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1. 发明公开

EP4281437A1 SULFUR-CONTAINING LIPIDS 审中-公开
公开(公告)号：EP4281437A1
公开(公告)日：2023-11-29
申请号：EP22741969.4
申请日：2022-01-12
申请人： The University of British Columbia
发明人： CIUFOLINI, Marco , FERGUSON, Mai Lam
IPC分类号： C07C323/12 , A61K9/51 , A61K47/20 , C07C323/25 , C12N15/10 , C12N15/87

2. 发明公开

EP4054553A1 COMPOUNDS AND IMPLANTS FOR TREATING OCULAR DISORDERS 审中-公开
公开(公告)号：EP4054553A1
公开(公告)日：2022-09-14
申请号：EP20884886.1
申请日：2020-11-06
申请人： Retina Foundation of the Southwest
发明人： CSAKY, Karl , BULUMULLA, Chandima , KULARATNE, Ruvanthi
IPC分类号： A61K31/223 , C07C323/25 , C07C323/59 , A61P27/02

3. 发明公开

EP3508510A1 CONTACT-KILLING, QAC FUNCTIONALIZED THERMOPLASTIC POLYURETHANE FOR CATHETER APPLICATIONS 审中-公开
公开(公告)号：EP3508510A1
公开(公告)日：2019-07-10
申请号：EP18199187.8
申请日：2018-10-08
申请人： The University of Akron , Cook Medical Technologies LLC
发明人： BECKER, Matthew L , ZANDER, Zachary K , CHAMBERS, Sean , CHIARI, Alec , McROY, Will
IPC分类号： C08G18/48 , A61L29/14 , C08G18/66 , C08G18/67 , C08G18/75 , C08G18/83 , C08G18/32 , C08G18/08 , A61L27/34 , A61L27/18 , A61L29/06 , A61L29/16 , A61L31/06 , A61L15/26 , A61L31/16 , A61L15/46 , A61L17/04 , C07C319/20 , C07C323/25 , C08L75/04 , C07C323/52
摘要： In various embodiments, the present invention provides a functionalized thermoplastic polyurethane (TPU) containing bulk incorporated or surface-grafted quaternary ammonium compounds (QAC)s for contact-killing of a variety of microbes, where the QACs are on the surface of TPU to provide a sterile surface material that prevents bacteria commonly involved in device-associated infections (DAIs) from proliferating. The functionalized TPUs of the present invention can be formed into a wide variety of 3-dimensional shapes, such as catheters, medical tubing, laryngeal or tracheal stents, sutures, prosthetics, wound dressings, and/or a coating for medical devices and contains the residue of either a QAC containing diol monomer or an alkene functional diol monomer, which then allows the TPU to be functionalized with a QAC containing disulfide or free thiol compound, to form a quaternary ammonium functionalized thermoplastic polyurethane compound having antimicrobial properties for use in medical devices.

4. 发明授权

EP2860169B1 Method for obtaining novel derivatives of naphtalene for the in vivo diagnosis of Alzheimer's disease 有权
公开(公告)号：EP2860169B1
公开(公告)日：2018-08-29
申请号：EP14075021.7
申请日：2010-04-17
申请人： Centro De Neurociencias De Cuba
发明人： Sablón Carrazana, Marquiza , Rodriguez-Tanty, Chryslaine , Perera Pintado, Alejandro , Rivera Marrero, Suchitil , Perez Perera, Rafaela , López Barroso, Rosa Maria , Prats Capote, Anaís , Vélez Castro, Hermán , Pérez Martínez, Carlos Serafin , Valdés Sosa, Pedro
IPC分类号： C07C43/20 , C07C39/38 , C07C43/225 , C07C233/07 , C07C233/36 , C07C233/47 , C07C323/25 , C07D207/06 , C07D207/46 , A61K51/04
CPC分类号： A61K51/0446 , A61K51/0402 , A61K51/0482 , C07B2200/05 , C07C43/225 , C07C233/07 , C07C233/36 , C07C233/47 , C07C323/25 , C07D207/06 , C07D207/46
摘要： This invention relates to a chemistry branch, particularly to the field of compounds' organic synthesis that belongs to the aromatic bicyclic or naphthalene category, used in the detection of amyloid sheets. These new naphthalene derivatives have a general formula: Where R represents mutually independent groups. In I: R 1 : -alkylenyl-C(O)NH-alkylenyl-R 3 , -alkylenyl-C(O)O-R 4 ; R 3 : -COOH, -OH, - SH, -NH 2 , -alkyl-NH, -alkyl-N-dithiocarbamate alkaline earth metal salts. R 4 : succinimidyl group. R 2 : -H, -alkyl. The term "alkyl" is characterized by a linear or branched aliphatic chain, hydrogen and saturated carbon atoms, comprising a methyl, ethyl, n -propyl, iso -propyl, n -butyl or iso -butyl groups. The term "alkylenyl" refers to a divalent analog of a linear or branched alkyl group, preferably ethylenyl (CH 2 CH 2 ) or butylenyl (CH 2 CH 2 CH 2 CH 2 ) radicals. In II: R 1 : -alkyl, and R 2 is -alkylenyl- O -arylsulfonate, -alkylenyl-halide, -CH(O), alkylenyl-NH 2 , -alkylenyl-NH-alkyl, -alkylenyl-alkyl- N -dithiocarbamate salts such as cesium, potassium or sodium. The term "alkyl" is characterized by a linear or branched aliphatic chain, hydrogen and saturated carbon atoms, preferably methyl, ethyl, n -propyl, iso -propyl, n -butyl or iso -butyl. The term "alkylenyl" refers to a divalent analog of a linear or branched alkyl group, preferably propylenyl (-CH 2 CH 2 CH 2 ) radical. The term halide refers to fluorine, bromine or iodine. or, In II: R 1 : -alkylenyl-halide, -alkylenyl- O -arylsulfonate and R 2 : -halide, -alkylenyl- O- arylsulfonate, -alkylenyl- O -alkylsulfonate, -alkylenyl-halide, -CH(O), -HC=C(CN) 2 , - HC=CHNO 2 , -alkylenyl-NH 2 , -alkylenyl-NH-alkyl, -alkylenyl-alkyl- N -dithiocarbamate salts such as cesium, potassium or sodium. The term "alkylenyl" refers to a divalent analog of a linear or branched alkyl group, preferably propylenyl (-CH 2 CH 2 CH 2 ) radical. The term halide refers to fluorine, bromine or iodine. These compounds are neutral, lipophilic and have low molecular weight and therefore they cross the blood brain barrier and attach to the amyloid sheets. The present invention provides procedures for obtaining naphthalene derivatives with good yields, which can be practical, economical and adapted to a larger-scale manufacturing. We are unaware whether the compounds presented in this invention have been previously reported.

5. 发明授权

EP2580204B1 CYSTEAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NASH 有权
标题翻译：半胱胺衍生物和它们在NASH的治疗
公开(公告)号：EP2580204B1
公开(公告)日：2017-03-08
申请号：EP11749511.9
申请日：2011-06-03
申请人： Krisani Bioscience (P) Ltd.
发明人： KANDULA, Mahesh
IPC分类号： C07C323/25 , A61K31/16 , A61K31/27 , A61P1/16
CPC分类号： C07C323/44

6. 发明公开

EP2860169A3 Method for obtaining novel derivatives of naphtalene for the in vivo diagnosis of Alzheimer's disease 审中-公开
标题翻译：获得萘新的衍生物用于治疗阿尔茨海默氏病的体内诊断方法
公开(公告)号：EP2860169A3
公开(公告)日：2015-10-21
申请号：EP14075021.7
申请日：2010-04-17
申请人： Centro De Neurociencias De Cuba
发明人： Sablón Carrazana, Marquiza , Rodriguez-Tanty, Chryslaine , Perera Pintado, Alejandro , Rivera Marrero, Suchitil , Perez Perera, Rafaela , López Barroso, Rosa Maria , Prats Capote, Anaís , Vélez Castro, Hermán , Pérez Martínez, Carlos Serafin , Valdés Sosa, Pedro
IPC分类号： C07C43/20 , C07C39/38 , C07C43/225 , C07C233/07 , C07C233/36 , C07C233/47 , C07C323/25 , C07D207/06 , C07D207/46 , A61K51/04
CPC分类号： A61K51/0446 , A61K51/0402 , A61K51/0482 , C07B2200/05 , C07C43/225 , C07C233/07 , C07C233/36 , C07C233/47 , C07C323/25 , C07D207/06 , C07D207/46
摘要： This invention relates to a chemistry branch, particularly to the field of compounds' organic synthesis that belongs to the aromatic bicyclic or naphthalene category, used in the detection of amyloid sheets. These new naphthalene derivatives have a general formula:

Where R represents mutually independent groups.
In I: R 1 : -alkylenyl-C(O)NH-alkylenyl-R 3 , -alkylenyl-C(O)O-R 4 ; R 3 : -COOH, -OH, - SH, -NH 2 , -alkyl-NH, -alkyl-N-dithiocarbamate alkaline earth metal salts. R 4 : succinimidyl group. R 2 : -H, -alkyl. The term "alkyl" is characterized by a linear or branched aliphatic chain, hydrogen and saturated carbon atoms, comprising a methyl, ethyl, n -propyl, iso -propyl, n -butyl or iso -butyl groups. The term "alkylenyl" refers to a divalent analog of a linear or branched alkyl group, preferably ethylenyl (CH 2 CH 2 ) or butylenyl (CH 2 CH 2 CH 2 CH 2 ) radicals.
In II: R 1 : -alkyl, and R 2 is -alkylenyl- O -arylsulfonate, -alkylenyl-halide, -CH(O), alkylenyl-NH 2 , -alkylenyl-NH-alkyl, -alkylenyl-alkyl- N -dithiocarbamate salts such as cesium, potassium or sodium. The term "alkyl" is characterized by a linear or branched aliphatic chain, hydrogen and saturated carbon atoms, preferably methyl, ethyl, n -propyl, iso -propyl, n -butyl or iso -butyl. The term "alkylenyl" refers to a divalent analog of a linear or branched alkyl group, preferably propylenyl (-CH 2 CH 2 CH 2 ) radical. The term halide refers to fluorine, bromine or iodine.
or,
In II: R 1 : -alkylenyl-halide, -alkylenyl- O -arylsulfonate and R 2 : -halide, -alkylenyl- O- arylsulfonate, -alkylenyl- O -alkylsulfonate, -alkylenyl-halide, -CH(O), -HC=C(CN) 2 , - HC=CHNO 2 , -alkylenyl-NH 2 , -alkylenyl-NH-alkyl, -alkylenyl-alkyl- N -dithiocarbamate salts such as cesium, potassium or sodium. The term "alkylenyl" refers to a divalent analog of a linear or branched alkyl group, preferably propylenyl (-CH 2 CH 2 CH 2 ) radical. The term halide refers to fluorine, bromine or iodine.
These compounds are neutral, lipophilic and have low molecular weight and therefore they cross the blood brain barrier and attach to the amyloid sheets.
The present invention provides procedures for obtaining naphthalene derivatives with good yields, which can be practical, economical and adapted to a larger-scale manufacturing.
We are unaware whether the compounds presented in this invention have been previously reported.
摘要翻译：本发明涉及一种化学分支，特别是涉及的化合物有机合成领域确实属于芳族双环或萘类，在检测淀粉样蛋白片的使用。这些新的萘衍生物具有以下通式：其中R darstellt相互独立的基团。在我R 1：亚烷基-C（O）NH-亚烷基-R 3， - 亚烷基-C（O）O-R 4; ，R 3：-COOH，-OH， - SH，-NH 2，烷基-NH，烷基-N-硫代氨基甲酸碱土金属盐。，R 4：琥珀酰亚胺基团。 R 2：-H，烷基。术语“烷基”是由线性或支链脂族，氢和饱和碳原子上为特征的，包括甲基，乙基，正丙基，异丙基，正丁基或异丁基。术语“亚烷基”是指直链的二价类似物或支链烷基，优选为亚乙基（CH 2 CH 2）或butylenyl（CH 2 CH 2 CH 2 CH 2）自由基。在II，R 1：烷基，和R 2是O -alkylenyl-芳基磺酸盐，亚烷基 - 卤化物，-CH（O），亚烷基-NH 2亚烷基-NH-烷基，亚烷基 - 烷基-N - 二硫代氨基甲酸盐类：如铯，钾或钠。术语“烷基”是由线性或支链脂族，氢和饱和碳原子，优选甲基，乙基，正丙基，异丙基，正丁基或异丁基特征的。术语“亚烷基”是指直链的二价类似物或支链烷基，优选为丙烯基（CH 2 CH 2 CH 2）基团。术语卤化物是指氟，溴或碘。或者，在II R 1：亚烷基卤化物，-alkylenyl-ö芳基磺酸盐和R 2 - 卤化物，-alkylenyl- O-芳基磺酸盐，烷基磺酸盐-alkylenyl- O，亚烷基 - 卤化物，-CH（O），-HC = C（CN）2， - HC = CHNO 2，亚烷基-NH 2亚烷基-NH-烷基，亚烷基 - 烷基 - ñ-dithiocarbamate盐：如铯，钾或钠。术语“亚烷基”是指直链的二价类似物或支链烷基，优选为丙烯基（CH 2 CH 2 CH 2）基团。术语卤化物是指氟，溴或碘。这些化合物是中性的，亲脂性，并且具有低分子量，因此，它们穿过血脑屏障并附着在淀粉样薄片。本发明提供了用于获得萘衍生物具有良好产率，其可以是实用的，经济的和angepasst到较大规模的生产程序。我们不知道是否在本发明提供的化合物havebeen此前报道。

7. 发明公开

EP2860169A2 Method for obtaining novel derivatives of naphtalene for the in vivo diagnosis of Alzheimer's disease 审中-公开
标题翻译：获得新的萘衍生物用于体内诊断阿尔茨海默病的方法
公开(公告)号：EP2860169A2
公开(公告)日：2015-04-15
申请号：EP14075021.7
申请日：2010-04-17
申请人： Centro De Neurociencias De Cuba
发明人： Sablón Carrazana, Marquiza , Rodriguez-Tanty, Chryslaine , Perera Pintado, Alejandro , Rivera Marrero, Suchitil , Perez Perera, Rafaela , López Barroso, Rosa Maria , Prats Capote, Anaís , Vélez Castro, Hermán , Pérez Martínez, Carlos Serafin , Valdés Sosa, Pedro
IPC分类号： C07C43/20 , C07C39/38 , C07C43/225 , C07C233/07 , C07C233/36 , C07C233/47 , C07C323/25 , C07D207/06 , C07D207/46
CPC分类号： A61K51/0446 , A61K51/0402 , A61K51/0482 , C07B2200/05 , C07C43/225 , C07C233/07 , C07C233/36 , C07C233/47 , C07C323/25 , C07D207/06 , C07D207/46
摘要： This invention relates to a chemistry branch, particularly to the field of compounds' organic synthesis that belongs to the aromatic bicyclic or naphthalene category, used in the detection of amyloid sheets. These new naphthalene derivatives have a general formula:

Where R represents mutually independent groups.
In I: R 1 : -alkylenyl-C(O)NH-alkylenyl-R 3 , -alkylenyl-C(O)O-R 4 ; R 3 : -COOH, -OH, - SH, -NH 2 , -alkyl-NH, -alkyl-N-dithiocarbamate alkaline earth metal salts. R 4 : succinimidyl group. R 2 : -H, -alkyl. The term "alkyl" is characterized by a linear or branched aliphatic chain, hydrogen and saturated carbon atoms, comprising a methyl, ethyl, n -propyl, iso -propyl, n -butyl or iso -butyl groups. The term "alkylenyl" refers to a divalent analog of a linear or branched alkyl group, preferably ethylenyl (CH 2 CH 2 ) or butylenyl (CH 2 CH 2 CH 2 CH 2 ) radicals.
In II: R 1 : -alkyl, and R 2 is -alkylenyl- O -arylsulfonate, -alkylenyl-halide, -CH(O), alkylenyl-NH 2 , -alkylenyl-NH-alkyl, -alkylenyl-alkyl- N -dithiocarbamate salts such as cesium, potassium or sodium. The term "alkyl" is characterized by a linear or branched aliphatic chain, hydrogen and saturated carbon atoms, preferably methyl, ethyl, n -propyl, iso -propyl, n -butyl or iso -butyl. The term "alkylenyl" refers to a divalent analog of a linear or branched alkyl group, preferably propylenyl (-CH 2 CH 2 CH 2 ) radical. The term halide refers to fluorine, bromine or iodine.
or,
In II: R 1 : -alkylenyl-halide, -alkylenyl- O -arylsulfonate and R 2 : -halide, -alkylenyl- O- arylsulfonate, -alkylenyl- O -alkylsulfonate, -alkylenyl-halide, -CH(O), -HC=C(CN) 2 , - HC=CHNO 2 , -alkylenyl-NH 2 , -alkylenyl-NH-alkyl, -alkylenyl-alkyl- N -dithiocarbamate salts such as cesium, potassium or sodium. The term "alkylenyl" refers to a divalent analog of a linear or branched alkyl group, preferably propylenyl (-CH 2 CH 2 CH 2 ) radical. The term halide refers to fluorine, bromine or iodine.
These compounds are neutral, lipophilic and have low molecular weight and therefore they cross the blood brain barrier and attach to the amyloid sheets.
The present invention provides procedures for obtaining naphthalene derivatives with good yields, which can be practical, economical and adapted to a larger-scale manufacturing.
We are unaware whether the compounds presented in this invention have been previously reported.
摘要翻译：本发明涉及化学分支，特别涉及属于芳族双环或萘类的化合物的有机合成领域，用于检测淀粉样蛋白片。这些新的萘衍生物具有通式：其中R代表相互独立的基团。在I中：R1： - 亚烷基-C（O）NH-亚烷基-R3， - 亚烷基-C（O）O-R4; R3：-COOH，-OH，-SH，-NH2， - 烷基-NH， - 烷基-N-二硫代氨基甲酸盐碱土金属盐。 R4：琥珀酰亚胺基。 R2：-H， - 烷基。术语“烷基”的特征在于包含甲基，乙基，正丙基，异丙基，正丁基或异丁基的直链或支链脂族链，氢和饱和碳原子。术语“亚烷基”是指直链或支链烷基的二价类似物，优选乙烯基（CH 2 CH 2）或丁烯基（CH 2 CH 2 CH 2 CH 2）基团。在II：R1：烷基和R2是 - 亚烷基-O-芳基磺酸盐， - 亚烷基 - 卤化物，-CH（O），亚烷基-NH2， - 亚烷基-NH-烷基， - 亚烷基 - 烷基-N-二硫代氨基甲酸盐如铯，钾或钠。术语“烷基”的特征在于直链或支链脂族链，氢和饱和碳原子，优选甲基，乙基，正丙基，异丙基，正丁基或异丁基。术语“亚烷基”是指直链或支链烷基，优选丙基（-CH 2 CH 2 CH 2）基团的二价类似物。术语卤化物是指氟，溴或碘。或II中：R1： - 亚烷基 - 卤化物， - 亚烷基-O-芳基磺酸盐和R2：卤化物， - 亚烷基-O-芳基磺酸盐， - 亚烷基-O-烷基磺酸盐， - 亚烷基卤化物，-CH（O） HC = C（CN）2，-HC = CHNO2， - 亚烷基-NH2， - 亚烷基-NH-烷基， - 亚烷基 - 烷基-N-二硫代氨基甲酸盐如铯，钾或钠。术语“亚烷基”是指直链或支链烷基，优选丙基（-CH 2 CH 2 CH 2）基团的二价类似物。术语卤化物是指氟，溴或碘。这些化合物是中性的，亲脂性的并且具有低分子量，因此它们穿过血脑屏障并附着到淀粉样蛋白片上。本发明提供了获得具有良好收率的萘衍生物的方法，其可以是实用的，经济的并适合于大规模生产。我们不知道本发明中呈现的化合物是否先前已经报道过。

8. 发明公开

EP2788321A1 6,7-DIHYDRO-5H-BENZO[7]ANNULEN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG, PHARMAZEUTISCHE PRÄPARATE DIE DIESE ENTHALTEN, SOWIE DEREN VERWENDUNG ZUR HERSTELLUNG VON ARZNEIMITTELN 审中-公开
标题翻译： 6,7-二氢-5H-苯并[7]轮烯衍生物，用于生产药物制剂含有它们和它们在药物的生产
公开(公告)号：EP2788321A1
公开(公告)日：2014-10-15
申请号：EP12795806.4
申请日：2012-12-04
申请人： Bayer Intellectual Property GmbH
发明人： WINTERMANTEL, Tim , MOELLER, Carsten , BOTHE, Ulrich , NUBBEMEYER, Reinhard , ZORN, Ludwig , TER LAAK, Antonius , BOHLMANN, Rolf , WORTMANN, Lars
IPC分类号： C07C317/28 , C07C317/32 , C07C323/25 , A61P5/32 , A61P5/30 , A61K31/10
CPC分类号： C07D213/38 , A61K31/145 , A61K31/4406 , A61K45/06 , C07C317/28 , C07C317/32 , C07C323/25
摘要： The invention relates to selective estrogen receptor modulators (SERMs), to methods for the production thereof, to the use thereof to treat and/or prevent diseases, and to the use thereof to produce drugs for the treatment and/or prevention of diseases, in particular bleeding disorders, osteoporosis, endometriosis, myomas, hormone-dependent tumors, for hormone replacement therapy, and for contraception.
摘要翻译：本发明涉及一种选择性雌激素受体调节剂（SERMs）和它们的制备方法，涉及其用于疾病的治疗和/或预防和它们用于制备药物用于疾病的治疗和/或预防，在特定用途使用出血性疾病，骨质疏松症，子宫内膜异位，肌瘤，激素依赖性肿瘤，用于激素替代疗法以及用于避孕。

9. 发明公开

EP2781507A1 CATIONIC LIPID HAVING IMPROVED INTRACELLULAR KINETICS 有权转让
标题翻译：具有改进的帧内蜂窝动力学阳离子脂质
公开(公告)号：EP2781507A1
公开(公告)日：2014-09-24
申请号：EP12850198.8
申请日：2012-11-09
申请人： NOF Corporation , National University Corporation Hokkaido University
发明人： TANGE, Kota , ARAI, Masaya , KUBO, Kazuhiro , AKITA, Hidetaka , HARASHIMA, Hideyoshi , HATAKEYAMA, Hiroto , ISHIBA, Ryohei , UKAWA, Masami , TANAKA, Hiroki
IPC分类号： C07C323/25 , A61K47/20 , A61K47/44 , A61K48/00
CPC分类号： C12N15/88 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K47/20 , A61K47/22 , C07C323/25 , C07C2601/16 , C07D311/72
摘要： Provided is a cationic lipid capable of achieving high intracellular expression efficiency when used as a nucleic acid delivery carrier.
A compound represented by the formula (1)

wherein X a and X b are each independently X 1 or X 2 ;

s is 1 or 2,
R 4 is an alkyl group having 1 - 6 carbon atoms,
n a and n b are each independently 0 or 1,
R 1a and R 1b are each independently an alkylene group having 1 - 6 carbon atoms,
R 2a and R 2b are each independently an alkylene group having 1 - 6 carbon atoms,
Y a and Y b are each independently an ester bond, an amide bond, a carbamate bond, an ether bond or a urea bond, and
R 3a and R 3b are each independently a sterol residue, a liposoluble vitamin residue or an aliphatic hydrocarbon group having 12 - 22 carbon atoms.

10. 发明公开

EP2509636A4 COMPOSITIONS FOR NUCLEIC ACID DELIVERY 有权转让
标题翻译： ZUSAMMENSETZUNGENFÜRNUKLEINSÄUREFREISETZUNG
公开(公告)号：EP2509636A4
公开(公告)日：2013-08-14
申请号：EP10836504
申请日：2010-12-07
申请人： TEKMIRA PHARMACEUTICALS CORP
发明人： MANOHARAN MUTHIAH , RAJEEV KALLANTHOTTAHIL G , JAYARAMAN MUTHUSAMY , BUTLER DAVID , KAPOOR MAMTA , KAINTHAN RAJESH KUMAR
IPC分类号： A61K48/00 , C07C27/20 , C07C217/08 , C07C219/08 , C07C229/12 , C07C251/40 , C07C269/02 , C07C271/12 , C07C323/25 , C07D317/28 , C07D317/44 , C07D317/72 , C07D491/10 , C12N15/88
CPC分类号： A61K47/18 , A61K31/7105 , A61K31/713 , A61K47/186 , A61K47/22 , C07C217/08 , C07C219/08 , C07C229/12 , C07C251/40 , C07C271/12 , C07C271/20 , C07C323/25 , C07C2601/02 , C07D317/28 , C07D317/44 , C07D317/72 , C07D491/10 , C12N15/88
摘要： A method for delivering a nucleic acid to a cell can include exposing sample cells to a composition which includes charged lipids.
摘要翻译：将核酸递送至细胞的方法可包括将样品细胞暴露于包含带电脂质的组合物中。

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