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1. 发明公开

EP2855423A1 SYNTHESIS OF DIAMIDO GELLANTS BY USING AMINO ACID N-CARBOXYANHYDRIDES 有权
标题翻译：合成氨基甘氨酸氨基转移酶
公开(公告)号：EP2855423A1
公开(公告)日：2015-04-08
申请号：EP13724207.9
申请日：2013-05-13
申请人： Evonik Industries AG
发明人： BINDI, Martin , HERMANN, Roland , KNAUP, Günter
IPC分类号： C07C231/02 , C07D263/44 , C11D3/32 , C11D7/32
CPC分类号： C07C231/02 , C07C2601/14 , C07D263/44 , C07C237/20 , C07C237/10
摘要： The invention relates to a method for the synthesis of a compound according to formula I comprising the following steps: a) reacting a N-carboxyanhydride according to formula II and a N-carboxy- anhydride according to formula III with a diamine according to formula IV and b) adding an acid to the reaction to adjust the pH value of the reaction to 2 -C
20 alkyl group, a C
6 -C
20 aryl group, or a C
7 -C
20 alkylaryl group; and R
1 and R
2 can be identical or different and represent a hydrogen atom, a C
1 -C
4 alkyl group, a C
1 -C
4 hydroxyalkyl group, a C
1 -C
4 thioether group, a C
6 -C
20 aryl group, a C
7 -C
20 alkylaryl group, a C
7 -C
20 alkylhydroxyaryl group, a C
4 -C
20 alkylheteroaryl group with 1 to 4 heteroatoms; or a C
1 -C
4 alkylcarboxylic moiety, which may be an acid, an amide, or which may be esterified with a C
1 -C
6 alkyl group or a C
7 -C
20 alkylaryl group.
摘要翻译：本发明涉及一种合成式I化合物的方法，包括以下步骤：a）使根据式II的N-羧酸酐和根据式III的N-羧酸酐与根据式IV的二胺反应和b）向反应物中加入酸以将反应的pH值调节至<7; 其中L表示C2-C20烷基，C6-C20芳基或C7-C20烷基芳基; R1和R2可以相同或不同，表示氢原子，C1-C4烷基，C1-C4羟烷基，C1-C4硫醚基，C6-C20芳基，C7-C20烷基芳基， C 7 -C 20烷基羟基芳基，具有1至4个杂原子的C 4 -C 20烷基杂芳基; 或C 1 -C 4烷基羧酸部分，其可以是酸，酰胺或可以被C 1 -C 6烷基或C 7 -C 20烷基芳基酯化。

2. 发明公开

EP2855422A1 SYNTHESIS OF DIAMIDO GELLANTS BY USING DANE SALTS OF AMINO ACIDS 有权
标题翻译：合成DIAMIDGELIERMITTELN的使用氨基酸的DANE基盐
公开(公告)号：EP2855422A1
公开(公告)日：2015-04-08
申请号：EP13723079.3
申请日：2013-05-13
申请人： Evonik Industries AG
发明人： BINDL, Martin , HERRMANN, Roland , KNAUP, Günter
IPC分类号： C07C227/18 , C07C231/02 , C11D3/32 , C11D7/32
CPC分类号： C07C231/02 , C07C227/18 , C07C2601/14 , C11D3/32 , C11D7/3263 , C11D17/003 , C07C237/10 , C07C237/20
摘要： The invention relates to a method for the synthesis of a compound according to formula I comprising the following steps: a) reacting a Dane salt according to formula II and a Dane salt according to formula III with a coupling reagent; b) adding a diamine according to formula IV to the reaction mixture; and c) adding an acid to the reaction mixture to adjust the p H value of the reaction to 2 -C
20 alkyl group, a C
6 -C
20 aryl group, or a C
7 –C
20 alkylaryl group; R
1 and R
2 can be identical or different and represent a hydrogen atom, a C
1 -C
4 alkyl group, a C
1 -C
4 hydroxyalkyl group, a C
1 -C
4 thioether group, a C
6 -C
20 aryl group, a C
7 –C
20 alkylaryl group, a C
7 –C
20 alkylhydroxyaryl group, a C
4 –C
20 alkylheteroaryl group with 1 to 4 heteroatoms; or a C
1 -C
4 alkylcarboxylic moiety, which may be an acid, an amide, or which may be esterified with a C
1 -C
6 alkyl group or a C
7 -C
20 alkylaryl group; R
3 represents a C
1 -C
4 alkyl group; R
4 represents a hydrogen atom, or a C
1 -C
4 alkyl group; R
5 represents a C
1 -C
4 alkyl group; and X represents an alkali metal.

3. 发明公开

EP2825157A1 AMINOACID LIPIDS 有权
标题翻译： AMINOSÄURELIPIDE
公开(公告)号：EP2825157A1
公开(公告)日：2015-01-21
申请号：EP13710787.6
申请日：2013-03-11
申请人： Merck Patent GmbH
发明人： PLATSCHER, Michael Wilhelm , BEHRENDT, Raymond , GROEHN, Viola , HOERTNER, SimoneRachel , PASSAFARO, Marco Silvio , BAUER, Finn
IPC分类号： A61K9/127 , C07C271/22 , C07C237/08
CPC分类号： C07C237/30 , A61K9/1272 , C07C59/185 , C07C237/06 , C07C237/08 , C07C237/10 , C07C237/22 , C07C271/22 , C07C2603/18 , Y02P20/55
摘要： The present invention is directed to a new class of lipids, more specifically ether-lipids having a polar headgroup, as well as vesicles comprising these lipids, methods of their preparation as well as their uses in medical applications, wherein the ether-lipids are represented by general formula I
摘要翻译：本发明涉及一类新的脂质，更具体地是具有极性头团的醚 - 脂质，以及包含这些脂质的囊泡，其制备方法及其在医学应用中的用途，其中所述醚 - 脂质被表示通过通式I

4. 发明公开

EP2696678A4 AGENTS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS 有权转让
标题翻译： MEANS对于核酸进入真核细胞中提高，交货期
公开(公告)号：EP2696678A4
公开(公告)日：2014-11-12
申请号：EP12771294
申请日：2012-04-16
申请人： MOLECULAR TRANSFER INC
发明人： JESSEE JOEL A , GEBEYEHU GULILAT
IPC分类号： A01N37/12 , A01N37/44 , A61K31/195
CPC分类号： C12N15/88 , A61K9/1272 , A61K31/195 , A61K31/713 , C07C217/08 , C07C237/10 , C07C237/12 , C07D233/64 , C12N15/1137 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.

5. 发明授权

EP1986622B1 SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY 有权
标题翻译：在TRP-P8活性的小分子调节剂
公开(公告)号：EP1986622B1
公开(公告)日：2013-10-02
申请号：EP07750861.2
申请日：2007-02-15
申请人： DENDREON CORPORATION
发明人： MORENO, Ofir , NATARAJAN, Sateesh , DUNCAN, David F.
IPC分类号： A61K31/12 , C07C233/60 , C07D231/40
CPC分类号： C07C237/04 , C07C233/60 , C07C233/62 , C07C237/10 , C07C237/42 , C07C237/44 , C07C323/40 , C07C323/63 , C07C2601/14 , C07D231/40 , C07D235/26 , C07D401/12 , C07D403/04 , C07D405/04

7. 发明公开

EP2362890A4 ANTHRAQUINONE BASED NEAR IR EMITTING COMPOUNDS AND USES THEREOF 有权
标题翻译：蒽醌系NAHINFRAROTEMITTIERENDE化合物及其用途
公开(公告)号：EP2362890A4
公开(公告)日：2012-10-24
申请号：EP09829545
申请日：2009-10-20
申请人： LIFE TECHNOLOGIES CORP
发明人： YUE STEPHEN , HUANG SHIH-JUNG , BRADFORD JOLENE
IPC分类号： C09K11/06 , H01L51/54 , H05B33/14
CPC分类号： G01N33/52 , C07C225/36 , C07C237/10 , C07C2603/24 , C07D205/04 , C07D213/36 , C07D233/61 , C07D249/04 , C07D295/13 , C07D295/192 , C07H21/04 , C09B1/5165 , C12Q1/6816 , C12Q1/6841 , G01N21/6428 , G01N2021/6441

8. 发明授权

EP1777246B1 Amidhaltige Polymere zur Rheologiesteuerung 有权转让
标题翻译：用于流变控制含酰胺的聚合物
公开(公告)号：EP1777246B1
公开(公告)日：2012-06-06
申请号：EP06021298.2
申请日：2006-10-11
申请人： BYK-Chemie GmbH
发明人： Haubennestel, Karlheinz , Mössmer, Stefan, Dr. , Orth, Ulrich, Dr. , Leutfeld, Daniela
IPC分类号： C08G69/34 , C08G69/40 , C08G69/44 , C08G69/48 , C07C233/36 , C07C233/38 , C07C237/06 , C07C237/10 , C07C275/40 , C09D7/00
CPC分类号： C07C237/10 , C07C233/36 , C07C233/38 , C07C237/06 , C07C275/40 , C09D7/43 , Y10T428/2933 , Y10T428/294 , Y10T428/2947

9. 发明公开

EP1864968A4 COMPLEX COMPOUND AND MRI PROBE MADE OF SAME 审中-公开
标题翻译：复杂及有关物品生产MRI PROBE
公开(公告)号：EP1864968A4
公开(公告)日：2011-04-27
申请号：EP06715394
申请日：2006-03-08
申请人： JAPAN SCIENCE & TECH AGENCY
发明人： SUZUKI KOJI , HIFUMI HIROKI , TANIMOTO AKIHIRO , MAKINO MEGUMI
IPC分类号： C07C237/10 , A61B5/055 , A61K49/10 , C07D257/02 , C07D323/00 , C07F5/02
CPC分类号： C07D323/00 , A61K49/10 , A61K49/103 , A61K49/106 , C07C237/10 , C07D257/02 , C07F5/025

10. 发明授权

EP1713822B1 HCV NS-3 SERINE PROTEASE INHIBITORS 有权
标题翻译： HCV NS-3丝氨酸蛋白酶抑制剂
公开(公告)号：EP1713822B1
公开(公告)日：2010-03-17
申请号：EP05704764.9
申请日：2005-01-28
申请人： Medivir AB
发明人： ROSENQUIST, Asa, c/o Medivir AB , THORSTENSSON, Fredrik, c/o IFM Faculty , JOHANSSON, Per-Ola, c/o IFM Faculty , KVARNSTRÖM, Ingemar, c/o IFM Faculty , AYESA, Susana, c/o Medivir AB , CLASSON, Björn, c/o Medivir AB , RAKOS, Lazlo, c/o Medivir AB , SAMUELSSON, Bertil, c/o Medivir AB
IPC分类号： C07K5/02 , C07D401/12 , C07D409/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D207/16 , A61K31/47 , A61P31/12 , C07D487/04
CPC分类号： A61K31/47 , C07C235/40 , C07C237/04 , C07C237/10 , C07C247/04 , C07C271/22 , C07C281/02 , C07C309/73 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/10 , C07D207/16 , C07D215/20 , C07D215/233 , C07D245/04 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07K5/0205 , C07K5/06034 , C07K5/06052
摘要： Compounds of the formula where the variables are as defined in the specification inhibit the NS3 protease of flavivirus sych as hepatitis C virus (HCV). The compounds comprise a novel linkage between a heterocyclic P2 unit and those portions of the inhibitor more distal to the nominal cleavage site of the native substrate, which linkage reverses the orientation of peptidic bonds on the distal side relative to those proximal to the cleavage site.
摘要翻译：变量如本说明书中定义的式的化合物抑制黄病毒sych的NS3蛋白酶作为丙型肝炎病毒（HCV）。这些化合物包括杂环P2单元与位于天然底物标称切割位点的更远端的抑制剂部分之间的新连接，该连接反转相对于靠近切割位点的端部的肽侧的肽取向。

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