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1. 发明公开

EP3224237A4 NECROSIS INHIBITORS 审中-公开
公开(公告)号：EP3224237A4
公开(公告)日：2018-02-07
申请号：EP15871953
申请日：2015-12-23
申请人： NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING
发明人： ZHANG ZHIYUAN , WANG XIAODONG , LEI XIAOGUANG , SU YANING , HE SUDAN , RUAN HANYING , SUN LIMING
IPC分类号： C07C233/05 , A61K31/16 , A61P31/00 , C07C235/06 , C07C275/06 , C07C311/03 , C07D213/06 , C07D215/12 , C07D233/64 , C07D277/20 , C07D333/06
CPC分类号： A61K31/165 , A61K31/10 , C07C25/02 , C07C25/13 , C07C233/01 , C07C233/05 , C07C233/13 , C07C233/18 , C07C233/47 , C07C233/59 , C07C235/10 , C07C237/06 , C07C237/22 , C07C255/60 , C07C259/06 , C07C275/24 , C07C311/14 , C07C313/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/74 , C07D211/28 , C07D213/40 , C07D213/61 , C07D213/64 , C07D217/14 , C07D231/12 , C07D277/28 , C07D307/14 , C07D307/52 , C07D333/20
摘要： The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

2. 发明授权

EP2036882B1 Zwitterionische Verbindungen und deren Verwendung 有权转让
标题翻译：两性离子化合物及其使用
公开(公告)号：EP2036882B1
公开(公告)日：2014-09-03
申请号：EP08158822.0
申请日：2008-06-24
申请人： Evonik Degussa GmbH
发明人： Herrwerth, Sascha, Dr. , Wenk, Hans, Henning, Dr. , Grüning, Burghard, Dr. , Allef, Petra, Dr. , Begoihn, Uwe
IPC分类号： C07C233/36 , C07C235/10 , C07C271/02 , A61K31/205 , A61K31/164 , A61P17/00
CPC分类号： C07C235/10 , C07C233/36 , C07C271/02

3. 发明公开

EP2629889A2 NOVEL RUTHENIUM COMPLEXES AND THEIR USES IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND DERIVATIVES THEREOF 有权
标题翻译：新钌和它们在程序对教育和/或加氢酯，酰胺及其衍生物的
公开(公告)号：EP2629889A2
公开(公告)日：2013-08-28
申请号：EP11788587.1
申请日：2011-10-11
申请人： Yeda Research and Development Co. Ltd.
发明人： MILSTEIN, David , BALARAMAN, Ekambaram , GUNANATHAN, Chidambaram , GNANAPRAKASAM, Boopathy , ZHANG, Jing
IPC分类号： B01J31/18
CPC分类号： C07K5/12 , B01J31/18 , B01J31/189 , B01J31/2404 , B01J31/2409 , B01J31/248 , B01J31/2485 , B01J2231/40 , B01J2231/49 , B01J2231/643 , B01J2231/763 , B01J2531/0244 , B01J2531/821 , C07B41/02 , C07B41/08 , C07B41/12 , C07B43/04 , C07B43/06 , C07C29/136 , C07C29/149 , C07C29/177 , C07C41/16 , C07C41/26 , C07C45/002 , C07C45/006 , C07C51/00 , C07C51/02 , C07C51/23 , C07C51/295 , C07C67/00 , C07C67/03 , C07C67/297 , C07C209/00 , C07C209/62 , C07C213/00 , C07C213/02 , C07C231/02 , C07C231/10 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07D207/06 , C07D207/08 , C07D211/12 , C07D213/38 , C07D241/08 , C07D241/12 , C07D295/023 , C07D295/027 , C07D295/185 , C07D305/06 , C07D307/14 , C07D307/33 , C07D307/44 , C07D307/52 , C07D307/83 , C07D309/30 , C07D487/14 , C07F9/58 , C07F9/65583 , C07F15/0046 , C07F15/0053 , C07K1/00 , C08G69/00 , Y02P20/52 , C07C233/05 , C07C235/06 , C07C233/07 , C07C235/16 , C07C235/14 , C07C235/10 , C07C211/27 , C07C211/07 , C07C211/35 , C07C211/46 , C07C211/10 , C07C215/28 , C07C217/58 , C07C69/14 , C07C69/24 , C07C31/125 , C07C31/12 , C07C49/78 , C07C49/04 , C07C49/10 , C07C49/08 , C07C49/403 , C07C31/205 , C07C31/202 , C07C31/04 , C07C31/08 , C07C33/20 , C07C33/22 , C07C31/1355 , C07C31/10 , C07C43/13 , C07C69/78 , C07C69/75 , C07C53/124 , C07C53/126 , C07C59/125 , C07C57/32 , C07C61/08 , C07C57/30 , C07C65/21 , C07C63/08 , C07C63/06
摘要： The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water to form carboxylic acids; and (10) dehydrogenation of beta-amino alcohols to form pyrazines. The present invention further relates to the novel uses of certain pyridine Ruthenium catalysts.
摘要翻译：本发明涉及新的钌络合物和相关的硼氢化物，及对（1）酰胺（包括聚酰胺），以醇和cardamines的氢化使用; （2）制备的酰胺从醇与cardamines（包括通过使二元醇与二胺或由氨基醇的聚合制备聚酰胺（例如，多肽））; （3）酯的氢化，以醇（包括环状酯的氢化（内酯），环状二酯（二 - 内酯）或聚酯）; （4）的有机碳酸酯（包括聚碳酸酯）醇类和氨基甲酸酯类（包括聚氨基甲酸酯）或尿素衍生物为醇和cardamines的加氢; （5）的醇脱氢以酯的耦合; （6）仲醇到酮的加氢; （7）酯的酰胺化（从酯和cardamines酰胺的合成）; （8）使用酯醇的酰化; （9）与水的醇的偶联以形成羧酸; 和（10）的β-氨基醇的脱氢以形成吡嗪。本发明还涉及某些吡啶钌配合物的新颖用途。

4. 发明授权

EP2280933B1 2 -AMINOTETRALIN DERIVATIVES AS MU OPIOID RECEPTOR ANTAGONISTS 有权
标题翻译： 2-AMINOTETRALINDERIVATE ALS ANTAGONISTEN DES MU-OPIOID-REZEPTORS
公开(公告)号：EP2280933B1
公开(公告)日：2013-07-24
申请号：EP09727561.4
申请日：2009-03-31
申请人： Theravance, Inc.
发明人： TRAPP, Sean, G. , LEADBETTER, Michael, R. , LONG, Daniel, D. , JIANG, Lan , AXT, Sabine
IPC分类号： C07C233/36 , C07C233/78 , C07C235/10 , C07C237/48 , C07C255/24 , C07C275/24 , C07C275/34 , C07C311/14 , C07D307/68 , C07D333/38 , A61P1/00 , A61P25/04 , A61K31/16 , A61K31/13 , C07C335/16
CPC分类号： C07C237/48 , C07C233/36 , C07C233/37 , C07C233/40 , C07C233/62 , C07C233/78 , C07C235/10 , C07C255/24 , C07C275/14 , C07C275/18 , C07C275/24 , C07C275/28 , C07C275/30 , C07C275/34 , C07C311/05 , C07C311/14 , C07C311/16 , C07C311/18 , C07C311/46 , C07C317/44 , C07C335/08 , C07C335/12 , C07C335/16 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D203/02 , C07D203/26

5. 发明公开

EP2526084A1 SALICYLATE FATTY ACID DERIVATIVES 审中-公开
标题翻译：水杨酸脂肪酸衍生物
公开(公告)号：EP2526084A1
公开(公告)日：2012-11-28
申请号：EP11734428.3
申请日：2011-01-20
申请人： Pronova BioPharma Norge AS
发明人： HOVLAND, Ragnar , SKJÆRET, Tore , ROSMAN, Jenny
IPC分类号： C07C233/49 , A61K31/166 , A61K31/167 , A61K31/194 , A61P3/00 , A61P29/00 , C07C65/19 , C07C233/55 , C07C233/64 , C07C321/20
CPC分类号： C07C323/60 , C07C59/60 , C07C69/734 , C07C235/08 , C07C235/10 , C07C235/12 , C07C235/16 , C07C235/60 , C07C237/22 , C07C265/04 , C07C271/16 , C07C271/20 , C07C271/28 , C07C275/42 , C07C323/52
摘要： Fatty acid conjugates of salicylate derivatives and compositions thereof are disclosed. Further disclosed are methods for treating and/or preventing an inflammatory disease including inflammation and/or inflammatory bowel disease (IBD), dyslipidemia including mixed dyslipidemia and/or hypertriglyceridemia, elevated blood lipids including, e.g., triglycerides and/or cholesterol, metabolic syndrome, peripheral insulin resistance, diabetes, atherosclerosis; a method for lowering non-HDL cholesterol; and a method for raising HDL-cholesterol comprising the administration of an effective amount of at least one compound according to the present disclosure.

6. 发明公开

EP2149539A1 BORON ADSORBENT UTILIZING SUGAR AMIDE DERIVATIVE, AND BORON REMOVAL METHOD 审中-公开
标题翻译：利用糖酰胺衍生物的硼吸附剂及硼去除方法
公开(公告)号：EP2149539A1
公开(公告)日：2010-02-03
申请号：EP08764428.2
申请日：2008-05-21
申请人： Kowa Company. Ltd.
发明人： YABUSAKI, Katsumi
IPC分类号： C02F1/28 , B01J20/22 , C07C235/06 , C07C235/74
CPC分类号： C07C235/06 , B01J20/22 , C02F1/001 , C02F1/285 , C02F1/66 , C02F2101/108 , C02F2103/16 , C02F2209/06 , C02F2305/04 , C07C235/10 , C07C305/04 , Y10S210/902
摘要： Disclosed is a boron adsorbent having an excellent adsorbing ability against boron contained in a solution, which is inexpensive and has haigh general versatility. Also disclosed is a boron removal method which can remove boron efficiently in a simple manner. An amide derivative represented by the general formula (1) is added to a boron-containing water under alkaline conditions to cause the adsorption of boron to the amide derivative. Then, a cation source having two or more valencies is added to the water to cause the aggregation of the amide body. The aggregated amide body is removed from the water. In the general formula (1), m represens 1 or 2; X represents -CH 2 OH, -CHO or -COOH; n represents an integer of 2 to 5; X are independent from each other and n are independent from each other when m represents 2; and Y represents a monovalent hydrocarbon group having 6 to 16 carbon atoms when m is 1, and represents a divalent hydrocarbon group having 8 to 18 carbon atoms when m is 2.
摘要翻译：本发明公开了一种对溶液中所含的硼具有优异的吸附能力的硼吸附剂，其价格便宜且通用性高。还公开了能够以简单的方式有效地去除硼的硼去除方法。在碱性条件下将通式（1）表示的酰胺衍生物加到含硼水中，使硼吸附到酰胺衍生物上。然后，将具有两个或更多化合价的阳离子源添加到水中以引起酰胺体的聚集。聚集的酰胺体从水中去除。在通式（1）中，m表示1或2; X代表-CH 2 OH，-CHO或-COOH; n表示2至5的整数; X彼此独立，当m代表2时，n彼此独立; Y表示m为1时的碳原子数为6〜16的一价烃基，m为2时表示碳原子数为8〜18的二价烃基。

7. 发明授权

EP1670849B1 ASPARTATE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 有权
标题翻译： ASPARTATDERIVATE及其制造方法
公开(公告)号：EP1670849B1
公开(公告)日：2009-03-25
申请号：EP04789122.1
申请日：2004-09-27
申请人： Bayer MaterialScience LLC
发明人： ROESLER, Richard, R. , WICKS, Douglas, A. , WAYT, Terrell, Dean , LONG, Brian , DANIELMEIER, Karsten , GAMBINO, Charles, A.
IPC分类号： C08G69/02 , C07C233/00 , C07C269/04 , C07C271/00
CPC分类号： C07C235/10 , C07C271/20 , C07C271/24 , C07C2601/14 , C08G18/3821 , C08G18/792 , C09D175/02
摘要： The present invention relates to novel aspartates, their method of production and the use of these mono and polyaspartates as reactive components for polyisocyanates in two-component polyurethane coating compositions and for preparing polyurethane prepolymers.

9. 发明授权

EP1091928B1 NOUVEAUX PSEUDODIPEPTIDES ACYLES, LEUR MODE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES EN RENFERMANT 有权
标题翻译： NEW酰化pseudodipeptides，用于生产和含有药物组合物
公开(公告)号：EP1091928B1
公开(公告)日：2007-02-28
申请号：EP99957636.6
申请日：1999-06-23
申请人： OM Pharma
发明人： BAUER, Jacques , MARTIN, Olivier, Richard
IPC分类号： C07C237/00 , C07F9/09 , A61K31/66 , A61P37/02
CPC分类号： C07C237/22 , C07C235/10 , C07F9/091 , C07K5/02 , C07K5/06191
摘要： The invention concerns the field of chemistry and more particularly of therapeutic chemistry. It concerns N-acyl pseudodipeptides corresponding to general formula (I) wherein the substituents A, B, X, Y, R1, R2, n, m, p and q are as defined in the claims. The invention also concerns pharmaceutical compositions containing as active principle at least one compound of general formula (I) in acid form or salified by a mineral or organic base. Said compounds have interesting pharmacological properties which make them useful as medicines.

10. 发明公开

EP1642887A1 Quaternisierte Fettsäureamidoamine 审中-公开
标题翻译： QuaternisierteFettsäureamidoamine
公开(公告)号：EP1642887A1
公开(公告)日：2006-04-05
申请号：EP04022273.9
申请日：2004-09-18
申请人： Cognis IP Management GmbH
发明人： Bigorra Llosas, Joaquin, Dr. , Bonastre Gilabert, Nuria, Dr. , Sanchez, Agustin
IPC分类号： C07C235/10 , C11D1/62
CPC分类号： C07C235/10 , C11D1/62 , C11D3/0073
摘要： Vorgeschlagen werden kationische Tenside der Formel (I)

in der R für einen Alkyl- oder Alkenylrest mit 11 Kohlenstoffatomen, R 1 und R 2 für Wasserstoff oder Alkylreste mit 1 bis 4 Kohlenstoffatomen, R 3 für einen Alkylrest mit 1 bis 4 Kohlenstoffatomen, R 4 für Wasserstoff oder eine Methylgruppe, A für eine lineare oder verzweigte Alkylengruppe mit 2 bis 6 Kohlenstoffatomen, n für Zahlen von 1 bis 25 und X für Halogen oder Alkylsulfat steht.
摘要翻译：阳离子表面活性剂（I）是新的。式（[R-CH（O（CH 2 CHR 4 O）n H）（CH 2）5 -CO-NH-AN +>（R 1>）（R 3）-R 2>的阳离子表面活性剂（I） ] X - >）是新的。 R 11 C烷基或11 C烯基; R 1>，R 2> H或1-4C烷基; R 3> 1-4C烷基; R 4> H或甲基; A：2-6C烷基; n：1-25; 和X：卤素或烷基硫酸盐。还包括编制（I）的独立索赔。

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