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1. 发明公开

EP2819988A4 COMPOSITION OF MATTER POLYOLS FOR POLYURETHANE APPLICATIONS 有权
标题翻译： MASSEPOLYOLS用于聚氨酯应用的组合物
公开(公告)号：EP2819988A4
公开(公告)日：2015-03-18
申请号：EP13755591
申请日：2013-02-28
申请人： PETROLIAM NASIONAL BERHAD
发明人： GARBARK DANIEL B , BENECKE HERMAN PAUL
IPC分类号： C07C67/05 , C07C69/18 , C07C69/38 , C08G18/42
CPC分类号： C07C67/08 , C07C57/02 , C08G18/14 , C08G18/36 , C08G18/7657 , C08G18/8048 , C08G2101/0008 , C08G2101/0025 , C09D175/06 , C11C1/005 , C11C1/04 , C11C3/00 , C11C3/003 , C11C3/006 , C11C3/02 , C07C69/48

2. 发明公开

EP1075533A4 SMALL MOLECULE ANTICANCER COMPOUNDS AND RELATED PRODUCTION PROCESS 有权
标题翻译：低分子抗癌成分和工艺，以这种效果
公开(公告)号：EP1075533A4
公开(公告)日：2005-03-09
申请号：EP99917310
申请日：1999-04-14
申请人： YANG ZHENHUA
发明人： YANG ZHENHUA
IPC分类号： A01N20060101 , C07C20060101 , C07C53/126 , C07C57/02 , C07C69/24 , C12N20060101 , C12P20060101 , C12P7/64 , A01N37/00 , A01N37/12 , C07C53/00 , C07C69/74 , C12N1/12 , C12N1/20 , C12N9/50 , C12N9/52 , C12N9/58 , C12N9/99 , C12P7/62
CPC分类号： C12P7/6409 , A61K31/202 , C07C53/126 , C07C57/02 , C07C69/24 , C12P7/6427

3. 发明授权

EP1268386B1 PROCESS FOR THE BRANCHING OF SATURATED AND/OR UNSATURATED FATTY ACIDS AND/OR ALKYL ESTERS THEREOF 有权
标题翻译：方法结饱和和/或不饱和脂肪酸和/或其酯
公开(公告)号：EP1268386B1
公开(公告)日：2004-08-04
申请号：EP01916375.7
申请日：2001-03-02
申请人： THE PROCTER & GAMBLE COMPANY
发明人： KENNEALLY, Corey, James , CONNOR, Daniel, Stedman
IPC分类号： C07C51/353 , C07C67/333 , C07C69/24 , C07C53/126 , C07C57/02
CPC分类号： C07C51/353 , C07C67/333 , C07C57/02 , C07C53/126 , C07C69/24

4. 发明公开

EP1063223A1 POLYENEPOLYCARBOXYLIC ACIDS, DERIVATIVES THEREOF WITH RESPECT TO CARBOXYL GROUPS, OR SALTS OF THESE 审中-公开
标题翻译：多伦多碳酸氢钠，贝伐单独生物柴油碳酸氢盐
公开(公告)号：EP1063223A1
公开(公告)日：2000-12-27
申请号：EP99939187.3
申请日：1999-03-11
申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
发明人： KASUGA, Shinobu , KAKIUCHI, Toshihito , YAMANISHI, Ryo , OKADA, Kazuki
IPC分类号： C07C57/02 , C07C69/604 , C07C233/15 , C07D207/444 , C07D307/60 , A61K7/00 , B01F17/00 , C12P7/44 , C12P17/04 , C12P17/16
CPC分类号： A61K8/362 , A61Q19/00 , B01F17/0021 , B01F17/0028 , B01F17/0042 , B01F17/005 , C04B24/04 , C04B2103/408 , C07C57/02 , C07D307/60 , C11D3/2082
摘要： Polyenepolycarboxylic acids represented by the following formula (1):
(wherein n represents an integer of 0 to 5 and m represents an integer of 1 or 2, provided m is 1 when n is 0), or derivatives thereof at their carboxyl group(s) or their salts.
The above compounds originate from natural products and are capable of exhibiting excellent dispersing ability.
摘要翻译：由下式（1）表示的多烯多羧酸：其中n表示0〜5的整数，m表示1或2的整数，n为0时m为1）或其衍生物组或其盐。上述化合物来自天然产物，能够表现出优异的分散能力。

5. 发明公开

EP0451420A1 Accelerators for cationic aqueous bituminous emulsion-aggregate slurries 失效
标题翻译： Beschleunigerfürkationische wasserhaltigebituminöseEmulsionsaggregat-Schlämme。
公开(公告)号：EP0451420A1
公开(公告)日：1991-10-16
申请号：EP90401001.4
申请日：1990-04-11
申请人： WESTVACO CORPORATION
发明人： Schilling, Peter , Schreuders, Hans G.
IPC分类号： C07D295/185 , C07D295/13 , C07D209/48 , C08L95/00 , C08K5/20 , C08K5/34
CPC分类号： C07C55/02 , C07C55/21 , C07C57/02 , C07C61/22 , C08K5/20 , C08L95/005 , C09F1/04 , Y10S516/07 , C08L2666/02
摘要： Compositions of matter are disclosed which act as cure rate accelerators for bituminous emulsion-aggregate slurries which compositions are formed as the reaction products of aminoethylpiperazine and either C₂₂-tricarboxylic acid or C₂₁-dicarboxylic acid in a molar ratio of from 0.5:1 to 1:1, respectively.
摘要翻译：公开了作为沥青乳液聚集浆料的固化速率促进剂的物质组合物，该组合物形成为氨基乙基哌嗪和摩尔比为0.5:1至1::1的C22-三羧酸或C21-二羧酸的反应产物， 1。

6. 发明授权

EP0125690B2 Fractionation of polymerized fatty acids 失效
标题翻译：聚合脂肪酸的分离
公开(公告)号：EP0125690B2
公开(公告)日：1990-11-14
申请号：EP84105516.3
申请日：1984-05-15
申请人： Union Camp Corporation
发明人： Frihart, Charles Richard
IPC分类号： C07C51/48 , C07C57/13 , C07C57/02
CPC分类号： C07C51/48 , B01D11/0203 , Y02P20/544 , C07C57/02 , C07C57/13

7. 发明公开

EP0069405A1 Process for the trimerization of unsaturated fatty acids 失效
标题翻译：一种用于不饱和脂肪酸三聚过程。
公开(公告)号：EP0069405A1
公开(公告)日：1983-01-12
申请号：EP82200692.0
申请日：1982-06-07
申请人： UNILEVER N.V. , UNILEVER PLC
发明人： van Dijk, Jacob , Renken, Johannes Willem , Dekker, Jan Gerrit , Helmond, Johannes
IPC分类号： C11C3/00 , C07C57/02 , C07C51/353 , C07C69/52 , C07C67/343
CPC分类号： C08F20/62 , C07C51/353 , C07C57/02
摘要： A process is provided whereby high trimer content products are obtained by the polymerization of unsaturated fatty acids or lower alkyl esters thereof. The process entails heating the fatty acid/ester material at a temperature of at least 120°C in the presence of a sulphonic acid catalyst which is dissolved therein.

8. 发明授权

EP2528889B1 PROCESS FOR PREPARING AND PURIFYING FATTY ACIDS 有权转让
公开(公告)号：EP2528889B1
公开(公告)日：2018-10-31
申请号：EP11702490.1
申请日：2011-01-27
申请人： BASF Pharma (Callanish) Limited
发明人： KELLIHER, Adam , MORRISON, Angus , KNOWLES, Phil
IPC分类号： C07C51/38 , C07C51/487 , C07C51/41 , C07C51/42 , C07C51/48
CPC分类号： C07C51/487 , C07C51/38 , C07C51/41 , C07C51/412 , C07C51/42 , C07C51/48 , C07C53/126 , C07C57/02
摘要： There is provided a process for purifying a fatty acid, which process comprises reacting a fatty acid with a lithium salt in a first solution and under conditions to allow formation of a precipitate of a lithium salt of the fatty acid; isolating the precipitate; dissolving the precipitate in a second solution followed by separation of the organic and aqueous layers so formed; and evaporating the organic layer to isolate the purified fatty acid. There is also provided a process for increasing the length of a fatty acid, and the use of a lithium salt to purify a fatty acid.

9. 发明公开

EP3157571A1 FATTY ACIDS AND THEIR USE IN CONJUGATION TO BIOMOLECULES 有权
标题翻译：达赖喇嘛在德累斯顿的VENBIOMOLEKÜLEN
公开(公告)号：EP3157571A1
公开(公告)日：2017-04-26
申请号：EP15732508.5
申请日：2015-06-18
申请人： Novartis AG
发明人： BARNES, David Weninger , YAMADA, Ken , IBEBUNJO, Chikwendu , DUTTAROY, Alokesh , KIRMAN, Louise Clare , BRUCE, Alexandra Marshall , USERA, Aimee Richardson , ZECRI, Frederic , YUAN, Jun , LOU, Changgang , KANTER, Aaron , BOSE, Avirup
IPC分类号： A61K47/50 , A61P3/00 , C07K14/475
CPC分类号： A61K47/48038 , A61K38/08 , A61K38/164 , A61K38/1709 , A61K38/1825 , A61K38/1841 , A61K38/2221 , A61K45/06 , A61K47/542 , C07C55/02 , C07C55/22 , C07C57/02 , C07C57/18 , C07C59/245 , C12N15/113 , C12N2310/14 , C12N2310/351
摘要： The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3: wherein R1, R2, R3, R4, Ak, n, m and p are defined herein. The invention also relates to a method for manufacturing the conjugate of the invention such as GDF15 conjugate, and its therapeutic uses such as treatment or prevention of metabolic disorders or diseases, type 2 diabetes mellitus, obesity, pancreatitis, dyslipidemia, alcoholic and nonalcoholic fatty liver disease/steatohepatitis and other progressive liver diseases, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, metabolic syndrome, hypertension, cardiovascular disease, atherosclerosis, peripheral arterial disease, stroke, heart failure, coronary heart disease, diabetic complications (including but not limited to chronic kidney disease), neuropathy, gastroparesis and other metabolic disorders. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供了一种缀合物，其包含通过接头与脂肪酸连接的生物分子，其中脂肪酸具有下列式A1，A2或A3：其中R1，R2，R3，R4，Ak，n，m和p如本文所定义。本发明还涉及制备本发明缀合物如GDF15缀合物的方法及其治疗用途，例如治疗或预防代谢紊乱或疾病，2型糖尿病，肥胖症，胰腺炎，血脂异常，酒精和非酒精性脂肪肝疾病/脂肪性肝炎和其他进行性肝病，胰岛素抵抗，高胰岛素血症，葡萄糖不耐受，高血糖症，代谢综合征，高血压，心血管疾病，动脉粥样硬化，外周动脉疾病，中风，心力衰竭，冠心病，糖尿病并发症（包括但不限于慢性肾脏疾病），神经病，胃轻瘫等代谢紊乱。本发明还提供药理活性剂和药物组合物的组合。

10. 发明公开

EP2847152A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME 无效
标题翻译： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG DES STOFFWECHSELSYNDROMS
公开(公告)号：EP2847152A1
公开(公告)日：2015-03-18
申请号：EP13788579.4
申请日：2013-02-03
申请人： Cellixbio Private Limited
发明人： KANDULA, Mahesh
IPC分类号： C07C23/00 , C07C22/00 , A61K31/381 , A61K31/429 , A61K31/11 , A61K31/12 , A61K31/192 , A61P3/02 , A61P3/04 , A61P3/06 , A61P3/08 , A61P9/00 , A61P9/10 , A61P13/00 , A61P13/12
CPC分类号： A61K31/198 , A61K31/202 , A61K31/216 , A61K31/385 , C07C57/02 , C07C59/68 , C07D339/04
摘要： The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of metabolic syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of hyperuricemia, gout; dyslipidemia, obesity, urea cycle disorders, hyperglycemia, insulin resistance, diabetes mellitus, diabetes insipidus, type 1 diabetes, type 2 diabetes, microvascular complications,.macrovascular complications, lipid disorders, prediabetes., obesity, arrhythmia, myocardial infarction, stroke, neuropathy, renal complications, hypertriglyceridemia, cardiovascular complications, and post prandial hyperglycemia.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。包含有效量的式（I）化合物的药物组合物和治疗代谢综合征的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。此类组合物可用于治疗高尿酸血症，痛风; 血脂异常，肥胖症，尿素循环障碍，高血糖症，胰岛素抵抗，糖尿病，尿崩症，1型糖尿病，2型糖尿病，微血管并发症，血管并发症，脂质障碍，糖尿病前期，肥胖，心律失常，心肌梗死，中风，神经病肾脏并发症，高甘油三酯血症，心血管并发症和餐后高血糖症。

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