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23. 发明授权

EP0411460B1 Perfumery composition comprising 2-cyclohexylpropionic acid or its derivative 失效
标题翻译： 2-环己基丙酸或它们的含香料组合物的衍生物。
公开(公告)号：EP0411460B1
公开(公告)日：1995-03-22
申请号：EP90114262.0
申请日：1990-07-25
申请人： KAO CORPORATION
发明人： Koshino, Junji , Fujikura, Yoshiaki , Toi, Nao
IPC分类号： C11B9/00 , A61K7/46
CPC分类号： C07C69/608 , C07C53/134 , C11B9/0034

24. 发明公开

EP0486948A3 Retroviral protease inhibiting compounds 失效
标题翻译：复方蛋白抑制化合物
公开(公告)号：EP0486948A3
公开(公告)日：1993-08-25
申请号：EP91119464.5
申请日：1991-11-04
申请人： ABBOTT LABORATORIES
发明人： Kempf, Dale J. , Codacovi, Lynn M. , Norbeck, Daniel W. , Plattner, Jacob J. , Sham, Hing L. , Wittenberger, Steven J. , Zhao, Chen
IPC分类号： C07D213/26 , C07D213/30 , C07D213/40 , C07K5/06 , A61K37/64 , C07D213/56 , C07D211/16 , C07D295/20 , C07D277/30 , C07D277/42 , C07D417/12 , C07D277/40 , C07D401/12 , C07D277/24 , C07D277/28 , C07D235/14 , C07D235/16
CPC分类号： C07D213/30 , A61K38/00 , C07C53/134 , C07C215/18 , C07C215/20 , C07C215/28 , C07C233/40 , C07C237/10 , C07C237/22 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/24 , C07D213/26 , C07D213/34 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/75 , C07D231/12 , C07D233/56 , C07D233/64 , C07D233/84 , C07D235/14 , C07D235/16 , C07D239/26 , C07D241/12 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/30 , C07D277/36 , C07D277/40 , C07D277/42 , C07D277/56 , C07D295/13 , C07D295/205 , C07D295/215 , C07D303/36 , C07D307/42 , C07D333/16 , C07D401/12 , C07D413/10 , C07D417/12 , C07K5/06026 , C07K5/06078
摘要： A retroviral protease inhibiting compound of the formula A -X- B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhibitors.

25. 发明授权

EP0152697B1 Heterocyclically substituted ethanes and their use in liquid crystal materials and devices 失效
标题翻译：杂环取代的乙烯及其在液晶材料和器件中的应用
公开(公告)号：EP0152697B1
公开(公告)日：1988-12-07
申请号：EP84308931.9
申请日：1984-12-31
申请人： Secretary of State for Defence in Her Britannic Majesty's Gov. of the United Kingdom of Great Britain and Northern Ireland
发明人： Gray, George William , Nicholas (nee Andrews) B. M.
IPC分类号： C07D319/06 , C07D239/26 , C09K19/34
CPC分类号： C07D239/26 , C07C31/1355 , C07C47/11 , C07C53/134 , C07C309/00 , C07D239/34 , C07D319/06 , C09K19/3402 , C09K19/3458 , C09K2019/3422

26. 发明公开

EP0213547A1 Cyclohexanealkanoic acids 失效
标题翻译：环己烷链烷酸
公开(公告)号：EP0213547A1
公开(公告)日：1987-03-11
申请号：EP86111522.8
申请日：1986-08-20
申请人： MERRELL DOW PHARMACEUTICALS INC.
发明人： Cregge, Robert J. , Sabol, Jeffrey S.
IPC分类号： C07C321/22 , A61K31/19
CPC分类号： C07F7/1856 , A61K31/19 , C07C53/134 , C07C323/52 , C07C2601/14 , C07D303/40 , Y10S514/826
摘要： The present invention is directed to 2-hydroxy-4-alkylidenecyclohexanealkanoic acids having a mercaptoalkanoic acid substituent at the 3-position. Esters and amides corresponding to the acids referred to above are also encompassed by the present invention. These compounds are useful in the treatment of bronchial asthma and they are obtained by the reaction of an appropriate 2,3-epoxy-4-alkylidenecyclohexanealkanoate with a mercapto alkanoic acid ester in the presence of a tertiary amine. The indicated process gives the esters of the present invention which can be hydrolyzed to the corresponding free acids by standard procedures. The compoudns described can be subjected to other known reactions to give the other compounds of the present invention.
摘要翻译：本发明涉及在3-位具有巯基链烷酸取代基的2-羟基-4-亚烷基环己烷链烷酸。对应于上述酸的酯和酰胺也包括在本发明中。这些化合物可用于治疗支气管哮喘，它们通过适当的2,3-环氧-4-亚烷基环己烷链烷酸酯与巯基链烷酸酯在叔胺存在下反应而得到。所示方法得到本发明的酯，其可通过标准程序水解为相应的游离酸。所描述的化合物可以进行其他已知的反应以得到本发明的其它化合物。

27. 发明公开

EP0077550A3 1.4-Naphthoquinones, methods for their preparation and veterinary formulations thereof 有权
标题翻译： 1.4萘醌，其制备方法及其兽药配方
公开(公告)号：EP0077550A3
公开(公告)日：1983-09-28
申请号：EP82109568
申请日：1982-10-15
申请人： THE WELLCOME FOUNDATION LIMITED
发明人： Hudson, Alan Thomas , Randall, Anthony Winchester
IPC分类号： C07C50/32 , C07C46/00 , C07C46/06 , A61K31/12 , C07C69/14 , C07C69/78
CPC分类号： C07C61/22 , C07C50/32 , C07C51/08 , C07C51/36 , C07C51/487 , C07C53/134 , C07C61/08 , C07C61/15
摘要： 1,4-Naphthoquinones of formula (I), methods for their preparation veterinary formulations thereof, and the use thereof in animal therapy are disclosed.
Particularly preferred compounds of formula (I) are, 2-[trans-(4-t-butylcyclohexyl)methyl]-3-hydroxy-1,4-naphthoquinone, and 2-[trans-(4-t-pentyl cyclohexyl)-methyl]-3-hydroxy-1,4-naphthoquinone. The compounds are of value as anti-protozoal agents, in particular as anti-theilerial agents.

28. 发明公开

EP3191088A1 AN ANTICONVULSANT COMPOUND 有权
标题翻译：抗痤疮化合物
公开(公告)号：EP3191088A1
公开(公告)日：2017-07-19
申请号：EP15766568.8
申请日：2015-09-10
申请人： Royal Holloway And Bedford New College
发明人： WILLIAMS, Robin , WALKER, Matthew
IPC分类号： A61K31/13 , A61K31/136 , A61K31/137 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/445 , C07C61/08 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/28 , A61P9/10
CPC分类号： C07D211/60 , A61K31/13 , A61K31/136 , A61K31/137 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/445 , C07C53/134 , C07C59/13 , C07C61/08 , C07C61/09 , C07C61/35 , C07C62/10 , C07C229/28 , C07C2601/14
摘要： The invention relates to pharmaceutical uses of compounds of formula (II). Particular aspects of the invention relate to the use of those compounds in treating, preventing or ameliorating a seizure-related disorder, bipolar disorder, mania, migraine, Alzheimer's disease, Parkinson's disease or stroke.
摘要翻译：本发明涉及式（II）化合物的药物用途。本发明的具体方面涉及这些化合物在治疗，预防或改善癫痫相关病症，双相型精神障碍，躁狂症，偏头痛，阿尔茨海默氏病，帕金森病或中风中的用途。

29. 发明公开

EP3035925A4 METHOD FOR TREATING NEUROPATHIC PAIN 审中-公开
标题翻译： VERFAHREN ZUR BEHANDLUNG VON NEUROPATHISCHEM SCHMERZ
公开(公告)号：EP3035925A4
公开(公告)日：2017-03-29
申请号：EP14838126
申请日：2014-08-21
申请人： SUCAMPO AG
发明人： UENO RYUJI
IPC分类号： A61K31/19 , A61P25/02 , A61P25/04
CPC分类号： C07C57/26 , A61K31/352 , C07C53/134
摘要： A method for treating neuropathic pain in a mammalian subject, which comprises administering an effective amount of a fatty acid derivative, is provided.
摘要翻译：提供一种治疗哺乳动物受试者神经性疼痛的方法，其包括施用有效量的脂肪酸衍生物。

30. 发明公开

EP3140316A1 COMPOSITIONS AND METHODS RELATING TO IONIC SALTS OF PEPTIDES 审中-公开
标题翻译：组合物和方法 - 关于肽离子盐
公开(公告)号：EP3140316A1
公开(公告)日：2017-03-15
申请号：EP15724849.3
申请日：2015-05-04
申请人： Thetis Pharmaceuticals LLC
发明人： MATHIAS, Gary , MYLARI, Banavara L. , SCIAVOLINO,Frank C.
IPC分类号： C07K7/08 , C07C51/41 , C07C57/03 , C11C3/00
CPC分类号： C07K5/06086 , A23L33/12 , A23V2002/00 , C07C51/412 , C07C53/134 , C07C57/02 , C07C57/03 , C07C229/28 , C07C237/12 , C07C317/04 , C07C2601/14 , C07D213/80 , C07K5/06095 , C07K7/08 , C11C3/00
摘要： The present invention relates to compounds of Formula I, compositions containing same, and methods of use.
摘要翻译：本发明涉及式I的化合物，COMPOSITIONS CONTAINING相同，和使用方法。

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