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1. 发明授权

EP2694466B1 PREPARATION OF SITAGLIPTIN INTERMEDIATES 有权
公开(公告)号：EP2694466B1
公开(公告)日：2018-10-24
申请号：EP12719932.1
申请日：2012-04-06
申请人： LEK Pharmaceuticals d.d.
发明人： CASAR, Zdenko , STAVBER, Gaj , SOVA, Matej
IPC分类号： C07C67/343 , C07C227/08 , C07F5/02 , C07C229/34
CPC分类号： C07C229/30 , C07B53/00 , C07C67/31 , C07C67/343 , C07C227/06 , C07C227/08 , C07C231/06 , C07C233/47 , C07F5/02 , C07F5/025 , C07F5/027 , C07F5/04 , C07C69/732 , C07C69/65 , C07C229/34
摘要： The invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.

2. 发明授权

EP2861555B1 PROCESS FOR DEPIGMENTING KERATIN MATERIALS USING NOVEL RESORCINOL-BASED COMPOUNDS 有权
公开(公告)号：EP2861555B1
公开(公告)日：2018-08-29
申请号：EP13729385.8
申请日：2013-06-18
申请人： L'Oréal
发明人： MARAT, Xavier
IPC分类号： C07C69/732 , C07C235/34 , A61Q19/02 , C07D209/40 , C07D211/68 , C07D265/30 , A61K8/42 , A61K8/44 , C07D313/08 , C07C323/59 , C07D307/33 , A61K8/49
CPC分类号： A61Q19/02 , A61K8/42 , A61K8/44 , A61K8/492 , A61K8/4926 , C07C69/732 , C07C235/34 , C07C323/59 , C07C2601/14 , C07D265/30 , C07D307/33 , C07D313/08
摘要： Process for depigmenting keratin materials using novel resorcinol-based compounds The invention relates to compounds of formula (I): in which: · R denotes a hydrogen atom or an acetyl group; · Y denotes a radical chosen from OR' and NAR''; The invention also relates to a cosmetic process for depigmenting, lightening and/or bleaching keratin materials, especially the skin, using these compounds (I).

3. 发明公开

EP3353147A1 SYNTHESIS OF TERPHENYL COMPOUNDS 有权
公开(公告)号：EP3353147A1
公开(公告)日：2018-08-01
申请号：EP16847641.4
申请日：2016-09-21
申请人： Vectus Biosystems Limited
发明人： KAYE, Anthony , QUAZI, Nurul , FEAST, George , LAKSHMAN, Marshnil
IPC分类号： C07C231/14 , C07C231/02 , C07C57/30 , C07C51/09 , C07C69/732 , C07C67/08 , C07C67/343 , C07C309/66 , C07C303/28
CPC分类号： C07C231/02 , C07C51/09 , C07C53/134 , C07C59/52 , C07C67/03 , C07C67/31 , C07C69/616 , C07C69/732 , C07C231/12 , C07C235/34 , C07C303/28 , C07C309/66
摘要： The present invention relates novel methods of synthesizing terphenyl compounds and in particular to novel methods for the synthesis of a compound of Formula I or intermediates thereof.

4. 发明公开

EP3257839A4 POLYMERIZABLE POLAR COMPOUND, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT 审中-公开
公开(公告)号：EP3257839A4
公开(公告)日：2018-08-01
申请号：EP16749134
申请日：2016-02-04
申请人： JNC CORP , JNC PETROCHEMICAL CORP
发明人： TANAKA HIROYUKI , YANO MASAKAZU , KONDOU FUMITAKA , OGITA KAZUHIRO
IPC分类号： C07C69/732 , C07C229/08 , C07C229/30 , C07C321/10 , C07D213/55 , C07D239/26 , C07D295/145 , C07D309/06 , C07D319/06 , C07F5/02 , C07F7/18 , C09K19/12 , C09K19/34 , C09K19/42 , C09K19/54 , G02F1/1337
CPC分类号： C07C69/732 , C07C69/003 , C07C69/013 , C07C69/017 , C07C229/08 , C07C229/12 , C07C229/30 , C07C321/10 , C07C2601/14 , C07D213/55 , C07D239/26 , C07D295/145 , C07D309/06 , C07D319/06 , C07F5/02 , C07F7/18 , C07J9/00 , C09K19/04 , C09K19/062 , C09K19/063 , C09K19/12 , C09K19/126 , C09K19/18 , C09K19/3003 , C09K19/32 , C09K19/322 , C09K19/34 , C09K19/3402 , C09K19/3483 , C09K19/36 , C09K19/42 , C09K19/54 , C09K2019/0444 , C09K2019/0448 , C09K2019/122 , C09K2019/123 , C09K2019/181 , C09K2019/3004 , C09K2019/3006 , C09K2019/3009 , C09K2019/301 , C09K2019/3015 , C09K2019/3016 , C09K2019/3019 , C09K2019/3025 , C09K2019/303 , C09K2019/3077 , C09K2019/3422 , G02F1/1337 , G02F1/133788 , G02F1/1362
摘要： Provided is a polar compound having high chemical stability, high ability to align liquid crystal molecules, and high solubility in a liquid crystal composition, and which has a large voltage holding ratio when used in a liquid crystal display element. A compound represented by formula (1). For example, R 2 represents a C1-15 alkyl, MES represents a mesogenic group having at least one ring, Sp 1 represents a single bond or a C1-10 alkylene, M 1 and M 2 represent hydrogen, R 2 represents a group represented by formulas (1a) through (1c) , Sp 2 and Sp 3 are single bonds or C1-10 alkylenes, S 1 represents >CH-, S 2 represents >C

5. 发明公开

EP3225615A4 PREPARATION METHOD FOR MEDICINAL CHLOROGENIC ACID 审中-公开
公开(公告)号：EP3225615A4
公开(公告)日：2018-07-11
申请号：EP14906812
申请日：2014-11-26
申请人： SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECH CO LTD
发明人： ZHANG JIE , ZHANG LIANG , HUANG WANG
IPC分类号： C07C67/48 , A61K31/216 , C07C67/52 , C07C67/56 , C07C69/732
CPC分类号： C07C67/52 , A61K31/216 , B01D9/0022 , B01D9/04 , B01D2009/0086 , C07C35/14 , C07C39/10 , C07C67/48 , C07C67/56 , C07C69/732
摘要： The present invention provides a method for the preparation of pharmaceutically acceptable chlorogenic acid, which comprises the following steps: a. Treating the sample aqueous solution; b. Freezing; c. Thawing and filtering; d. Treating the residue organic phase; e. Concentrating and crystallizing; f. Choosing the number of times to repeat steps aˆ¼e according to the variability of chlorogenic acid content in samples; g. Drying. If the chlorogenic acid extract is isolated and purified using this method, water-soluble impurities and liposoluble impurities can be well removed, that allows the impurity content of final products has fulfilled the requirements for medicine; meanwhile, the procedures of this method are simple, and organic solvents can be recycled for further use, with low cost. This method can be applied for the further isolation and purification of chlorogenic acid extract obtained by various ways, especially for the preparation of pharmaceutically acceptable chlorogenic acid.

6. 发明授权

EP2881381B1 Polyglycerinpartialester, ihre Herstellung und Verwendung 有权转让
公开(公告)号：EP2881381B1
公开(公告)日：2018-06-27
申请号：EP14191990.2
申请日：2014-11-06
申请人： Evonik Degussa GmbH
发明人： Schuch, Dominik , Berkels, Wolfgang , Springer, Oliver , Hartung, Christian , Condé, Hilke , Klann-Metz, Bärbel
IPC分类号： A61K8/37 , A61K8/39 , A61K8/86 , A61Q1/14 , A61Q15/00 , A61Q5/02 , A61Q19/10 , C07C67/08 , C07C69/52 , C07C69/732
CPC分类号： C07C69/52 , A61K8/375 , A61K8/39 , A61K8/86 , A61K2800/30 , A61K2800/49 , A61Q1/14 , A61Q5/02 , A61Q15/00 , A61Q19/10 , C07C67/08 , C07C69/732

7. 发明公开

EP3141540A4 CRYSTALLINE FORM OF CHLOROGENIC ACID AND PREPARATION METHOD THEREFOR 有权
公开(公告)号：EP3141540A4
公开(公告)日：2018-01-03
申请号：EP14891224
申请日：2014-05-16
申请人： SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECH CO LTD
发明人： ZHANG JIE , ZHANG LIANG , HUANG WANG
IPC分类号： C07C67/52 , C07C69/732
CPC分类号： C07C69/618 , C07B2200/13 , C07C67/52 , C07C69/732 , C07C2601/14
摘要： Provided is a crystalline form of chlorogenic acid. The crystalline form is an orthorhombic crystal system, the space group is P2 1 2 1 2 1 , the cell parameters are a=7.7291 (2) Å, b=10.9808 (2) Å, and c= 36.5334 (7) Å, ±=²=³=90.00°, Z=8, and the cell volume is 3100.65 (11) Å 3 . Also provided is a preparation method for the crystalline form. The present crystalline form has good stability and does not significantly change during storage for 48 months in a cool, dark place, and the various indices all meet the relevant requirements for active pharmaceutical ingredients. The crystallisation process provided by the present invention can not only use raw materials having different purities to prepare the same crystalline form of chlorogenic acid, but can also significantly reduce solvent residue in the raw materials, thereby improving product safety.

8. 发明公开

EP3257839A1 POLYMERIZABLE POLAR COMPOUND, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT 审中-公开
标题翻译：可聚合的极性化合物，液晶组合物和液晶显示元件
公开(公告)号：EP3257839A1
公开(公告)日：2017-12-20
申请号：EP16749134.9
申请日：2016-02-04
申请人： JNC Corporation , JNC Petrochemical Corporation
发明人： TANAKA, Hiroyuki , YANO, Masakazu , KONDOU, Fumitaka , OGITA, Kazuhiro
IPC分类号： C07C69/732 , C07C229/08 , C07C229/30 , C07C321/10 , C07D213/55 , C07D239/26 , C07D295/145 , C07D309/06 , C07D319/06 , C07F5/02 , C07F7/18 , C09K19/12 , C09K19/34 , C09K19/42 , C09K19/54 , G02F1/1337
CPC分类号： C07C69/732 , C07C69/003 , C07C69/013 , C07C69/017 , C07C229/08 , C07C229/12 , C07C229/30 , C07C321/10 , C07C2601/14 , C07D213/55 , C07D239/26 , C07D295/145 , C07D309/06 , C07D319/06 , C07F5/02 , C07F7/18 , C07J9/00 , C09K19/04 , C09K19/062 , C09K19/063 , C09K19/12 , C09K19/126 , C09K19/18 , C09K19/3003 , C09K19/32 , C09K19/322 , C09K19/34 , C09K19/3402 , C09K19/3483 , C09K19/36 , C09K19/42 , C09K19/54 , C09K2019/0444 , C09K2019/0448 , C09K2019/122 , C09K2019/123 , C09K2019/181 , C09K2019/3004 , C09K2019/3006 , C09K2019/3009 , C09K2019/301 , C09K2019/3015 , C09K2019/3016 , C09K2019/3019 , C09K2019/3025 , C09K2019/303 , C09K2019/3077 , C09K2019/3422 , G02F1/1337 , G02F1/133788 , G02F1/1362
摘要： Provided is a polar compound having high chemical stability, high ability to align liquid crystal molecules, and high solubility in a liquid crystal composition, and which has a large voltage holding ratio when used in a liquid crystal display element. A compound represented by formula (1). For example, R 2 represents a C1-15 alkyl, MES represents a mesogenic group having at least one ring, Sp 1 represents a single bond or a C1-10 alkylene, M 1 and M 2 represent hydrogen, R 2 represents a group represented by formulas (1a) through (1c) , Sp 2 and Sp 3 are single bonds or C1-10 alkylenes, S 1 represents >CH-, S 2 represents >C 1 represents -OH.
摘要翻译：本发明提供化学稳定性高，液晶分子取向能力高，在液晶组合物中的溶解性高的极性化合物，用于液晶显示元件时电压保持率大的极性化合物。由式（1）表示的化合物。例如，R 2表示C 1-15烷基，MES表示具有至少一个环的介晶基团，Sp 1表示单键或C 1-10亚烷基，M 1和M 2表示氢，R 2表示由式（1a）表示的基团，通过（1c），Sp2和Sp3是单键或C1-10亚烷基，S1代表> CH-，S2代表> C <，并且X1代表-OH。

9. 发明公开

EP3225615A1 PREPARATION METHOD FOR MEDICINAL CHLOROGENIC ACID 审中-公开
标题翻译：药用氯乙酸的制备方法
公开(公告)号：EP3225615A1
公开(公告)日：2017-10-04
申请号：EP14906812.4
申请日：2014-11-26
申请人： Sichuan Jiuzhang Biological Science And Technology Co., Ltd
发明人： ZHANG, Jie , ZHANG, Liang , HUANG, Wang
IPC分类号： C07C69/732 , C07C67/48 , C07C67/52
CPC分类号： C07C67/52 , A61K31/216 , B01D9/0022 , B01D9/04 , B01D11/02 , B01D2009/0086 , C07C35/14 , C07C39/10 , C07C67/48 , C07C67/56 , C07C69/732
摘要： The present invention provides a method for the preparation of pharmaceutically acceptable chlorogenic acid, which comprises the following steps: a. Treating the sample aqueous solution; b. Freezing; c. Thawing and filtering; d. Treating the residue organic phase; e. Concentrating and crystallizing; f. Choosing the number of times to repeat steps a∼e according to the variability of chlorogenic acid content in samples; g. Drying. If the chlorogenic acid extract is isolated and purified using this method, water-soluble impurities and liposoluble impurities can be well removed, that allows the impurity content of final products has fulfilled the requirements for medicine; meanwhile, the procedures of this method are simple, and organic solvents can be recycled for further use, with low cost. This method can be applied for the further isolation and purification of chlorogenic acid extract obtained by various ways, especially for the preparation of pharmaceutically acceptable chlorogenic acid.
摘要翻译：本发明提供了制备药学上可接受的绿原酸的方法，其包括以下步骤：a。处理样品水溶液; 湾冷冻; C。解冻和过滤; d。处理残余有机相; 即浓缩和结晶; F。根据样品中绿原酸含量的变化选择重复步骤a〜e的次数; G。烘干。如果使用该方法分离并纯化绿原酸提取物，则可以很好地去除水溶性杂质和脂溶性杂质，这使得最终产物的杂质含量已经满足了药物的要求; 同时该方法操作简单，有机溶剂可循环使用，成本低廉。该方法可用于通过各种途径进一步分离纯化绿原酸提取物，特别是制备药学上可接受的绿原酸。

10. 发明公开

EP3224234A1 PROCESS FOR PREPARING ESTERS OF LACTIC ACID, AND 2-HYDROXY-3-BUTENOIC ACID OR ALFA-HYDROXY METHIONINE ANALOGUES FROM SUGARS 有权
标题翻译：从乳糖制备乳酸酯和2-羟基-3-丁烯酸或α-卤代羟基蛋氨酸类似物的方法
公开(公告)号：EP3224234A1
公开(公告)日：2017-10-04
申请号：EP15793830.9
申请日：2015-11-12
申请人： Haldor Topsøe A/S
发明人： SADABA ZUBIRI, Irantzu , TAARNING, Esben
IPC分类号： C07C67/44 , C07C67/475 , C07C69/732 , C07C69/68 , C07C319/18
CPC分类号： C07C319/18 , C07C67/00 , C07C67/44 , C07C67/475 , C07C69/68 , C07C69/732 , C07C323/58
摘要： A continuous flow process for the preparation of one or more esters of lactic acid and 2-hydroxy-3-butenoic acid or ±-hydroxy methionine analogues from a sugar in the presence of a solid Lewis acid catalyst and a solvent comprising an organic solvent and water. The invention provides a means for stabilizing a Lewis acid catalyst for use in a continuous reaction process wherein the water is present in an amount of up to or equal to 10 vol. % of the organic solvent.
摘要翻译：在固体路易斯酸催化剂和包含有机溶剂的溶剂存在下由糖制备一种或多种乳酸和2-羟基-3-丁烯酸或α-羟基甲硫氨酸类似物的酯的连续流动方法和水。本发明提供了一种稳定路易斯酸催化剂的方法，用于连续反应过程中，其中水的存在量为至多或等于10体积％％的有机溶剂。

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