervous system disorder. A selected signal of a selected channel may be blanked if it is determined that the selected signal may be affected by an artifact when the medical device system delivers a treatment therapy. The selected signal may be blanked by hardware, in which the selected electrode is disconnected from the selected channel (which may include an selected amplifier) and is connected to a fixed voltage in order to avoid saturation of the selected amplifier. The selected channel may be blanked by software, in which a signal processor is instructed not to process neurological data on the selected channel for a determined time duration. Embodiments may combine hardware and software blanking for the selected signal.
摘要翻译：装置和方法选择性地将医疗装置系统的神经通道置于神经系统疾病的治疗中。如果在医疗设备系统递送治疗疗法时确定所选择的信号可能受到伪像的影响，则选定信道的所选信号可能被消隐。所选择的信号可能被硬件消隐，其中所选择的电极与所选择的通道（其可以包括所选择的放大器）断开连接，并且连接到固定电压，以避免所选放大器的饱和。所选择的通道可以被软件置空，其中指示信号处理器不在所选择的通道上处理确定的持续时间的神经学数据。实施例可以组合所选信号的硬件和软件消隐。

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