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1. 发明授权

US5486698A Thermal imaging system with integrated thermal chopper 失效
标题翻译：具有集成热切割机的热成像系统
公开(公告)号：US5486698A
公开(公告)日：1996-01-23
申请号：US229497
申请日：1994-04-19
申请人： Charles M. Hanson , Dana Dudley , James E. Robinson
发明人： Charles M. Hanson , Dana Dudley , James E. Robinson
IPC分类号： G01J5/10 , H04N5/33
CPC分类号： G01J5/02 , G01J5/0245 , G01J5/10 , H04N5/33
摘要： A thermal imaging system (10) contains a focal plane array (14) including a plurality of thermal sensors (50) mounted on a substrate (52). The focal plane array (14) generates both a reference signal which represents the temperature of the substrate (52) and a biased signal corresponding to the total radiance emitted by a scene (11). Electronics (16) process the reference signal and the biased signal to obtain an unbiased signal representing radiance differences emitted by objects in the scene (11). A thermoelectric cooler/heater (38) may be provided to optimally adjust the temperature of the substrate (52) to improve overall image quality. Each thermal sensor (50) contains an electrode (66 and 68) that electrically couples the thermal sensor (50) to the substrate (52) and also allows the thermal sensor (50) to deflect, contact, and thermally shunt with the substrate (52).
摘要翻译：热成像系统（10）包含焦平面阵列（14），其包括安装在基底（52）上的多个热传感器（50）。焦平面阵列（14）产生表示衬底（52）的温度的参考信号和对应于由场景（11）发射的总辐射度的偏置信号。电子设备（16）处理参考信号和偏置信号以获得表示场景（11）中物体发射的辐射差的无偏信号。可以提供热电冷却器/加热器（38）以最佳地调节基板（52）的温度以提高整体图像质量。每个热传感器（50）包含一个将热传感器（50）电耦合到衬底（52）的电极（66和68），并且还允许热传感器（50）偏转，接触并与衬底热分流 52）。

2. 发明授权

US4242706A Visible light and near infrared imaging device 失效
标题翻译：可见光和近红外成像装置
公开(公告)号：US4242706A
公开(公告)日：1980-12-30
申请号：US960496
申请日：1978-11-13
申请人： Kent McCormack , James E. Robinson , William M. Knight, Jr. , Dana Dudley
发明人： Kent McCormack , James E. Robinson , William M. Knight, Jr. , Dana Dudley
IPC分类号： H01L27/146 , H04N5/335 , H04N3/14
CPC分类号： H04N5/335 , H01L27/14649 , H04N3/1512
摘要： A visible light and near infrared imaging device is disclosed. The imaging device comprises X-Y addressing means, an array of opto-electronic semiconductor elements or cells, a multiplexer, a precharge switch, and an amplifier. The X-Y addressing means selectively addresses each cell of the array of opto-electronic semiconductor cells and corresponding multiplexer switch for connecting a reference voltage to each cell to charge each element to the reference voltage, then to isolate each element and vary its voltage in proportion to the intensity of the impinging light, and finally to read out selectively the voltage of each element to the amplifier for amplifying the electrical signals representative of the light intensity to a working level for processing into video signals.
摘要翻译：公开了可见光和近红外成像装置。成像装置包括X-Y寻址装置，光电子半导体元件或电池阵列，多路复用器，预充电开关和放大器。 XY寻址装置选择性地寻址光电子半导体单元阵列的每个单元和对应的多路复用器开关，用于将参考电压连接到每个单元，以将每个元件充电到参考电压，然后隔离每个元件并将其电压按比例变化入射光的强度，最后将每个元件的电压选择性地读出到放大器，用于将表示光强度的电信号放大到工作电平，以便处理成视频信号。

3. 发明授权

US5604977A Method of fabricating focal plane array 失效
标题翻译：焦平面阵列的制作方法
公开(公告)号：US5604977A
公开(公告)日：1997-02-25
申请号：US478570
申请日：1995-06-07
申请人： James E. Robinson , James F. Belcher , Howard R. Beratan , Steven N. Frank , Charles M. Hanson , Paul O. Johnson , Robert J. S. Kyle , Edward G. Meissner , Robert A. Owen , Gail D. Shelton , William K. Walker
发明人： James E. Robinson , James F. Belcher , Howard R. Beratan , Steven N. Frank , Charles M. Hanson , Paul O. Johnson , Robert J. S. Kyle , Edward G. Meissner , Robert A. Owen , Gail D. Shelton , William K. Walker
IPC分类号： G01J1/02 , G01J5/34 , G01J5/48 , H01L37/02 , H04N5/33 , H01R43/00
CPC分类号： G01J5/34 , H01L37/02 , Y10T29/49117 , Y10T29/49126 , Y10T29/49144
摘要： A thermal detection system (10) includes a focal plane array (12), a thermal isolation structure (14), and an integrated circuit substrate (16). Focal plane array (12) includes thermal sensors (28), each having an associated thermal sensitive element (30). Thermal sensitive element (30) is coupled with one side to infrared absorber and common electrode assembly (36) and on the opposite side to an associated contact pad (20) disposed on the integrated circuit substrate (16). Reticulation kerfs (52a, 52b) separate adjacent thermal sensitive elements (30a, 30b, 30c) by a distance at least half the average width (44, 46) of a single thermal sensitive element (30a, 30b, 30c). A continuous, non-reticulated optical coating (38) may be disposed over thermal sensitive elements (30a, 30b, 30c) to maximize absorption of thermal radiation incident to focal plane array (12).
摘要翻译：热检测系统（10）包括焦平面阵列（12），热隔离结构（14）和集成电路基板（16）。焦平面阵列（12）包括热传感器（28），每个具有相关联的热敏元件（30）。热敏元件（30）与一侧耦合到红外线吸收器和公共电极组件（36），并且与设置在集成电路衬底（16）上的相关接触焊盘（20）的相对侧耦合。相邻的热敏元件（30a，30b，30c）与单个热敏元件（30a，30b，30c）的平均宽度（44,46）的至少一半的距离分开。可以在热敏元件（30a，30b，30c）上设置连续的非网状光学涂层（38），以最大程度地吸收入射到焦平面阵列（12）的热辐射。

4. 发明授权

US5457318A Thermal detector apparatus and method using reduced thermal capacity 失效
标题翻译：热检测装置和使用降低热容量的方法
公开(公告)号：US5457318A
公开(公告)日：1995-10-10
申请号：US235413
申请日：1994-04-29
申请人： James E. Robinson , James F. Belcher , Howard R. Beratan , Steven N. Frank , Charles M. Hanson , Paul O. Johnson , Robert J. S. Kyle , Edward G. Meissner , Robert A. Owen , Gail D. Shelton , William K. Walker
发明人： James E. Robinson , James F. Belcher , Howard R. Beratan , Steven N. Frank , Charles M. Hanson , Paul O. Johnson , Robert J. S. Kyle , Edward G. Meissner , Robert A. Owen , Gail D. Shelton , William K. Walker
IPC分类号： G01J1/02 , G01J5/34 , G01J5/48 , H01L37/02 , H04N5/33 , G01J5/06
CPC分类号： G01J5/34 , H01L37/02 , Y10T29/49117 , Y10T29/49126 , Y10T29/49144
摘要： A thermal detection system (10) includes a focal plane array (12), a thermal isolation structure (14), and an integrated circuit substrate (16). Focal plane array (12) includes thermal sensors (28), each having an associated thermal sensitive element (30). Thermal sensitive element (30) is coupled with one side to infrared absorber and common electrode assembly (36) and on the opposite side to an associated contact pad (20) disposed on the integrated circuit substrate (16). Reticulation kerfs (52a, 52b) separate adjacent thermal sensitive elements (30a, 30b, 30c) by a distance at least half the average width (44, 46) of a single thermal sensitive element (30a, 30b, 30c). A continuous, non-reticulated optical coating (38) may be disposed over thermal sensitive elements (30a, 30b, 30c) to maximize absorption of thermal radiation incident to focal plane array (12).
摘要翻译：热检测系统（10）包括焦平面阵列（12），热隔离结构（14）和集成电路基板（16）。焦平面阵列（12）包括热传感器（28），每个具有相关联的热敏元件（30）。热敏元件（30）与一侧耦合到红外线吸收器和公共电极组件（36），并且与设置在集成电路衬底（16）上的相关接触焊盘（20）的相对侧耦合。相邻的热敏元件（30a，30b，30c）与单个热敏元件（30a，30b，30c）的平均宽度（44,46）的至少一半的距离分开。可以在热敏元件（30a，30b，30c）上设置连续的非网状光学涂层（38），以最大程度地吸收入射到焦平面阵列（12）的热辐射。

5. 发明授权

US4376623A Extruder with temperature control 失效
标题翻译：具有温度控制的挤出机
公开(公告)号：US4376623A
公开(公告)日：1983-03-15
申请号：US309460
申请日：1981-10-08
申请人： James E. Robinson , Eric I. Siwko
发明人： James E. Robinson , Eric I. Siwko
IPC分类号： B29C48/92 , B29B1/06
CPC分类号： B29C47/92 , B29C2947/92209 , B29C2947/92704 , B29C2947/92895 , B29C47/0009
摘要： A plastic material extruder having a barrel and an outer sheath with heating and cooling means in the outer sheath is disclosed, together with means for maintaining the temperature of the inner barrel, including two temperature sensing devices, one on the barrel and one on the other sheath, the sensing devices connected to control circuitry which actuates the heating and cooling means to maintain a temperature gradient between the two sensors by sensing the temperature change from the barrel and adjusting the set point of the sensing device on the sheath.
摘要翻译：公开了一种具有筒体和具有加热和冷却装置的外护套的塑料材料挤出机，其在外护套中具有用于保持内筒温度的装置，包括两个温度感测装置，一个在筒上，另一个在另一个上护套，连接到控制电路的感测装置，其致动加热和冷却装置，以通过感测来自筒的温度变化并调节护套上的感测装置的设定点来维持两个传感器之间的温度梯度。

6. 发明授权

US06190871B1 Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type I (HIV-1) gp120 and methods of use 失效
标题翻译：与人类免疫缺陷病毒I型（HIV-1）gp120的保守表位反应的免疫反应物及其使用方法
公开(公告)号：US06190871B1
公开(公告)日：2001-02-20
申请号：US09267941
申请日：1999-03-11
申请人： David D. Ho , James E. Robinson
发明人： David D. Ho , James E. Robinson
IPC分类号： G01N3353
CPC分类号： C07K14/70514 , A61K38/00 , C07K16/1063 , C07K16/462 , C07K2317/24 , C07K2317/732
摘要： The invention features immunoreagents which neutralize the Human Immunodeficiency Virus Type 1 (HIV-1) by binding to a novel conserved epitope of the HIV-1 gp120. These immunoreagents exhibit a broad neutralizing effect upon HIV attachment to host cells, and are therefore useful in the detection, prevention, amelioration and treatment of HIV disease, primarily AIDS (Acquired Immunodeficiency Syndrome) and ARC (AIDS Related Complex). More particularly, the invention relates to novel human monoclonal antibodies selectively reactive to a conserved conformation dependent determinant of the HIV-1 gp120, derivatives thereof, cell lines that produce these antibodies, and the use of the monoclonal antibodies and their derivatives for the detection, prevention, amelioration and treatment of HIV related disease.
摘要翻译：本发明的特征在于通过与HIV-1 gp120的新型保守表位结合而中和人类免疫缺陷病毒1型（HIV-1）的免疫反应物。这些免疫反应物对HIV附着于宿主细胞表现出广泛的中和作用，因此可用于检测，预防，改善和治疗HIV疾病，主要是AIDS（获得性免疫缺陷综合征）和ARC（AIDS相关综合征）。更具体地说，本发明涉及与HIV-1 gp120的保守构象依赖性决定簇，其衍生物，产生这些抗体的细胞系选择性反应的新型人单克隆抗体，以及使用单克隆抗体及其衍生物进行检测，预防，改善和治疗艾滋病相关疾病。

7. 发明授权

US6054284A Immunoreagents reactive with a conserved epitope of human immunodeficiency virus type I (HIV-1) GP120 and methods of use 失效
标题翻译：与人类免疫缺陷病毒I型（HIV-1）GP120的保守表位反应的免疫反应物及其使用方法
公开(公告)号：US6054284A
公开(公告)日：2000-04-25
申请号：US870531
申请日：1997-06-06
申请人： David D. Ho , James E. Robinson
发明人： David D. Ho , James E. Robinson
IPC分类号： A61K39/395 , A61K38/00 , C07K14/155 , C07K14/705 , C07K14/73 , C07K16/00 , C07K16/08 , C07K16/10 , C07K16/46 , C07K19/00 , C12N5/10 , C12N5/22 , C12N15/09 , C12P21/08 , C12Q1/70 , C12R1/91 , G01N33/53 , G01N33/569 , G01N33/537 , G01N33/543 , G01N33/567
CPC分类号： C07K14/70514 , C07K16/1063 , C07K16/462 , A61K38/00 , C07K2317/24 , C07K2317/732
摘要： The invention features immunoreagents which neutralize the Human Immunodeficiency Virus Type 1 (HIV-1) by binding to a novel conserved epitope of the HIV-1 gp120. These immunoreagents exhibit a broad neutralizing effect upon HIV attachment to host cells, and are therefore useful in the detection, pervention of HIV disease, primarily AIDS (Acquired Immunodeficiency Syndrome) and ARC (AIDS Related Complex). More particularly, the invention relates to novel human monoclonal antibodies selectively reactive to a conserved conformation dependent determinant of the HIV-1 gp120, derivatives thereof, cell lines that produce these antibodies, and the use of the monoclonal antibodies and their derivatives for the detection, prevention, amelioration and treatment of HIV related disease.
摘要翻译：本发明的特征在于通过与HIV-1 gp120的新型保守表位结合而中和人类免疫缺陷病毒1型（HIV-1）的免疫反应物。这些免疫反应物对HIV附着于宿主细胞表现出广泛的中和作用，因此可用于检测，预防艾滋病病毒，主要是艾滋病（获得性免疫缺陷综合征）和ARC（艾滋病相关复合物）。更具体地说，本发明涉及与HIV-1 gp120的保守构象依赖性决定簇，其衍生物，产生这些抗体的细胞系选择性反应的新型人单克隆抗体，以及使用单克隆抗体及其衍生物进行检测，预防，改善和治疗艾滋病相关疾病。

8. 发明授权

US4308756A Vacuum sample introduction unit 失效
标题翻译：真空样品引入单元
公开(公告)号：US4308756A
公开(公告)日：1982-01-05
申请号：US162580
申请日：1980-06-23
申请人： James E. Robinson , Aniket Pant , Roger C. Legg
发明人： James E. Robinson , Aniket Pant , Roger C. Legg
IPC分类号： G01N1/00 , H01J37/18
CPC分类号： H01J37/18
摘要： A sample loading device for loading samples into and unloading samples from an ultra high vacuum analysis chamber without the necessity to raise and lower pressure each time a sample loading or unloading is effected, is described. The sample is initially positioned in a chamber of comparatively small volume which can be rapidly and simply evacuated to a vacuum approximating that of the analysis chamber. A gate valve between the small volume chamber and the analysis chamber then is opened and the sample introduced to the analysis chamber by a simple rack-and-pinion mechanism. Fine positioning of the sample and release of the carrier from the insertion fork is achieved by external X- and Y-axis adjustments.
摘要翻译：描述了用于将样品加载到超高真空分析室中并从其卸载样品的样品加载装置，而不需要在每次进行样品加载或卸载时升高和降低压力。样品最初定位在相对较小体积的室中，其可以快速且简单地抽真空至接近分析室的真空。然后打开小容积室和分析室之间的闸阀，并通过简单的齿条 - 齿轮机构将样品引入分析室。通过外部X轴和Y轴调整，可以精确定位样品和从插入叉释放载体。

9. 发明授权

US4252755A Co-extrusion method and apparatus 失效
标题翻译：共挤出方法和装置
公开(公告)号：US4252755A
公开(公告)日：1981-02-24
申请号：US40710
申请日：1979-05-21
申请人： James K. Normanton , James E. Robinson
发明人： James K. Normanton , James E. Robinson
IPC分类号： B29C44/22 , B29C47/00 , B29C47/06 , B29C47/62 , B29D27/00 , B29F3/10
CPC分类号： B29C47/128 , B29C44/22 , B29C47/62 , B29C47/00 , B29C47/0014 , B29C47/0016 , B29C47/0019 , B29C47/0021 , B29C47/0023
摘要： An extruder for simultaneously extruding two plastics materials without intermixing thereof prior to exiting the extruder. The extruder barrel has two feed hoppers at one end and an outlet at the opposite end and contains a rotatable screw with two spaced screw threads of the same handedness which form two helical channels, each fed from one of the hoppers. One channel extends from a hopper to the outlet and the other channel is blocked in advance of the outlet so that substantially all the material therein is forced to enter a passage in the screw which extends to the outlet. Also, a process for extruding the two plastics materials and for coating a wire with two layers with a die having a single material receiving channel.
摘要翻译：用于在离开挤出机之前同时挤出两种塑料材料而不混合的挤出机。挤出机筒体的一端具有两个进料漏斗和相对端的出口，并且包含具有相同螺旋度的两个间隔开的螺纹的可旋转螺杆，其形成两个螺旋通道，每个螺旋通道从一个料斗进料。一个通道从料斗延伸到出口，另一个通道在出口之前被阻挡，使得其中的基本上所有的材料被迫进入延伸到出口的螺钉中的通道。另外，挤出两种塑料材料并用具有单一材料接收通道的模具涂覆具有两层的导线的方法。

10. 发明授权

US08637234B2 Molecular scaffolds for HIV-1 epitopes 失效
标题翻译： HIV-1表位的分子支架
公开(公告)号：US08637234B2
公开(公告)日：2014-01-28
申请号：US11578761
申请日：2005-04-08
申请人： George M. Shaw , James E. Robinson , Frederic Bibollet-Ruche , Julie M. Decker , Beatrice H. Hahn , Peter D. Kwong
发明人： George M. Shaw , James E. Robinson , Frederic Bibollet-Ruche , Julie M. Decker , Beatrice H. Hahn , Peter D. Kwong
IPC分类号： C12Q1/70 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/38 , C07K16/00
CPC分类号： G01N33/56988 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C07K2317/34 , C07K2317/76 , G01N2469/20
摘要： Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The HIV-1 epitopes can be recognized by HIV-1 binding antibodies, HIV-1 neutralizing antibodies and/or CD4-induced antibodies. Thus, methods are provided for detecting HIV-1 binding antibodies in a subject infected with HTV-1. Further provided are methods to determine an epitope for an HIV-1 binding antibody; methods to assay for an HIV-1 binding antibody; methods to identify a soluble CD4 mimic; methods to neutralize an non-HIV-1 virus; diagnostic assays to monitor HIV disease in a subject or to monitor the subject's response to immunization by a HIV vaccine; and methods to alter the neutralization potential of an HIV-1 derived CD4-induced antibody. Chimeric polypeptides, chimeric polynucleotides, kits, cells and viruses are also provided.
摘要翻译：提供了使用来自不是HIV-1作为HIV-1表位的分子支架的慢病毒的包膜多肽或其功能变体的方法和组合物。 HIV-1表位可被HIV-1结合抗体，HIV-1中和抗体和/或CD4诱导的抗体识别。因此，提供了用于检测感染HTV-1的受试者中的HIV-1结合抗体的方法。还提供了确定HIV-1结合抗体的表位的方法; 测定HIV-1结合抗体的方法; 识别可溶性CD4模拟物的方法; 中和非HIV-1病毒的方法; 用于监测受试者中艾滋病病毒的诊断测定或监测受试者对HIV疫苗免疫接种的反应; 以及改变HIV-1衍生的CD4诱导抗体的中和电位的方法。还提供嵌合多肽，嵌合多核苷酸，试剂盒，细胞和病毒。

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