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1. 发明公开

EP4377296A1 METHODS OF MANUFACTURING A BIFUNCTIONAL COMPOUND 审中-公开
公开(公告)号：EP4377296A1
公开(公告)日：2024-06-05
申请号：EP22783075.9
申请日：2022-07-26
申请人： Arvinas Operations, Inc.
发明人： CHEN, Chungpin Herman , DONG, Hanqing
IPC分类号： C07D207/16 , C07C235/00 , C07D209/46 , C07D211/32 , C07D295/205 , C07D401/04 , C07D401/14
CPC分类号： C07D401/14 , C07D211/32 , C07D207/16 , C07D209/46 , C07D401/04 , C07D295/205 , C07C303/32 , C07C231/12

3. 发明授权

EP3845523B1 SYNTHESIS METHOD FOR CARIPRAZINE 有权
公开(公告)号：EP3845523B1
公开(公告)日：2024-05-29
申请号：EP19856405.6
申请日：2019-08-06
IPC分类号： C07D295/135
CPC分类号： C07D295/135 , Y02P20/55

4. 发明公开

EP4361132A1 PURIFICATION METHOD AND SYSTEM FOR N-METHYLMORPHOLINE-N-OXIDE, AND OBTAINED N-METHYLMORPHOLINE-N-OXIDE 审中-公开
公开(公告)号：EP4361132A1
公开(公告)日：2024-05-01
申请号：EP22830362.4
申请日：2022-06-23
申请人： B-FCTL Co., Ltd.
发明人： LU, Wanli , MA, Jie
IPC分类号： C07D295/24 , D01F11/00 , D01F13/00
CPC分类号： Y02P70/62
摘要： The invention discloses a purification method and system of N-methylmorpholine N-oxide (NMMO), and a N-methylmorpholine N-oxide obtained thereof. The invention is used for recovering and purifying NMMO in a lyocell fiber coagulation bath. The method comprises: performing flocculation, microfiltration, ultrafiltration and nanofiltration membrane separation process to the lyocell fiber coagulation bath to remove macromolecular impurities such as suspending substance, heavy metal ions, heavy metal complexes, polysaccharides, etc., and then performing cooling crystallization between -20°C and 78°C to obtain NMMO hydrate crystals. The NMMO hydrate crystals obtained by the method provided in the invention do not contain PG, PG oxidation products, cellulose breakdown products such as various carbohydrates, sugar ketones, sugar acid, furans, furfurals, phenols, and NMMO decomposition products, which are present in the coagulation bath. The NMMO hydrate crystals do not contain various metal ions and anions as well. The NMMO hydrate crystals are added with water to prepare a NMMO aqueous solution with a concentration of 19.8%, and the electrical conductivity is about 14.8µs/cm. The crystalline NMMO obtained by a first crystallization is added with water to perform crystallization again, and a crystalline NMMO with higher purity can be obtained. The crystalline NMMO with higher purity is added with water to prepare a NMMO aqueous solution with a concentration of 19.8% and the electrical conductivity is reduced to less than 12.4µs/cm.

5. 发明公开

EP4347576A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR USE IN NEURODEGENERATIVE DISORDERS 审中-公开
公开(公告)号：EP4347576A1
公开(公告)日：2024-04-10
申请号：EP22732100.7
申请日：2022-06-02
申请人： Universiteit Hasselt , Universiteit Maastricht , Academisch ziekenhuis Maastricht
发明人： VANMIERLO, Tim , SCHEPERS, Melissa , PICCART, Elisabeth , PRICKAERTS, Jos
IPC分类号： C07D295/08 , A61K31/4155 , A61P25/28 , C07D261/08 , C07D413/06

6. 发明公开

EP4296257A3 PROCESS OF PREPARING A PEPTIDE EPOXYKETONE IMMUNOPROTEASOME INHIBITOR 审中-公开
公开(公告)号：EP4296257A3
公开(公告)日：2024-03-20
申请号：EP23191555.4
申请日：2017-06-29
申请人： Kezar Life Sciences
发明人： JOHNSON, Henry , DALZIEL, Sean , MCMINN, Dustin
IPC分类号： C07D295/15 , C07D303/12 , C07D303/32 , C07D303/46 , C07C69/612
摘要： Disclosed herein are methods for preparing [(2 S ,3 R )- N- [(2S)-3-(cyclopent-1-en-1-yl)-1-[(2 R )-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[(2( S )-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide (compound "G"):

and precursors thereof.

8. 发明公开

EP4335842A1 PURIFICATION METHOD, SYSTEM AND DETECTION METHOD FOR N-METHYLMORPHOLINE N-OXIDE AND OBTAINED N-METHYLMORPHOLINE-N-OXIDE 审中-公开
公开(公告)号：EP4335842A1
公开(公告)日：2024-03-13
申请号：EP22803748.7
申请日：2022-04-24
申请人： B-FCTL Co., Ltd.
发明人： LU, Wanli , MA, Jie
IPC分类号： C07D295/24 , B01D1/22
摘要： Disclosed are a purification method, system and detection method for N-methylmorpholine N-oxide (NMMO) and an obtained NMMO. The NMMO is derived from a crude product of NMMO prepared by reacting N-methylmorpholine with hydrogen peroxide. The mass concentration of NMMO in the crude NMMO product is 50-60%. The purification method comprises: cooling a crude NMMO product to -20°C-78°C for crystallization so as to obtain a crystal of NMMO. The NMMO purification method of the present invention has low costs. The obtained NMMO product has high purity and almost no "three wastes" are generated. Different from current NMMO purification process, the purification method of the present invention does not require an ion exchange resin; therefore, environmental problems such as large amounts of high-salt and high-COD wastewater and waste ion exchange resin brought about by the regeneration of an ion exchange resin are completely solved.

9. 发明授权

EP4008715B1 HALOGEN SUBSTITUTED COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 有权
公开(公告)号：EP4008715B1
公开(公告)日：2024-03-06
申请号：EP19940643.0
申请日：2019-12-20
发明人： WANG, Mingchun , LI, Qingyi
IPC分类号： C07D295/104 , C07D295/145 , C07D231/14 , A01N43/56 , A01P3/00

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