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    • 2. 发明授权
    • Molecular scaffolds for HIV-1 immunogens
    • HIV-1免疫原的分子支架
    • US08647818B2
    • 2014-02-11
    • US11816624
    • 2006-02-16
    • George M. ShawBeatrice H. HahnFrederic Bibollet-RuchePeter D. Kwong
    • George M. ShawBeatrice H. HahnFrederic Bibollet-RuchePeter D. Kwong
    • C12Q1/70A61K39/00A61K39/12A61K39/21A61K39/38C07K16/00
    • A61K39/21A61K39/12A61K39/385A61K2039/53A61K2039/6075A61K2039/64C07K14/005C07K2319/00C12N2740/15022C12N2740/16122C12N2740/16134
    • Methods and compositions are provided which employ chimeric polypeptides having at least one heterologous epitope for a human immunodeficiency virus type 1 (HIV-1) neutralizing antibody. These chimeric polypeptides behave as molecular scaffolds which are capable of presenting the various heterologous HIV-1 epitopes. The invention demonstrates that a heterologous epitope recognized by the HIV-1 neutralizing antibody can be more fully exposed to neutralizing antibodies when presented within the backbone of the chimeric polypeptide than when the epitope is presented within the context of an HIV-1 backbone. Polynucleotides encoding these chimeric polypeptides are also provided. Immunogenic compositions are provided which comprise a chimeric polypeptide having at least one heterologous epitope that interacts with an HIV-1 neutralizing antibody. Immuno genie compositions comprising chimeric polynucleotides encoding the chimeric polypeptides of the invention are also provided. Vaccines comprising such immunogenic compositions are also provided. Further provided are methods which employ the immunogenic compositions of the invention. Such methods include, for example, methods for eliciting an immune response in a subject, methods for generating antibodies specific for the chimeric polypeptide or the chimeric polypeptide, and methods for inhibiting or preventing infection by HIV-1 in a subject.
    • 提供了使用针对人免疫缺陷病毒1型(HIV-1)中和抗体具有至少一个异源表位的嵌合多肽的方法和组合物。 这些嵌合多肽表现为能够呈递各种异源HIV-1表位的分子支架。 本发明证明当HIV-1中和抗体在HIV-1主链的上下文中呈现时,HIV-1中和抗体识别的异源表位可以更好地暴露于中和抗体。 还提供了编码这些嵌合多肽的多核苷酸。 提供免疫原性组合物,其包含具有至少一种与HIV-1中和抗体相互作用的异源表位的嵌合多肽。 还提供了包含编码本发明的嵌合多肽的嵌合多核苷酸的免疫精华组合物。 还提供了包含这种免疫原性组合物的疫苗。 还提供了采用本发明的免疫原性组合物的方法。 这样的方法包括例如在受试者中引发免疫应答的方法,用于产生对嵌合多肽或嵌合多肽具有特异性的抗体的方法,以及用于抑制或预防受试者中HIV-1感染的方法。
    • 3. 发明申请
    • Molecular Scaffolds for HIV-1 Immunogens
    • HIV-1免疫原的分子支架
    • US20090162390A1
    • 2009-06-25
    • US11816624
    • 2006-02-16
    • George M. ShawBeatrice H. HahnFrederic Bibollet-RuchePeter D. Kwong
    • George M. ShawBeatrice H. HahnFrederic Bibollet-RuchePeter D. Kwong
    • A61K39/21A61K31/711C07K14/155C12N15/31A61P31/18
    • A61K39/21A61K39/12A61K39/385A61K2039/53A61K2039/6075A61K2039/64C07K14/005C07K2319/00C12N2740/15022C12N2740/16122C12N2740/16134
    • Methods and compositions are provided which employ chimeric polypeptides having at least one heterologous epitope for a human immunodeficiency virus type 1 (HIV-1) neutralizing antibody. These chimeric polypeptides behave as molecular scaffolds which are capable of presenting the various heterologous HIV-1 epitopes. The invention demonstrates that a heterologous epitope recognized by the HIV-1 neutralizing antibody can be more fully exposed to neutralizing antibodies when presented within the backbone of the chimeric polypeptide than when the epitope is presented within the context of an HIV-1 backbone. Polynucleotides encoding these chimeric polypeptides are also provided. Immunogenic compositions are provided which comprise a chimeric polypeptide having at least one heterologous epitope that interacts with an HIV-1 neutralizing antibody. Immuno genie compositions comprising chimeric polynucleotides encoding the chimeric polypeptides of the invention are also provided. Vaccines comprising such immunogenic compositions are also provided. Further provided are methods which employ the immunogenic compositions of the invention. Such methods include, for example, methods for eliciting an immune response in a subject, methods for generating antibodies specific for the chimeric polypeptide or the chimeric polypeptide, and methods for inhibiting or preventing infection by HIV-1 in a subject.
    • 提供了使用针对人免疫缺陷病毒1型(HIV-1)中和抗体具有至少一个异源表位的嵌合多肽的方法和组合物。 这些嵌合多肽表现为能够呈递各种异源HIV-1表位的分子支架。 本发明证明当HIV-1中和抗体在HIV-1主链的上下文中呈现时,HIV-1中和抗体识别的异源表位可以更好地暴露于中和抗体。 还提供了编码这些嵌合多肽的多核苷酸。 提供免疫原性组合物,其包含具有至少一种与HIV-1中和抗体相互作用的异源表位的嵌合多肽。 还提供了包含编码本发明的嵌合多肽的嵌合多核苷酸的免疫精华组合物。 还提供了包含这种免疫原性组合物的疫苗。 还提供了采用本发明的免疫原性组合物的方法。 这样的方法包括例如在受试者中引发免疫应答的方法,用于产生对嵌合多肽或嵌合多肽具有特异性的抗体的方法,以及用于抑制或预防受试者中HIV-1感染的方法。